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    Ethylenediamine and guanidine-derivatives
    27.
    发明授权
    Ethylenediamine and guanidine-derivatives 失效
    乙二胺和胍衍生物

    公开(公告)号：US4738983A

    公开(公告)日：1988-04-19

    申请号：US558984

    申请日：1983-12-07

    申请人： Peter Emig ,  Gerhard Scheffler ,  Klaus Thiemer ,  Carl-Heinrich Weischer

    发明人： Peter Emig ,  Gerhard Scheffler ,  Klaus Thiemer ,  Carl-Heinrich Weischer

    IPC分类号： A61K31/34 ,  A61K31/341 ,  A61K31/38 ,  A61K31/381 ,  A61P1/04 ,  C07D307/52 ,  C07D333/20 ,  C07D307/02

    CPC分类号： C07D307/52 ,  C07D333/20

    摘要： This invention relates to new compounds corresponding to the general formula: ##STR1## R.sub.1 represents a C.sub.3 -C.sub.10 cycloalkyl group substituted by C.sub.1 -C.sub.6 alkyl radicals, a C.sub.3 -C.sub.19 -cycloalkyl-C.sub.1 -C.sub.4 alkyl group which may be substituted by C.sub.1 -C.sub.6 alkyl radicals, a C.sub.6 -C.sub.8 bicycloalkyl group, a C.sub.6 -C.sub.8 bicycloalkyl-C.sub.1 -C.sub.4 alkyl group, a C.sub.6 -C.sub.10 tricycloalkyl group, a C.sub.6 -C.sub.10 tricycloalkyl-C.sub.1 -C.sub.4 alkyl group, a C.sub.6 -C.sub.9 tetracycloalkyl group or a C.sub.6 -C.sub.9 -tetracycloalkyl-C.sub.1 -C.sub.4 alkyl group,R.sub.2 represents hydrogen, a C.sub.1 -C.sub.6 alkyl group, a phenyl-C.sub.1 -C.sub.4 alkyl group or a C.sub.1 -C.sub.6 alkyl group which is substituted by halogen atoms, nitro groups, hydroxy groups, C.sub.2 -C.sub.6 alkanoyloxy groups, C.sub.1 -C.sub.4 alkoxy groups, C.sub.1 -C.sub.4 alkoxy carbonyl groups or carboxy groups,R.sub.3 represented hydrogen, the 2-[5-(dimethylaminomethyl)-2-furyl-methylthio]-ethyl group, a C.sub.1 -C.sub.18 -alkyl group, a C.sub.3 -C.sub.6 -cycloalkyl group, a C.sub.3 -C.sub.6 -alkenyl group, a C.sub.3 -C.sub.6 -alkinyl group, an amino-C.sub.1 -C.sub.4 -alkyl group, a C.sub.2 -C.sub.6 -alkanoylamino-C.sub.1 -C.sub.4 -alkyl group, a mono-C.sub.1 -C.sub.6 -alkylamino-C.sub.1 -C.sub.4 -alkyl group, a di-C.sub.1 -C.sub.6 -alkylamino-C.sub.1 -C.sub.4 -alkyl group or a C.sub.1 -C.sub.18 -alkyl group, which is substituted by halogen atoms, nitro groups, hydroxy groups, C.sub.2 -C.sub.6 alkanoyloxy groups, C.sub.1 -C.sub.4 alkoxy groups, C.sub.1 -C.sub.4 alkoxycarbonyl groups or carboxy groups,A represents a nitrogen atom or a methine group,B represents a cyano radical or a nitro group, andX represents an oxygen atom or a sulphur atom, and salts thereof.The compounds inhibit the secretion of gastric juice. Moreover, they have an ulcer-inhibiting and stomach-spasmolytic effect.

    摘要翻译： 本发明涉及对应于通式的新化合物：其中R1表示被C1-C6烷基取代的C3-C10环烷基，可被C1取代的C3-C19-环烷基-C1-C4烷基 -C 6烷基，C 6 -C 8双环烷基，C 6 -C 8双环烷基-C 1 -C 4烷基，C 6 -C 10三环烷基，C 6 -C 10三环烷基-C 1 -C 4烷基，C 6 -C 9四环烷基或 C 6 -C 9 - 四环烷基-C 1 -C 4烷基，R 2表示氢，C 1 -C 6烷基，苯基-C 1 -C 4烷基或被卤素原子取代的C 1 -C 6烷基，硝基，羟基 基团，C 2 -C 6烷酰氧基，C 1 -C 4烷氧基，C 1 -C 4烷氧基羰基或羧基，R 3表示氢，2- [5-（二甲基氨基甲基）-2-呋喃基 - 甲硫基] - 乙基， -C 18 - 烷基，C 3 -C 6 - 环烷基，C 3 -C 6 - 烯基，C 3 -C 6 - 炔基，氨基-C 1 -C 4 - 烷基，C 2 -C 6 - 烷酰基氨基-C 1 -C 4 - 烷基，单-C 1 -C 6烷基 烯基-C 1 -C 4 - 烷基，被卤素原子取代的二-C 1 -C 6烷基氨基-C 1 -C 4 - 烷基或C 1 -C 18烷基，硝基，羟基，C 2 -C 6烷酰氧基 基团，C 1 -C 4烷氧基，C 1 -C 4烷氧基羰基或羧基，A表示氮原子或次甲基，B表示氰基或硝基，X表示氧原子或硫原子， 其中。 这些化合物抑制胃液的分泌。 此外，它们具有溃疡抑制和胃解痉作用。