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    Magnetic resonance imaging
    21.
    发明授权
    Magnetic resonance imaging 失效
    磁共振成像

    公开(公告)号：US06574496B1

    公开(公告)日：2003-06-03

    申请号：US09572949

    申请日：2000-05-18

    申请人： Klaes Golman ,  Oskar Axelsson ,  Haukur Johannesson

    发明人： Klaes Golman ,  Oskar Axelsson ,  Haukur Johannesson

    IPC分类号： A61B505

    CPC分类号： G01R33/5601 ,  G01R33/56308

    摘要： A method of magnetic resonance investigation of a sample by (i) reacting ortho-deuterium enriched hydrogen with a hydrogenatable MR imaging agent precursor to produce a hydrogenated (i.e. deuterated) MR imaging agent; (ii) optionally, subjecting the hydrogenated MR imaging agent to a low magnetic field;(iii) administering the hydrogenated MR imaging agent to the sample; (iv) exposing the sample to radiation of a frequency selected to excite nuclear spin transitions of selected non-zero nuclear spin nuclei in said hydrogenated MR imaging agent; (v) detecting magnetic resonance signals of the selected non-zero nuclear spin nuclei from the sample; and (vi) optionally, generating an image or biological functional data or dynamic flow data from the detected signals.

    摘要翻译： 通过（i）使富氘氢与可氢化MR显像剂前体反应以产生氢化（即氘代）MR成像剂，对样品进行磁共振研究的方法; （ii）任选地，使氢化MR成像剂经受低磁场;（iii）向该样品施用氢化MR显像剂; （iv）将所述样品暴露于所选择的用于激发所述氢化MR成像剂中选定的非零核自旋核的核自旋跃迁的频率的辐射; （v）从所述样品检测所选择的非零核自旋核的磁共振信号; 和（vi）可选地，从检测到的信号生成图像或生物功能数据或动态流量数据。

    MULTI-FUNCTION BROADBAND PHASED-ARRAY SOFTWARE DEFINED SONAR SYSTEM AND METHOD
    22.
    发明申请
    MULTI-FUNCTION BROADBAND PHASED-ARRAY SOFTWARE DEFINED SONAR SYSTEM AND METHOD 有权
    多功能宽带相位阵列软件定义的SONAR系统和方法

    公开(公告)号：US20110202278A1

    公开(公告)日：2011-08-18

    申请号：US13026036

    申请日：2011-02-11

    申请人： Didier Caute ,  Oskar Axelsson ,  Karl Kenny

    发明人： Didier Caute ,  Oskar Axelsson ,  Karl Kenny

    IPC分类号： G01V1/04 ,  G06F19/00

    CPC分类号： G01V1/38 ,  G01S7/003 ,  G01S7/521 ,  G01S15/02

    摘要： A software defined platform is provided for subsea acoustic applications that utilizes a broadband phased array transducer and a configurable, multi-function software defined transducer that is configurable on the fly to enable various subsea acoustic systems to be achieved in a single unit thus reducing the space required on the vessel and the cost of having such multiple functions.

    摘要翻译： 为海底声学应用提供软件定义的平台，该平台利用宽带相控阵列换能器和可配置的多功能软件定义换能器，可在飞行中配置，以使单个单元能够实现各种海底声学系统，从而减少空间 船上需要和具有这种多功能的费用。

    CONTRAST AGENTS
    24.
    发明申请
    CONTRAST AGENTS 审中-公开
    对比剂

    公开(公告)号：US20100284936A1

    公开(公告)日：2010-11-11

    申请号：US11913095

    申请日：2006-05-19

    申请人： Oskar Axelsson ,  Kathrin Bjerknes

    发明人： Oskar Axelsson ,  Kathrin Bjerknes

    IPC分类号： A61K49/04 ,  B01J13/02

    CPC分类号： A61K49/0409

    摘要： The present invention relates to liposomes comprising particles with cores of tungsten or tungsten in mixture with other metallic elements as the contrast enhancing material and to the use of such pharmaceuticals, specifically as contrast agents in diagnostic imaging and in particular in X-ray imaging of liver tumours.

    摘要翻译： 本发明涉及包含具有与其它金属元素作为对比增强材料的钨或钨核心的颗粒的脂质体，以及这些药物的用途，特别是作为造影剂在诊断成像中，特别是在肝脏的X射线成像中 肿瘤。

    Methods and devices for polarized NMR samples
    27.
    发明申请
    Methods and devices for polarized NMR samples 审中-公开
    用于极化NMR样品的方法和装置

    公开(公告)号：US20060192559A1

    公开(公告)日：2006-08-31

    申请号：US11191140

    申请日：2005-07-28

    申请人： Jan Ardenkjaer-Larsen ,  Oskar Axelsson ,  Klaes Golman ,  Jan Wolber ,  Mark Howard

    发明人： Jan Ardenkjaer-Larsen ,  Oskar Axelsson ,  Klaes Golman ,  Jan Wolber ,  Mark Howard

    IPC分类号： G01V3/00

    CPC分类号： G01R33/307 ,  G01N1/44 ,  G01R33/282 ,  G01R33/62

    摘要： The present invention relates to devices and methods for melting a solid polarised sample while retaining a high level of polarisation. In an embodiment of the present invention a sample is polarised in a sample-retaining cup in a strong magnetic field in a polarising means in a cryostat and then melted inside the cryostat by melting means such as a laser connected by an optical fibre to the interior of the cryostat.

