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公开(公告)号：US11958018B2
公开(公告)日：2024-04-16
申请号：US17091616
申请日：2019-05-28
申请人： REPLIGEN CORPORATION
发明人： Michael Bransby , Derek Carroll , Philip Yuen , Ralf Kuriyel
CPC分类号： B01D63/06 , B01D61/147 , B01D63/02 , B01D65/08 , C12M33/14 , B01D2315/10 , B01D2321/20
摘要： The disclosure provides tangential flow depth filtration (TFDF) systems which exhibit improved filter fluxes and process capacities and reduced fouling characteristics. The TFDF systems of the disclosure optionally utilize tubular depth filters (TDF). Methods are provided which include the passage of a non-laminar flow through at least a portion of a length of a TDF in a TFDF system.
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公开(公告)号：US20220331724A1
公开(公告)日：2022-10-20
申请号：US17721846
申请日：2022-04-15
申请人： Repligen Corporation
发明人： Rudolf Pavlik , Ralf Kuriyel
摘要： A fluid filtration system includes a fluid storage vessel such as a bioreactor, a filter housing including a filter element disposed therein, a pump coupled between the fluid storage vessel and the filter housing, and a flow diverter disposed between the pump and the filter housing. The pump is configured to move fluid from the fluid storage vessel through the filter element, and the flow diverter is configured for selectively directing fluid received from the pump to the first or second end of the filter housing. In a first mode of operation, the flow diverter directs flow through the filter housing in a first direction, while in a second mode of operation, the flow diverter directs flow through the filter housing in a second direction opposite the first direction.
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公开(公告)号：US20240335776A1
公开(公告)日：2024-10-10
申请号：US18748880
申请日：2024-06-20
申请人： Repligen Corporation
发明人： Rudolf Pavlik , Ralf Kuriyel
CPC分类号： B01D35/26 , B01D29/11 , B01D29/66 , B01D29/902 , B01D29/908 , B01D65/02 , B01D69/08 , C12M29/16 , C12M41/44 , B01D2201/165 , B01D2321/04 , B01D2321/12
摘要： A fluid filtration system includes a fluid storage vessel such as a bioreactor, a filter housing including a filter element disposed therein, a pump coupled between the fluid storage vessel and the filter housing, and a flow diverter disposed between the pump and the filter housing. The pump is configured to move fluid from the fluid storage vessel through the filter element, and the flow diverter is configured for selectively directing fluid received from the pump to the first or second end of the filter housing. In a first mode of operation, the flow diverter directs flow through the filter housing in a first direction, while in a second mode of operation, the flow diverter directs flow through the filter housing in a second direction opposite the first direction.
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公开(公告)号：US20240238731A1
公开(公告)日：2024-07-18
申请号：US18605090
申请日：2024-03-14
申请人： REPLIGEN CORPORATION
发明人： Michael Bransby , Derek Carroll , Philip Yuen , Ralf Kuriyel
CPC分类号： B01D63/06 , B01D61/147 , B01D63/02 , B01D65/08 , C12M33/14 , B01D2315/10 , B01D2321/20
摘要： The disclosure provides tangential flow depth filtration (TFDF) systems which exhibit improved filter fluxes and process capacities and reduced fouling characteristics. The TFDF systems of the disclosure optionally utilize tubular depth filters (TDF). Methods are provided which include the passage of a non-laminar flow through at least a portion of a length of a TDF in a TFDF system.
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公开(公告)号：US11673083B2
公开(公告)日：2023-06-13
申请号：US17721846
申请日：2022-04-15
申请人： Repligen Corporation
发明人： Rudolf Pavlik , Ralf Kuriyel
CPC分类号： B01D35/26 , B01D29/11 , B01D29/66 , B01D29/902 , B01D29/908 , B01D65/02 , B01D69/08 , C12M29/16 , C12M41/44 , B01D2201/165 , B01D2321/04 , B01D2321/12
摘要： A fluid filtration system includes a fluid storage vessel such as a bioreactor, a filter housing including a filter element disposed therein, a pump coupled between the fluid storage vessel and the filter housing, and a flow diverter disposed between the pump and the filter housing. The pump is configured to move fluid from the fluid storage vessel through the filter element, and the flow diverter is configured for selectively directing fluid received from the pump to the first or second end of the filter housing. In a first mode of operation, the flow diverter directs flow through the filter housing in a first direction, while in a second mode of operation, the flow diverter directs flow through the filter housing in a second direction opposite the first direction.
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公开(公告)号：US20220331725A1
公开(公告)日：2022-10-20
申请号：US17852643
申请日：2022-06-29
申请人： Repligen Corporation
发明人： Rudolf Pavlik , Ralf Kuriyel
摘要： A fluid filtration system includes a fluid storage vessel such as a bioreactor, a filter housing including a filter element disposed therein, a pump coupled between the fluid storage vessel and the filter housing, and a flow diverter disposed between the pump and the filter housing. The pump is configured to move fluid from the fluid storage vessel through the filter element, and the flow diverter is configured for selectively directing fluid received from the pump to the first or second end of the filter housing. In a first mode of operation, the flow diverter directs flow through the filter housing in a first direction, while in a second mode of operation, the flow diverter directs flow through the filter housing in a second direction opposite the first direction.
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公开(公告)号：US20220080359A1
公开(公告)日：2022-03-17
申请号：US17091616
申请日：2019-05-28
申请人： REPLIGEN CORPORATION
发明人： Michael Bransby , Derek Carroll , Philip Yuen , Ralf Kuriyel
摘要： The disclosure provides tangential flow depth filtration (TFDF) systems which exhibit improved filter fluxes and process capacities and reduced fouling characteristics. The TFDF systems of the disclosure optionally utilize tubular depth filters (TDF). Methods are provided which include the passage of a non-laminar flow through at least a portion of a length of a TDF in a TFDF system.
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