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39 条记录 (耗时 0.08 秒)

    Polynucleotide encoding a novel human G-protein coupled receptor variant of the relaxin receptor HGPRBMY5v1, and variants thereof
    22.
    发明申请
    Polynucleotide encoding a novel human G-protein coupled receptor variant of the relaxin receptor HGPRBMY5v1, and variants thereof 有权
    编码松质素受体HGPRBMY5v1的新型人G蛋白偶联受体变体的多核苷酸及其变体

    公开(公告)号：US20060257918A1

    公开(公告)日：2006-11-16

    申请号：US11486332

    申请日：2006-07-13

    申请人： Chandra Ramanathan ,  John Feder ,  Gabriel Mintier

    发明人： Chandra Ramanathan ,  John Feder ,  Gabriel Mintier

    IPC分类号： C12Q1/68 ,  G01N33/53 ,  C07H21/04 ,  C12P21/06 ,  C07K14/705

    CPC分类号： C07K14/723

    摘要： The present invention provides novel polynucleotides encoding HGPRBMY5v1 and HGPRBMY5v2 polypeptides, fragments and homologues thereof. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The invention further relates to diagnostic and therapeutic methods for applying these novel HGPRBMY5v1 and HGPRBMY5v2 polypeptides to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention.

    摘要翻译： 本发明提供编码HGPRBMY5v1和HGPRBMY5v2多肽的新型多核苷酸，其片段及其同源物。 还提供了载体，宿主细胞，抗体以及用于产生所述多肽的重组和合成方法。 本发明还涉及将这些新型HGPRBMY5v1和HGPRBMY5v2多肽应用于诊断，治疗和/或预防与这些多肽相关的各种疾病和/或病症的诊断和治疗方法。 本发明还涉及用于鉴定本发明的多核苷酸和多肽的激动剂和拮抗剂的筛选方法。

    Polynucleotide encoding a novel human G-protein coupled receptor variant of HM74, HGPRBMY74
    23.
    发明申请
    Polynucleotide encoding a novel human G-protein coupled receptor variant of HM74, HGPRBMY74 有权

    公开(公告)号：US20060177903A1

    公开(公告)日：2006-08-10

    申请号：US11377517

    申请日：2006-03-16

    申请人： Chandra Ramanathan ,  John Feder

    发明人： Chandra Ramanathan ,  John Feder

    IPC分类号： C07K14/705 ,  C07H21/04 ,  C12P21/06

    CPC分类号： C07K14/705

    摘要： The present invention provides novel polynucleotides encoding HGPRBMY74 polypeptides, fragments and homologues thereof. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The invention further relates to diagnostic and therapeutic methods for applying these novel HGPRBMY74 polypeptides to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention.

    Polynucleotide encoding a novel human G-protein coupled receptor, HGPRBMY39
    24.
    发明申请
    Polynucleotide encoding a novel human G-protein coupled receptor, HGPRBMY39 有权
    编码新型人G蛋白偶联受体的多核苷酸HGPRBMY39

    公开(公告)号：US20060084140A1

    公开(公告)日：2006-04-20

    申请号：US10237813

    申请日：2002-09-06

    申请人： Chandra Ramanathan ,  Shuba Gopal ,  Gabriel Mintier ,  John Feder

    发明人： Chandra Ramanathan ,  Shuba Gopal ,  Gabriel Mintier ,  John Feder

    IPC分类号： C07K14/705 ,  C07H21/04 ,  C12P21/06

    CPC分类号： C07K14/723 ,  A61K38/00 ,  C07K2319/00

    摘要： The present invention provides novel polynucleotides encoding HGPRBMY39 polypeptides, fragments and homologues thereof. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The invention further relates to diagnostic and therapeutic methods for applying these novel HGPRBMY39 polypeptides to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention.

