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    Handheld device for determining skin age, proliferation status and photodamage level
    21.
    发明申请
    Handheld device for determining skin age, proliferation status and photodamage level 审中-公开
    用于确定皮肤年龄，增殖状态和光损伤水平的手持设备

    公开(公告)号：US20070004972A1

    公开(公告)日：2007-01-04

    申请号：US11170129

    申请日：2005-06-29

    申请人： Curtis Cole ,  Nikiforos Kollias ,  Frederick Hartman

    发明人： Curtis Cole ,  Nikiforos Kollias ,  Frederick Hartman

    IPC分类号： A61B5/00

    CPC分类号： A61B5/442 ,  A61B5/0059 ,  A61B5/0071

    摘要： A self-contained, handheld probe for measuring at least one parameter of skin condition, has one or more light sources that may be used to project light upon the skin. The light projected is of a selected wavelength known to generate a specific fluorescence that is indicative of the skin parameter of interest in accordance with a known correlation. To produce the proper excitation light, a light source generating that wavelength is used or a broader spectrum of light is selectively filtered to pass the wavelength of interest. Lenses, fiber optic elements or waveguides may be employed to project the light onto the skin at a specific location and/or to deliver the skin response to a light detector, which measures the light signal from the skin. and generates an output signal indicative of the value of the at least one parameter. The probe may be used to measure skin age, photodamage and/or proliferation.

    摘要翻译： 用于测量皮肤状况至少一个参数的独立式手持式探头具有一个或多个可用于将光投射到皮肤上的光源。 所投射的光具有已知的选择波长，以根据已知的相关性产生指示感兴趣的皮肤参数的特定荧光。 为了产生适当的激发光，使用产生该波长的光源或选择性地过滤较宽光谱以通过感兴趣的波长。 可以使用透镜，光纤元件或波导将光投射到特定位置处的皮肤上和/或将光皮肤响应递送到光检测器，光检测器测量来自皮肤的光信号。 并且产生指示所述至少一个参数的值的输出信号。 探针可用于测量皮肤年龄，光损伤和/或增殖。

    Device and method for demonstrating and quantifying skin texture
    25.
    发明申请
    Device and method for demonstrating and quantifying skin texture 审中-公开
    用于展示和量化皮肤纹理的装置和方法

    公开(公告)号：US20060182323A1

    公开(公告)日：2006-08-17

    申请号：US11059797

    申请日：2005-02-17

    申请人： Nikiforos Kollias ,  Paulo Rodrigues Bargo

    发明人： Nikiforos Kollias ,  Paulo Rodrigues Bargo

    IPC分类号： G06K9/00

    CPC分类号： A61B5/442

    摘要： A device and a method for demonstrating skin texture are disclosed. The device includes a camera having a rotating linear analyzer and a polarized light source. The method includes taking a photograph of an individual using a device comprising a flash lamp having a rotating linear polarizer and a digital camera with a rotating linear analyzer, wherein the camera is positioned at 90 degrees from the flash lamp and the individual is placed such that the illumination angle to its surface normal is from about 45 degrees to about 135 degrees; exporting the photograph to a computer; and making a determination selected from the group consisting of the mean, the median, the intensity distribution and the autocorrelation on a region of interest of the image to demonstrate the texture of the skin.

    摘要翻译： 公开了用于展示皮肤纹理的装置和方法。 该装置包括具有旋转线性分析器和偏振光源的照相机。 该方法包括使用包括具有旋转线性偏振器的闪光灯和具有旋转线性分析仪的数字照相机的装置拍摄个体的照片，其中相机位于与闪光灯成90度的位置，并且个体被放置成 其表面法线的照明角度为约45度至约135度; 将照片导出到计算机; 并且从图像的感兴趣区域中的平均值，中值，强度分布和自相关性中选出的测定结果，以证明皮肤的质地。

    Method of assessing skin
    28.
    发明申请
    Method of assessing skin 有权
    皮肤评估方法

    公开(公告)号：US20050131304A1

    公开(公告)日：2005-06-16

    申请号：US10735188

    申请日：2003-12-12

    申请人： Georgios Stamatas ,  Nikiforos Kollias

    发明人： Georgios Stamatas ,  Nikiforos Kollias

    IPC分类号： A61B5/00 ,  A61B5/103 ,  G01N21/64 ,  G01N33/50 ,  A61B6/00

    CPC分类号： A61B5/442 ,  A61B5/0071 ,  G01N21/64 ,  G01N33/5091

    摘要： The present invention relates to a method of determining skin health of an area of skin by exposing the area of skin to a first exposure radiation to induce the area of skin to emit a first fluorescent emission, measuring the intensity of the first fluorescent emission, exposing the area of skin to a second exposure radiation to induce the area of skin to emit a second fluorescent emission, measuring the intensity of the second fluorescent emission, calculating a ratio of these intensities, and comparing the ratio to a control ratio.