    摘要翻译： 本发明涉及用于熔化固体极化样品同时保持高水平偏振的装置和方法。 在本发明的一个实施例中，样品在低温恒温器中的偏振装置中的强磁场中的样品保持杯中极化，然后通过诸如通过光纤连接到内部的激光器的熔化装置在低温恒温器内熔化 的低温恒温器。

    Process for preparation of MR contrast agents
    28.
    发明授权
    Process for preparation of MR contrast agents 有权
    制备MR造影剂的方法

    公开(公告)号：US06872380B2

    公开(公告)日：2005-03-29

    申请号：US09990537

    申请日：2001-11-16

    申请人： Oskar Axelsson ,  Charlotte Olofsson ,  Axel Morgenstjerne ,  Georg Hansson ,  Haukur Johannesson ,  Jan-Henrik Ardenkjaer-Larsen

    发明人： Oskar Axelsson ,  Charlotte Olofsson ,  Axel Morgenstjerne ,  Georg Hansson ,  Haukur Johannesson ,  Jan-Henrik Ardenkjaer-Larsen

    IPC分类号： A61K49/00 ,  A61K49/18 ,  C07C67/303 ,  C07C69/675 ,  G01R33/28 ,  G01R33/483 ,  A61B5/055 ,  C07C69/02

    CPC分类号： A61K49/1815

    摘要： The present invention provides a process for the preparation of an MR contrast agent, said process comprising: i) obtaining a solution in a solvent of a hydrogenatable, unsaturated substrate compound and a catalyst for the hydrogenation of said substrate compound; ii) introducing said solution in droplet form into a chamber containing hydrogen gas (H2) enriched in para-hydrogen (p-1H2) and/or ortho-deuterium (o-2H2) whereby to hydrogenate said substrate to form a hydrogenated imaging agent; iii) optionally subjecting said hydrogenated imaging agent to a magnetic field having a field strength below earth's ambient field strength; iv) optionally dissolving said imaging agent in an aqueous medium; v) optionally separating said catalyst from the solution of said imaging agent in said aqueous medium; vi) optionally separating said solvent from the solution of said imaging agent in said aqueous medium; and vii) optionally freezing the solution of said imaging agent in said aqueous medium.

    摘要翻译： 本发明提供一种制备MR造影剂的方法，所述方法包括：i）获得在可氢化不饱和底物化合物的溶剂中的溶液和用于所述底物化合物氢化的催化剂; ii）将所述溶液 以液滴形式进入含有富氢对氢（对 - 氢）和/或邻 - 氘（o- 2 H 2）的氢气（H 2）和/或邻 - 氘（o- 2 H 2）的室中，由此氢化所述基底以形成氢化显像剂 iii）任选地使所述氢化显像剂经受场强低于地球环境场强的磁场; iv）任选地将所述成像剂溶解在水性介质中; v）任选地将所述催化剂与所述成像剂在所述 水性介质; vi）任选地将所述溶剂与所述显影剂的溶液在所述水性介质中分离; 和任选地将所述显像剂的溶液冷冻在所述水性介质中。

    Disubstituted morpholine, oxazepine or thiazepine derivatives, their preparation and their use as dopamine d4 receptor antagonists
    29.
    发明授权
    Disubstituted morpholine, oxazepine or thiazepine derivatives, their preparation and their use as dopamine d4 receptor antagonists 失效
    二取代的吗啉，氧氮杂或硫氮衍生物，其制备及其作为多巴胺d4受体拮抗剂的用途

    公开(公告)号：US06479491B1

    公开(公告)日：2002-11-12

    申请号：US09709297

    申请日：2000-11-13

    申请人： Oskar Axelsson ,  Dan Peters ,  Jorgen Scheel-Kruger ,  Elsebet Ostergaard Nielsen

    发明人： Oskar Axelsson ,  Dan Peters ,  Jorgen Scheel-Kruger ,  Elsebet Ostergaard Nielsen

    IPC分类号： A61K31535

    CPC分类号： C07D265/30 ,  C07D267/10 ,  C07D413/06

    摘要： The present invention relates to compounds of formula (I), any of it enantiomers, or any mixture thereof, or a pharmaceutically acceptable acid addition salt thereof, wherein R1, R2, R3, R4, R11, R12, R13, R14 and R15 each independently are hydrogen, alkyl, alkoxy, halogen, trifluoromethyl, nitro, cyano, amino, acyl, alkylamino, dialkylamino, aminocarbonyl, or acylamino; R5 is hydrogen, alkyl, alkoxyalkyl, or phenylalkyl; X is —CH2—Z—, Z—CH2—, NH—CO—, —CO—NH—, or —CH═CH—; wherein Z is O, S, CH2, or NH; Y is O, —CH2—W—, —W—CH2—; wherein W is O, or S; and n is 0, 1 or 2. The compounds are useful in the treatment of psychotic disorders.

    摘要翻译： 本发明涉及式（I）化合物，其任何对映异构体或其任何混合物或其药学上可接受的酸加成盐，其中R 1，R 2，R 3，R 4，R 11，R 12，R 13，R 14和R 15各自 氰基，氨基，酰基，烷基氨基，二烷基氨基，氨基羰基或酰氨基; R5是氢，烷基，烷氧基烷基或苯基烷基; X是-CH 2 -Z-，Z-CH 2 - ，NH-CO - ， - CO-NH-或-CH = CH-; 其中Z是O，S，CH 2或NH; Y是O，-CH 2 -W-，-W-CH 2 - ; 其中W是O或S; 并且n为0,1或2.该化合物可用于治疗精神病。