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公开(公告)号：US20220355251A1
公开(公告)日：2022-11-10
申请号：US17869077
申请日：2022-07-20
Applicant: REPLIGEN CORPORATION
Inventor： Rudolf Pavlik
IPC: B01D63/02 , C12M1/00 , B01D69/08 , B01D37/04 , C12M1/12 , B01D35/26 , B01D29/11 , B01D29/90 , F04B43/00 , F04B43/067 , F04B53/20
Abstract: A fluid filtration assembly includes a filter housing having a first end for fluid connection with a fluid storage vessel. A filter cartridge is disposable within the filter housing, and a plunger pump is coupled at a second end of the filter housing. The plunger pump includes a housing having a rigid portion and a flexible portion. The flexible portion has a plunger-engaging portion for coupling to the plunger of an actuator. The flexible portion selectively movable with respect to the rigid portion via the actuator. The filter cartridge can be a hollow fiber filter. The plunger pump can be configured to induce alternating tangential flow in at least a portion of the assembly. The fluid filtration assembly can be provided as a disposable single-use arrangement.
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公开(公告)号：US20220331725A1
公开(公告)日：2022-10-20
申请号：US17852643
申请日：2022-06-29
Applicant: Repligen Corporation
Inventor： Rudolf Pavlik , Ralf Kuriyel
Abstract: A fluid filtration system includes a fluid storage vessel such as a bioreactor, a filter housing including a filter element disposed therein, a pump coupled between the fluid storage vessel and the filter housing, and a flow diverter disposed between the pump and the filter housing. The pump is configured to move fluid from the fluid storage vessel through the filter element, and the flow diverter is configured for selectively directing fluid received from the pump to the first or second end of the filter housing. In a first mode of operation, the flow diverter directs flow through the filter housing in a first direction, while in a second mode of operation, the flow diverter directs flow through the filter housing in a second direction opposite the first direction.
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公开(公告)号：US10792594B2
公开(公告)日：2020-10-06
申请号：US15856204
申请日：2017-12-28
Applicant: REPLIGEN CORPORATION
Inventor： Rudolf Pavlik
Abstract: A fluid filtration assembly includes a filter housing having first and second ends and a connector for fluid communication with a fluid storage vessel. A filter element is disposable within the filter housing, and first and second pumps are coupled at the first and second ends of the filter housing. A controller may coordinate the operation of the first and second pumps to induce alternating tangential flow of fluid between the filter housing and the first and second pumps. At least one of the first and second pumps is a diaphragm pump or a plunger pump. The fluid storage vessel can be a bioreactor.
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Patent Agency Ranking
公开(公告)号：US20220362692A1
公开(公告)日：2022-11-17
申请号：US17878981
申请日：2022-08-02
Applicant: Repligen Corporation
Inventor： Rudolf Pavlik
Abstract: A fluid filtration assembly includes a filter housing having first and second ends and a connector for fluid communication with a fluid storage vessel. A filter element is disposable within the filter housing, and first and second pumps are coupled at the first and second ends of the filter housing. A controller may coordinate the operation of the first and second pumps to induce alternating tangential flow of fluid between the filter housing and the first and second pumps. At least one of the first and second pumps is a diaphragm pump or a plunger pump. The fluid storage vessel can be a bioreactor.
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公开(公告)号：US20220331724A1
公开(公告)日：2022-10-20
申请号：US17721846
申请日：2022-04-15
Applicant: Repligen Corporation
Inventor： Rudolf Pavlik , Ralf Kuriyel
Abstract: A fluid filtration system includes a fluid storage vessel such as a bioreactor, a filter housing including a filter element disposed therein, a pump coupled between the fluid storage vessel and the filter housing, and a flow diverter disposed between the pump and the filter housing. The pump is configured to move fluid from the fluid storage vessel through the filter element, and the flow diverter is configured for selectively directing fluid received from the pump to the first or second end of the filter housing. In a first mode of operation, the flow diverter directs flow through the filter housing in a first direction, while in a second mode of operation, the flow diverter directs flow through the filter housing in a second direction opposite the first direction.
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公开(公告)号：US20220325226A1
公开(公告)日：2022-10-13
申请号：US17752231
申请日：2022-05-24
Applicant: Repligen Corporation
Inventor： Rudolf Pavlik
IPC: C12M1/36 , F04B49/20 , C12M1/34 , F04B23/04 , C12M1/00 , F04B43/073 , F04B43/00 , F04B49/06 , B01D61/22 , B01D61/58 , B01D63/02 , B01D61/20
Abstract: A control unit includes a first connector configured to connect a proportional pressure regulator to a positive pressure supply and a second connector configured to connect the proportional pressure regulator to a negative pressure supply. The control unit further includes at least one sensor configured to detect an amount of air flow (volume per unit of time), positive or negative, within an air flow line connected to an output of the proportional pressure regulator, and a third connector configured to connect the air flow line to an air side of a diaphragm. Additionally, the control unit includes a controller programmed to control at least an opening and closing function of the proportional pressure regulator to attain a desired amount of air flow (volume per unit of time), positive or negative, within the air flow line.
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公开(公告)号：US20200377839A1
公开(公告)日：2020-12-03
申请号：US16908225
申请日：2020-06-22
Applicant: Repligen Corporation
Inventor： Rudolf Pavlik
IPC: C12M1/00 , F04B49/20 , F04B43/02 , F04B43/06 , C12M1/34 , F04B23/04 , C12M1/36 , F04B43/073 , F04B43/00 , F04B49/06
Abstract: A control unit includes a first connector configured to connect a proportional pressure regulator to a positive pressure supply and a second connector configured to connect the proportional pressure regulator to a negative pressure supply. The control unit further includes at least one sensor configured to detect an amount of air flow (volume per unit of time), positive or negative, within an air flow line connected to an output of the proportional pressure regulator, and a third connector configured to connect the air flow line to an air side of a diaphragm. Additionally, the control unit includes a controller programmed to control at least an opening and closing function of the proportional pressure regulator to attain a desired amount of air flow (volume per unit of time), positive or negative, within the air flow line.
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公开(公告)号：US10774297B2
公开(公告)日：2020-09-15
申请号：US15892214
申请日：2018-02-08
Applicant: Repligen Corporation
Inventor： Rudolf Pavlik
IPC: C12M1/00 , F04B49/20 , F04B43/02 , F04B43/06 , C12M1/34 , F04B23/04 , C12M1/36 , F04B43/073 , F04B43/00 , F04B49/06
Abstract: A control unit includes a first connector configured to connect a proportional pressure regulator to a positive pressure supply and a second connector configured to connect the proportional pressure regulator to a negative pressure supply. The control unit further includes at least one sensor configured to detect an amount of air flow (volume per unit of time), positive or negative, within an air flow line connected to an output of the proportional pressure regulator, and a third connector configured to connect the air flow line to an air side of a diaphragm. Additionally, the control unit includes a controller programmed to control at least an opening and closing function of the proportional pressure regulator to attain a desired amount of air flow (volume per unit of time), positive or negative, within the air flow line.
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