公开(公告)号：US11412940B2

公开(公告)日：2022-08-16

申请号：US16465379

申请日：2017-11-30

Applicant: Shiming Lin ,  BIV MEDICAL, LTD.

Inventor： Shiming Lin ,  Shih-Wei Chiang ,  Cheng-Yan Guo ,  Tai-Cun Lin ,  Wei-Chih Huang ,  Chun-Nan Chen ,  Ya-Ting Chang

IPC: A61B5/02 ,  A61B5/021 ,  A61B5/00 ,  A61B5/024 ,  A61B5/022 ,  A61B7/04 ,  A61B5/30 ,  A61B5/282 ,  A61B5/332 ,  A61B5/25

Abstract: The present invention provides a dynamic measurement device with a blood pressure determination function, comprising: a heartbeat sensing module disposed on the chest area of a user wherein the heartbeat sensing module comprising a heart sound sensor for obtaining heartbeat signals; a pulse sensing module disposed on a limb area of the user, the pulse sensing module comprising a pulse wave sensor for obtaining pulse signals; and a data calculating module for calculating a mean arterial pressure and a value of systolic blood pressure and diastolic blood pressure based on the heartbeat signals and pulse signals. In addition to dynamically monitoring the blood pressure of a user for 24 hours, the present invention can dynamically monitor the heart sounds of the user for 24 hours individually in order to monitor user's physical condition. Therefore, the present invention has important medical meanings.

公开(公告)号：US08419271B2

公开(公告)日：2013-04-16

申请号：US12789289

申请日：2010-05-27

Applicant: Long-Sun Huang ,  Yu-Fu Ku ,  Yi-Kuang Yen ,  Shu Kuan ,  Kuang-Chong Wu ,  Shiming Lin ,  Ping-Yen Lin

Inventor： Long-Sun Huang ,  Yu-Fu Ku ,  Yi-Kuang Yen ,  Shu Kuan ,  Kuang-Chong Wu ,  Shiming Lin ,  Ping-Yen Lin

IPC: G01K7/16

CPC classification number: G01N29/022

Abstract: A system for compensating a thermal effect is provided and includes a substrate structure and a microcantilever. The substrate structure includes a first piezoresistor. The first piezoresistor is buried in the substrate structure and has a first piezoresistance having a first relation to a first variable temperature. The microcantilever has the thermal effect and a second piezoresistance having a second relation to the first variable temperature, wherein the thermal effect is compensated based on the first and the second relations.

Abstract translation: 提供了用于补偿热效应的系统，并且包括衬底结构和微悬臂梁。 衬底结构包括第一压电电阻器。 第一压电电阻器被埋在衬底结构中，并且具有与第一可变温度具有第一关系的第一压电阻。 微悬臂梁具有热效应和与第一可变温度具有第二关系的第二压阻，其中基于第一和第二关系补偿热效应。

公开(公告)号：US07271914B2

公开(公告)日：2007-09-18

申请号：US11049085

申请日：2005-02-02

Applicant: Chii-Wann Lin ,  Chih Kung Lee ,  Zhi-Hsiang Sung ,  Shiming Lin

Inventor： Chii-Wann Lin ,  Chih Kung Lee ,  Zhi-Hsiang Sung ,  Shiming Lin

IPC: G01N21/55

CPC classification number: G01N21/553

Abstract: A biomolecular sensor system utilizing a transverse propagation wave of surface plasmon resonance (SPR) is described. The system comprises: a substrate; a dielectric layer, having a groove therein and standing on top of the substrate; a sensing film layer, sitting at the groove; a pair of prism devices, each resting on one side of the groove and both separating a tunable distance. Besides, the sensor system further comprises a light source, a light detector (a frontend of which connecting to a spectrometer and a backend connecting to a differential amplifier) and a channel with a cover forming inside the groove for the acquisition of the reflected light from the prism devices. Since the sensor system is constructed by exploiting the SPR technique on the transverse propagation, a whole contact surface is under detection (parallel detection) which differentiates it from the traditional method of single-area SPR detection. The sensor system is applicable not only for the far-infrared remote sensing with a transverse distance of several centimeters, but further for the biomedical sensing applications in the miniature sizing and high throughput.

Abstract translation: 描述了利用表面等离子体共振（SPR）的横向传播波的生物分子传感器系统。 该系统包括：基板; 介电层，其中具有凹槽并站立在所述基板的顶部上; 位于凹槽处的感测膜层; 一对棱镜装置，每个棱镜装置分别搁置在凹槽的一侧并且两者分离可调距离。 此外，传感器系统还包括光源，光检测器（其前端连接到光谱仪和连接到差分放大器的后端）以及形成在凹槽内的盖的通道，用于获取反射光的反射光 棱镜装置。 由于传感器系统是通过利用SPR技术在横向传播中构建的，因此整个接触面被检测（并行检测），与传统的单区域SPR检测方法相区分。 传感器系统不仅适用于横向距离为几厘米的远红外遥感，而且适用于微型尺寸和高通量的生物医学传感应用。

公开(公告)号：US07148057B2

公开(公告)日：2006-12-12

申请号：US10216911

申请日：2002-08-13

Applicant: Yo-Hsin Su ,  Hsi-Lien Lu ,  Hsun-Min Lung ,  Chung-Ho Tung ,  Ta-Chang Liu ,  Chih-Kung Lee ,  Su-Ming Hsu ,  Shiming Lin ,  Long-Sun Huang ,  Chii-Wann Lin

