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公开(公告)号:US08691850B2
公开(公告)日:2014-04-08
申请号:US11661820
申请日:2005-08-30
申请人: Jens-Kerim Ergüden , Gunter Karig , Ulrich Rosentreter , Barbara Albrecht , Kerstin Henninger , Joachim Hütter , Nicole Diedrichs , Peter Nell , Sabine Arndt , Walter Hübsch , Andreas Knorr , Karl-Heinz Schlemmer , Dirk Brohm
发明人: Jens-Kerim Ergüden , Gunter Karig , Ulrich Rosentreter , Barbara Albrecht , Kerstin Henninger , Joachim Hütter , Nicole Diedrichs , Peter Nell , Sabine Arndt , Walter Hübsch , Andreas Knorr , Karl-Heinz Schlemmer , Dirk Brohm
IPC分类号: A61K31/4436 , C07D417/12
CPC分类号: C07D417/12
摘要: The present application relates to novel phenylaminothiazole derivatives, to processes for their preparation, to their use for the treatment and/or prophylaxis of diseases and to their use for preparing medicaments for the treatment and/or prophylaxis of diseases, preferably for the treatment and/or prevention of hypertension and other cardiovascular disorders.
摘要翻译: 本申请涉及新的苯基氨基噻唑衍生物,其制备方法,其用于治疗和/或预防疾病的用途及其用于制备用于治疗和/或预防疾病的药物的用途,优选用于治疗和/ 或预防高血压和其他心血管疾病。
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公开(公告)号:US20080269300A1
公开(公告)日:2008-10-30
申请号:US11661820
申请日:2005-08-30
申请人: Jens-Kerim Erguden , Gunter Karig , Ulrich Rosentreter , Barbara Albrecht , Kerstin Henninger , Joachim Hutter , Nicole Diedrichs , Peter Nell , Sabine Arndt , Walter Hubsch , Andreas Knorr , Karl-Heinz Schlemmer , Dirk Brohm
发明人: Jens-Kerim Erguden , Gunter Karig , Ulrich Rosentreter , Barbara Albrecht , Kerstin Henninger , Joachim Hutter , Nicole Diedrichs , Peter Nell , Sabine Arndt , Walter Hubsch , Andreas Knorr , Karl-Heinz Schlemmer , Dirk Brohm
IPC分类号: A61K31/4439 , C07D417/12 , A61P9/12
CPC分类号: C07D417/12
摘要: The present application relates to novel phenylaminothiazole derivatives, to processes for their preparation, to their use for the treatment and/or prophylaxis of diseases and to their use for preparing medicaments for the treatment and/or prophylaxis of diseases, preferably for the treatment and/or prevention of hypertension and other cardiovascular disorders.
摘要翻译: 本申请涉及新的苯基氨基噻唑衍生物,其制备方法,其用于治疗和/或预防疾病的用途及其用于制备用于治疗和/或预防疾病的药物的用途,优选用于治疗和/ 或预防高血压和其他心血管疾病。
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公开(公告)号:US07109218B2
公开(公告)日:2006-09-19
申请号:US10497120
申请日:2002-11-28
申请人: Ulrich Rosentreter , Thomas Krämer , Mitsuyuki Shimada , Walter Hübsch , Nicole Diedrichs , Thomas Krahn , Kerstin Henninger , Johannes-Peter Stasch , Ralf Wischnat
发明人: Ulrich Rosentreter , Thomas Krämer , Mitsuyuki Shimada , Walter Hübsch , Nicole Diedrichs , Thomas Krahn , Kerstin Henninger , Johannes-Peter Stasch , Ralf Wischnat
IPC分类号: C07D417/12 , A61K31/4418
CPC分类号: C07D417/12 , C07D213/85 , C07D417/14
摘要: Compounds of the formula (I) a process for their preparation and their use as medicaments are described.
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4.Substituted 2-thio-3,5-dicyano-4-phenyl-6-aminopyridines and the use of the same 审中-公开
标题翻译: 取代的2-硫代-3,5-二氰基-4-苯基-6-氨基吡啶并使用它们公开(公告)号:US20060217373A1
公开(公告)日:2006-09-28
申请号:US11443693
申请日:2006-05-30
申请人: Ulrich Rosentreter , Thomas Kramer , Mitsuyuki Shimada , Walter Hubsch , Nicole Diedrichs , Thomas Krahn , Kerstin Henninger , Johannes-Peter Stasch , Ralf Wischnat
发明人: Ulrich Rosentreter , Thomas Kramer , Mitsuyuki Shimada , Walter Hubsch , Nicole Diedrichs , Thomas Krahn , Kerstin Henninger , Johannes-Peter Stasch , Ralf Wischnat
IPC分类号: A61K31/541 , A61K31/5377 , A61K31/496 , A61K31/497 , A61K31/4439 , A61K31/44
CPC分类号: C07D417/12 , C07D213/85 , C07D417/14
摘要: Compounds of the formula (I) a process for their preparation and their use as medicaments are described.
