公开(公告)号：US08731847B2

公开(公告)日：2014-05-20

申请号：US13174514

申请日：2011-06-30

申请人： Kim Johnson ,  Jeremy Jordan ,  Peter Levine ,  Mark Milgrew

发明人： Kim Johnson ,  Jeremy Jordan ,  Peter Levine ,  Mark Milgrew

IPC分类号： G06F19/00 ,  G01N27/414

CPC分类号： G01N27/4148 ,  C12Q1/6869 ,  G01J1/46 ,  G01N27/4143 ,  G01N27/4145 ,  G01N33/00 ,  G01R29/26 ,  H01L27/14609 ,  H01L27/14632 ,  H01L27/14643 ,  H01L29/66 ,  H01L2924/0002 ,  H04N5/374 ,  Y10T436/25875 ,  H01L2924/00

摘要： The described embodiments may provide a chemical detection circuit that may comprise a plurality of first output circuits at a first side and a plurality of second output circuits at a second side of the chemical detection circuit. The chemical detection circuit may further comprise a plurality of tiles of pixels each placed between respective pairs of first and second output circuits. Each tile may include four quadrants of pixels. Each quadrant may have columns with designated first columns interleaved with second columns. Each first column may be coupled to a respective first output circuit in first and second quadrants, and to a respective second output circuit in third and fourth quadrants. Each second column may be coupled to a respective second output circuit in first and second quadrants, and to a respective first output circuit in third and fourth quadrants.

摘要翻译： 所描述的实施例可以提供化学检测电路，其可以包括在第一侧的多个第一输出电路和在化学检测电路的第二侧的多个第二输出电路。 化学检测电路还可以包括多个像素瓦片，每个瓷砖分别放置在相应的第一和第二输出电路对之间。 每个瓦片可以包括四个像素象限。 每个象限可以具有与第二列交错的指定的第一列的列。 每个第一列可以耦合到第一和第二象限中的相应的第一输出电路，以及耦合到第三和第四象限中的相应的第二输出电路。 每个第二列可以耦合到第一和第二象限中的相应的第二输出电路，以及耦合到第三和第四象限中的相应的第一输出电路。

公开(公告)号：US08421437B2

公开(公告)日：2013-04-16

申请号：US13421705

申请日：2012-03-15

申请人： Peter Levine

发明人： Peter Levine

IPC分类号： G01R27/00

CPC分类号： G01N27/4148 ,  C12Q1/6869 ,  G01J1/46 ,  G01N27/4143 ,  G01N27/4145 ,  G01N33/00 ,  G01R29/26 ,  H01L27/14609 ,  H01L27/14632 ,  H01L27/14643 ,  H01L29/66 ,  H01L2924/0002 ,  H04N5/374 ,  Y10T436/25875 ,  H01L2924/00

摘要： Circuits are described for reading a chemically-sensitive field-effect transistor (chemFET) with an improved signal-to-noise ratio. In one embodiment, a device is described that includes a chemFET including a first terminal and a second terminal, and a floating gate coupled to a passivation layer. An integrator circuit is coupled to the second source/drain terminal of the chemFET via a data line. The integrator circuit applies a bias voltage to the data line during a read interval, thereby inducing a current through the chemFET based on a threshold voltage of the chemFET. The integrator circuit then generates an output signal proportional to an integral of the induced current through the chemFET during the read interval.

