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公开(公告)号:US08466288B2
公开(公告)日:2013-06-18
申请号:US13349868
申请日:2012-01-13
申请人: Alex Aronov , Jon H. Come , Robert J. Davies , Albert Charles Pierce , Philip N. Collier , Ronald Lee Grey, Jr. , Hardwin O'Dowd , James A. Henderson , Elaine B. Krueger , Arnaud Le Tiran , Yusheng Liao , David Messersmith , Jian Wang , Suganthini S. Nanthakumar , Jingrong Cao , Upul Keerthi Bandarage , Anne-Laure Grillot
发明人: Alex Aronov , Jon H. Come , Robert J. Davies , Albert Charles Pierce , Philip N. Collier , Ronald Lee Grey, Jr. , Hardwin O'Dowd , James A. Henderson , Elaine B. Krueger , Arnaud Le Tiran , Yusheng Liao , David Messersmith , Jian Wang , Suganthini S. Nanthakumar , Jingrong Cao , Upul Keerthi Bandarage , Anne-Laure Grillot
IPC分类号: C07D471/02 , C07D213/04 , C07D401/00 , C07D401/02 , C12N9/99 , A61K31/437
CPC分类号: C07D409/14 , C07D401/04 , C07D401/14 , C07D405/14 , C07D417/14 , C07D471/04 , C07D471/20 , C07D491/20
摘要: The present invention relates to compounds useful as inhibitors of PI3K, particularly of PI3Kγ. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders.
摘要翻译: 本发明涉及可用作PI3K抑制剂,特别是PI3Kgamma的化合物。 本发明还提供包含所述化合物的药学上可接受的组合物和使用该组合物治疗各种疾病,病症或病症的方法。
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公开(公告)号:US06763224B2
公开(公告)日:2004-07-13
申请号:US09954645
申请日:2001-09-18
IPC分类号: H04B700
摘要: A data transmission system comprises a large number of networked data beacons interconnected and grouped together in respective clusters. In the system, a first (12) and two or more second (13, 14, 15) beacon devices are interconnected (11) as a cluster capable of wireless message transmission, and at least one mobile device (10) capable of receiving such message transmissions. The first beacon (12) is arranged to broadcast a series of inquiry messages (INQ) according to a first communications protocol, such as Bluetooth, but with the addition of an identifier for the cluster (CL). The mobile device (10) detects such inquiry messages and replies with an identifier for itself, together with message reason data. The link (A) from the first beacon device is then re-established between a selected one (14) of the second beacon devices, with interaction between the mobile device (10) and selected second beacon device (14) being controlled at least partly by the message reason data.
摘要翻译: 数据传输系统包括大量联网数据信标,并将它们分组在一起成为各自的集群。 在系统中,将第一(12)和两个或更多个第二(13,14,15)信标设备互连(11)作为能够进行无线消息传输的集群,以及至少一个能够接收这样的信息的移动设备(10) 消息传输。 第一信标(12)被布置为根据第一通信协议(例如蓝牙)广播一系列查询消息(INQ),但是添加了用于集群(CL)的标识符。 移动设备(10)与消息原因数据一起检测这样的查询消息和对自己的标识符的回复。 然后,在所选择的第一信标设备(14)之间重新建立来自第一信标设备的链路(A),移动设备(10)与所选择的第二信标设备(14)之间的交互被至少部分地控制 通过消息原因数据。
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公开(公告)号:US06734712B2
公开(公告)日:2004-05-11
申请号:US10156731
申请日:2002-05-24
IPC分类号: G06G724
CPC分类号: G06G7/24
摘要: A parallel-summation logarithmic amplifier is described that uses a novel topology of cascaded and parallel amplifiers to achieve extremely high bandwidth. Included in the topology is a unique delay matching scheme for logarithmic amplifiers that is amenable to fabrication in integrated circuit form. The result is flat group delay over broad frequency ranges and different power levels. The resulting log amplifier is suitable for radar applications and for use in high data rate fiber-optic networks. Also described is a unique design process that yields a set of amplifier gains that closely approximate a logarithm. Also described is the novel idea of using a parallel feedback amplifier (PFA) in piecewise-approximate logarithmic amplifiers. This innovation allows for the design of broadband amplifiers with significantly different gains and similar phase characteristics, which is extremely useful when designing high-frequency logarithmic amplifiers.
