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公开(公告)号：US20160115196A1
公开(公告)日：2016-04-28
申请号：US14894043
申请日：2014-05-28
Applicant: NORTHWESTERN UNIVERSITY , RAMOT AT TEL-AVIV UNIVERSITY LTD.
Inventor： Galit FICHMAN , Lihi ADLER-ABRAMOVICH , Ehud GAZIT , Phillip B. MESSERSMITH
CPC classification number: C07K5/06078 , A01N37/46 , A61K38/00 , C07K5/0812 , C07K7/06 , C07K17/04
Abstract: The present invention discloses self-assembled bioadhesive anti-microbial, anti-fouling and/or anti-oxidant micro- and nano-structures comprising a plurality of amino acids or peptides, wherein each amino acid is an aromatic amino acid comprising a catecholic moiety, and/or each peptide comprises at least one aromatic amino acid comprising a catecholic moiety. Further disclosed are methods and kits for preparing these micro- and nano-structures. Further disclosed are uses of these micro- and nano-structures in pharmaceutical, cosmetic and medical devices applications.
Abstract translation: 本发明公开了包含多个氨基酸或肽的自组装生物粘附性抗微生物，抗结垢和/或抗氧化微生物和纳米结构，其中每个氨基酸是包含儿茶素部分的芳族氨基酸， 和/或每个肽包含至少一种包含儿茶素部分的芳族氨基酸。 还公开了用于制备这些微结构和纳米结构的方法和试剂盒。 进一步公开的是这些微米和纳米结构在制药，化妆品和医疗器械应用中的应用。
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公开(公告)号：US20220390471A1
公开(公告)日：2022-12-08
申请号：US17831232
申请日：2022-06-02
Applicant: Ramot at Tel-Aviv University Ltd.
Inventor： Ehud GAZIT , Dana LAOR , Dorin SADE YAZDI
IPC: G01N33/68
Abstract: The present disclosure provides yeast screening system/s and methods for screening of candidate therapeutic compound/s for treating, at least one proteniopathy and/or protein misfolding disorder. More specifically, the present disclosure provides systems and methods for identifying a therapeutic compound that inhibit Hcy fibril formation and uses thereof in treating Alzheimer's disease.
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公开(公告)号：US20210395312A1
公开(公告)日：2021-12-23
申请号：US17467297
申请日：2021-09-06
Applicant: Ramot at Tel-Aviv University Ltd.
Inventor： Ehud GAZIT , Kai TAO , Yu CHEN , Sharon GILEAD , Sigal LAZAR , Pandeeswar MAKAM
IPC: C07K7/64
Abstract: Self-assembled structures formed of a plurality of cyclic peptides which are in association with metal ions is provided. The cyclic peptides are each of from 2 to 6 amino acid residues, and two or more of the amino acid residues are each independently an aromatic amino acid residue. The self-assembled structures exhibit photoluminescence and can be used or incorporated in light emitting systems.
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公开(公告)号：US20200325203A1
公开(公告)日：2020-10-15
申请号：US16914388
申请日：2020-06-28
Applicant: TEL HASHOMER MEDICAL RESEARCH INFRASTRUCTURE AND SERVICES LTD. , RAMOT AT TEL AVIV UNIVERSITY LTD.
Inventor： Genady KOSTENICH , Mor ORON-HERMAN , Arie ORENSTEIN , Talia SHEKHTER ZAHAVI , Ehud GAZIT , Yoseph SALITRA , Ludmila BUZHANSKY
Abstract: Disclosed are Somatostatin receptor ligands comprising a peptide moiety, pharmaceutical compositions and uses thereof. Disclosed are also synthetic Somatostatin receptor ligands comprising a cyclic peptide moiety and an active agent moiety covalently bonded to the cyclic peptide moiety through a nitrogen atom of a side chain functional group of an internal residue of the cyclic peptide moiety, pharmaceutical compositions and uses thereof. Disclosed are also synthetic Somatostatin receptor ligands comprising a cyclic peptide moiety and a nanoparticle active agent moiety covalently bonded to the cyclic peptide moiety, pharmaceutical compositions and uses thereof.
