公开(公告)号：US20240145227A1

公开(公告)日：2024-05-02

申请号：US18410961

申请日：2024-01-11

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Martin Rempt ,  Manuel Josef Seitz ,  Christoph Zuth

IPC: H01J49/16 ,  G01N27/623

CPC classification number: H01J49/164 ,  G01N27/623

Abstract: A target (110) for use in a laser desorption mass spectrometer is disclosed. The target (110) has at least one surface (112). wherein the surface (112) is covered at least partially with at least one layer (114), wherein the layer (114) is a hydrogen comprising, silicon-incorporated amorphous carbon (a-C:H:Si) layer (116), wherein the a-C:H:Si layer (116) comprises:



40 at. % to 80 at. % of carbon;
1 at. % to 20 at. % of hydrogen; and
10 at. % to 40 at. % of silicon.

公开(公告)号：US20240219401A1

公开(公告)日：2024-07-04

申请号：US18608690

申请日：2024-03-18

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Martin Rempt ,  Manuel Josef Seitz ,  Christoph Zuth

IPC: G01N33/68 ,  G01N33/543

CPC classification number: G01N33/6851 ,  G01N33/54326

Abstract: The present invention relates to a method for determining at least one analyte of interest. The present invention further relates to a sample element, an inlet, a composition, a kit and the use thereof for determining at least one analyte of interest.

公开(公告)号：US20240110932A1

公开(公告)日：2024-04-04

申请号：US18541624

申请日：2023-12-15

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Johannes Pflieger ,  Nicole Pirkl ,  Martin Rempt ,  Christoph Zuth

IPC: G01N33/74 ,  G01N30/72 ,  G01N33/68 ,  H01J49/00

CPC classification number: G01N33/743 ,  G01N30/7233 ,  G01N33/6848 ,  H01J49/0009 ,  G01N2030/027 ,  G01N2333/575 ,  G01N2496/00

Abstract: The present invention relates to a method of determining an analyte in a sample by mass spectrometry (MS), the method comprising (a) admixing a pre-determined amount of internal calibrator to said sample, wherein said internal calibrator comprises at least two non-identical isotopologues of the analyte at predetermined amounts; (b) determining MS signals of ions generated from said analyte (analyte signal) and from said at least two isotopologues (isotopologue signals); (c) providing a calibration based on the analyte signal and the isotopologue signals determined in step (b); and (d) determining said analyte based on the calibration provided in step (c). Further, the present invention relates to devices, systems, and uses related thereto.

公开(公告)号：US20240159631A1

公开(公告)日：2024-05-16

申请号：US18393378

申请日：2023-12-21

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Martin Rempt ,  Manuel Josef Seitz ,  Christoph Zuth

IPC: G01N1/40

CPC classification number: G01N1/405

Abstract: A method for detecting at least one analyte (110) in a sample (112) is disclosed. The method comprises the following steps:



a) providing at least one sample (112) having at least one analyte (110);
b) incubating the sample (112) with microparticles (118) having at least one surface (120) whereby the analyte (110) is adsorbed on the surface (120) of the microparticles (118) and an analyte-microparticle-complex (122) is formed;
c) providing at least one fiber sheet material (128) having at least one tip (130) and contacting the tip (130) of the fiber sheet material (128) to the sample (112) comprising the analyte-microparticle-complex (122), whereby at least the analyte-microparticle-complex (122) is sucked into the tip (130) of the fiber sheet material (128);
d) contacting the tip (130) of the fiber sheet material (128) to a port of an analytical device;
e) adding an extracting solvent (138) to the fiber sheet material (128) and applying an electrical voltage to the fiber sheet material (128) whereby ions of the analyte (110) are generated and are expelled from the tip (130) of the fiber sheet material (128); and
f) detecting the at least one analyte (110) with the analytical device (134).

公开(公告)号：US20230333113A1

公开(公告)日：2023-10-19

申请号：US18306195

申请日：2023-04-24

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Dieter Heindl ,  Uwe Kobold ,  Martin Rempt ,  Christoph Zuth

IPC: G01N33/58 ,  G01N33/74

CPC classification number: G01N33/58 ,  G01N33/743 ,  G01N2560/00

Abstract: The present invention relates to a method, a diagnostic system, a kit and the use thereof for efficiently detection of an analyte of interest by nanoESI mass spectrometry.

公开(公告)号：US20230266283A1

公开(公告)日：2023-08-24

申请号：US18107996

申请日：2023-02-09

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Dieter Heindl ,  Martin Rempt ,  Manuel Josef Seitz ,  Christoph Zuth

IPC: G01N30/72 ,  G01N33/543 ,  G01N33/53

CPC classification number: G01N30/72 ,  G01N33/54386 ,  G01N33/5304 ,  G01N2560/00

Abstract: The present invention relates to a method for determining at least one analyte of interest. The present invention further relates to a sample element, a device, a kit and the use thereof for determining at least one analyte of interest.