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公开(公告)号：US20070276355A1
公开(公告)日：2007-11-29
申请号：US10589946
申请日：2005-02-17
申请人： Jens Nielsen , Morten Ludvigsen , Soren Jensen , Oria Mathiasen
发明人： Jens Nielsen , Morten Ludvigsen , Soren Jensen , Oria Mathiasen
IPC分类号： A61M5/158
CPC分类号： A61M39/04 , A61M5/158 , A61M25/02 , A61M2005/1581 , A61M2025/024 , Y10T29/494
摘要： The invention concerns an infusion device for subcutaneous administering a medication or a therapeutic fluid to a patient. Said infusion device comprises a base element (1), which comprises fluid receiving means for receiving said fluid and fluid communication means for transferring said fluid into a cannula, said base element being provided with at least one recess (20) accommodating a septum (5) being pierceable by a needle. Said septum is secured to said base element by a septum housing (3) in such a way that a fluid transfer volume is formed in said at least one recess between an internal surface of said septum and an inner section of said recess. Said fluid transfer volume is communicating with said fluid communication means, and said septum housing is accommodating a premounted septum. The infusion device is characterized in that the septum housing is fixed and fluid sealed to said base element in said inner section of said recess.
摘要翻译： 本发明涉及用于向患者皮下施用药物或治疗流体的输注装置。 所述输注装置包括基部元件（1），其包括用于接收所述流体的流体接收装置和用于将所述流体转移到套管中的流体连通装置，所述基座元件设置有至少一个容纳隔膜（5） ）被针刺伤。 所述隔膜通过隔膜壳体（3）固定到所述基座元件，使得在所述隔膜的内表面和所述凹部的内部部分之间的所述至少一个凹部中形成流体转移体积。 所述流体传送体积与所述流体连通装置连通，并且所述隔膜壳体容纳预先安装的隔膜。 输液装置的特征在于，隔垫壳体是固定的并且在所述凹部的所述内部部分中流体密封到所述基座元件。
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22.发明申请Metabolically engineered micro-organisms having reduced production of undesired metabolic products 审中-公开经代谢改造的微生物减少不需要的代谢产物的产生公开(公告)号：US20060257983A1
公开(公告)日：2006-11-16
申请号：US10536495
申请日：2003-11-25
摘要： A metabolically engineered micro-organism has an operative first metabolic pathway in which a first metabolite is transformed into a second metabolite in a reaction in which NAD is a cofactor for a first enzyme, suitably a phosphorylating dehydrogenase, said reaction step producing NADH. Said second metabolite is transformed into at least one further metabolite in a reaction catalysed by a second enzyme, suitably a kinase. The organism has an operative second metabolic pathway characterised by an enzyme activity in excess of a native level in respect of a third enzyme, suitably a non-phosphorylating dehydrogenase, e.g. GAPN, catalysing a non-reversible reaction in which NADP is a cofactor and NADPH is a product. Said first metabolite is transformed into a said further metabolite without the involvement of said second enzyme.
摘要翻译： 代谢工程微生物具有有效的第一代谢途径，其中第一代谢物在其中NAD是第一种酶的辅因子（合适的是磷酸化脱氢酶）的反应中转化成第二种代谢物，所述反应步骤产生NADH。 所述第二代谢物在由第二种酶（合适的是激酶）催化的反应中转化成至少一种其它代谢物。 生物体具有可操作的第二代谢途径，其特征在于对于第三种酶，合适地为非磷酸化脱氢酶，例如，超过天然水平的酶活性。 GAPN，催化NADP是辅因子和NADPH是一种产物的不可逆反应。 所述第一代谢物被转化成所述另外的代谢物，而不涉及所述第二种酶。
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23.发明授权Metabolically engineered microbial cell with an altered metabolite production 有权具有改变的代谢产物的代谢工程的微生物细胞公开(公告)号：US07018829B1
公开(公告)日：2006-03-28
申请号：US09743414
申请日：1999-07-12
CPC分类号： C12N9/0036 , C12N9/0016 , C12N9/93 , C12P7/06 , Y02E50/17
摘要： A recombinant microbial cell comprises at least one increased expressible enzyme activity controlling anabolic metabolism of ammonia as a nutrient source, the increased enzyme activity being an NADH-dependent activity catalysing the reaction (a) 2-oxoglutarate+NH3+NADH→glutamate+NAD or being an activity catalysing the reaction (b) 2-oxoglutarate+glutamine+NADH→2 glutamate+NAD or being an activity catalysing the reaction (c) glutamate+NH3+ATP→glutamine+ADP+Pi. The increased enzyme activity is encoded by a nucleic acid coding sequence linked to an expression signal not natively associated with the nucleic acid coding sequence and is increased as compared to the expression of the enzyme activity when the nucleic acid coding sequence is associated with its native expression signal.
