公开(公告)号：US06602905B1

公开(公告)日：2003-08-05

申请号：US10110465

申请日：2002-08-21

Applicant: Sheila Margaret Gardiner ,  Terence Bennett ,  Barrie Walsham Bycroft ,  David Idris Pritchard ,  Paul Williams

Inventor： Sheila Margaret Gardiner ,  Terence Bennett ,  Barrie Walsham Bycroft ,  David Idris Pritchard ,  Paul Williams

IPC: A01K3134

CPC classification number: A61K31/365

Abstract: Compounds having anti-fibrotic effects are provided. Also provided is a method for treating disorders, diseases or conditions associated with pathological fibrotic states. The compounds useful in the present invention are homocysteine thiolactone and selected derivatives thereof.

Abstract translation: 提供具有抗纤维化作用的化合物。 还提供了用于治疗与病理性纤维化状态相关的疾病，疾病或病症的方法。 可用于本发明的化合物是同型半胱氨酸硫内酯及其选择的衍生物。

公开(公告)号：US5969158A

公开(公告)日：1999-10-19

申请号：US97371

申请日：1998-06-15

Applicant: Barrie Walsham Bycroft ,  Herbert Fitzgerald Sewell ,  Gordon Sydney Anderson Birnie Stewart ,  Paul Williams

Inventor： Barrie Walsham Bycroft ,  Herbert Fitzgerald Sewell ,  Gordon Sydney Anderson Birnie Stewart ,  Paul Williams

IPC: C07D333/32 ,  A61K31/34 ,  A61K31/341 ,  A61K31/365 ,  A61K31/38 ,  A61K31/381 ,  A61K31/39 ,  A61K31/40 ,  A61K31/445 ,  A61P11/00 ,  A61P11/08 ,  A61P29/00 ,  A61P31/04 ,  A61P31/12 ,  A61P31/18 ,  A61P37/02 ,  A61P37/04 ,  A61P37/06 ,  A61P37/08 ,  C07D211/56 ,  C07D307/33 ,  C07D333/36 ,  C07D305/12

CPC classification number: A61K31/40 ,  A61K31/365 ,  A61K31/38 ,  A61K31/381 ,  A61K31/39

Abstract: A compound having formula (1) for use as a medicament wherein n is 2 or 3; Y is O, S or NH; X is O, S or NH; and R is C.sub.1 -C.sub.18 alkyl or acyl which may be substituted. ##STR1##

Abstract translation: 一种具有式（1）的化合物，其用作药物，其中n为2或3; Y是O，S或NH; X是O，S或NH; 且R为可被取代的C 1 -C 18烷基或酰基。

公开(公告)号：US5625196A

公开(公告)日：1997-04-29

申请号：US453272

申请日：1995-05-30

Applicant: Paul Williams

Inventor： Paul Williams

IPC: G01N21/89 ,  G05B23/02 ,  G05D5/03 ,  G01N21/86

CPC classification number: G05B23/0297 ,  G01N21/8903 ,  G05D5/03

Abstract: A detector of a measuring system sensitive to light energy receives light from a process being measured and also from a separate light source which is modulated such that it can be detected in signals generated by the detector. The separate light source is turned on and off to modulate its output such that output signals from the detector can be separated into on-times and off-times of the separate light source. The difference in on and off signal levels generated by the detector, or elements of the detector if the detector has a plurality of elements, are used to calibrate the detector. The light energy is conveyed to the detector by an energy conduit which may be a "leaky" optical fiber which receives light at one end and leaks the light out one sidewall along a portion of the fiber which is positioned adjacent to and preferably secured to the detector. The leaky optical fiber can be made by removing cladding from at least a portion of the sidewall along the portion of the fiber which is to leak light to the detector. Alternately, a bundle of fiber optics can be utilized with one end of the bundle receiving light and the other end being broken out to direct one or more of the fibers toward elements of the detector.