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公开(公告)号：US20170298113A1
公开(公告)日：2017-10-19
申请号：US15509842
申请日：2015-09-10
Applicant: TEL HASHOMER MEDICAL RESEARCH INFRASTRUCTURE AND SERVICES LTD. , RAMOT AT TEL AVIV UNIVERSITY LTD.
Inventor： Genady KOSTENICH , Mor ORON-HERMAN , Arie ORENSTEIN , Talia SHEKHTER ZAHAVI , Ehud GAZIT , Yoseph SALITRA , Ludmila BUZHANSKY
IPC: C07K14/655 , A61K38/12 , A61K38/08
CPC classification number: C07K14/655 , A61K38/08 , A61K38/12 , A61K47/62 , A61K47/6923 , A61K47/6933 , A61K47/6937
Abstract: Disclosed are Somatostatin receptor ligands comprising a peptide moiety, pharmaceutical compositions and uses thereof. Disclosed are also synthetic Somatostatin receptor ligands comprising a cyclic peptide moiety and an active agent moiety covalently bonded to the cyclic peptide moiety through a nitrogen atom of a side chain functional group of an internal residue of the cyclic peptide moiety, pharmaceutical compositions and uses thereof. Disclosed are also synthetic Somatostatin receptor ligands comprising a cyclic peptide moiety and a nanoparticle active agent moiety covalently bonded to the cyclic peptide moiety, pharmaceutical compositions and uses thereof.
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Patent Agency Ranking
公开(公告)号：US20140044949A1
公开(公告)日：2014-02-13
申请号：US14061771
申请日：2013-10-24
Applicant: Ramot at Tel-Aviv University Ltd.
Inventor： Ehud GAZIT , Meital Reches
IPC: D01F4/00
CPC classification number: D01F4/00 , C07K5/06078 , C07K5/06191 , C08J5/18 , C08J2300/16 , D01D5/00 , D01F1/10 , D01F6/68 , Y10T428/253 , Y10T428/298 , Y10T442/60 , Y10T442/614
Abstract: A method of forming a fiber made of peptide nanostructures is disclosed. The method comprises: providing peptide nanostructures in solution, and fiberizing the solution thereby forming at least one fiber of the peptide nanostructures. Also disclosed are methods of forming films and other articles using the peptide nanostructures.
Abstract translation: 公开了一种形成由肽纳米结构制成的纤维的方法。 该方法包括：在溶液中提供肽纳米结构，并使溶液纤维化，从而形成肽纳米结构的至少一种纤维。 还公开了使用肽纳米结构形成膜和其它制品的方法。
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公开(公告)号：US20210170048A1
公开(公告)日：2021-06-10
申请号：US16071168
申请日：2017-01-19
Applicant: RAMOT AT TEL-AVIV UNIVERSITY LTD. , TEL HASHOMER MEDICAL RESEARCH INFRASTRUCTURE AND SERVICES LTD.
Inventor： Talia SHEKHTER ZEHAVI , Ehud GAZIT , Mor HERMAN-ORON , Genady KOSTENICH , Arie ORENSTEIN
Abstract: The present invention provides nanoparticle conjugates incorporating the self-assembling module diphenylalanine (FF) dipeptide into a bioactive moiety. The conjugate self-assembles to form distinct nanometric structures such as nanospheres. The present invention further provides nanoparticles formed by supramolecular co-assembly of the conjugates with a diphenylalanine (FF) dipeptide or analog thereof, to generate bioactive self-assembled nanostructures.
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公开(公告)号：US20160108434A1
公开(公告)日：2016-04-21
申请号：US14880311
申请日：2015-10-12
Applicant: RAMOT AT TEL-AVIV UNIVERSITY LTD.