摘要翻译: 描述了式(I)化合物的制备方法及其作为药物的用途。
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5.Substituted 2-thio-3, 5-dicyano-4-phenyl-6-aminopyridines and their use as adenosine receptor-selective ligands 失效
标题翻译: 取代的2-硫代-3,5-二氰基-4-苯基-6-氨基吡啶并将其用作腺苷受体选择配体公开(公告)号:US07045631B2
公开(公告)日:2006-05-16
申请号:US10484133
申请日:2002-07-03
申请人: Ulrich Rosentreter , Thomas Kramer , Mitsuyuki Shimada , Walter Hubsch , Nicole Diedrichs , Thomas Krahn , Kerstin Henninger , Johannes-Peter Stasch
发明人: Ulrich Rosentreter , Thomas Kramer , Mitsuyuki Shimada , Walter Hubsch , Nicole Diedrichs , Thomas Krahn , Kerstin Henninger , Johannes-Peter Stasch
IPC分类号: C07D213/62 , C07D417/12
CPC分类号: C07D417/12 , C07D213/85
摘要: Compounds of the formula (I) a process for preparing them, and their use as medicaments are described.
摘要翻译: 描述了式(I)化合物的制备方法及其作为药物的用途。
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6.Substituted 2-thio-3,5-dicyano-4-phenyl-6-aminopyridines and the use of the same 有权
标题翻译: 取代的2-硫代-3,5-二氰基-4-苯基-6-氨基吡啶并使用它们公开(公告)号:US20050227972A1
公开(公告)日:2005-10-13
申请号:US10497120
申请日:2002-11-28
申请人: Ulrich Rosentreter , Thomas Kramer , Mitsuyuki Shimada , Walter Hubsch , Nicole Diedrichs , Thomas Krahn , Kerstin Henninger , Johannes-Peter Stasch , Ralf Wischnat
发明人: Ulrich Rosentreter , Thomas Kramer , Mitsuyuki Shimada , Walter Hubsch , Nicole Diedrichs , Thomas Krahn , Kerstin Henninger , Johannes-Peter Stasch , Ralf Wischnat
IPC分类号: A61K31/454 , A61K31/4545 , A61K31/5377 , A61K45/00 , A61P3/10 , A61P9/00 , A61P9/06 , A61P9/10 , A61P9/12 , A61P11/00 , A61P11/06 , A61P13/00 , A61P13/10 , A61P15/00 , A61P15/10 , A61P17/00 , A61P25/00 , A61P25/04 , A61P25/28 , A61P29/00 , A61P29/02 , A61P35/00 , A61P43/00 , C07D213/85 , C07D417/12 , C07D417/14 , A61K31/541 , A61K31/444 , A61K31/496 , C07D413/14
CPC分类号: C07D417/12 , C07D213/85 , C07D417/14
摘要: Compounds of the formula (I) a process for their preparation and their use as medicaments are described.
摘要翻译: 描述了式(I)化合物的制备方法及其作为药物的用途。
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公开(公告)号:US20080004275A1
公开(公告)日:2008-01-03
申请号:US10594343
申请日:2005-03-11
申请人: Holger Zimmermann , David Bruckner , Dirk Heimbach , Martin Hendrix , Kerstin Henninger , Guy Hewlett , Ulrich Rosentreter , Jorg Keldenich , Dieter Lang , Martin Radtke
发明人: Holger Zimmermann , David Bruckner , Dirk Heimbach , Martin Hendrix , Kerstin Henninger , Guy Hewlett , Ulrich Rosentreter , Jorg Keldenich , Dieter Lang , Martin Radtke
IPC分类号: A61K31/5377 , A61K31/4155 , A61K31/4178 , A61K31/4184 , A61P31/12 , C07D233/88 , C07D249/12 , C07D403/12 , C07D413/12 , C07D401/12 , C07D249/04 , C07D233/44 , A61K31/4192 , A61K31/4196 , A61K31/4439
CPC分类号: C07D233/90 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/12
摘要: The invention relates to the substituted imidazoles of formula (I) and to methods for producing the same, to their use in the treatment and/or prophylaxis of diseases and to their use for producing drugs for use in the treatment and/or prophylaxis of diseases, especially for use as antiviral agents, especially against cytomegaloviruses.
