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公开(公告)号：US5525714A
公开(公告)日：1996-06-11
申请号：US133248
申请日：1993-10-08
Applicant: Christine Van Broeckhoven , Jean-Jacques Martin , Lydia Hendriks , Patrick Cras
Inventor： Christine Van Broeckhoven , Jean-Jacques Martin , Lydia Hendriks , Patrick Cras
CPC classification number: C07K14/4711 , A01K2217/05
Abstract: The invention relates to a polypeptide containing a sequence of contiguous amino acids of the polypeptide sequence coded by exon 17 of the cDNA of the APP 770 gene, with said sequence of contiguous amino acids being such that:it has from 5 to the total number of amino acids coded by said exon 17,and it contains the amino acid corresponding to codon 692 in the cDNA of the APP 770 gene and which is alanine substituted for glycine. (no figure).
Abstract translation: 本发明涉及包含由APP770基因的cDNA的外显子17编码的多肽序列的连续氨基酸序列的多肽，所述连续氨基酸序列使得：其具有5至总数 由所述外显子17编码的氨基酸，并且其包含对应于APP770基因的cDNA中的密码子692的氨基酸，其是丙氨酸取代甘氨酸。 （无图）。
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公开(公告)号：US09259325B2
公开(公告)日：2016-02-16
申请号：US12986714
申请日：2011-01-07
Applicant: Guy Matge , Jean-Jacques Martin
Inventor： Guy Matge , Jean-Jacques Martin
CPC classification number: A61F2/442 , A61B17/7059 , A61B17/86 , A61F2/30767 , A61F2/30771 , A61F2/4455 , A61F2002/2835 , A61F2002/30018 , A61F2002/30571 , A61F2002/30578 , A61F2002/30616 , A61F2002/30784 , A61F2002/30879 , A61F2002/30892 , A61F2230/0093 , A61F2250/0029 , A61F2310/00023
Abstract: The implant includes two side walls resting against the vertebral end-plates and an intermediate wall joining the supporting walls. The implant can be deformed for insertion between the vertebrae to be treated to restore the attenuated mobility of the vertebrae, and includes mounting elements mounting on the vertebrae. The side walls have a curved shape, whose convexity is oriented towards the outside of the implant; the intermediate wall has a curved shape, whose convexity is oriented towards the outside of the implant such that it does not form any pronounced angles with the supporting side walls. The supporting side walls and the intermediate wall, have a partially oval shape; and the mounting elements are configured such that the implant can be mounted on the vertebrae.
Abstract translation: 植入物包括搁置在椎骨端板上的两个侧壁和连接支撑壁的中间壁。 植入物可以变形以插入待治疗的椎骨之间以恢复椎骨的减弱的移动性，并且包括安装在椎骨上的安装元件。 侧壁具有弯曲形状，其凸起朝向植入物的外侧; 中间壁具有弯曲形状，其凸起朝向植入物的外侧，使得其不与支撑侧壁形成任何明显的角度。 支撑侧壁和中间壁具有部分椭圆形形状; 并且安装元件构造成使得植入物可以安装在椎骨上。
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公开(公告)号：US20120089143A1
公开(公告)日：2012-04-12
申请号：US13239438
申请日：2011-09-22
Applicant: Jean-Jacques Martin , Tristan LASCAR , Laurent Obert
Inventor： Jean-Jacques Martin , Tristan LASCAR , Laurent Obert
CPC classification number: A61B17/56 , A61B17/0469 , A61B17/06 , A61B17/06166 , A61B17/72 , A61B17/842 , A61B2017/06028 , A61B2017/564 , A61F2/4059 , A61F2002/0847 , A61F2002/0882
Abstract: This method comprises the use of a repair equipment including a humeral rod (2) intended to be placed in the medullary cavity of the humerus, comprising at least one hole (6) for receiving a thread (11) for repositioning the tuberosities (101, 102) and for maintaining the latter with respect to the rest of the bone. Said hole (6) is formed in the metaphyseal portion of the humeral rod (2), in the anteroposterior direction thereof; and the repair equipment further comprises a so-called “guying” subassembly (3), to maintain the tuberosities (101, 102) when they re-installed, two second so-called “traction” subassemblies (4), for pulling of the tuberosities (101, 102) one toward the other, and two so-called third “pressing” subassemblies (5), for tackling the tuberosities (101, 102); each of these sub-assemblies comprises a needle and thread (11) connected to this needle, this thread (11) forming a loop.
