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公开(公告)号：US06140084A
公开(公告)日：2000-10-31
申请号：US203623
申请日：1998-12-01
CPC分类号： C07K14/47 , A01K2217/05
摘要： The present invention relates to polynucleotide and polypeptide molecules for zsig45, a novel human protein expressed in thyroid. The polypeptides, and polynucleotides encoding them, may be used for detecting human disease states and chromosomal abnormalities, and as a therapeutic. The present invention also includes antibodies to the zsig45 polypeptides.
摘要翻译： 本发明涉及用于zsig45的多核苷酸和多肽分子，其是在甲状腺中表达的新型人蛋白质。 多肽和编码它们的多核苷酸可用于检测人类疾病状态和染色体异常，以及作为治疗剂。 本发明还包括针对zsig45多肽的抗体。
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公开(公告)号：US07445919B2
公开(公告)日：2008-11-04
申请号：US10921371
申请日：2004-08-19
CPC分类号： C07K14/63 , A61K38/00 , C07K14/575
摘要： The present invention relates to polynucleotide related to the zsig33 peptide, including agonists, antagonists, and antibodies. Methods of modulating gastric contractility, nutrient uptake, growth hormones, the secretion of digestive enzymes and hormones, and/or secretion of enzymes and/or hormones in the pancreas are also included.
摘要翻译： 本发明涉及与zsig33肽相关的多核苷酸，包括激动剂，拮抗剂和抗体。 还包括调节胃收缩力，营养摄取，生长激素，消化酶和激素分泌和/或胰腺中酶和/或激素分泌的方法。
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公开(公告)号：US06395890B1
公开(公告)日：2002-05-28
申请号：US09253316
申请日：1999-02-19
申请人： Paul O. Sheppard , Stephen R. Jaspers , Zeren Gao
发明人： Paul O. Sheppard , Stephen R. Jaspers , Zeren Gao
IPC分类号： C07H2104
CPC分类号： C07K14/475
摘要： This present invention is directed to polypeptide and polynucleotide molecules that encode a new connective tissue growth factor homolog polypeptide. The human polypeptides have been designated zCTGF4 and the mouse orthologs have been designated zCTGF2. The invention also includes antibodies, expression vectors, host cells expressing zCTGF4 and variants. Also included are methods for producing the polypeptides and using the polynucleotides and polypeptides.
摘要翻译： 本发明涉及编码新的结缔组织生长因子同源多肽的多肽和多核苷酸分子。 已经将人多肽称为zCTGF4，并将小鼠直向同源物称为zCTGF2。 本发明还包括抗体，表达载体，表达zCTGF4的宿主细胞和变体。 还包括用于产生多肽和使用多核苷酸和多肽的方法。
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公开(公告)号：US20090156795A1
公开(公告)日：2009-06-18
申请号：US12239535
申请日：2008-09-26
IPC分类号： C07H21/04
CPC分类号： C07K14/63 , A61K38/00 , C07K14/575
摘要： The present invention relates to polynucleotide related to the zsig33 peptide, including agonists, antagonists, and antibodies. Methods of modulating gastric contractility, nutrient uptake, growth hormones, the secretion of digestive enzymes and hormones, and/or secretion of enzymes and/or hormones in the pancreas are also included.
摘要翻译： 本发明涉及与zsig33肽相关的多核苷酸，包括激动剂，拮抗剂和抗体。 还包括调节胃收缩力，营养摄取，生长激素，消化酶和激素分泌和/或胰腺中酶和/或激素分泌的方法。
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公开(公告)号：US07655447B2
公开(公告)日：2010-02-02
申请号：US12239535
申请日：2008-09-26
CPC分类号： C07K14/63 , A61K38/00 , C07K14/575
摘要： The present invention relates to polynucleotide related to the zsig33 peptide, including agonists, antagonists, and antibodies. Methods of modulating gastric contractility, nutrient uptake, growth hormones, the secretion of digestive enzymes and hormones, and/or secretion of enzymes and/or hormones in the pancreas are also included.