摘要翻译： 重组微生物细胞包含控制氨作为营养源的合成代谢的至少一种增加的可表达酶活性，增加的酶活性是催化反应的NADH依赖性活性（a）2-氧戊二酸盐+ NH 3 > NAD +>谷氨酸+ NAD或作为催化反应的活性（b）2-氧戊二酸+谷氨酰胺+ NADH->谷氨酸+ NAD或催化反应的活性（c）谷氨酸+ NH 3 SUB> + ATP->谷氨酰胺+ ADP + Pi。 增加的酶活性由与核酸编码序列本身不相关的表达信号连接的核酸编码序列编码，并且当核酸编码序列与其天然表达相关时与酶活性的表达相比增加 信号。
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公开(公告)号：US20050238610A1
公开(公告)日：2005-10-27
申请号：US11040813
申请日：2005-01-21
申请人： Jens Nielsen , Thomas Raschke , Nadine Voigt
发明人： Jens Nielsen , Thomas Raschke , Nadine Voigt
摘要： Cosmetic and/or dermatological oil-in-water (O/W) emulsion with a viscosity of 100 to 1900 mPaS, containing a) one or more electrolytes in a concentration of 0.5 to 8% by weight, b) a thickener in a concentration of 0.05 to 1% by weight, and c) an emulsifier combination in a concentration of 0.5 to 6% by weight, which comprises polyethylene glycol stearate esters and at least one further emulsifier selected from polyoxyethylene cetylstearyl ethers and glyceryl stearate, wherein the weight percentages are based on the total weight of the emulsion.
摘要翻译： 化妆品和/或皮肤病学油包水（O / W）乳液，其粘度为100至1900mPaS，含有a）一种或多种浓度为0.5至8重量％的电解质，b）浓度增稠剂 为0.05〜1重量％，c）浓度为0.5〜6重量％的乳化剂组合，其包含聚乙二醇硬脂酸酯和至少一种选自聚氧乙烯鲸蜡硬脂基醚和硬脂酸甘油酯的其它乳化剂，其中重量百分数 基于乳液的总重量。
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公开(公告)号：US20050058679A1
公开(公告)日：2005-03-17
申请号：US10915143
申请日：2004-08-09
申请人： Rainer Kropke , Jens Nielsen , Kathrin Wolter
发明人： Rainer Kropke , Jens Nielsen , Kathrin Wolter
CPC分类号： A61K8/345 , A61K9/0014 , A61K47/10 , A61K2800/59 , A61Q19/00 , A61Q19/007
摘要： The invention is a cosmetic or dermatological formulation comprising a) at least one polyol in a concentration of from 0.1 to 20% by weight, based on the total weight of the formulation, and b) at least one diol selected from the group consisting of 2-methyl-1,3-propanediol, pentanediol, and hexanediol, in a concentration of from 0.1 to 25% by weight, based on the total weight of the formulation. The invention also includes formulations further comprising at least one antioxidant, and formulations further comprising at least one UV filter. The invention also includes a method of moisturizing skin comprising applying the formulation to the skin. The invention further includes a method for reducing the tacky sensation, a method for reducing the viscosity, and a method for increasing the stability of a polyol-containing formulation comprising adding a diol selected from the group consisting of 2-methyl-1,3-propanediol, pentanediol, and hexanediol.