Inventor： Iftach YACOBY , Ehud GAZIT , Nathan NELSON , Itai BENHAR
CPC classification number: C12P3/00 , C12M21/02 , C12M21/18 , C12M31/10 , C12M47/10 , C12N9/0067 , C12N9/96 , C12N15/62 , C12Y112/98002
Abstract: An isolated polypeptide comprising a hydrogen generating enzyme attached to a heterologous ferredoxin is disclosed, as well as polynucleotides encoding same, nucleic acid constructs capable of expressing same and cells expressing same. A method for generating hydrogen using the isolated polypeptide is also disclosed.
Abstract translation: 公开了包含与异源铁氧还蛋白连接的产氢酶的分离的多肽，以及编码其的多核苷酸，能够表达其的核酸构建体和表达相同的细胞。 还公开了使用分离的多肽产生氢的方法。
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9.发明申请NAPHTHOQUINONE DERIVATIVES USEFUL FOR PREVENTION OF AMYLOID DEPOSITS AND TREATMENT OF DISEASES INVOLVING AMYLOIDOGENESIS 有权用于预防淀粉样沉积物和治疗涉及淀粉样变性疾病的萘普隆酮衍生物公开(公告)号：US20140213627A1
公开(公告)日：2014-07-31
申请号：US14168550
申请日：2014-01-30
Applicant: RAMOT AT TEL AVIV UNIVERSITY LTD.
Inventor： Roni SCHERZER , Ehud GAZIT , Daniel SEGAL
IPC: C07C309/14 , C07C211/54 , C07D245/04 , C07C229/18 , C07D207/09 , C07C229/60 , C07D209/14 , C07D209/20
CPC classification number: C07C309/14 , A61K31/198 , A61K31/255 , A61K31/395 , A61K31/405 , C07C211/54 , C07C229/18 , C07C229/60 , C07D207/09 , C07D209/14 , C07D209/20 , C07D245/04
Abstract: The present invention provides pharmaceutical compositions comprising substituted 1,4 naphthoquinones that are effective in preventing oligomerization of beta amyloid and subsequent pathologies associated with amyloid fibrils. These compositions are useful for the treatment of disease involving amyloidogenesis including neurodegenerative diseases such as Alzheimer's Disease or senile dementia. Particularly effective compositions comprise 1,4 naphthoquinones substituted with an amino acid residue selected from a heterocyclic or aromatic amino acid.
Abstract translation: 本发明提供了包含取代的1,4-萘醌的药物组合物，其有效预防β淀粉样蛋白的低聚和随后与淀粉样蛋白原纤维相关的病理学。 这些组合物可用于治疗包括淀粉样变性（包括神经变性疾病如阿尔茨海默病或老年痴呆）的疾病。 特别有效的组合物包含被选自杂环或芳族氨基酸的氨基酸残基取代的1,4萘醌。
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公开(公告)号：US20220190232A1
公开(公告)日：2022-06-16
申请号：US17442765
申请日：2020-03-25
Applicant: Ramot at Tel-Aviv University Ltd. , Xidian University
Inventor： Ehud GAZIT , Santu BERA , Yu CHEN , Sharon GILEAD , Kai TAO , Sigal LAZAR , Rusen YANG , Sudipta MONDAL , Vasantha BASAVALINGAPPA
IPC: H01L41/193 , C07K5/097 , C07K5/083 , C07K5/087 , C07K5/065
Abstract: A piezoelectric transducer is provided herein, comprising a three-dimensional structure made of a plurality of peptides, the peptides being self-assembling and the structure being piezoelectric, wherein at least a portion, or each, of said plurality of peptides comprises peptides of 2 to 10 amino acid residues, provided that the plurality of peptides is not consisted of a plurality of Phe-Phe dipeptides. Further described herein are peptides having an amino acid sequence Hyp-Phe-Phe, Boc-Dip-Dip, (L)Trp-(D)Trp or (D)Trp-(L)Trp, as well as three-dimensional structures comprising such peptides.
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