公开(公告)号：US4705822A

公开(公告)日：1987-11-10

申请号：US872275

申请日：1986-06-10

申请人： James H. Kawakami ,  James E. Harris ,  Louis M. Maresca ,  Lloyd M. Robeson ,  Robert J. Cotter

发明人： James H. Kawakami ,  James E. Harris ,  Louis M. Maresca ,  Lloyd M. Robeson ,  Robert J. Cotter

IPC分类号： C08G64/08 ,  C08G63/62 ,  C08L69/00

CPC分类号： C08G64/081

摘要： This invention relates to moldable polycarbonate compositions and in particular to moldable polycarbonates which have ordered, alternating repeating units derived from bis-(3,5-dimethyl-4-hydroxyphenyl)sulfone (TMBS) and 2,2-bis-(4-hydroxyphenyl)propane (Bisphenol A) dihaloformate, or ordered, alternating repeating units derived from bis-(3,5-dimethyl-4-hydroxyphenyl) sulfone (TMBS) dihaloformate and a bisphenol compound such as 2,2-bis-(4-hydroxyphenyl)propane (Bisphenol A). Such polycarbonate exhibit improved hydrolytic stability and also excellent processability in molding applications.

摘要翻译： 本发明涉及可模制的聚碳酸酯组合物，特别是涉及可衍生的聚碳酸酯，其具有衍生自双 - （3,5-二甲基-4-羟基苯基）砜（TMBS）和2,2-双 - （4-羟基苯基） ）丙二醇（双酚A）二卤代甲酸酯或有序的衍生自二 - （3,5-二甲基-4-羟基苯基）砜（TMBS）二卤代甲酸酯和双酚化合物的交替重复单元，例如2,2-双 - （4-羟基苯基） ）丙烷（双酚A）。 这样的聚碳酸酯表现出改善的水解稳定性和在模塑应用中的优异加工性能。

公开(公告)号：US4229559A

公开(公告)日：1980-10-21

申请号：US34996

申请日：1979-05-01

申请人： Robert J. Cotter ,  Hugh C. Gardner

发明人： Robert J. Cotter ,  Hugh C. Gardner

IPC分类号： C07C69/675 ,  C08F20/00 ,  C08F20/02 ,  C08F22/20 ,  C08F222/12 ,  C07C69/34

CPC分类号： C08F22/20 ,  Y10T428/2933 ,  Y10T428/2998 ,  Y10T442/2992

摘要： This invention is directed to a half ester characterized by the following empirical formula: ##STR1## wherein n is a number having an average value of 1.7 to 2, and m is equal to 2-n. Also described herein is a composition comprising said half ester, maleic anhydride and an ethylenically unsaturated monomer, wherein at least 75 mole percent of the half ester is in the maleate form.

摘要翻译： 本发明涉及一种以下述经验式为特征的半酯：其中n为平均值为1.7〜2，m为2-n的数。 本文还描述了包含所述半酯，马来酸酐和烯属不饱和单体的组合物，其中至少75摩尔％的半酯是马来酸盐形式。

公开(公告)号：US20100137420A1

公开(公告)日：2010-06-03

申请号：US11857742

申请日：2007-09-19

申请人： Avindra Nath ,  Caroline F. Anderson ,  David Irani ,  Robert J. Cotter ,  Joseph P. Steiner ,  Norman Haughey

发明人： Avindra Nath ,  Caroline F. Anderson ,  David Irani ,  Robert J. Cotter ,  Joseph P. Steiner ,  Norman Haughey

IPC分类号： G01N33/53 ,  C07K16/18 ,  A61K31/352

CPC分类号： G01N33/564 ,  C07K14/8139 ,  G01N2800/285

摘要： Biological markers for multiple sclerosis, and their use in the diagnosis and prognosis of the disease, are described. Also described are methods for treating multiple sclerosis by administering an inhibitor of cathepsin B activity or a neuroprotective composition comprising a modified terpenoid compound. Also described are isolated polypeptide biomarkers, polynucleotides encoding the polypeptide biomarkers, and antibodies that bind specifically to the polypeptide biomarkers. Further described are kits that include the above-mentioned isolated polypeptide biomarkers, the polynucleotides encoding them, or specific antibodies against the polypeptide biomarkers.