Abstract translation: 对光能敏感的测量系统的检测器从被测量的过程接收光，并且还从被调制的单独的光源接收来自检测器产生的信号中的光。 单独的光源被打开和关闭以调制其输出，使得来自检测器的输出信号可以分离成分开的光源的接通和关闭时间。 由检测器产生的开和关信号电平的差异，或者如果检测器具有多个元件，则使用检测器的元件来校准检测器。 光能通过能量管道传送到检测器，该能量管道可以是“泄漏”光纤，其在一端接收光并沿着沿着纤维的一部分将光排出一个侧壁，该部分邻近并优选地固定到 探测器。 泄漏的光纤可以通过从沿着光纤的部分的光纤的至少一部分去除包层来制造，该部分将光泄漏到检测器。 或者，可以使用一束光纤，其中束的一端接收光，另一端被分解以将一个或多个光纤引导到检测器的元件。

公开(公告)号：US5398538A

公开(公告)日：1995-03-21

申请号：US10652

申请日：1993-01-28

Applicant: Paul Williams ,  Bradley M. Pankonin

Inventor： Paul Williams ,  Bradley M. Pankonin

IPC: G01N29/07 ,  G01N29/30 ,  G01N33/34 ,  G01N29/18 ,  G01N29/24

CPC classification number: G01N29/07 ,  G01N29/30 ,  G01N33/346 ,  G01N2291/0237 ,  G01N2291/0421 ,  G01N2291/0422

Abstract: The velocity or speed of ultrasonic energy in moving webs of material is measured on-line as the webs are manufactured by engaging and preferably scanning a measuring head over the web of material. Improved ultrasonic energy transducers are employed wherein a material contacting member is secured to an interface region between oppositely operated first and second regions which intensify and amplify the movement of the interface region and hence the material contacting member by operating in a push-pull mode relative to the interface region. The transducers are calibrated by means of reference paths having known ultrasonic transmission characteristics which reference paths are separate and apart from the web of material which is being measured. The transducers can be selectively contacted with the web of material or not under the influence of vacuum which is applied to a measuring head into which the transducers are installed. A large plurality of ultrasonic energy signals are received by one or more receiving transducers and digitally integrated or summed and averaged to eliminate substantial noise which is present on the received ultrasonic energy signals due to the relative motion of the transducers and the web of material being measured. The travel time between the transmitting transducer and the receiving transducer or transducers is then combined with the distance or distances therebetween to arrive at the velocity or speed of the ultrasonic energy in a web being measured.

Abstract translation: 在移动的材料网中的超声波能量的速度或速度在线测量，因为通过接合并优选地在测量材料网上扫描测量头来制造网。 使用改进的超声波能量换能器，其中材料接触构件被固定到相对操作的第一和第二区域之间的界面区域，其通过以相对于第二和第二区域的推挽模式操作来强化和放大界面区域以及因此的材料接触构件的移动 接口区域。 传感器通过具有已知超声波传输特性的参考路径进行校准，该参考路径与待测量的材料卷材分开并分开。 传感器可以选择性地与材料卷材接触，或者不受真空的影响，所述真空的影响被施加到安装有换能器的测量头。 大量的超声波能量信号由一个或多个接收换能器接收并且数字地积分或相加和平均以消除由于换能器和所测量的材料幅材的相对运动而在接收到的超声能量信号上存在的实质噪声 。 然后将发射换能器和接收换能器或换能器之间的行进时间与它们之间的距离或距离组合，以得到所测量的腹板中的超声能量的速度或速度。

公开(公告)号：US4917676A

公开(公告)日：1990-04-17

申请号：US251016

申请日：1988-09-27

Applicant: Werner Heiber ,  Robert Andriola ,  Paul Williams ,  Charles Ebert

Inventor： Werner Heiber ,  Robert Andriola ,  Paul Williams ,  Charles Ebert

IPC: A61K9/70

CPC classification number: A61K9/703 ,  A61K9/7084 ,  A61K9/7092

Abstract: A transdermal drug delivery system which is manufactured in a pre-activated state for at least one of storage stability, manufacture safety, user safety, or control of release characteristic considerations and which is activated by a patient (or other person applying the system to the patient) just prior to or immediately after applying the system to the patient's skin is disclosed.

