-
公开(公告)号：US06444228B1
公开(公告)日：2002-09-03
申请号：US09063338
申请日：1998-04-20
IPC分类号： A61K3516
CPC分类号： A61L24/106
摘要： In general, the present invention relates to a two-phase method for forming an autologous bioadhesive sealant composition or fibrin glue wherein all of the blood components for the bioadhesive sealant are derived from a patient to whom the bioadhesive sealant will be applied. First, a platelet rich plasma and a platelet poor plasma are formed by centrifuging a quantity of anticoagulated whole blood that was previously drawn from the patient. The platelet rich plasma and platelet poor plasma are then divided into two portions. To the first portion, which is used in phase-one, a compound that reverses the effect of the anticoagulant is added, and a clot is allowed to form. The clot is then triturated and the resulting serum, containing autologous thrombin, is collected. The serum obtained from phase-one is then mixed with the second portion of the platelet rich plasma or platelet poor plasma, used in phase-two, to form the bioadhesive sealant of the present invention.
摘要翻译： 通常，本发明涉及用于形成自体生物粘附密封剂组合物或纤维蛋白胶的两相方法，其中用于生物粘附密封剂的所有血液成分衍生自将要施用生物粘附密封剂的患者。 首先，通过离心从患者预先抽取的一定数量的抗凝血形成血小板富血浆和血小板不足等离子体。 然后将富血小板血浆和血小板不良血浆分成两部分。 在第一阶段使用的第一部分，加入逆转抗凝血剂作用的化合物，并允许形成凝块。 然后研磨凝块，收集含有自体凝血酶的血清。 然后从第一阶段获得的血清与第二阶段使用的富血小板血浆或血小板贫血血浆的第二部分混合，形成本发明的生物粘附密封剂。
-
公开(公告)号：US06221672B1
公开(公告)日：2001-04-24
申请号：US09225051
申请日：1999-01-04
IPC分类号： G01N3386
CPC分类号： G01N33/86 , G01N33/4905 , Y10T436/101666 , Y10T436/12
摘要： A method of determining a dose response for a platelet inhibitor. The method includes the steps of placing a predetermined amount of heparin in each cell of a multicell test cartridge, placing an optimized amount of a clotting activator in each cell, and placing a measured amount of platelet inhibitor in each cell, the amount of inhibitor in each cell differing from the amount in each other cell. An aliquot of a blood sample is added to each cell, and the blood sample aliquot, clotting reagent and platelet inhibitor are mixed. Each cell sample is allowed to clot, and the clotting time for each cell is measured. The relative clotting times are used to calculate and determine the platelet inhibition effect of the platelet inhibitor.
摘要翻译： 确定血小板抑制剂的剂量反应的方法。 该方法包括以下步骤：在多细胞测试盒的每个细胞中放置预定量的肝素，在每个细胞中放置优化量的凝血活化剂，并将测量量的血小板抑制剂置于每个细胞中， 每个细胞与每个细胞中的量不同。 将血液样品的等分试样加入到每个细胞中，并将血液样品等分试样，凝血试剂和血小板抑制剂混合。 允许每个细胞样品凝块，并测量每个细胞的凝固时间。 使用相对凝血时间来计算并确定血小板抑制剂的血小板抑制作用。
-
公开(公告)号：US5925319A
公开(公告)日：1999-07-20
申请号：US640275
申请日：1996-04-30
CPC分类号： G01N33/86
摘要： Apparatus and method for evaluating platelet functionality of a blood sample. A cartridge includes a plurality of test cells. Each cell receives an aliquot part of a blood sample. A measured amount of clotting reagent is provided in each cell. A measured amount of platelet activation reagent is provided in each cell, the amount of such reagent in each cell differing from the amount of such reagent in each other cell. The relative clotting times of the aliquot samples in the cells are determinative of the platelet functionality of the blood sample.
摘要翻译： 用于评估血液样品的血小板功能的装置和方法。 盒包括多个测试单元。 每个细胞接收血液样品的等分部分。 在每个细胞中提供测量量的凝血试剂。 在每个细胞中提供测量量的血小板活化试剂，每个细胞中的这种试剂的量与每个其它细胞中的这种试剂的量不同。 细胞中等分试样的相对凝血时间决定了血液样品的血小板功能。
-
公开(公告)号：US5755939A
公开(公告)日：1998-05-26
申请号：US640273
申请日：1996-04-30
申请人： Michael Dror , Robert F. Baugh
发明人： Michael Dror , Robert F. Baugh
CPC分类号： G01N27/40
摘要： An ion selective electrode membrane is selective to polyions in a limited molecular weight range. The membrane is formed by a heparin polyion selective polymeric layer and an outer filter layer permeable to polyions of limited molecular weight range. The outer filter may be cellulose acetate while the polyion selective membrane is a polyvinyl chloride containing plasticizer and a quaternary ammonium salt.