摘要翻译： 描述了用于多发性硬化的生物标志物及其在该疾病的诊断和预后中的用途。 还描述了通过施用组织蛋白酶B活性抑制剂治疗多发性硬化的方法或包含修饰的萜类化合物的神经保护组合物。 还描述了分离的多肽生物标志物，编码多肽生物标志的多核苷酸，以及特异性结合多肽生物标志物的抗体。 进一步描述的是包括上述分离的多肽生物标志物，编码它们的多核苷酸或针对多肽生物标志物的特异性抗体的试剂盒。

公开(公告)号：US5572025A

公开(公告)日：1996-11-05

申请号：US450464

申请日：1995-05-25

申请人： Robert J. Cotter ,  Vladimir M. Doroshenko

发明人： Robert J. Cotter ,  Vladimir M. Doroshenko

IPC分类号： H01J49/16 ,  H01J49/42 ,  B01D59/44 ,  H01J49/00

CPC分类号： H01J49/424 ,  H01J49/0009 ,  H01J49/429

摘要： A method of operation of an ion trap mass spectrometer having a ring electrode and pair of end-cap electrodes in a resonance ejection mode is disclosed. The method includes producing ions from a plurality of biomolecules, applying a trapping RF voltage to the ring electrode, applying an excitation voltage to the end-cap electrodes, scanning the trapping RF voltage in order to sequentially eject the ions, controlling a ration of the amplitude of the trapping RF voltage to the amplitude of the excitation voltage in order that the ratio is generally constant, and determining a ratio of mass to charge of the ejected ions. In one embodiment, a feedback voltage which is proportional to the trapping RF voltage is sensed, and the amplitude of the excitation voltage is controlled as a function of the amplitude of the feedback voltage. In another embodiment, a first value related to the amplitude of the trapping RF voltage and a second value, which is proportional to the first value and related to the amplitude of the excitation voltage, are determined. The amplitude of the trapping RF voltage is modulated employing the first value and the amplitude of the excitation voltage is modulated employing the second value. Preferably, the determined mass-to-charge ratio (m/z) of the ejected ions is equal to a constant (.alpha.) times the trapping RF voltage (V). Associated apparatus and method of calibration are also disclosed.

摘要翻译： 公开了一种具有环形电极和一对端帽电极的共振喷射模式的离子阱质谱仪的操作方法。 该方法包括从多个生物分子产生离子，向环形电极施加捕获RF电压，向端帽电极施加激发电压，扫描捕获RF电压以顺序地喷射离子，控制 将捕获的RF电压的幅度调节到激励电压的幅度，以使该比率基本上恒定，并且确定所排出的离子的质量与电荷的比率。 在一个实施例中，感测与捕获RF电压成比例的反馈电压，并且激励电压的幅度被控制为反馈电压的幅度的函数。 在另一个实施例中，确定与捕获RF电压的幅度相关的第一值和与第一值成比例并且与激励电压的幅度相关的第二值。 使用第一值调制捕获RF电压的幅度，并且使用第二值调制激励电压的幅度。 优选地，所确定的喷射离子的质荷比（m / z）等于捕获RF电压（V）的常数（α）。 还公开了相关装置和校准方法。

公开(公告)号：US5101105A

公开(公告)日：1992-03-31

申请号：US608435

申请日：1990-11-02

申请人： Catherine Fenselau ,  Robert J. Cotter

发明人： Catherine Fenselau ,  Robert J. Cotter

IPC分类号： H01J49/14

CPC分类号： H01J49/145 ,  H01J49/14

摘要： A mass spectrometer system including a device for supplying a protonated ion species; a single chamber having an entrance and an exit slit, the chamber receiving the supplied protonated ion and transmitting a reprotonated ion through the exit slit; a device for supplying a predetermined reagent gas within the chamber; a device for supplying an electron beam in said chamber such that the electron beam reacts with the supplied predetermined reagent gas to provide neutral reagent gas and protonated reagent gas within the chamber, the supplied ion species reacting with the neutral reagent gas to neutralize the ion species, thereby providing neutral species within the chamber, the neutral species reacting with the protonated reagent gas to provide reionized species within the chamber; and a device, coupled to the exit slit of the chamber, for extracting the reionized species.