摘要翻译： 描述了用于读取具有改善的信噪比的化学敏感场效应晶体管（chemFET）的电路。 在一个实施例中，描述了包括包括第一端子和第二端子的chemFET以及耦合到钝化层的浮动栅极的器件。 积分器电路通过数据线耦合到chemFET的第二源极/漏极端子。 积分器电路在读取间隔期间向数据线施加偏置电压，从而基于chemFET的阈值电压感生通过chemFET的电流。 然后，积分器电路在读取间隔期间产生与通过chemFET的感应电流的积分成比例的输出信号。

公开(公告)号：US20120228159A1

公开(公告)日：2012-09-13

申请号：US13421721

申请日：2012-03-15

申请人： Peter Levine

发明人： Peter Levine

IPC分类号： G01N27/414

CPC分类号： G01N27/4148 ,  C12Q1/6869 ,  G01J1/46 ,  G01N27/4143 ,  G01N27/4145 ,  G01N33/00 ,  G01R29/26 ,  H01L27/14609 ,  H01L27/14632 ,  H01L27/14643 ,  H01L29/66 ,  H01L2924/0002 ,  H04N5/374 ,  Y10T436/25875 ,  H01L2924/00

摘要： Methods are described for reading a chemically-sensitive field-effect transistor (chemFET) with an improved signal-to-noise ratio. In one embodiment, a method is described for reading a chemFET having a first terminal and a second terminal, and a floating gate coupled to a passivation layer. The method includes biasing the first terminal of the chemFET to a first bias voltage during a read interval. The second terminal of the chemFET is coupled to a data line during the read interval. A current is induced through the chemFET via the data line. An output signal proportional to an integral of a voltage or current on the data line is generated in response to the induced current through the chemFET during the read interval.

摘要翻译： 描述了用于读取具有改善的信噪比的化学敏感场效应晶体管（chemFET）的方法。 在一个实施例中，描述了一种用于读取具有第一端子和第二端子的chemFET以及耦合到钝化层的浮动栅极的方法。 该方法包括在读取间隔期间将chemFET的第一端偏压到第一偏置电压。 chemFET的第二个端子在读取间隔期间耦合到数据线。 通过chemFET通过数据线感应出电流。 响应于在读取间隔期间通过chemFET的感应电流，产生与数据线上的电压或电流的积分成比例的输出信号。

公开(公告)号：US20120228136A1

公开(公告)日：2012-09-13

申请号：US13421705

申请日：2012-03-15

申请人： Peter Levine

发明人： Peter Levine

IPC分类号： G01N27/414

CPC分类号： G01N27/4148 ,  C12Q1/6869 ,  G01J1/46 ,  G01N27/4143 ,  G01N27/4145 ,  G01N33/00 ,  G01R29/26 ,  H01L27/14609 ,  H01L27/14632 ,  H01L27/14643 ,  H01L29/66 ,  H01L2924/0002 ,  H04N5/374 ,  Y10T436/25875 ,  H01L2924/00

摘要： Circuits are described for reading a chemically-sensitive field-effect transistor (chemFET) with an improved signal-to-noise ratio. In one embodiment, a device is described that includes a chemFET including a first terminal and a second terminal, and a floating gate coupled to a passivation layer. An integrator circuit is coupled to the second source/drain terminal of the chemFET via a data line. The integrator circuit applies a bias voltage to the data line during a read interval, thereby inducing a current through the chemFET based on a threshold voltage of the chemFET. The integrator circuit then generates an output signal proportional to an integral of the induced current through the chemFET during the read interval.

摘要翻译： 描述了用于读取具有改善的信噪比的化学敏感场效应晶体管（chemFET）的电路。 在一个实施例中，描述了包括包括第一端子和第二端子的chemFET以及耦合到钝化层的浮动栅极的器件。 积分器电路通过数据线耦合到chemFET的第二源极/漏极端子。 积分器电路在读取间隔期间向数据线施加偏置电压，从而基于chemFET的阈值电压感生通过chemFET的电流。 然后，积分器电路在读取间隔期间产生与通过chemFET的感应电流的积分成比例的输出信号。

