公开(公告)号：US20240219401A1

公开(公告)日：2024-07-04

申请号：US18608690

申请日：2024-03-18

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Martin Rempt ,  Manuel Josef Seitz ,  Christoph Zuth

IPC: G01N33/68 ,  G01N33/543

CPC classification number: G01N33/6851 ,  G01N33/54326

Abstract: The present invention relates to a method for determining at least one analyte of interest. The present invention further relates to a sample element, an inlet, a composition, a kit and the use thereof for determining at least one analyte of interest.

公开(公告)号：US20230227338A1

公开(公告)日：2023-07-20

申请号：US18099412

申请日：2023-01-20

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Kay Hagedorn ,  Dieter Heindl ,  Dirk Kessler ,  Hubert Paul ,  Martin Rempt ,  Hans Zahn

IPC: C02F1/66 ,  C02F1/52

CPC classification number: C02F1/66 ,  C02F1/52 ,  C02F2101/30

Abstract: The present invention relates to a method for treating a liquid sample comprising at least one diagnostic assay reagent after use. The present invention further relates to a tablet, a purified liquid sample, a diagnostic assay reagent, a waste water treatment system, a kit and uses thereof for treating the said liquid sample.

公开(公告)号：US20230160904A1

公开(公告)日：2023-05-25

申请号：US17991366

申请日：2022-11-21

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Robert Hahn ,  Dieter Heindl ,  Hans-Peter Josel ,  Uwe Kobold ,  Hannes Kuchelmeister ,  Simon Loibl ,  Heribert Maerz ,  Giuseppe Prencipe ,  Martin Rempt

IPC: G01N33/68 ,  C07C243/34 ,  C07D401/04 ,  C07D213/55 ,  C07D213/74 ,  C07D213/56

CPC classification number: G01N33/6848 ,  C07C243/34 ,  C07D401/04 ,  C07D213/55 ,  C07D213/74 ,  C07D213/56 ,  G01N2560/00

Abstract: The present invention relates to compounds which are suitable to be used in mass spectrometry as well as methods of mass spectrometric determination of analyte molecules using said compounds.

公开(公告)号：US11275065B2

公开(公告)日：2022-03-15

申请号：US16718296

申请日：2019-12-18

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Uwe Kobold ,  Hubert Paul ,  Martin Rempt

IPC: G01N30/72 ,  G01N30/86 ,  G01N30/88 ,  G01N33/487 ,  G01N30/02

Abstract: A diagnostic system and method and an interconnected laboratory system comprising clinical diagnostic systems are presented. The diagnostic system comprises a sample preparation module, a liquid chromatography (LC) separation module coupled to the sample preparation module via a sample preparation/LC interface, a mass spectrometer (MS) module coupled to the LC separation module via an LC/MS interface, and a result calculation module for identifying and/or quantifying analytes or substances of interest contained in the samples and passed through the LC separation and MS modules. The diagnostic system comprises a controller programmed to monitor operational parameters (1-n) indicative of a performance status of the diagnostic system, to trigger a quality control procedure and/or a maintenance procedure whenever one or more parameters (1-n) of the operational parameters (1-n) is out of specification, and to minimize the quality control and/or maintenance procedures as long as the operational parameters (1-n) remains within specification.

公开(公告)号：US20210198217A1

公开(公告)日：2021-07-01

申请号：US17155020

申请日：2021-01-21

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Dieter Heindl ,  Hans-Peter Josel ,  Uwe Kobold ,  Christoph Seidel ,  Martin Rempt ,  Andreas Leinenbach ,  Giuseppe Prencipe ,  Silvia Baecher ,  Simon Ferdinand Loibl ,  Anna-Skrollan Geiermann ,  Jelena Milic ,  Nicole Pirkl

IPC: C07D249/06 ,  C07D257/04 ,  C07D203/04 ,  G01N30/72

Abstract: The present invention relates to reagents which are suitable to be used in mass spectrometry as well as methods of mass spectrometric determination of analyte molecules using said reagents.

公开(公告)号：US20200041470A1

公开(公告)日：2020-02-06

申请号：US16520696

申请日：2019-07-24

Applicant: Roche Diagnostics Operations, Inc. ,  Ludwig-Maximilians-Universitaet Muenchen

Inventor： Thomas Carell ,  Uwe Kobold ,  Dieter Heindl ,  Silvia Baecher ,  Andreas Leinenbach ,  Martin Rempt ,  Toni Pfaffeneder ,  Angie Kirchner ,  Olesea Kosmatchev ,  Rene Rahimoff ,  Sarah Schiffers ,  Markus Muller

IPC: G01N30/72 ,  H01J49/10 ,  H01J49/00 ,  H01J49/06 ,  C07D249/04

Abstract: The present invention relates to reagents suitable in the mass spectrometric determination of analyte molecules such as carbohydrates as well as adducts of such reagents and analyte molecules and applications of said reagents and adducts. Further, the present invention relates to methods for the mass spectrometric determination of analyte molecules.

公开(公告)号：US20190293615A1

公开(公告)日：2019-09-26

申请号：US16438787

申请日：2019-06-12

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Dieter Heindl ,  Uwe Kobold ,  Martin Rempt ,  Christoph Seidel

IPC: G01N30/86 ,  G01N30/72 ,  G01N30/34 ,  G01N30/88

Abstract: A method for tracking a sample identity during a process in an analysis system is disclosed. The analysis system comprises a liquid chromatograph and a mass spectrometer. The method comprises providing a sample, adding a composition of different chemical substances to the sample with a concentration being above a detection level of the mass spectrometer, processing the sample together with the composition with the analysis system, detecting and measuring a component and/or components of the sample with the mass spectrometer, detecting and measuring the composition or parts of the composition of different chemical substances with the mass spectrometer, and identifying the sample based on a detection of a substance detection signal pattern of the mass spectrometer including substance detection signals representing the composition of chemical substances.