摘要翻译： 离子选择性电极膜对于有限分子量范围内的聚阴离子是选择性的。 膜由肝素聚离子选择性聚合物层和可渗透有限分子量范围的聚离子的外部过滤层形成。 外部过滤器可以是乙酸纤维素，而聚离子选择性膜是含有增塑剂和季铵盐的聚氯乙烯。
-
公开(公告)号：US08303993B2
公开(公告)日：2012-11-06
申请号：US11159482
申请日：2005-06-23
IPC分类号： A61K35/16
CPC分类号： A61L26/0057 , A61L24/0005 , A61L24/106 , A61M1/3693 , A61M2202/0415 , A61M2202/0427 , A61M2205/331 , Y10T436/25375
摘要： The present relates to an autologous bioadhesive sealant composition, or fibrin glue prepared by a two-phase method, wherein all of the blood components for the bioadhesive sealant are derived from a patient to whom the bioadhesive sealant will be applied. A platelet rich plasma and a platelet poor plasma are formed by centrifuging a quantity of anticoagulated whole blood that was previously drawn from the patient. In one embodiment the platelet rich plasma is divided into two portions. In phase one, a compound that reverses the effect of the anticoagulant is added to the first portion and a clot is allowed to form. The clot is then triturated, and the resulting, serum containing autologous thrombin is collected. In phase two, the serum obtained from phase one is mixed with the second portion of the-platelet rich plasma to form the bioadhesive sealant of the invention.
摘要翻译： 本发明涉及一种通过两相方法制备的自体生物粘附密封剂组合物或纤维蛋白胶，其中用于生物粘附密封剂的所有血液成分衍生自将要施用生物粘附密封剂的患者。 通过离心一定数量的抗凝血全血形成血小板富血浆和不血小板血浆。 在一个实施方案中，富血小板血浆被分成两部分。 在第一阶段中，将反转抗凝血剂作用的化合物加入第一部分，并形成凝块。 然后将凝块研磨，并收集所得的含有自体凝血酶的血清。 在第二阶段，将从第一阶段获得的血清与富含血小板的血浆的第二部分混合以形成本发明的生物粘附密封剂。
-
26.发明申请System for the production of autologus platelet gel useful for the delivery of medicinal and genetic agents 审中-公开用于生产用于输送药物和遗传剂的自体血小板凝胶的系统公开(公告)号：US20090026123A1
公开(公告)日：2009-01-29
申请号：US12228965
申请日：2008-08-18
IPC分类号： B01D33/35
CPC分类号： A61L24/106
摘要： A system for the production of a blood component composition is provided. The system includes a centrifuge having a blood reservoir for receiving and separating a blood sample into multiple components; a dispenser disposed outside of the centrifuge having a first collection chamber containing an activation agent and a second collection chamber containing one or more medicinal agents; means for removing a first portion at least one separated blood component from the centrifuge to the first container and a second portion to the second collection chamber, wherein the first collection chamber activates the first portion and stores the resulting clot and thrombin; a filter for separating the thrombin from the clot; and a nozzle for entraining and mixing the thrombin with the second portion containing the one or more medicinal components.
摘要翻译： 提供了一种用于制备血液成分组合物的系统。 该系统包括具有血液储存器的离心机，用于将血液样品接收和分离成多个部件; 设置在离心机外部的分配器具有含有活化剂的第一收集室和含有一种或多种药剂的第二收集室; 用于将第一部分至少一个分离的血液成分从离心机移除到第一容器的装置，以及将第二部分移除到第二收集室的装置，其中第一收集室激活第一部分并储存所得凝块和凝血酶; 用于从凝块分离凝血酶的过滤器; 以及用于夹带和混合凝血酶与含有一种或多种药物成分的第二部分的喷嘴。
-
公开(公告)号：US07413652B2
公开(公告)日：2008-08-19
申请号：US11115076
申请日：2005-04-26
CPC分类号： A61L26/0057 , A61L24/0005 , A61L24/106 , A61M1/3693 , A61M2202/0415 , A61M2202/0427 , A61M2205/331 , Y10T436/25375
摘要： A system for the production of a blood component composition is provided. The system includes a centrifuge having a blood reservoir for receiving and separating a blood sample into multiple components; a dispenser disposed outside of the centrifuge having a first collection chamber containing an activation agent and a second collection chamber containing one or more medicinal agents; means for removing a first portion at least one separated blood component from the centrifuge to the first container and a second portion to the second collection chamber, wherein the first collection chamber activates the first portion and stores the resulting clot and thrombin; a filter for separating the thrombin from the clot; and a nozzle for entraining and mixing the thrombin with the second portion containing the one or more medicinal components.