Inventor： Yo-Hsin Su ,  Hsi-Lien Lu ,  Hsun-Min Lung ,  Chung-Ho Tung ,  Ta-Chang Liu ,  Chih-Kung Lee ,  Su-Ming Hsu ,  Shiming Lin ,  Long-Sun Huang ,  Chii-Wann Lin

IPC: C12M1/34

CPC classification number: B01L9/527 ,  B01F11/0266 ,  B01F13/0059 ,  B01L2200/027 ,  B01L2300/0819 ,  G01N1/312 ,  G01N35/1074 ,  G01N2035/00158 ,  G01N2035/1039

Abstract: A microarray biochip workstation allowing positioning of chips, immobilization of molecules, mixing of sample solution, molecular interactions and washing and processing qualitative and quantitative analyses consists of a positioning device for holding a biochip, a mixing device for acting on the sample solution applied on the biochip, a pumping device for removing the sample solution from the biochip surface that does not react, and a reading device for detecting reaction results of the biochip. The workstation thus constructed provides an integrated and effective work interface.

Abstract translation: 一种微阵列生物芯片工作站，用于定位芯片，分子固定，样品溶液混合，分子相互作用以及洗涤和加工定性和定量分析，包括用于保持生物芯片的定位装置，用于作用在样品溶液上的混合装置 生物芯片，用于从未反应的生物芯片表面去除样品溶液的泵送装置，以及用于检测生物芯片的反应结果的读取装置。 这样构造的工作站提供了一个集成且有效的工作界面。

公开(公告)号：US06844935B2

公开(公告)日：2005-01-18

申请号：US10761116

申请日：2004-01-20

Applicant: Chih-Kung Lee ,  Shuen-Chen Shiue ,  Shu-Sheng Lee ,  Jiun-Yan Wu ,  Chii-Wann Lin ,  Shiming Lin

Inventor： Chih-Kung Lee ,  Shuen-Chen Shiue ,  Shu-Sheng Lee ,  Jiun-Yan Wu ,  Chii-Wann Lin ,  Shiming Lin

IPC: G01B11/00 ,  G01B9/02

CPC classification number: G01B11/00

Abstract: A multi-function opto-electronic detection apparatus for detecting molecular characteristics of a test sample. The appratuses comprises functional mode subsystems including a detecting light source subsystem for generating sampling beams for illuminating the test sample; a manipulation optics subsystem for aligning the sampling beam onto the test sample; a target signal processing subsystem for analyzing target beams emerging from the test sample resulting from the illuminating of the sampling beam; and a sample fixation subsystem for holding the test sample. The detecting light source subsystem, manipulation optics subsystem and target signal processing subsystem are assembled into one of several possible optical sampling setups for the detection characteristics of the test sample. The functional mode setups include at least ellispometer, confocal image scanner, photon tunneling scanning microscope and interferometer.

Abstract translation: 一种用于检测试样的分子特性的多功能光电检测装置。 该装置包括功能模式子系统，包括用于产生用于照亮测试样本的采样光束的检测光源子系统; 用于将采样光束对准到测试样品的操纵光学子系统; 目标信号处理子系统，用于分析从采样光束的照明产生的从测试样本出射的目标光束; 以及用于保持测试样本的样本固定子系统。 检测光源子系统，操作光学子系统和目标信号处理子系统被组合成用于测试样本的检测特性的几种可能的光学采样设置之一。 功能模式设置至少包括椭圆计，共焦图像扫描仪，光子隧道扫描显微镜和干涉仪。

公开(公告)号：US06828807B2

公开(公告)日：2004-12-07

申请号：US10334910

申请日：2003-01-02

Applicant: Yo-Hsin Su ,  Hsi-Lien Lu ,  Ta-Chang Liu ,  Hsun-Min Lung ,  Long-Sun Huang ,  Shiming Lin ,  Der-Xing Liou ,  Chien-Hsun Chen ,  Chih-Kung Lee

Inventor： Yo-Hsin Su ,  Hsi-Lien Lu ,  Ta-Chang Liu ,  Hsun-Min Lung ,  Long-Sun Huang ,  Shiming Lin ,  Der-Xing Liou ,  Chien-Hsun Chen ,  Chih-Kung Lee

IPC: G01R2708

CPC classification number: C12M23/12 ,  C12M35/02 ,  C12M41/46

Abstract: A biological cell test method and apparatus employs a conventional perforated cell carrier which has a plurality of holes. Each hole has two metal electrodes. A cell is disposed in the hole to contact the two electrodes. The electrodes are connected to electric current or voltage. The electric current or field flows from one electrode through the cell to another electrode. Through the inherent impedance, inductance or capacitance of the cell, the presence or property reactions of the cell may be detected.

Abstract translation: 生物细胞试验方法和装置采用具有多个孔的常规穿孔细胞载体。 每个孔都有两个金属电极。 一个电池设置在孔中以接触两个电极。 电极连接电流或电压。 电流或场从一个电极通过电池流到另一个电极。 通过电阻的固有阻抗，电感或电容，可以检测电池的存在或性质反应。