摘要翻译: 本发明涉及式(I)的取代的咪唑及其制备方法,用于治疗和/或预防疾病及其用于制备用于治疗和/或预防疾病的药物的用途 特别是用作抗病毒药物,特别是针对巨细胞病毒。
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公开(公告)号:US07919489B2
公开(公告)日:2011-04-05
申请号:US11894307
申请日:2007-08-20
申请人: Holger Zimmermann , David Brueckner , Kerstin Henninger , Ulrich Rosentreter , Martin Hendrix , Joerg Keldenich , Dieter Lang , Martin Radtke , Daniela Paulsen , Armin Kern
发明人: Holger Zimmermann , David Brueckner , Kerstin Henninger , Ulrich Rosentreter , Martin Hendrix , Joerg Keldenich , Dieter Lang , Martin Radtke , Daniela Paulsen , Armin Kern
IPC分类号: A61P31/12 , A61K31/4178 , A61K31/4164 , C07D401/12 , C07D233/90
CPC分类号: C07D233/90 , C07D401/12
摘要: The invention relates to heterocyclylamide-substituted imidazoles and methods for their preparation, their use for the treatment and/or prophylaxis of diseases as well as their use for the production of medicaments for the treatment and/or prophylaxis of diseases, in particular for the use as antiviral agents, especially against cytomegaloviruses.
摘要翻译: 本发明涉及杂环基酰胺取代的咪唑及其制备方法,它们用于治疗和/或预防疾病及其用于生产用于治疗和/或预防疾病的药物的用途,特别是用于 作为抗病毒剂,特别是针对巨细胞病毒。
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公开(公告)号:US07767704B2
公开(公告)日:2010-08-03
申请号:US10594343
申请日:2005-03-11
申请人: Holger Zimmermann , David Brueckner , Dirk Heimbach , Martin Hendrix , Kerstin Henninger , Guy Hewlett , Ulrich Rosentreter , Joerg Keldenich , Dieter Lang , Martin Radtke
发明人: Holger Zimmermann , David Brueckner , Dirk Heimbach , Martin Hendrix , Kerstin Henninger , Guy Hewlett , Ulrich Rosentreter , Joerg Keldenich , Dieter Lang , Martin Radtke
IPC分类号: A61K31/4164 , C07D233/54
CPC分类号: C07D233/90 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/12
摘要: The invention relates to the substituted imidazoles of formula (I) and to methods for producing the same, to their use in the treatment and/or prophylaxis of diseases and to their use for producing drugs for use in the treatment and/or prophylaxis of diseases, especially for use as antiviral agents, especially against cytomegaloviruses.
摘要翻译: 本发明涉及式(I)的取代的咪唑及其制备方法,用于治疗和/或预防疾病及其用于制备用于治疗和/或预防疾病的药物的用途 特别是用作抗病毒剂,特别是抗巨细胞病毒。
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公开(公告)号:US20100105673A1
公开(公告)日:2010-04-29
申请号:US12518717
申请日:2007-12-08
申请人: Adrian Tersteegen , Dirk Heimbach , Kai Thede , Reinhold Welker , Beate Fast , Arnold Paessens , Frank Dittmer , Rudolf Schohe-Loop , Axel Harrenga , Alexander Hillisch , Kerstin Henninger , Walter Hübsch , Marcus Bauser , Susanne Greschat , Dirk Schneider , Tobias Marquardt , Andreas Göller , Andreas Urban , Steffen Wildum , Daniela Paulsen
发明人: Adrian Tersteegen , Dirk Heimbach , Kai Thede , Reinhold Welker , Beate Fast , Arnold Paessens , Frank Dittmer , Rudolf Schohe-Loop , Axel Harrenga , Alexander Hillisch , Kerstin Henninger , Walter Hübsch , Marcus Bauser , Susanne Greschat , Dirk Schneider , Tobias Marquardt , Andreas Göller , Andreas Urban , Steffen Wildum , Daniela Paulsen
IPC分类号: A61K31/365 , A61K31/5377 , A61K31/438 , C07D413/12 , C07D491/107 , C07D307/94 , A61P31/18 , A61P31/12
CPC分类号: C07D307/94 , C07D491/10
摘要: The present invention relates to novel substituted aminofurans, to methods for their preparation, to their use in the treatment and/or prophylaxis of diseases as well as their use in the manufacture of medical products for the treatment and/or prophylaxis of diseases, in particular retroviral disorders, in humans and/or animals.
摘要翻译: 本发明涉及新型取代的氨基呋喃,其制备方法,其用于治疗和/或预防疾病及其在制备用于治疗和/或预防疾病的医药产品中的用途,特别是 逆转录病毒疾病,在人和/或动物中。
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