摘要翻译: 描述了并联对数放大器,其使用级联和并联放大器的新颖拓扑来实现极高带宽。 在拓扑中包括一个独特的对数放大器的延迟匹配方案,可以以集成电路形式制造。 结果是在宽频率范围和不同功率水平上的平坦组延迟。 所产生的对数放大器适用于雷达应用和用于高数据速率光纤网络。 还描述了一种独特的设计过程,其产生一组近似对数的放大器增益。 还描述了在分段近似对数放大器中使用并联反馈放大器(PFA)的新颖思想。 该创新允许宽带放大器的设计具有显着不同的增益和类似的相位特性,这在设计高频对数放大器时非常有用。
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公开(公告)号:US06664891B2
公开(公告)日:2003-12-16
申请号:US09878684
申请日:2001-06-11
申请人: Robert J. Davies , Paul J. Rankin
发明人: Robert J. Davies , Paul J. Rankin
IPC分类号: G08B2600
摘要: A communications system comprises at least one first portable communications device (12) capable of wireless message transmission and at least one second portable communications device (10) capable of receiving such a message transmission. The first device (12) is arranged to broadcast a series of inquiry messages (60) each in the form of a plurality of predetermined data fields (INQ) arranged according to a first communications protocol, such as Bluetooth. For the delivery of additional data via broadcast, the first device (12) adds to each inquiry message prior to transmission an additional data field (BCD) carrying broadcast data, with the second portable device (10) receiving the transmitted inquiry messages and reading the broadcast data from the additional data field.
摘要翻译: 通信系统包括能够进行无线消息传输的至少一个第一便携式通信设备(12)和能够接收这样的消息传输的至少一个第二便携式通信设备(10)。 第一设备(12)被布置为以根据诸如蓝牙的第一通信协议布置的多个预定数据字段(INQ)的形式广播一系列查询消息(60)。 为了通过广播传递附加数据,第一设备(12)在发送附加数据字段(BCD)之前,在传送广播数据的附加数据字段(BCD)中添加每个查询消息,第二便携式设备(10)接收所发送的查询消息并读取 从附加数据字段广播数据。
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公开(公告)号:USRE35540E
公开(公告)日:1997-06-24
申请号:US296145
申请日:1994-08-26
CPC分类号: B65D83/62
摘要: A product dispenser include a unique product bag/valve configuration. The product is stored in the product bag. Pressure in the container surrounding the bag determines the dispensing pressure. The valve has a valve extender with a unique shape to enhance sealing the valve to the bag. The product bag includes a gusset along a bottom portion. The gusset opens when product is introduced into the bag. The gusset supports the bag when in contact with a bottom dome shaped portion of the container.
摘要翻译: 产品分配器包括独特的产品袋/阀配置。 产品存放在产品袋中。 围绕袋子的容器中的压力决定了分配压力。 该阀具有一个具有独特形状的阀增量器,以增强阀门对袋的密封性。 产品袋包括沿底部的角撑板。 当产品进入袋子时,角撑板打开。 当与容器的底部圆顶形部分接触时,角撑板支撑袋子。
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公开(公告)号:US20120202784A1
公开(公告)日:2012-08-09
申请号:US13349868
申请日:2012-01-13
申请人: Alex Aronov , Jon H. Come , Robert J. Davies , Albert Charles Pierce , Philip N. Collier , Ronald Lee Grey, JR. , Hardwin O'Dowd , James A. Henderson , Elaine B. Krueger , Arnaud Le Tiran , Yusheng Liao , David Messersmith , Jian Wang , Suganthini S. Nanthakumar , Jingrong Cao , Upul Keerthi Bandarage , Anne-Laure Grillot
发明人: Alex Aronov , Jon H. Come , Robert J. Davies , Albert Charles Pierce , Philip N. Collier , Ronald Lee Grey, JR. , Hardwin O'Dowd , James A. Henderson , Elaine B. Krueger , Arnaud Le Tiran , Yusheng Liao , David Messersmith , Jian Wang , Suganthini S. Nanthakumar , Jingrong Cao , Upul Keerthi Bandarage , Anne-Laure Grillot
IPC分类号: A61K31/437 , A61K31/5377 , C12N9/99 , A61K31/496 , A61K31/551 , C07D471/20 , C07D471/04 , C07D491/20
CPC分类号: C07D409/14 , C07D401/04 , C07D401/14 , C07D405/14 , C07D417/14 , C07D471/04 , C07D471/20 , C07D491/20
摘要: The present invention relates to compounds useful as inhibitors of PI3K, particularly of PI3Kγ. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders.