Abstract translation: 该方法包括使用包括旨在放置在肱骨的髓腔中的肱骨杆（2）的修复设备，该修复设备包括至少一个孔（6），用于接收用于重新定位块茎（101， 102）并且用于相对于骨的其余部分保持后者。 所述孔（6）形成在肱骨杆（2）的干al端部的前后方向上; 并且修理设备还包括所谓的“guying”子组件（3），以在其重新安装时保持结节（101,102），两个第二所谓的“牵引”子组件（4），用于拉动 一个朝向另一个的结块（101,102）和两个所谓的第三“按压”子组件（5），用于处理结节（101,102）; 这些子组件中的每一个包括连接到该针的针和线（11），该线（11）形成环。
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公开(公告)号：US20050125063A1
公开(公告)日：2005-06-09
申请号：US10506219
申请日：2003-03-13
Applicant: Guy Matge , Jean-Jacques Martin
Inventor： Guy Matge , Jean-Jacques Martin
CPC classification number: A61F2/442 , A61B17/7059 , A61B17/86 , A61F2/30767 , A61F2/30771 , A61F2/4455 , A61F2002/2835 , A61F2002/30018 , A61F2002/30571 , A61F2002/30578 , A61F2002/30616 , A61F2002/30784 , A61F2002/30879 , A61F2002/30892 , A61F2230/0093 , A61F2250/0029 , A61F2310/00023
Abstract: The implant includes two side walls resting against the vertebral end-plates and an intermediate wall joining the supporting walls. The implant can be deformed for insertion between the vertebrae to be treated to restore the attenuated mobility of the vertebrae, and includes mounting elements mounting on the vertebrae. The side walls have a curved shape, whose convexity is oriented towards the outside of the implant; the intermediate wall has a curved shape, whose convexity is oriented towards the outside of the implant such that it does not form any pronounced angles with the supporting side walls. The supporting side walls and the intermediate wall, have a partially oval shape; and the mounting elements are configured such that the implant can be mounted on the vertebrae.
Abstract translation: 植入物包括搁置在椎骨端板上的两个侧壁和连接支撑壁的中间壁。 植入物可以变形以插入待治疗的椎骨之间以恢复椎骨的减弱的移动性，并且包括安装在椎骨上的安装元件。 侧壁具有弯曲形状，其凸起朝向植入物的外侧; 中间壁具有弯曲形状，其凸起朝向植入物的外侧，使得其不与支撑侧壁形成任何明显的角度。 支撑侧壁和中间壁具有部分椭圆形形状; 并且安装元件构造成使得植入物可以安装在椎骨上。
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Patent Agency Ranking25.发明授权Nucleotide sequences, probes and a process for the in vitro diagnosis of chromosomal anomalies correlated with CMT1A disease 失效核苷酸序列，探针和体外诊断染色体异常的过程与CMT1A疾病相关
公开(公告)号：US6110670A
公开(公告)日：2000-08-29
申请号：US808032
申请日：1997-03-04
Applicant: Christine Van Broeckhoven , Peter Raeymaekers , Peter De Jonghe , Jean-Jacques Martin
Inventor： Christine Van Broeckhoven , Peter Raeymaekers , Peter De Jonghe , Jean-Jacques Martin
CPC classification number: C12Q1/6883 , C12Q2600/156 , C12Q2600/172
Abstract: The invention relates to a process for the in-vitro diagnosis of chromosomal anomalies liable to be correlated with CMT1a disease. The invention also relates to probes intended in this in-vitro diagnosis process and to kits containing said probes. The probes of the invention can contain a sequence constituted of from about 15 successive nucleotides of a Not1 fragment, with said Not1 fragment having 1.2.times.10.sup.6 base pairs and being obtained after digesting human DNA of patients with Not1, separating the fragments resulting from digestion by pulsed field gel electrophoresis and hybridizing the resulting fragments with any of the probes VAW409, EW401 or VAW412 or their derivatives, to about the total number of the successive nucleotides of the Not1 fragment. The probes enable the detection of the duplication of a part of chromosome 17p.
