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21.发明申请NOVEL SUBSTITUTED BIPYRIDINE DERIVATIVES AND THEIR USE AS ADENOSINE RECEPTOR LIGANDS 失效新的替代苄嘧啶衍生物及其作为腺苷受体配体使用公开(公告)号：US20100093728A1
公开(公告)日：2010-04-15
申请号：US12440423
申请日：2007-08-30
IPC分类号： A61K31/5377 , A61K31/495 , A61K31/506 , A61K31/4436 , C07D413/14 , C07D401/14 , C07D417/14 , A61P3/10 , A61P9/04
CPC分类号： C07D417/14 , A61K31/444 , A61K31/501 , A61K31/506 , A61K31/5377 , A61K45/06 , C07D213/85 , C07D401/14 , C07D409/14 , C07D413/14
摘要： The present invention relates to novel substituted 2,4′- and 3,4′-bipyridine derivatives, to processes for their preparation, to their use for the treatment and/or prophylaxis of diseases and to their use for preparing medicaments for the treatment and/or prophylaxis of diseases, preferably for the treatment and/or prevention of hypertension and other cardiovascular disorders.
摘要翻译： 本发明涉及新的取代的2,4'-和3,4'-联吡啶衍生物，其制备方法，其用于治疗和/或预防疾病的用途及其用于制备治疗用药物和 /或预防疾病，优选用于治疗和/或预防高血压和其它心血管疾病。
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22.发明申请公开(公告)号：US20100022544A1
公开(公告)日：2010-01-28
申请号：US12516917
申请日：2007-11-17
申请人： Peter Nell , Walter Hübsch , Barbara Albrecht-Küpper , Alexandros Vakalopoulos , Frank Süssmeier , Jörg Keldenich , Joachim Telser
发明人： Peter Nell , Walter Hübsch , Barbara Albrecht-Küpper , Alexandros Vakalopoulos , Frank Süssmeier , Jörg Keldenich , Joachim Telser
IPC分类号： A61K31/5377 , C07D417/12 , C07D409/14 , C07D413/14 , A61K31/44 , A61K31/497 , A61P3/10
CPC分类号： C07D417/14 , C07D405/04 , C07D413/14 , C07D417/12
摘要： The present application relates to novel 4-cycloalkyl- and 4-heterocycloalkyl-3,5-dicyano-2-thio-pyridine derivatives, to processes for their preparation, to their use for the treatment and/or prophylaxis of diseases and to their use for preparing medicaments for the treatment and/or prophylaxis of diseases, preferably for the treatment and/or prevention of hypertension and other cardiovascular disorders.
摘要翻译： 本申请涉及新的4-环烷基 - 和4-杂环烷基-3,5-二氰基-2-硫代吡啶衍生物，其制备方法，其用于治疗和/或预防疾病及其用途 用于制备用于治疗和/或预防疾病的药物，优选用于治疗和/或预防高血压和其它心血管疾病。
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公开(公告)号：US06756512B2
公开(公告)日：2004-06-29
申请号：US10258900
申请日：2002-10-30
IPC分类号： C07C4311
CPC分类号： C07C37/02 , C07C37/055 , C07C39/28
摘要： The invention relates to a novel process for preparing 2-alkyl-3-chlorophenols.
摘要翻译： 本发明涉及一种制备2-烷基-3-氯苯酚的新方法。
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24.发明授权公开(公告)号：US06734304B2
公开(公告)日：2004-05-11
申请号：US10221889
申请日：2002-09-17
申请人： Holger Weintritt , Uwe Stelzer , Herbert Gayer , Walter Hübsch
发明人： Holger Weintritt , Uwe Stelzer , Herbert Gayer , Walter Hübsch
IPC分类号： C07D23952
CPC分类号： C07D403/12 , C07D239/52 , C07D413/12 , C07D419/12
摘要： The invention relates to a novel process for preparing known asymmetrical 4,6-bis(aryloxy)pyrimidine derivatives.
