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21.发明申请Production Process for Methionine Using Microorganisms with Reduced Isocitrate Dehydrogenase Activity 审中-公开使用具有降低的异柠檬酸脱氢酶活性的微生物生产甲硫氨酸的方法公开(公告)号：US20110117614A1
公开(公告)日：2011-05-19
申请号：US12989772
申请日：2009-04-27
IPC分类号： C12P13/12
CPC分类号： C12P13/12
摘要： The present invention is directed to a method utilizing a microorganism with reduced isocitrate dehydrogenase activity for the production of methionine.
摘要翻译： 本发明涉及利用具有降低的异柠檬酸脱氢酶活性的微生物来生产甲硫氨酸的方法。
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公开(公告)号：US07968699B2
公开(公告)日：2011-06-28
申请号：US12048599
申请日：2008-03-14
摘要： The present invention relates to multiple promoters and to expression units comprising them; to the use thereof for regulating transcription and expression of genes; to expression cassettes which comprise multiple promoters or expression units of this kind; to vectors which comprise such expression cassettes; to genetically modified microorganisms which comprise vectors and/or expression units of this kind; and to processes for preparing biosynthetic products by culturing said genetically modified microorganisms.
摘要翻译： 本发明涉及多种启动子和包含它们的表达单元; 用于调节基因的转录和表达; 包括多种启动子或这种表达单位的表达盒; 包含这种表达盒的载体; 涉及包含这种载体和/或表达单元的转基因微生物; 以及通过培养所述转基因微生物来制备生物合成产物的方法。
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公开(公告)号：US20080274516A1
公开(公告)日：2008-11-06
申请号：US10583191
申请日：2004-12-16
CPC分类号： C12N15/77
摘要： The present invention relates to the use of nucleic acid sequences for regulating the transcription and expression of genes, the novel promoters and expression units themselves, methods for altering or causing the transcription rate and/or expression rate of genes, expression cassettes comprising the expression units, genetically modified microorganisms with altered or caused transcription rate and/or expression rate, and methods for preparing biosynthetic products by cultivating the genetically modified microorganisms.
摘要翻译： 本发明涉及核酸序列用于调节基因的转录和表达，新型启动子和表达单元本身的用途，用于改变或引起基因的转录速率和/或表达速率的方法，包含表达单位的表达盒 具有改变或引起的转录速率和/或表达速率的转基因微生物，以及通过培养转基因微生物来制备生物合成产物的方法。
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公开(公告)号：US20070269871A1
公开(公告)日：2007-11-22
申请号：US11632740
申请日：2005-07-16
摘要： The present invention relates to the use of nucleic acid sequences for regulating the transcription and expression of genes, the novel promoters and expression units themselves, methods for altering or causing the transcription rate and/or expression rate of genes, expression cassettes comprising the expression units, genetically modified microorganisms with altered or caused transcription rate and/or expression rate, and methods for preparing biosynthetic products by cultivating the genetically modified microorganisms.
摘要翻译： 本发明涉及核酸序列用于调节基因的转录和表达，新型启动子和表达单元本身的用途，用于改变或引起基因的转录速率和/或表达速率的方法，包含表达单位的表达盒 具有改变或引起的转录速率和/或表达速率的转基因微生物，以及通过培养转基因微生物来制备生物合成产物的方法。
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25.发明申请Gene variants coding for proteins from the metabolic pathway of fine chemicals 有权编码精细化学物质代谢途径蛋白质的基因变体公开(公告)号：US20070122887A1
公开(公告)日：2007-05-31
申请号：US10583404
申请日：2004-12-16
申请人： Corinna Klopprogge , Oskar Zelder , Burkhard Kroger , Hartwig Schroder , Stefan Haefner , Uwe Ruffer , Claudia Graef
发明人： Corinna Klopprogge , Oskar Zelder , Burkhard Kroger , Hartwig Schroder , Stefan Haefner , Uwe Ruffer , Claudia Graef
CPC分类号： C07K14/34
摘要： The present invention relates to mutated nucleic acids and proteins of the metabolic pathway of fine chemicals, to processes for preparing genetically modified producer organisms, to processes for preparing fine chemicals by culturing said genetically modified organisms and to said genetically modified organisms themselves.
摘要翻译： 本发明涉及精细化学品的代谢途径的突变核酸和蛋白质，制备经遗传修饰的生物体生物体的方法，通过培养所述转基因生物体和所述转基因生物本身来制备精细化学品的方法。
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公开(公告)号：US20090004705A1
公开(公告)日：2009-01-01
申请号：US12030575
申请日：2008-02-13
CPC分类号： C12N15/77
摘要： The present invention relates to the use of nucleic acid sequences for regulating the transcription and expression of genes, the novel promoters and expression units themselves, methods for altering or causing the transcription rate and/or expression rate of genes, expression cassettes comprising the expression units, genetically modified microorganisms with altered or caused transcription rate and/or expression rate, and methods for preparing biosynthetic products by cultivating the genetically modified microorganisms.
