利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

58 条记录 (耗时 0.075 秒)

    Process for the production of purified cytidinemonophosphate-sialic acid-polyalkylene oxide (CMP-SA-PEG) as modified nucleotide sugars via anion exchange chromatography
    23.
    发明授权
    Process for the production of purified cytidinemonophosphate-sialic acid-polyalkylene oxide (CMP-SA-PEG) as modified nucleotide sugars via anion exchange chromatography 有权
    通过阴离子交换色谱法制备纯化的胞苷磷酸唾液酸 - 唾液酸 - 聚环氧烷（CMP-SA-PEG）作为修饰的核苷酸糖的方法

    公开(公告)号：US09493499B2

    公开(公告)日：2016-11-15

    申请号：US12663748

    申请日：2008-06-12

    申请人： Shawn DeFrees ,  Caryn Bowe

    发明人： Shawn DeFrees ,  Caryn Bowe

    IPC分类号： C07H19/10

    CPC分类号： C07H19/10

    摘要： The current invention provides methods (e.g., large-scale processes) for the production of nucleotide sugars, which are modified with a polymeric modifying group, such as poly(alkylene oxide) moieties (e.g., poly(ethylene glycol) or poly(propylene glycol)) moieties. A typical process of the invention includes anion exchange chromatography followed by an ultrafiltration procedure, such as tangential flow filtration. The process of the invention provides modified nucleotide sugars in unexpectedly high purity and high overall yields.

    摘要翻译： 本发明提供用于生产核苷酸糖的方法（例如，大规模方法），其用聚合修饰基团修饰，例如聚（环氧烷）部分（例如聚（乙二醇）或聚（丙二醇） ）部分。 本发明的典型方法包括阴离子交换层析，然后进行超滤方法，例如切向流过滤。 本发明的方法提供了出乎意料的高纯度和高总产率的修饰的核苷酸糖。

    Glycopegylated Factor Ix
    24.
    发明申请
    Glycopegylated Factor Ix 审中-公开
    糖基化因子Ix

    公开(公告)号：US20080255026A1

    公开(公告)日：2008-10-16

    申请号：US11915239

    申请日：2006-05-25

    申请人： Shawn DeFrees ,  Robert J. Bayer ,  Caryn Bowe ,  Panneerselvam Krishnasamy

    发明人： Shawn DeFrees ,  Robert J. Bayer ,  Caryn Bowe ,  Panneerselvam Krishnasamy

    IPC分类号： A61K38/02 ,  C07K2/00 ,  C12P21/06

    CPC分类号： A61K38/4846 ,  A61K47/549 ,  A61K47/60 ,  C12N9/644 ,  C12Y304/21022

    摘要： The present invention provides conjugates between Factor Ix and PEG moieties. The conjugates are linked via a glycosyl linking group interposed between and covalently attached to the peptide and the modifying group. Conjugates are formed from glycosylated peptides by the action of a glycosyltransferase. The glycosyltransferase ligates a modified sugar moiety onto a glycosyl residue on the peptide. Also provided are methods for preparing the conjugates, methods for treating various disease conditions with the conjugates, and pharmaceutical formulations including the conjugates.

    摘要翻译： 本发明提供因子Ix和PEG部分之间的缀合物。 缀合物通过插入在肽和修饰基团之间并共价连接到肽上的糖基连接基团连接。 通过糖基转移酶的作用由糖基化肽形成缀合物。 糖基转移酶将修饰的糖部分连接到肽上的糖基残基上。 还提供了制备缀合物的方法，用缀合物治疗各种疾病状况的方法，以及包括缀合物的药物制剂。

    Glycopegylated Follicle Stimulating Hormone
    25.
    发明申请
    Glycopegylated Follicle Stimulating Hormone 审中-公开
    糖基化卵泡刺激激素

    公开(公告)号：US20080015142A1

    公开(公告)日：2008-01-17

    申请号：US10581538

    申请日：2004-12-03

    申请人： Shawn DeFrees ,  Robert J. Bayer ,  Caryn Bowe

    发明人： Shawn DeFrees ,  Robert J. Bayer ,  Caryn Bowe

    IPC分类号： A61K38/24 ,  C07K14/59

    CPC分类号： C07K14/59 ,  A61K38/17 ,  Y02A50/471

    摘要： The present invention provides conjugates between follicle stimulating hormone and PEG moieties. The conjugates are linked via an intact glycosyl linking group that is interposed between and covalently attached to the peptide and the modifying group. The conjugates are formed from both glycosylated and unglycosylated peptides by the action of a glycosyltransferase. The glycosyltransferase ligates a modified sugar moiety onto either an amino acid or glycosyl residue on the peptide. Also provided are pharmaceutical formulations including the conjugates. Methods for preparing the conjugates are also within the scope of the invention.

    摘要翻译： 本发明提供了促卵泡激素和PEG部分之间的缀合物。 缀合物经由完整的糖基连接基团连接，该基团介于并共价连接到肽和修饰基团之间。 通过糖基转移酶的作用，缀合物由糖基化和未糖基化的肽形成。 糖基转移酶将修饰的糖部分连接到肽上的氨基酸或糖基残基上。 还提供了包括缀合物的药物制剂。 缀合物的制备方法也在本发明的范围内。