摘要翻译： 本发明涉及制备已知的不对称4,6-双（芳氧基）嘧啶衍生物的新方法。
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公开(公告)号：US08691850B2
公开(公告)日：2014-04-08
申请号：US11661820
申请日：2005-08-30
申请人： Jens-Kerim Ergüden , Gunter Karig , Ulrich Rosentreter , Barbara Albrecht , Kerstin Henninger , Joachim Hütter , Nicole Diedrichs , Peter Nell , Sabine Arndt , Walter Hübsch , Andreas Knorr , Karl-Heinz Schlemmer , Dirk Brohm
发明人： Jens-Kerim Ergüden , Gunter Karig , Ulrich Rosentreter , Barbara Albrecht , Kerstin Henninger , Joachim Hütter , Nicole Diedrichs , Peter Nell , Sabine Arndt , Walter Hübsch , Andreas Knorr , Karl-Heinz Schlemmer , Dirk Brohm
IPC分类号： A61K31/4436 , C07D417/12
CPC分类号： C07D417/12
摘要： The present application relates to novel phenylaminothiazole derivatives, to processes for their preparation, to their use for the treatment and/or prophylaxis of diseases and to their use for preparing medicaments for the treatment and/or prophylaxis of diseases, preferably for the treatment and/or prevention of hypertension and other cardiovascular disorders.
摘要翻译： 本申请涉及新的苯基氨基噻唑衍生物，其制备方法，其用于治疗和/或预防疾病的用途及其用于制备用于治疗和/或预防疾病的药物的用途，优选用于治疗和/ 或预防高血压和其他心血管疾病。
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26.发明授权公开(公告)号：US08673903B2
公开(公告)日：2014-03-18
申请号：US13697342
申请日：2011-05-09
申请人： Walter Hübsch , Michael Hahn , Alexandros Vakalopoulos , Volkhart Min-Jian Li , Frank Wunder , Johannes-Peter Stasch , Karl-Heinz Schlemmer , Friederike Stoll , Niels Lindner
发明人： Walter Hübsch , Michael Hahn , Alexandros Vakalopoulos , Volkhart Min-Jian Li , Frank Wunder , Johannes-Peter Stasch , Karl-Heinz Schlemmer , Friederike Stoll , Niels Lindner
IPC分类号： C07C229/38 , C07D263/22 , C07D265/32 , C07D271/06 , A61K45/06 , A61K31/4015 , A61K31/421 , A61K31/5375 , A61K31/4245 , A61K31/4402 , C07D207/27 , A61K31/197 , C07D213/30
CPC分类号： C07C229/38 , A61K31/197 , A61K31/4015 , A61K31/421 , A61K31/4245 , A61K31/4402 , A61K31/5375 , A61K45/06 , C07C2602/10 , C07D207/27 , C07D213/30 , C07D263/22 , C07D265/32 , C07D271/06
摘要： The present application relates to novel substituted 8-alkoxy-2-aminotetraline derivatives, to processes for their preparation, to their use for the treatment and/or prevention of diseases and to their use for preparing medicaments for the treatment and/or prevention of diseases, in particular for the treatment and/or prevention of cardiovascular disorders.
摘要翻译： 本申请涉及新的取代的8-烷氧基-2-氨基四氢萘衍生物，其制备方法，其用于治疗和/或预防疾病的用途及其用于制备用于治疗和/或预防疾病的药物的用途 ，特别是用于治疗和/或预防心血管疾病。
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27.发明授权公开(公告)号：US08304412B2
公开(公告)日：2012-11-06
申请号：US12516917
申请日：2007-11-17
申请人： Peter Nell , Walter Hübsch , Barbara Albrecht-Küpper , Alexandros Vakalopoulos , Frank Süssmeier , Jörg Keldenich , Joachim Telser
发明人： Peter Nell , Walter Hübsch , Barbara Albrecht-Küpper , Alexandros Vakalopoulos , Frank Süssmeier , Jörg Keldenich , Joachim Telser
IPC分类号： A61K31/5377 , A61K31/44 , A61K31/497 , A61P3/10 , C07D417/12 , C07D409/14 , C07D413/14
CPC分类号： C07D417/14 , C07D405/04 , C07D413/14 , C07D417/12
摘要： The present application relates to novel 4-cycloalkyl- and 4-heterocycloalkyl-3,5-dicyano-2-thio-pyridine derivatives, to processes for their preparation, to their use for the treatment and/or prophylaxis of diseases and to their use for preparing medicaments for the treatment and/or prophylaxis of diseases, preferably for the treatment and/or prevention of hypertension and other cardiovascular disorders.