摘要翻译： 提供了一种用于制备血液成分组合物的系统。 该系统包括具有血液储存器的离心机，用于将血液样品接收和分离成多个部件; 设置在离心机外部的分配器具有含有活化剂的第一收集室和含有一种或多种药剂的第二收集室; 用于将第一部分至少一个分离的血液成分从离心机移除到第一容器的装置，以及将第二部分移除到第二收集室的装置，其中第一收集室激活第一部分并储存所得凝块和凝血酶; 用于从凝块分离凝血酶的过滤器; 以及用于夹带和混合凝血酶与含有一种或多种药物成分的第二部分的喷嘴。
-
公开(公告)号：US06955920B1
公开(公告)日：2005-10-18
申请号：US09330544
申请日：1999-06-11
IPC分类号： G01N33/86
CPC分类号： G01N33/86
摘要： Apparatus and method for evaluating platelet functionality of a blood sample. A cartridge includes a plurality of test cells. Each cell receives an aliquot part of a blood sample. A measured amount of clotting reagent is provided in each cell. A measured amount of platelet activation reagent is provided in each cell, the amount of such reagent in each cell differing from the amount of such reagent in each other cell. The relative clotting times of the aliquot samples in the cells are determinative of the platelet functionality of the blood sample.
摘要翻译： 用于评估血液样品的血小板功能的装置和方法。 盒包括多个测试单元。 每个细胞接收血液样品的等分部分。 在每个细胞中提供测量量的凝血试剂。 在每个细胞中提供测量量的血小板活化试剂，每个细胞中的这种试剂的量与每个其它细胞中的这种试剂的量不同。 细胞中等分试样的相对凝血时间决定了血液样品的血小板功能。
-
公开(公告)号：US06899813B2
公开(公告)日：2005-05-31
申请号：US10738439
申请日：2003-12-17
CPC分类号： A61L26/0057 , A61L24/0005 , A61L24/106 , A61M1/3693 , A61M2202/0415 , A61M2202/0427 , A61M2205/331 , Y10T436/25375
摘要： A system for the production of a blood component composition is provided. The system includes a centrifuge having a blood reservoir for receiving and separating a blood sample into multiple components; a dispenser disposed outside of the centrifuge having a first collection chamber containing an activation agent and a second collection chamber containing one or more medicinal agents; means for removing a first portion at least one separated blood component from the centrifuge to the first container and a second portion to the second collection chamber, wherein the first collection chamber activates the first portion and stores the resulting clot and thrombin; a filter for separating the thrombin from the clot; and a nozzle for entraining and mixing the thrombin with the second portion containing the one or more medicinal components.
-
公开(公告)号：US06719901B2
公开(公告)日：2004-04-13
申请号：US09832517
申请日：2001-04-09
IPC分类号： B01D2116
CPC分类号： A61L26/0057 , A61L24/0005 , A61L24/106 , A61M1/3693 , A61M2202/0415 , A61M2202/0427 , A61M2205/331 , Y10T436/25375
摘要： A system for the production of autologous thrombin, comprising a centrifuge including a blood reservoir for receiving and separating an autologous anticoagulated blood sample having multiple inactive blood components and means for removing at least one of said inactive blood components upon separation, and a dispenser having at least two collection chambers for receiving said at least one of said inactive blood components, wherein a first collection chamber activates a first portion of said inactive blood component and stores the resulting coagulated blood component comprising a clot and said autologous thrombin.
摘要翻译： 一种用于生产自体凝血酶的系统，包括离心机，其包括用于接收和分离具有多个非活性血液成分的自体抗凝血液样品的血液储存器和用于在分离时去除所述非活性血液成分中的至少一种的装置，以及分配器， 用于接收所述至少一种所述非活性血液成分的至少两个收集室，其中第一收集室激活所述非活性血液成分的第一部分并储存所产生的凝血血液成分，所述血液成分包含凝块和所述自体凝血酶。
-
-
-
-
-
-
-
-
-
搜索结果
35 条记录 (耗时 0.04 秒)