Abstract translation: 一种透皮药物递送系统，其以预激活状态制造，用于储存稳定性，制造安全性，用户安全性或释放特性考虑的控制中的至少一种，并且由患者（或其他人将该系统应用于 公开了在将系统应用于患者皮肤之前或之后的患者皮肤上。

公开(公告)号：US10657766B2

公开(公告)日：2020-05-19

申请号：US13288223

申请日：2011-11-03

Applicant: Lee Amaitis ,  Paul Williams

Inventor： Lee Amaitis ,  Paul Williams

IPC: G07F17/32

Abstract: Some embodiments related to account based wagering across multiple gaming operators. Users may pre-permission funding transfers from one account to another account. Each account may be usable for a specific purpose, such as wagering at a particular location and/or with a particular gaming operator. Some embodiments may include various sign on options that allow information and/or funding sharing across accounts. Various apparatus and methods are described.

公开(公告)号：US07686011B1

公开(公告)日：2010-03-30

申请号：US11522123

申请日：2006-09-15

Applicant: Paul Williams

Inventor： Paul Williams

IPC: F24B1/18 ,  F24B1/187 ,  F24H3/02 ,  F23K3/10 ,  F23K3/14 ,  F23N5/00

CPC classification number: F24H9/06 ,  F23B40/08 ,  F23N1/082 ,  F23N2025/10 ,  F23N2025/12 ,  F24D2200/067 ,  F24H3/067

Abstract: The invention relates to heating units mounted on a window of an existing building. Flue gases are expelled outside of the building without the need for wall modifications or an extra chimney. The actual burn chamber is mounted on a window mounting unit with an interior support which extends into the building thereby heating the air inside the building.

Abstract translation: 本发明涉及安装在现有建筑物的窗户上的加热单元。 烟道气体被排出建筑物外部，而不需要墙壁修改或额外的烟囱。 实际的燃烧室安装在具有延伸到建筑物中的内部支撑件的窗户安装单元上，从而加热建筑物内的空气。

公开(公告)号：US20060258919A1

公开(公告)日：2006-11-16

申请号：US11460186

申请日：2006-07-26

Applicant: John Burd ,  Paul Williams

Inventor： John Burd ,  Paul Williams

IPC: A61B5/00

CPC classification number: A61B5/6887 ,  A61B5/0002 ,  A61B5/14532 ,  A61B5/1455

Abstract: A method of non-invasively measuring the presence, absence or concentration of one or more analytes in an ocular element of a subject, the subject including an eye with an ocular surface and a tear layer, includes exposing at least a portion of the tear layer and/or other ocular elements of the subject to electromagnetic radiation without contact with the ocular surface; detecting electromagnetic radiation reflected from the tear layer and/or other ocular elements without contact with the ocular surface; and determining a radiation signature of the reflected electromagnetic radiation to determine the presence, absence or concentration of the one or more analytes in the tear layer and/or other ocular elements of the subject.

Abstract translation: 非侵入性地测量受试者的眼部元件中一种或多种分析物的存在，不存在或浓度的方法，所述受试者包括具有眼表面和泪液层的眼睛，包括将至少一部分泪液层 和/或其他眼部元件与电磁辐射无关，而不与眼表面接触; 检测从眼泪层和/或其他眼部元件反射的电磁辐射而不与眼表面接触; 以及确定所述反射的电磁辐射的辐射特征，以确定所述受试者的泪液层和/或其它眼部元件中的一种或多种分析物的存在，不存在或集中。