摘要翻译： 本申请涉及新的4-环烷基 - 和4-杂环烷基-3,5-二氰基-2-硫代吡啶衍生物，其制备方法，其用于治疗和/或预防疾病及其用途 用于制备用于治疗和/或预防疾病的药物，优选用于治疗和/或预防高血压和其它心血管疾病。
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28.发明授权Substituted 2-oxy-3,5-dicyano-4aryl-6-aminopyridines and use thereof 失效取代的2-氧基-3,5-二氰基-4-芳基-6-氨基吡啶及其用途公开(公告)号：US07855219B2
公开(公告)日：2010-12-21
申请号：US10469556
申请日：2002-02-20
申请人： Ulrich Rosentreter , Thomas Krämer , Andrea Vaupel , Walter Hübsch , Nicole Diedrichs , Thomas Krahn , Klaus Dembowsky , Johannes-Peter Stasch
发明人： Ulrich Rosentreter , Thomas Krämer , Andrea Vaupel , Walter Hübsch , Nicole Diedrichs , Thomas Krahn , Klaus Dembowsky , Johannes-Peter Stasch
IPC分类号： A61K31/44 , C07D405/00 , C07D401/00 , C07D417/00 , C07D409/00
CPC分类号： C07D405/04 , C07D213/85 , C07D409/14 , C07D417/14
摘要： This invention relates to compounds of formula (I) in which the variable groups are as defined in the text and claims. A pharmaceutical composition and methods of using these materials in treatment of various conditions are also disclosed and claimed.
摘要翻译： 本发明涉及式（I）化合物，其中可变基团如本文和权利要求中所定义。 还公开并要求保护的药物组合物和使用这些材料处理各种条件的方法。
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29.发明授权Substituted 2-carba-3,5-dicyano-4-aryl-6-aminopyridines and the use of the same as selective ligands of the adenosine receptor 失效取代的2-咔唑-3,5-二氰基-4-芳基-6-氨基吡啶并使用其作为腺苷受体的选择性配体公开(公告)号：US07129255B2
公开(公告)日：2006-10-31
申请号：US10473371
申请日：2002-03-25
申请人： Ulrich Rosentreter , Thomas Krämer , Andrea Vaupel , Walter Hübsch , Nicole Diedrichs , Thomas Krahn , Klaus Dembowsky , Johannes-Peter Stasch , Mitsuyuki Shimada
发明人： Ulrich Rosentreter , Thomas Krämer , Andrea Vaupel , Walter Hübsch , Nicole Diedrichs , Thomas Krahn , Klaus Dembowsky , Johannes-Peter Stasch , Mitsuyuki Shimada
IPC分类号： A61K31/44 , C07D213/85
CPC分类号： C07D405/04 , C07D213/85
摘要： This application relates to compounds of the formula wherein the groups R1–R6 are as defined in the specification and claims, and to a pharmaceutical composition containing the same, and to a method of using the same in treatment of cardiovascular disorders.
摘要翻译： 本申请涉及下式的化合物，其中基团R 1〜6 6如说明书和权利要求中所定义，并且含有该化合物的药物组合物，以及 使用该方法治疗心血管疾病的方法。
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公开(公告)号：US07109218B2
公开(公告)日：2006-09-19
申请号：US10497120
申请日：2002-11-28
申请人： Ulrich Rosentreter , Thomas Krämer , Mitsuyuki Shimada , Walter Hübsch , Nicole Diedrichs , Thomas Krahn , Kerstin Henninger , Johannes-Peter Stasch , Ralf Wischnat
发明人： Ulrich Rosentreter , Thomas Krämer , Mitsuyuki Shimada , Walter Hübsch , Nicole Diedrichs , Thomas Krahn , Kerstin Henninger , Johannes-Peter Stasch , Ralf Wischnat
IPC分类号： C07D417/12 , A61K31/4418
CPC分类号： C07D417/12 , C07D213/85 , C07D417/14
摘要： Compounds of the formula (I) a process for their preparation and their use as medicaments are described.
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