摘要翻译: 本发明涉及可用作PI3K抑制剂,特别是PI3Kγ的化合物。 本发明还提供包含所述化合物的药学上可接受的组合物和使用该组合物治疗各种疾病,病症或病症的方法。
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公开(公告)号:US20110081316A1
公开(公告)日:2011-04-07
申请号:US12896042
申请日:2010-10-01
IPC分类号: A61K31/4439 , C07D401/06 , C07D401/14 , C07D403/10 , A61K31/498 , A61K31/4709 , A61P37/00 , A61P29/00 , A61P25/00 , A61K38/21 , A61K39/395 , C12N9/99
CPC分类号: C07D401/08 , C07D401/14 , C07D403/08
摘要: The present invention relates to compounds useful as inhibitors of PI3K, particularly of PI3Kγ. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders.
摘要翻译: 本发明涉及可用作PI3K抑制剂,特别是PI3Kγ的化合物。 本发明还提供包含所述化合物的药学上可接受的组合物和使用该组合物治疗各种疾病,病症或病症的方法。
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公开(公告)号:US07902239B2
公开(公告)日:2011-03-08
申请号:US11774702
申请日:2007-07-09
申请人: Albert C. Pierce , Michael Arnost , Robert J. Davies , Cornelia J. Forster , Vincent Galullo , Ronald Grey, Jr. , Mark Ledeboer , Shi-Kai Tian , Jinwang Xu , Hayley Binch , Brian Ledford , David Messersmith , Suganthi Nanthakumar , Andrew Jayaraj , Greg Henkel , Francesco G. Salituro , Jian Wang
发明人: Albert C. Pierce , Michael Arnost , Robert J. Davies , Cornelia J. Forster , Vincent Galullo , Ronald Grey, Jr. , Mark Ledeboer , Shi-Kai Tian , Jinwang Xu , Hayley Binch , Brian Ledford , David Messersmith , Suganthi Nanthakumar , Andrew Jayaraj , Greg Henkel , Francesco G. Salituro , Jian Wang
IPC分类号: A61K31/541 , A61K31/55 , A61K31/4196 , A61K31/5377
CPC分类号: C07D401/04 , C07D249/10 , C07D249/14 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/10 , C07D403/12 , C07D403/14 , C07D405/04 , C07D405/06 , C07D405/12 , C07D405/14 , C07D417/04 , C07D417/12 , C07D417/14 , C07D471/14 , C07D487/04 , C07D495/04
摘要: The present invention relates to inhibitors of protein kinases. The invention also provides pharmaceutical compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.
摘要翻译: 本发明涉及蛋白激酶抑制剂。 本发明还提供包含本发明化合物的药物组合物和使用该组合物治疗各种疾病的方法。
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公开(公告)号:US20100316605A1
公开(公告)日:2010-12-16
申请号:US12796825
申请日:2010-06-09
IPC分类号: A61K38/21 , C07D417/14 , A61K31/4439 , C07D401/14 , A61K31/444 , C07D277/44 , A61K31/426 , A61K31/397 , A61K31/4545 , C07D241/42 , A61K31/498 , C07D215/12 , A61K31/4709 , C07D471/04 , A61K31/4375 , C07D413/14 , A61K31/5377 , A61K39/395 , A61P9/10 , A61P25/00 , A61P29/00 , A61P37/02 , C12N9/99
CPC分类号: C07D417/06
摘要: The present invention relates to compounds useful as inhibitors of PI3K, particularly of PI3Kγ. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders.
摘要翻译: 本发明涉及可用作PI3K抑制剂,特别是PI3Kγ的化合物。 本发明还提供包含所述化合物的药学上可接受的组合物和使用该组合物治疗各种疾病,病症或病症的方法。
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公开(公告)号:US07786107B2
公开(公告)日:2010-08-31
申请号:US11894092
申请日:2007-08-20
申请人: Robert J. Davies , Jinwang Xu
发明人: Robert J. Davies , Jinwang Xu
IPC分类号: C07D487/10 , C07D487/20 , C07D519/00 , A61K31/55
CPC分类号: A61K31/55 , C07D487/10 , C07D487/20 , C07D519/00
摘要: The present invention relates to modulators of muscarinic receptors. The present invention also provides compositions comprising such modulators, and methods therewith for treating muscarinic receptor mediated diseases.
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