Abstract translation: 本发明涉及一种用于体外诊断易于与CMT1a疾病相关的染色体异常的方法。 本发明还涉及旨在在该体外诊断过程中的探针和包含所述探针的试剂盒。 本发明的探针可以含有由Not1片段的大约15个连续核苷酸组成的序列，所述Not1片段具有1.2×106碱基对，并且在用Not1消化患者的人DNA后获得，将通过脉冲消化产生的片段分离 将所得片段与任何探针VAW409，EW401或VAW412或其衍生物杂交，得到Not1片段的连续核苷酸的总数。 这些探针可以检测染色体17p的一部分的重复。
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公开(公告)号：US20130066382A1
公开(公告)日：2013-03-14
申请号：US13617238
申请日：2012-09-14
Applicant: Jean-Jacques Martin
Inventor： Jean-Jacques Martin
IPC: A61B17/86
CPC classification number: A61B17/863 , A61B17/8645
Abstract: A bone screw having a threaded proximal portion, a threaded median portion, and a threaded distal portion. The threaded proximal portion has a proximal thread with a constant diameter and a proximal pitch. The threaded median portion has a median thread with a constant diameter smaller than the diameter of the proximal thread and a median pitch that becomes increasingly smaller from a distal end of the threaded median portion towards a proximal end of the threaded median portion The threaded distal portion has a distal thread having a constant diameter that is smaller than the diameter of the median thread and a distal pitch that is larger than the median pitch at the distal end of the threaded median portion.
Abstract translation: 具有螺纹近端部分，螺纹中间部分和螺纹远端部分的骨螺钉。 螺纹近端部分具有近似螺纹，其具有恒定直径和近端间距。 螺纹中间部分具有直径小于近端线的直径的中线，并且从螺纹中间部分的远端朝向螺纹中间部分的近端变得越来越小的中间间距。螺纹远端部分 具有直径小于中线的直径的远端螺纹和远大于螺纹中间部分的远端处的中间螺距的远端螺距。
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公开(公告)号：US08337555B2
公开(公告)日：2012-12-25
申请号：US12986722
申请日：2011-01-07
Applicant: Guy Matge , Jean-Jacques Martin
Inventor： Guy Matge , Jean-Jacques Martin
CPC classification number: A61F2/442 , A61B17/7059 , A61B17/86 , A61F2/30767 , A61F2/30771 , A61F2/4455 , A61F2002/2835 , A61F2002/30018 , A61F2002/30571 , A61F2002/30578 , A61F2002/30616 , A61F2002/30784 , A61F2002/30879 , A61F2002/30892 , A61F2230/0093 , A61F2250/0029 , A61F2310/00023
Abstract: The implant includes two side walls resting against the vertebral end-plates and an intermediate wall joining the supporting walls. The implant can be deformed for insertion between the vertebrae to be treated to restore the attenuated mobility of the vertebrae, and includes mounting elements mounting on the vertebrae. The side walls have a curved shape, whose convexity is oriented towards the outside of the implant; the intermediate wall has a curved shape, whose convexity is oriented towards the outside of the implant such that it does not form any pronounced angles with the supporting side walls. The supporting side walls and the intermediate wall, have a partially oval shape; and the mounting elements are configured such that the implant can be mounted on the vertebrae.