公开(公告)号：US20060202148A1

公开(公告)日：2006-09-14

申请号：US11074960

申请日：2005-03-08

Applicant: Frank Nicholas ,  Ashish Singh ,  Curtis Lamb ,  Paul Williams

Inventor： Frank Nicholas ,  Ashish Singh ,  Curtis Lamb ,  Paul Williams

IPC: F16K1/22

CPC classification number: F16K1/22 ,  F16K27/0218 ,  Y10T137/0525 ,  Y10T137/6048

Abstract: A vane-type throttle valve assembly including a body having a passage therethrough and a pivotable shaft transverse of the passage and supporting a vane for variably restricting the flow of material through the passage. The shaft is disposed in opposing bores in the valve body. Each bore includes an access slot. The valve is assembled by inserting an integrated shaft and vane into the passage, engaging the ends of the shaft into the access slots, and translating the shaft ends in the access slots until the ends of the shaft are positioned in the bores. The shaft is retained in the bores by bushings inserted from outside the valve body. In a currently preferred embodiment, the access slots are formed over an angle from an axis of the bores, and the shaft ends are entered into the bores by rotating the shaft and vane about the passage axis.

Abstract translation: 一种叶片式节气门组件，其包括具有通过其的通道的主体和横向于通道的可枢转轴，并且支撑叶片以可变地限制材料流过通道。 轴设置在阀体中的相对的孔中。 每个孔包括一个通道槽。 通过将一体的轴和叶片插入通道中来组装阀门，将轴的端部接合到进入狭槽中，并将轴端平移在进入狭槽中，直到轴的端部定位在孔中。 通过从阀体外部插入的衬套将轴保持在孔中。 在当前优选的实施例中，进入狭缝形成在与孔的轴线成一定角度上，并且轴端通过使轴和叶片围绕通道轴线旋转而进入孔中。

公开(公告)号：US5871922A

公开(公告)日：1999-02-16

申请号：US737825

申请日：1997-06-03

Applicant: George Peacock Copeland Salmond ,  Simon James McGowan ,  Mohammed Sebaihia ,  Anthony Richard John Cox ,  Matthew Thomas Geoffrey Holden ,  Lauren Elizabeth Porter ,  Barrie Walsham Bycroft ,  Paul Williams ,  Gordon Sidney Anderson Birnie Stewart

Inventor： George Peacock Copeland Salmond ,  Simon James McGowan ,  Mohammed Sebaihia ,  Anthony Richard John Cox ,  Matthew Thomas Geoffrey Holden ,  Lauren Elizabeth Porter ,  Barrie Walsham Bycroft ,  Paul Williams ,  Gordon Sidney Anderson Birnie Stewart

IPC: C12N15/09 ,  C12N9/00 ,  C12N15/00 ,  C12N15/52 ,  C12Q1/68 ,  C12R1/18 ,  C07H21/04 ,  C07K14/00 ,  C12P19/34

CPC classification number: C12Q1/6876 ,  C12N15/52

Abstract: DNA involved in the bacterial gene expression of carbapenem antibiotics comprising: a) at least one of the genes carA, carB, carC, carD, carE, carF, carG, carH, b) DNA capable of hybridizing to any of the genes defined in a) and capable of functioning as such genes in the biosynthetic pathway of a carbapenem, c) DNA which is a) or b) above by virtue of the degeneracy of the genetic code. Polypeptides encoded by such DNA.

Abstract translation: PCT No.PCT / GB95 / 01125 Sec。 371日期：1997年6月3日 102（e）日期1997年6月3日PCT提交1995年5月18日PCT公布。 出版物WO95 / 32294 1995年11月30日，涉及碳青霉烯类抗生素的细菌基因表达的DNA包括：a）carA，carB，carC，carD，carE，carF，carG，carH中的至少一个基因，b）能够与 a）中定义的基因并能够在碳青霉烯的生物合成途径中起到这种基因的作用，c）由于遗传密码的简并性，a）或b）以上的DNA。 由此DNA编码的多肽。