摘要:
The present invention relates to modulators of muscarinic receptors. The present invention also provides compositions comprising such modulators, and methods therewith for treating muscarinic receptor mediated diseases.
摘要:
The present invention relates to compounds useful of inhibitors of protein kinases. The invention also provides processes for preparing the compounds of this invention, pharmaceutically acceptable compositions comprising the compounds of the invention, and methods of using the compositions in the treatment of various disorders.
摘要:
This invention describes novel pyrazole compounds of formula IV: wherein Ring D is a 5-7 membered monocyclic ring or 8-10 membered bicyclic ring selected from aryl, heteroaryl, heterocyclyl or carbocyclyl; Rx and Ry are independently selected from T—R3, or taken together with their intervening atoms to form a fused, unsaturated or partially unsaturated, 5-8 membered ring having 1-3 ring heteroatoms selected from oxygen, sulfur, or nitrogen; and R2, R2′, T, and R3 are as described in the specification. The compounds are useful as protein kinase inhibitors, especially as inhibitors of aurora-2 and GSK-3, for treating diseases such as cancer, diabetes and Alzheimer's disease.
摘要翻译:本发明描述了式IV的新型吡唑化合物:其中环D是5-7元单环或选自芳基,杂芳基,杂环基或碳环基的8-10元双环; R x和R y独立地选自T-R 3,或与它们的插入原子一起形成具有1-3个选自氧,硫或氮的环杂原子的稠合的,不饱和的或部分不饱和的5-8元环; R2,R2',T和R3如说明书中所述。 这些化合物可用作蛋白激酶抑制剂,特别是作为用于治疗诸如癌症,糖尿病和阿尔茨海默病的疾病的极光-2和GSK-3的抑制剂。
摘要:
The present invention relates to modulators of muscarinic receptors. The present invention also provides compositions comprising such modulators, and methods therewith for treating muscarinic receptor mediated diseases.
摘要:
The present invention relates to novel classes of compounds which are caspase inhibitors, in particular interleukin-1β converting enzyme (“ICE”) inhibitors. This invention also relates to pharmaceutical compositions comprising these compounds. The compounds and pharmaceutical compositions of this invention are particularly well suited for inhibiting caspase activity and consequently, may be advantageously used as agents against interleukin-1-(“IL-1”), apoptosis-, interferon-γ inducing factor-(IGIF), or interferon-γ-(“IFN-γ”) mediated diseases, including inflammatory diseases, autoimmune diseases, destructive bone disorders, proliferative disorders, infectious diseases, and degenerative diseases. This invention also relates to methods for inhibiting caspase activity and decreasing IGIF production and IFN-γ production and methods for treating interleukin-1, apoptosis-, and interferon-γ-mediated diseases using the compounds and compositions of this invention. This invention also relates to methods of preparing the compounds of this invention.
摘要:
A multicast radio data communication system comprising a master and a plurality of slave stations uses a retransmission protocol. Data is transmitted by the master station and received by the slave stations. Slave stations having the weakest radio link are designated primary stations, and all other slaves are designated secondary stations. Any slave station may transmit a negative acknowledgement but only the primary stations may transmit a positive acknowledgement. Positive acknowledgements are transmitted in separate time slots, but negative acknowledgements transmitted by the secondary stations overlap the positive acknowledgements transmitted by primary stations. These negative acknowledgements corrupt reception of the positive acknowledgement by the master station, thereby ensuring that the data is retransmitted.
摘要:
An electro-optic modulator structure for particular use in narrowband optical subcarrier systems. A traveling wave is established across the active region of the device, instead of a standing wave. This is accomplished through the use of a directional resonator structure that prevents reverse-traveling waves from being established within the resonator. Hence, the electric field is applied to the traveling optical wave in a similar fashion to a traveling-wave modulator, except that the traveling wave has a much greater amplitude due to the build-up of energy inside the resonator. Since the modulator is operated in a traveling-wave fashion, it can be tuned to operate at any frequency using tuning elements, regardless of the length of the active region. Furthermore, the microwave and optical signals can be velocity-matched to mitigate optical transit time effects that are normally associated with a resonant modulator utilizing a standing-wave electrode structure.
摘要:
This invention provides novel pyrazole compounds that are useful as protein kinase inhibitors, especially as inhibitors of aurora-2 and GSK-3. The compounds may be used to treat abnormal physiological function leading to diseases such as cancer, diabetes and Alzheimer's disease. The compounds are represented by formula VI: wherein G is Ring C or Ring D; Ring C is selected from a phenyl, pyridinyl, pyrimidinyl, pyridazinyl, pyrazinyl, or 1,2,4-triazinyl ring, wherein said Ring C has one or two ortho substituents independently selected from —R1; Ring D is a 5-7 membered monocyclic ring or 8-10 membered bicyclic ring selected from aryl, heteroaryl, heterocyclyl or carbocyclyl; Ry is T—R3′; T is a valence bond or a C1-4 alkylidene chain; R3′ is an optionally substituted group selected from C1-6 aliphatic, C3-10 carbocyclyl, C6-10 aryl, a heteroaryl ring having 5-10 ring atoms, or a heterocyclyl ring having 5-10 ring atoms; and R1, R2, and R2′ are as described in the specification.
摘要翻译:本发明提供了可用作蛋白激酶抑制剂的新型吡唑化合物,特别是作为极光-2和GSK-3的抑制剂。 该化合物可用于治疗导致癌症,糖尿病和阿尔茨海默病等疾病的异常生理功能。 化合物由式VI表示:其中G是环C或环D; 环C选自苯基,吡啶基,嘧啶基,哒嗪基,吡嗪基或1,2,4-三嗪基,其中所述环C具有一个或两个独立地选自-R 1的邻位取代基; 环D是选自芳基,杂芳基,杂环基或碳环基的5-7元单环或8-10元双环; R y是T-R 3; T是价键或C 1-4亚烷基链; R 3是任选取代的基团,其选自C 1-6脂族基,C 3-10碳环基,C 6-10芳基,具有5-10个环原子的杂芳基环,或具有5-10个环原子的杂环基环; 和R 1,R 2和R 2'如说明书中所述。
摘要:
Bandwidth reduction methods and apparatus that offset the effects of dispersion on a signal transmitted through an optical fiber. The apparatus and methods employ a generator of modulated optical signals in cascade with a modulator. One of the generator and the modulator may be an optical intensity or amplitude modulator and the other a phase (or frequency) modulator. With the application of specific signals, the cascaded generator and modulator produce an optical signal with reduced energy in one half of the transmission bandwidth. One important benefit in the method is the fact that by exploiting the less obvious spectral characteristics of single sideband signals, a simple modulator design is achieved. All of the designs exploit a method of generating analytic signals via hybrid modulation.
摘要:
A holding device including a sheet member (1) shaped and configured to form a channel (5) therein, slots (7a, 7b) in the sheet member to receive the rims (11) of a plurality of articles each having a rim, and a separate bridge part (20) connected to the sheet member (1) so as to span the channel (5) to maintain the channel (5) in the sheet member (1) and thereby maintain the articles in engagement with the sheet member (1) in use.