摘要翻译： 本发明是一种化妆品或皮肤病学制剂，其包含a）至少一种浓度为0.1至20重量％的多元醇，基于制剂的总重量，和b）至少一种选自2 - 甲基-1,3-丙二醇，戊二醇和己二醇，其浓度为制剂总重量的0.1至25重量％。 本发明还包括进一步包含至少一种抗氧化剂的制剂，以及进一步包含至少一种UV过滤器的制剂。 本发明还包括一种保湿皮肤的方法，包括将制剂施用于皮肤。 本发明还包括降低粘性的方法，降低粘度的方法，以及提高含多元醇制剂的稳定性的方法，包括加入选自2-甲基-1,3-丙二醇的二醇， 丙二醇，戊二醇和己二醇。
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公开(公告)号：US20180237812A1
公开(公告)日：2018-08-23
申请号：US15927483
申请日：2018-03-21
申请人： Jens Nielsen , Shuobo Shi
发明人： Jens Nielsen , Shuobo Shi
摘要： The present invention relates to the provision of genetically modified fungal cells, such as yeast cells with an improved ability for producing different fatty acids and specifically fatty acid ethyl esters (FAEE), the main components of biodiesel. An increased in fatty acid production, and hence in FAEE, is obtained in the first place by expressing different heterologous polypeptides in combination with the down-regulation, attenuation, deletion or over-expression of specially selected genes, wherein said genes encode enzymes involved in the fatty acids synthesizing pathway, fatty acid consuming pathways, carbohydrate biosynthesis pathways or enzyme acting as wax ester transporters or a combination thereof. The methods and products of the invention would allow large-scale production of FAEE with carbohydrates as the only externally-supplied substrate.
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公开(公告)号：US20140283729A1
公开(公告)日：2014-09-25
申请号：US14127132
申请日：2012-06-15
摘要： The present invention relates to an evacuation system (4) for a vessel (1) or offshore facility, comprising a storage unit (7) having a length, a width and a height defining a volume of the storage unit (7), the storage unit (7) in a storage situation being adapted to house one or more self-propelling, inflatable floatable units (5), the inflatable floatable units each having a capacity of more than 150 persons, and a deployment arrangement (8) having a displacement device, wherein a maximum height of the storage unit is 2.7 metres, and the displacement device is adapted to displace the one or more self-propelling, inflatable floatable units in a substantially horizontal and linear direction out of the storage unit (7) below the maximum height and subsequently lower the one or more self-propelling, inflatable floatable units (5) into the water in a substantially vertical direction.
摘要翻译： 本发明涉及一种用于容器（1）或海上设施的抽空系统（4），其包括具有限定所述存储单元（7）的体积的长度，宽度和高度的存储单元（7），所述存储 存储状态下的单元（7）适于容纳一个或多个自推进的可充气可浮动单元（5），每个具有超过150人的容量的可膨胀的可浮动单元和具有位移的展开装置（8） 装置，其中所述存储单元的最大高度为2.7米，并且所述位移装置适于将基本上水平和线性方向上的所述一个或多个自推进的，可充气的可浮动单元移出所述存储单元（7）的下方 并且随后将一个或多个自推进的，可充气的可漂浮单元（5）沿基本垂直的方向下降到水中。
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公开(公告)号：US08529921B2
公开(公告)日：2013-09-10
申请号：US13123740
申请日：2009-10-12
IPC分类号： A61K8/02
摘要： Polyamide-5 compounds show an increase of the care and/or efficacy properties of cosmetic or dermatological preparations, such as waterproofness, long-term stability, skin moisture and stickiness. The preparations preferably comprise one or more care agents or active ingredients selected from the group of UV filter substances, anti-wrinkle active ingredients, skin moisturizers and/or lipids.
摘要翻译： 聚酰胺-5化合物显示化妆品或皮肤病学制剂的护理和/或功效性能的增加，例如防水性，长期稳定性，皮肤水分和粘性。 制剂优选包含一种或多种选自紫外线过滤物质，抗皱活性成分，皮肤保湿剂和/或脂质的护理剂或活性成分。
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公开(公告)号：USD666659S1
公开(公告)日：2012-09-04
申请号：US29368752
申请日：2010-08-27
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公开(公告)号：US07919275B2
公开(公告)日：2011-04-05
申请号：US12719648
申请日：2010-03-08
CPC分类号： C12Q1/6895 , C12N9/14
摘要： An isolated mutant host cell produced by disrupting or deleting, in a parent cell, a nucleic acid sequence encoding an oxaloacetate hydrolase, or a promoter thereof, which results in the mutant cell producing less of the oxaloacetate hydrolase than the parent cell is disclosed. The disclosure also relates to recombinant methods for producing the products such as polypeptides.
摘要翻译： 公开了一种分离的突变宿主细胞，其通过在母体细胞中破坏或缺失编码草酰乙酸水解酶的核酸序列或其启动子，导致突变体细胞产生比母细胞少的草酰乙酸酯水解酶。 本公开还涉及用于生产诸如多肽的产物的重组方法。
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