摘要翻译： 本发明涉及核酸序列用于调节基因的转录和表达，新型启动子和表达单元本身的用途，用于改变或引起基因的转录速率和/或表达速率的方法，包含表达单位的表达盒 具有改变或引起的转录速率和/或表达速率的转基因微生物，以及通过培养转基因微生物来制备生物合成产物的方法。
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公开(公告)号：US20080176295A1
公开(公告)日：2008-07-24
申请号：US12050146
申请日：2008-03-17
摘要： The present invention relates to the use of nucleic acid sequences for regulating the transcription and expression of genes, the novel promoters and expression units themselves, methods for altering or causing the transcription rate and/or expression rate of genes, expression cassettes comprising the expression units, genetically modified microorganisms with altered or caused transcription rate and/or expression rate, and methods for preparing biosynthetic products by cultivating the genetically modified microorganisms.
摘要翻译： 本发明涉及核酸序列用于调节基因的转录和表达，新型启动子和表达单元本身的用途，用于改变或引起基因的转录速率和/或表达速率的方法，包含表达单位的表达盒 具有改变或引起的转录速率和/或表达速率的转基因微生物，以及通过培养转基因微生物来制备生物合成产物的方法。
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公开(公告)号：US08044191B2
公开(公告)日：2011-10-25
申请号：US12038603
申请日：2008-02-27
摘要： The present invention relates to the use of nucleic acid sequences for regulating the transcription and expression of genes, the novel promoters and expression units themselves, methods for altering or causing the transcription rate and/or expression rate of genes, expression cassettes comprising the expression units, genetically modified microorganisms with altered or caused transcription rate and/or expression rate, and methods for preparing biosynthetic products by cultivating the genetically modified microorganisms.
摘要翻译： 本发明涉及核酸序列用于调节基因的转录和表达，新型启动子和表达单元本身的用途，用于改变或引起基因的转录速率和/或表达速率的方法，包含表达单位的表达盒 具有改变或引起的转录速率和/或表达速率的转基因微生物，以及通过培养转基因微生物来制备生物合成产物的方法。
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公开(公告)号：US08071365B2
公开(公告)日：2011-12-06
申请号：US12030575
申请日：2008-02-13
CPC分类号： C12N15/77
摘要： The present invention relates to the use of nucleic acid sequences for regulating the transcription and expression of genes, the novel promoters and expression units themselves, methods for altering or causing the transcription rate and/or expression rate of genes, expression cassettes comprising the expression units, genetically modified microorganisms with altered or caused transcription rate and/or expression rate, and methods for preparing biosynthetic products by cultivating the genetically modified microorganisms.
摘要翻译： 本发明涉及核酸序列用于调节基因的转录和表达，新型启动子和表达单元本身的用途，用于改变或引起基因的转录速率和/或表达速率的方法，包含表达单位的表达盒 具有改变或引起的转录速率和/或表达速率的转基因微生物，以及通过培养转基因微生物来制备生物合成产物的方法。
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30.发明授权公开(公告)号：US08048651B2
公开(公告)日：2011-11-01
申请号：US12533677
申请日：2009-07-31
申请人： Oskar Zelder , Corinna Klopprogge , Hartwig Schroder , Stefan Haefner , Burkhard Kröger , Patrick Kiefer , Elmar Heinzle , Christoph Wittmann
发明人： Oskar Zelder , Corinna Klopprogge , Hartwig Schroder , Stefan Haefner , Burkhard Kröger , Patrick Kiefer , Elmar Heinzle , Christoph Wittmann
IPC分类号： C12P13/06 , C12P13/08 , C12P13/10 , C12P13/12 , C12P23/00 , C12N9/16 , C12N15/70 , C12N1/20 , C12N15/74 , C07H21/04
摘要： The present invention features methods of increasing the production of a fine chemical, e.g., lysine from a microorganism, e.g., Corynebacterium by way of deregulating an enzyme encoding gene, i.e., fructose-1,6-bisphosphatase. In a preferred embodiment, the invention provides methods of increasing the production of lysine in Corynebacterium glutamicum by way of increasing the expression of fructose-1,6-bisphosphatase activity. The invention also provides a novel process for the production of lysine by way of regulating carbon flux towards oxaloacetate (OAA). In a preferred embodiment, the invention provides methods for the production of lysine by way of utilizing fructose or sucrose as a carbon source.
摘要翻译： 本发明的特征在于通过使酶编码基因（即果糖-1,6-二磷酸酶）失调来增加精细化学品例如来自微生物例如棒状杆菌的赖氨酸的生产方法。 在优选的实施方案中，本发明提供了通过增加果糖-1,6-二磷酸酶活性的表达来增加谷氨酸棒杆菌中赖氨酸的产生的方法。 本发明还提供了通过调节向草酰乙酸（OAA）的碳通量来生产赖氨酸的新方法。 在优选的实施方案中，本发明提供了通过使用果糖或蔗糖作为碳源来生产赖氨酸的方法。
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