公开(公告)号：US20240009177A1

公开(公告)日：2024-01-11

申请号：US18245970

申请日：2021-09-19

Applicant: RAMOT AT TEL-AVIV UNIVERSITY LTD.

Inventor： Dor ZAGURI ,  Topaz KREISER-SHEM-TOV ,  Ehud GAZIT ,  Daniel SEGAL ,  Josef MOGRABI ,  Eran BACHARACH

IPC: A61K31/4375 ,  A61K31/352 ,  A61K33/34 ,  A61K31/315 ,  A61P31/16

CPC classification number: A61K31/4375 ,  A61K31/352 ,  A61K33/34 ,  A61K31/315 ,  A61P31/16

Abstract: Combination compositions exhibiting anti-viral activities are provided, which are based on unique combinations of polyphenol zinc ionophores. Exemplary compositions comprise combinations of flavonoid zinc ionophores selected from EGCG, quercetin and taxifolin, preferably further comprising a zinc compound and a copper compound. The compositions preferably contain additional ingredients to further enhance the anti-viral effect of the composition and/or to provide additional benefits.

公开(公告)号：US20220162284A1

公开(公告)日：2022-05-26

申请号：US17591620

申请日：2022-02-03

Applicant: TEL HASHOMER MEDICAL RESEARCH INFRASTRUCTURE AND SERVICES LTD. ,  RAMOT AT TEL AVIV UNIVERSITY LTD.

Inventor： Genady KOSTENICH ,  Mor ORON-HERMAN ,  Arie ORENSTEIN ,  Talia SHEKHTER ZAHAVI ,  Ehud GAZIT ,  Yoseph SALITRA ,  Ludmilla BUZHANSKY

IPC: C07K14/655 ,  A61K47/62 ,  A61K47/69 ,  A61K38/08 ,  A61K38/12 ,  A61K49/00

Abstract: Disclosed are Somatostatin receptor ligands comprising a peptide moiety, pharmaceutical compositions and uses thereof. Disclosed are also synthetic Somatostatin receptor ligands comprising a cyclic peptide moiety and an active agent moiety covalently bonded to the cyclic peptide moiety through a nitrogen atom of a side chain functional group of an internal residue of the cyclic peptide moiety, pharmaceutical compositions and uses thereof. Disclosed are also synthetic Somatostatin receptor ligands comprising a cyclic peptide moiety and a nanoparticle active agent moiety covalently bonded to the cyclic peptide moiety, pharmaceutical compositions and uses thereof.

公开(公告)号：US20210030918A1

公开(公告)日：2021-02-04

申请号：US16942837

申请日：2020-07-30

Applicant: Ramot at Tel-Aviv University Ltd.

Inventor： Lihi ADLER-ABRAMOVICH ,  Ehud GAZIT ,  Irena GRIGORIANTS ,  Lialy KHADEJA ,  Sharon GILEAD

IPC: A61L15/32 ,  A61K31/12 ,  A61L15/42 ,  D06M10/02 ,  D06M15/01 ,  D04H13/00

Abstract: Provided herein are composite structures that include a core fiber and a plurality of peptide-based self-assembled nanostructures attached thereto, wherein the nanostructures may be loaded with a bioactive agent, such that the composite structures may act as slow-release drug-delivery medical device. Also provided is process for producing the composite structures, and uses thereof.

公开(公告)号：US20200165565A1

公开(公告)日：2020-05-28

申请号：US16630498

申请日：2018-07-13

Applicant: Ramot at Tel-Aviv University Ltd.

Inventor： Lihi ADLER-ABRAMOVICH ,  Rina SEVOSTIANOV ,  Irena GRIGORIANTS ,  Ehud GAZIT

IPC: C12N5/00

Abstract: Hybrid hydrogels, made of a three-dimensional network of fibrillar nanostructures, at least a portion of the fibrillar nanostructures being formed of at least two different types of aromatic moieties, at least one type of the aromatic moieties being an end-capping modified aromatic dipeptide and at least another type of the aromatic moieties being an amine-modified halogenated aromatic amino acid, are provided. Also provided are processes of preparing the hybrid hydrogels and uses thereof.

公开(公告)号：US20190054035A1

公开(公告)日：2019-02-21

申请号：US15949484

申请日：2018-04-10

Applicant: Yissum Research Development Company of the Hebrew University of Jerusalem Ltd. ,  Ramot at Tel-Aviv University Ltd.