Abstract translation: 植入物包括搁置在椎骨端板上的两个侧壁和连接支撑壁的中间壁。 植入物可以变形以插入待治疗的椎骨之间以恢复椎骨的减弱的移动性，并且包括安装在椎骨上的安装元件。 侧壁具有弯曲形状，其凸起朝向植入物的外侧; 中间壁具有弯曲形状，其凸起朝向植入物的外侧，使得其不与支撑侧壁形成任何明显的角度。 支撑侧壁和中间壁具有部分椭圆形形状; 并且安装元件构造成使得植入物可以安装在椎骨上。
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公开(公告)号：US07867276B2
公开(公告)日：2011-01-11
申请号：US10506219
申请日：2003-03-13
Applicant: Guy Matge , Jean-Jacques Martin
Inventor： Guy Matge , Jean-Jacques Martin
IPC: A61F2/44
CPC classification number: A61F2/442 , A61B17/7059 , A61B17/86 , A61F2/30767 , A61F2/30771 , A61F2/4455 , A61F2002/2835 , A61F2002/30018 , A61F2002/30571 , A61F2002/30578 , A61F2002/30616 , A61F2002/30784 , A61F2002/30879 , A61F2002/30892 , A61F2230/0093 , A61F2250/0029 , A61F2310/00023
Abstract: The implant includes two side walls resting against the vertebral end-plates and an intermediate wall joining the supporting walls. The implant can be deformed for insertion between the vertebrae to be treated to restore the attenuated mobility of the vertebrae, and includes mounting elements mounting on the vertebrae. The side walls have a curved shape, whose convexity is oriented towards the outside of the implant; the intermediate wall has a curved shape, whose convexity is oriented towards the outside of the implant such that it does not form any pronounced angles with the supporting side walls. The supporting side walls and the intermediate wall, have a partially oval shape; and the mounting elements are configured such that the implant can be mounted on the vertebrae.
Abstract translation: 植入物包括搁置在椎骨端板上的两个侧壁和连接支撑壁的中间壁。 植入物可以变形以插入待治疗的椎骨之间以恢复椎骨的减弱的移动性，并且包括安装在椎骨上的安装元件。 侧壁具有弯曲形状，其凸起朝向植入物的外侧; 中间壁具有弯曲形状，其凸起朝向植入物的外侧，使得其不与支撑侧壁形成任何明显的角度。 支撑侧壁和中间壁具有部分椭圆形形状; 并且安装元件构造成使得植入物可以安装在椎骨上。
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29.发明申请Equipment for repairing biological tissue, such as a tendon or a ligament and, in particular, the calcanean tendon 审中-公开用于修复生物组织的装置，例如腱或韧带，特别是跟骨肌腱公开(公告)号：US20060200125A1
公开(公告)日：2006-09-07
申请号：US10534379
申请日：2003-11-05
Applicant: Patrick Delponte , Jean-Jacques Martin
Inventor： Patrick Delponte , Jean-Jacques Martin
IPC: A61F5/04
CPC classification number: A61F2/08 , A61B17/06166 , A61B17/1146 , A61B2017/00004 , A61B2017/044 , A61F2/0805 , A61F2/0811 , A61F2002/0835 , A61F2002/0888
Abstract: The invention relates to equipment for repairing biological tissue, such as a tendon or a ligament and, in particular, the calcanean tendon. The inventive equipment comprises a link (3) and elements (5) which are used to stop the link (3) in relation to the fragments of tissue to be repaired. According to the invention: (i) one of the aforementioned stop elements comprises a bone screw (2) which can be implanted in a bone surrounding the tissue to be repaired, for example in the calcaneum in order to repair the calcanean tendon; (ii) the above-mentioned link (3) forms a tubular part (6) in which one part of the screw (2) can be tightly inserted along with at least two cords (4) which can be inserted through the fragments of the biological tissue to be repaired, for example the two fragments of a broken calcanean tendon; and (iii) other stop elements comprise at least two stop buttons (5).
Abstract translation: 本发明涉及用于修复生物组织的设备，例如腱或韧带，特别是跟骨肌腱。 本发明的设备包括链节（3）和元件（5），其用于相对于要修复的组织片段停止连杆（3）。 根据本发明：（i）上述停止元件之一包括骨螺钉（2），该骨螺钉（2）可被植入围绕要修复的组织的骨骼，例如在跟骨中以修复跟骨肌腱; （ii）上述连杆（3）形成管状部分（6），螺杆（2）的一部分可与至少两根绳索（4）紧紧地插入，该绳索可插入穿过 要修复的生物组织，例如破碎的跟骨肌腱的两个片段; 和（iii）其它停止元件包括至少两个停止按钮（5）。
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