公开(公告)号：US20090256942A1

公开(公告)日：2009-10-15

申请号：US12456167

申请日：2009-06-12

申请人： Nathaniel Joseph McCaffrey ,  Peter Zalud ,  Peter Levine ,  Gary Hughes

发明人： Nathaniel Joseph McCaffrey ,  Peter Zalud ,  Peter Levine ,  Gary Hughes

IPC分类号： H04N5/335

CPC分类号： H04N9/045 ,  H04N5/345 ,  H04N5/3456 ,  H04N5/3765

摘要： A new method of reading an imager is achieved. The method comprises providing an imager array comprising n rows and m columns where a pair of rows can be read during a single row access time. A first image field is completed by sequentially reading and storing pixel values of pairs of adjacent rows of the imager array. The reading begins at a first row, and the reading stops when less than three rows are unread. Thereafter pixel values of the next row are read and not stored. Thereafter pixel values of the first row of the imager array are read and not stored. A second image field is completed by sequentially reading and storing pixel values of pairs of adjacent rows. The reading begins at the second row, the reading stops when less than two rows are unread.

摘要翻译： 实现了读取成像器的新方法。 该方法包括提供包括n行m列的成像器阵列，其中在单行访问时间期间可以读取一对行。 通过顺序读取和存储成像器阵列的相邻行对的像素值来完成第一图像场。 读数从第一行开始，当未读取少于三行时，读数停止。 此后读取并不存储下一行的像素值。 此后，读取并不存储成像器阵列的第一行的像素值。 通过顺序读取和存储相邻行对的像素值来完成第二图像场。 读数从第二行开始，当未读取少于两行时，读数停止。

公开(公告)号：US20080103063A1

公开(公告)日：2008-05-01

申请号：US11968262

申请日：2008-01-02

申请人： Ben Hitt ,  Peter Levine ,  Emanuel Petricoin

发明人： Ben Hitt ,  Peter Levine ,  Emanuel Petricoin

IPC分类号： C40B50/02

CPC分类号： G01N33/6848 ,  C40B30/04 ,  G01N33/6803 ,  G16B25/00 ,  G16B40/00 ,  Y10T436/24

摘要： The present invention relates to a method of quality assurance/quality control for high-throughput bioassay processes. The method includes generating a bioassay process model, and then comparing spectral data based on a combination of a biochip and a test serum to the bioassay process model to determine if the test sample and the bioassay process are producing acceptable data. Alternatively, the method may include comparing spectral data based on a combination of serum and diluents used in an electrospray process to the bioassay process model. If the bioassay process and test sample fall within the model, then the spectrum produced may be further analyzed.

摘要翻译： 本发明涉及高通量生物测定方法的质量保证/质量控制方法。 该方法包括生成生物测定过程模型，然后将基于生物芯片和测试血清的组合的光谱数据与生物测定过程模型进行比较，以确定测试样品和生物测定过程是否产生可接受的数据。 或者，该方法可以包括将基于电喷雾过程中使用的血清和稀释剂的组合的光谱数据与生物测定过程模型进行比较。 如果生物测定过程和测试样品落在模型中，则可以进一步分析产生的光谱。

公开(公告)号：US20060022113A1

公开(公告)日：2006-02-02

申请号：US11189650

申请日：2005-07-26

申请人： John Tower ,  Peter Levine

发明人： John Tower ,  Peter Levine

IPC分类号： C12Q1/68 ,  H01J40/00

CPC分类号： H04N5/238

摘要： Methods and apparatus for imaging light are disclosed. Light is imaged by collecting light, converting the collected light into a electrical charge signal, multiplying the electrical charge signal to produce multiple electrical charge signals with associated levels of gain, converting the electrical charge signals to voltage signals, and developing an output signal from one or more of the voltage signals that represents the collected light. The electrical charge signal may be multiplied using an electron multiplication device associated with multiple taps to produce the electrical charge signal with different levels of gain.

摘要翻译： 公开了用于成像光的方法和装置。 光通过收集光成像，将收集的光转换成电荷信号，将电荷信号相乘以产生具有相关增益水平的多个电荷信号，将电荷信号转换为电压信号，以及从一个 或更多的表示所收集的光的电压信号。 可以使用与多个抽头相关联的电子倍增装置将电荷信号相乘以产生具有不同增益水平的电荷信号。