Inventor： Galia BLUM ,  Yael BEN-NUN ,  Ehud GAZIT ,  Lihi ADLER-ABRAMOVICH ,  Galit FICHMAN

IPC: A61K9/70 ,  A61K47/42 ,  A61K31/704

Abstract: Provided are peptide-based nanostructures, as well as diagnostic and therapeutic methods using same.

公开(公告)号：US20160115196A1

公开(公告)日：2016-04-28

申请号：US14894043

申请日：2014-05-28

Applicant: NORTHWESTERN UNIVERSITY ,  RAMOT AT TEL-AVIV UNIVERSITY LTD.

Inventor： Galit FICHMAN ,  Lihi ADLER-ABRAMOVICH ,  Ehud GAZIT ,  Phillip B. MESSERSMITH

IPC: C07K5/065 ,  C07K7/06 ,  A01N37/46 ,  C07K5/087

CPC classification number: C07K5/06078 ,  A01N37/46 ,  A61K38/00 ,  C07K5/0812 ,  C07K7/06 ,  C07K17/04

Abstract: The present invention discloses self-assembled bioadhesive anti-microbial, anti-fouling and/or anti-oxidant micro- and nano-structures comprising a plurality of amino acids or peptides, wherein each amino acid is an aromatic amino acid comprising a catecholic moiety, and/or each peptide comprises at least one aromatic amino acid comprising a catecholic moiety. Further disclosed are methods and kits for preparing these micro- and nano-structures. Further disclosed are uses of these micro- and nano-structures in pharmaceutical, cosmetic and medical devices applications.

Abstract translation: 本发明公开了包含多个氨基酸或肽的自组装生物粘附性抗微生物，抗结垢和/或抗氧化微生物和纳米结构，其中每个氨基酸是包含儿茶素部分的芳族氨基酸， 和/或每个肽包含至少一种包含儿茶素部分的芳族氨基酸。 还公开了用于制备这些微结构和纳米结构的方法和试剂盒。 进一步公开的是这些微米和纳米结构在制药，化妆品和医疗器械应用中的应用。

公开(公告)号：US20150322110A1

公开(公告)日：2015-11-12

申请号：US14805490

申请日：2015-07-22

Applicant: Ramot at Tel-Aviv University Ltd.

Inventor： Ehud GAZIT ,  Yaniv Amir ,  Ludmila Buzhansky ,  Ulrich Abel ,  Anat Frydman-Marom

IPC: C07K5/078

CPC classification number: C07K5/06156

Abstract: Dipeptide analogs comprising a tryptophan (Trp) moiety coupled to a beta-sheet breaker moiety derived from alpha-aminoisobutyric acid (Aib) are disclosed. The dipeptide analogs exhibit an improved performance in inhibiting amyloid fibril formation, as compared to previously described dipeptides. Compositions containing the dipetide analogs and uses thereof in treating amyloid-associated diseases and disorders are also disclosed.

Abstract translation: 公开了包含与衍生自α-氨基异丁酸（Aib）的β-折叠片断裂部分偶联的色氨酸（Trp）部分的二肽类似物。 与先前描述的二肽相比，二肽类似物在抑制淀粉样蛋白原纤维形成中表现出改进的性能。 还公开了含有二酰胺类似物的组合物及其在治疗淀粉样蛋白相关疾病和病症中的用途。

公开(公告)号：US20130075703A1

公开(公告)日：2013-03-28

申请号：US13680217

申请日：2012-11-19

Applicant: Ramot at Tel-Aviv University Ltd.

Inventor： Ehud GAZIT ,  Meital Reches

IPC: H01L29/78 ,  H01L29/82

CPC classification number: H01L29/78 ,  A61K9/0092 ,  A61K47/6925 ,  B82Y5/00 ,  B82Y99/00 ,  C07K5/06078 ,  H01L29/82

Abstract: A composition comprising a material at least partially enclosed by a tubular, spherical or planar nanostructure composed of a plurality of peptides, wherein each of the plurality of peptides includes no more than 4 amino acids and whereas at least one of the 4 amino acids is an aromatic amino acid.

Abstract translation: 一种组合物，其包含至少部分地被由多个肽组成的管状，球形或平面纳米结构封闭的材料，其中所述多个肽中的每一个包含不超过4个氨基酸，而所述4个氨基酸中的至少一个是 芳香族氨基酸。