摘要翻译： 一种质谱仪系统，包括用于提供质子化离子物质的装置; 具有入口和出口狭缝的单个室，所述室接收所提供的质子离子并将再现离子透过出口狭缝; 用于在所述室内供应预定的反应气体的装置; 用于在所述室中供应电子束的装置，使得电子束与所提供的预定反应气体反应以在室内提供中性反应气体和质子化反应气体，所供应的离子物质与中性反应气体反应以中和离子种类 从而在室内提供中性物质，中性物质与质子化的反应气体反应以在室内提供去离子物质; 以及耦合到所述室的出口狭缝的用于提取所述再离子化物质的装置。

公开(公告)号：US5096997A

公开(公告)日：1992-03-17

申请号：US83153

申请日：1987-08-10

申请人： James H. Kawakami ,  Lloyd M. Robeson ,  Robert J. Cotter

发明人： James H. Kawakami ,  Lloyd M. Robeson ,  Robert J. Cotter

IPC分类号： C08G63/19

CPC分类号： C08G63/19

摘要： Described herein are novel polyarylates derived from mixtures of terephthalic and isophthalic acids, hydroquinone and 4,4'-dihydroxydiphenyl sulfone. The instant polyarylates exhibit excellent stress-crack resistance in a wide variety of solvents. Moreover, the materials display very good mechanical and thermal properties.

摘要翻译： 本文描述了衍生自对苯二甲酸和间苯二甲酸，氢醌和4,4'-二羟基二苯砜的混合物的新型聚芳酯。 本发明的多芳基化合物在各种溶剂中表现出优异的抗应力开裂性。 此外，材料显示出非常好的机械和热性能。

公开(公告)号：US4760106A

公开(公告)日：1988-07-26

申请号：US1464

申请日：1987-01-08

申请人： Hugh C. Gardner ,  Michael J. Michno, Jr. ,  George L. Brode ,  Robert J. Cotter

发明人： Hugh C. Gardner ,  Michael J. Michno, Jr. ,  George L. Brode ,  Robert J. Cotter

IPC分类号： C08G59/50 ,  C08L63/00 ,  C08K7/00 ,  C08K7/04 ,  C08K7/14

CPC分类号： C08G59/504 ,  C08G59/50 ,  C08L63/00 ,  Y10T428/31511 ,  Y10T428/31525

摘要： Described herein is a composition which contains a specific group of hardeners, an epoxy resin and a thermoplastic polymer. When combined with a structural fiber the composition produces composites which have improved impact resistance, improved tensile properties and high compressive properties.

摘要翻译： 本文描述的是包含特定组的硬化剂，环氧树脂和热塑性聚合物的组合物。 当与结构纤维结合时，组合物产生具有改善的耐冲击性，改进的拉伸性能和高压缩性能的复合材料。

公开(公告)号：US4608404A

公开(公告)日：1986-08-26

申请号：US728469

申请日：1985-05-02

申请人： Hugh C. Gardner ,  George L. Brode ,  Robert J. Cotter

发明人： Hugh C. Gardner ,  George L. Brode ,  Robert J. Cotter

IPC分类号： C08G59/50 ,  C08L63/00

CPC分类号： C08G59/504 ,  C08L63/00

摘要： Described herein are compositions which contain a specific group of oligomeric diamine hardeners and epoxy compounds which when combined with structural fibers produce composites which have improved tensile properties, high compressive strengths, and improved impact resistance. These compositions also exhibit low moisture absorption.

摘要翻译： 这里描述的是含有特定组的低聚二胺硬化剂和环氧化合物的组合物，当与结构纤维组合时，它们具有改进的拉伸性能，高抗压强度和改善的抗冲击性的复合材料。 这些组合物也表现出低的吸湿性。

公开(公告)号：US4263413A

公开(公告)日：1981-04-21

申请号：US129884

申请日：1980-03-27

申请人： Hugh C. Gardner ,  Robert J. Cotter

发明人： Hugh C. Gardner ,  Robert J. Cotter

IPC分类号： C07C67/08 ,  C08F222/20 ,  C08G63/76

CPC分类号： C08F222/20 ,  C07C67/08

摘要： The invention comprises a homogeneous liquid mixture of (a) a half ester of an organic polyol characterized by the following empirical formula: ##STR1## wherein n is a number having an average value of about 1.8 to less than about 4, m is equal to the free valence of R less the average value of n, R is the hydroxyl-free residue of an organic polyol which contained from 2 to 4, inclusive, hydroxyl groups, OH, in formula (I), (b) maleic anhydride, (c) an ethylenically unsaturated monomer which forms a liquid homogeneous mixture with and is copolymerizable with the half ester and maleic anhydride, and (d) a basic compound.

摘要翻译： 本发明包括（a）有机多元醇的半酯的均匀液体混合物，其特征在于以下经验式：其中n是平均值为约1.8至小于约4的数，m 等于R的平均值的R的自由价，R是在式（I）中，（b）马来酸酐中含有2至4个（包括端值的羟基）OH的有机多元醇的无羟基残基 酸酐，（c）烯键式不饱和单体，其与半酯和马来酸酐形成液体均匀混合物并且可与其共聚，和（d）碱性化合物。