    摘要翻译： 本发明涉及一种通过将皮肤区域暴露于第一曝光辐射来诱导皮肤区域发射第一荧光发射，测量第一荧光发射强度，曝光的方法来确定皮肤区域的皮肤健康 皮肤的区域到第二曝光辐射以诱导皮肤区域发射第二荧光发射，测量第二荧光发射的强度，计算这些强度的比率，并将该比率与对照比率进行比较。

    Phototherapy method for treatment of acne
    29.
    发明授权
    Phototherapy method for treatment of acne 失效
    治疗痤疮的光疗法

    公开(公告)号：US06663658B1

    公开(公告)日：2003-12-16

    申请号：US09559139

    申请日：2000-04-27

    申请人： Nikiforos Kollias ,  Robert Gillies ,  Wei Dong Tian

    发明人： Nikiforos Kollias ,  Robert Gillies ,  Wei Dong Tian

    IPC分类号： A61B1818

    CPC分类号： A61N5/0616 ,  A61N2005/0661 ,  A61N2005/067

    摘要： The present invention is directed to methods for treating acne. The methods include exposing the subject afflicted with acne to ultraviolet light having a wavelength between about 320 to about 350 nm, such that the acne is treated, e.g., inhibited, diminished, eradicated or prevented. In a preferred embodiment, the wavelength is 335 nm and is emitted by either a nitrogen laser or a third harmonic of a NdYAG laser. Treatments can be administered over a several week period, where the subject is exposed to sequential doses of ultraviolet light to obtain beneficial effects, e.g., a reduction or elimination of the acne, e.g., an eradication or diminishment of the bacteria responsible for acne, e.g., Propionibacterium acnes.

    摘要翻译： 本发明涉及治疗痤疮的方法。 所述方法包括将患有痤疮的受试者暴露于波长在约320至约350nm之间的紫外线，使得治疗，例如抑制，减少，消除或预防痤疮。 在优选实施例中，波长为335nm，并且由氮激光器或NdYAG激光器的三次谐波发射。 治疗可以在几周的时间内施用，其中受试者暴露于连续剂量的紫外线以获得有益效果，例如减少或消除痤疮，例如消除或减少负责痤疮的细菌，例如 ，丙酸杆菌属。

    Polarized material inspection apparatus
    30.
    发明授权
    Polarized material inspection apparatus 失效
    极化材料检验仪器

    公开(公告)号：US5742392A

    公开(公告)日：1998-04-21

    申请号：US634311

    申请日：1996-04-16

    申请人： Richard Rox Anderson ,  William A. Farinelli ,  Nikiforos Kollias

    发明人： Richard Rox Anderson ,  William A. Farinelli ,  Nikiforos Kollias

    IPC分类号： A61B5/00 ,  A61B5/103 ,  G01N21/21

    CPC分类号： A61B5/14558 ,  A61B5/442

    摘要： Light reflected from skin has two components: regular reflectance, or "glare" arising from the surface, and light backscattered from within the tissue. The regular reflectance contains the visual cues related to surface texture, whereas the backscattered component contains the cues related to pigmentation, erythema, infiltrates, vessels and other intracutaneous structures. Unlike the backscattered component, regular reflectance preserves the plane of polarization of polarized incident light. Thus, viewing skin through a linear polarizer, under linearly polarized illumination, separates the two components of tissue reflectance. When the planes of polarization are parallel, images with enhanced surface detail are obtained. When the planes are orthogonal, wrinkles and surface detail disappear, and an enhanced view of vasculature and pigmented lesions is obtained. Apparatus for performing such inspection is disclosed.

    摘要翻译： 从皮肤反射的光具有两个组成部分：正常的反射率或表面产生的“眩光”，以及从组织内反射的光。 正反射率包含与表面纹理相关的视觉提示，而背散射成分包含与色素沉着，红斑，浸润，血管和其他皮内结构相关的线索。 与反向散射分量不同，反射率保持偏振入射光的偏振平面。 因此，通过线性偏振器观察皮肤，在线性偏振照明下，分离组织反射率的两个分量。 当极化平面平行时，获得具有增强的表面细节的图像。 当平面正交时，皱纹和表面细节消失，并获得脉管系统和着色损伤的增强视图。 公开了进行这种检查的装置。