摘要翻译： 本发明涉及与zsig33肽相关的多核苷酸，包括激动剂，拮抗剂和抗体。 还包括调节胃收缩力，营养摄取，生长激素，消化酶和激素分泌和/或胰腺中酶和/或激素分泌的方法。
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公开(公告)号：US07122349B2
公开(公告)日：2006-10-17
申请号：US10982168
申请日：2004-11-05
申请人： Paul O. Sheppard , Paul D. Bishop
发明人： Paul O. Sheppard , Paul D. Bishop
CPC分类号： C07K14/52 , A61K38/00 , C07K14/4702 , C07K2319/00 , C12Q1/6888 , C12Q2600/158
摘要： The present invention provides two members of a new family of human proteins, designated as “Zven.” The Zven1 gene, which resides in human chromosome 3p21.1-3p14.3, is expressed in testicular tissue and peripheral blood lymphocytes.
摘要翻译： 本发明提供了两个称为“Zven”的人类蛋白质家族的成员。 位于人染色体3p21.1-3p14.3中的Zven1基因在睾丸组织和外周血淋巴细胞中表达。
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公开(公告)号：US06828425B2
公开(公告)日：2004-12-07
申请号：US10212355
申请日：2002-08-02
申请人： Paul O. Sheppard , Paul D. Bishop
发明人： Paul O. Sheppard , Paul D. Bishop
IPC分类号： C07K1600
CPC分类号： C07K14/52 , A61K38/00 , C07K14/4702 , C07K2319/00 , C12Q1/6888 , C12Q2600/158
摘要： The present invention provides two members of a new family of human proteins, designated as “Zven.” The Zven1 gene, which resides in human chromosome 3p21.1-3p14.3, is expressed in testicular tissue and peripheral blood lymphocytes.
摘要翻译： 本发明提供了两个称为“Zven”的人类蛋白质家族的成员。 位于人染色体3p21.1-3p14.3中的Zven1基因在睾丸组织和外周血淋巴细胞中表达。
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公开(公告)号：US06485938B1
公开(公告)日：2002-11-26
申请号：US09712529
申请日：2000-11-14
申请人： Paul O. Sheppard , Paul D. Bishop
发明人： Paul O. Sheppard , Paul D. Bishop
IPC分类号： C12P2106
CPC分类号： C07K14/52 , A61K38/00 , C07K14/4702 , C07K2319/00 , C12Q1/6888 , C12Q2600/158
摘要： The present invention provides two members of a new family of human proteins, designated as “Zven.” The Zven1 gene, which resides in human chromosome 3p21.1-3p14.3, is expressed in testicular tissue and peripheral blood lymphocytes.
摘要翻译： 本发明提供了两个称为“Zven”的人类蛋白质家族的成员。 位于人染色体3p21.1-3p14.3中的Zven1基因在睾丸组织和外周血淋巴细胞中表达。
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公开(公告)号：US06448221B1
公开(公告)日：2002-09-10
申请号：US09506855
申请日：2000-02-17
IPC分类号： C07K100
CPC分类号： A61K38/1709
摘要： The present invention relates to polynucleotide and polypeptide molecules for use as inhibitors in hemostasis and immune function. Such inhibitors are members of the family of proteins bearing a collagen-like domain and a globular domain. The inhibitors are useful for promoting blood flow in the vasculature by reducing thrombogenic and complement activity. The inhibitors are also useful for pacifying collagenous surfaces and modulating wound healing.
摘要翻译： 本发明涉及用作止血和免疫功能抑制剂的多核苷酸和多肽分子。 这种抑制剂是具有胶原样结构域和球状结构域的蛋白家族的成员。 抑制剂可用于通过降低血栓形成和补体活性来促进脉管系统中的血液流动。 抑制剂也可用于平缓胶原表面和调节伤口愈合。
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30.发明授权公开(公告)号：US08759066B2
公开(公告)日：2014-06-24
申请号：US12935235
申请日：2009-04-07
CPC分类号： C12N9/6418 , C07K2319/50
摘要： Disclosed are compositions for activating thrombin precursors to thrombin. The compositions provided include polypeptide compositions wherein the pre-pro-sequence comprises a thrombin cleavage site. The compositions provided also include polynucleotides encoding said polypeptides and recombinant systems for expressing said polypeptides. This disclosure also relates to methods for producing said compositions, recovering said compositions, activating said compositions purifying said compositions and producing active thrombin molecules using the active form of said compositions.
摘要翻译： 公开了用于激活凝血酶凝血酶前体的组合物。 提供的组合物包括多肽组合物，其中前序列包含凝血酶切割位点。 提供的组合物还包括编码所述多肽的多核苷酸和用于表达所述多肽的重组系统。 本公开还涉及生产所述组合物的方法，回收所述组合物，使用所述组合物的活性形式活化所述组合物来纯化所述组合物并产生活性凝血酶分子。
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