    摘要翻译： 本发明提供了编码HGPRBMY39多肽的新型多核苷酸，其片段及其同源物。 还提供了载体，宿主细胞，抗体以及用于产生所述多肽的重组和合成方法。 本发明还涉及将这些新型HGPRBMY39多肽应用于诊断，治疗和/或预防与这些多肽相关的各种疾病和/或病症的诊断和治疗方法。 本发明还涉及用于鉴定本发明的多核苷酸和多肽的激动剂和拮抗剂的筛选方法。

    Polynucleotides encoding two novel human G-protein coupled receptors, HGPRBMY28 and HGPRBMY29, and splice variants thereof
    25.
    发明申请
    Polynucleotides encoding two novel human G-protein coupled receptors, HGPRBMY28 and HGPRBMY29, and splice variants thereof 有权
    编码两种新型人G蛋白偶联受体的多核苷酸HGPRBMY28和HGPRBMY29及其剪接变体

    公开(公告)号：US20080064094A1

    公开(公告)日：2008-03-13

    申请号：US11890963

    申请日：2007-08-08

    申请人： John Feder ,  Chandra Ramanathan ,  Gabriel Mintier ,  David Bol ,  Donald Hawken

    发明人： John Feder ,  Chandra Ramanathan ,  Gabriel Mintier ,  David Bol ,  Donald Hawken

    IPC分类号： C12N5/00 ,  C07K1/00 ,  C07K16/00

    CPC分类号： A61K49/0008 ,  A61K38/00 ,  C07K14/705 ,  C07K16/2863 ,  C07K2317/21 ,  C07K2317/622 ,  Y10S435/975

    摘要： The present invention provides novel polynucleotides encoding HGPRBMY28 and HGPRBMY29 polypeptides, fragments and homologues thereof. The present invention also provides polynucleotides encoding splice variants of HGPRBMY29 polypeptides, HGPRBMY29v1 and HGPRBMY29v2. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The invention further relates to diagnostic and therapeutic methods for applying these novel HGPRBMY28, HGPRBMY29, HGPRBMY29v1, and HGPRBMY29v2 polypeptides to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention.

    摘要翻译： 本发明提供编码HGPRBMY28和HGPRBMY29多肽的新型多核苷酸，其片段及其同源物。 本发明还提供编码HGPRBMY29多肽，HGPRBMY29v1和HGPRBMY29v2的剪接变体的多核苷酸。 还提供了载体，宿主细胞，抗体以及用于产生所述多肽的重组和合成方法。 还提供了载体，宿主细胞，抗体以及用于产生所述多肽的重组和合成方法。 本发明还涉及将这些新型HGPRBMY28，HGPRBMY29，HGPRBMY29v1和HGPRBMY29v2多肽应用于诊断，治疗和/或预防与这些多肽相关的各种疾病和/或病症的诊断和治疗方法。 本发明还涉及用于鉴定本发明的多核苷酸和多肽的激动剂和拮抗剂的筛选方法。

    Acetyl CoA carboxylase 2 sequences and methods
    27.
    发明申请
    Acetyl CoA carboxylase 2 sequences and methods 有权
    乙酰CoA羧化酶2序列和方法

    公开(公告)号：US20060019364A1

    公开(公告)日：2006-01-26

    申请号：US11186999

    申请日：2005-07-21

    申请人： Dong Cheng ,  John Feder ,  Luping Chen ,  Ching-Hsuen Chu

    发明人： Dong Cheng ,  John Feder ,  Luping Chen ,  Ching-Hsuen Chu

    IPC分类号： C12N9/00 ,  C07H21/04 ,  C12P21/06

    CPC分类号： C12N9/93 ,  C12Y604/01002

    摘要： The present invention relates generally to novel nucleotide and amino acid sequences, and more particularly to novel human acetyl CoA carboxylase 2 (ACC2) and rat ACC2 sequences. The sequences provided herein can be expressed in a recombinant format. Methods of isolating the ACC2 sequence are also provided, which can be employed to isolate any ACC sequence. The ACC2 sequences can be employed in therapeutic applications to diagnose or treat a condition associated with ACC2. The invention also relates to the identification of modulators of ACC activity using the recombinant human ACC2 enzyme as the screening target.

    摘要翻译： 本发明一般涉及新的核苷酸和氨基酸序列，更具体地涉及新的人乙酰CoA羧化酶2（ACC2）和大鼠ACC2序列。 本文提供的序列可以以重组形式表达。 还提供了分离ACC2序列的方法，其可用于分离任何ACC序列。 ACC2序列可用于治疗应用以诊断或治疗与ACC2相关的病症。 本发明还涉及使用重组人ACC2酶作为筛选靶标鉴定ACC活性的调节剂。

    Human leucine-rich repeat containing protein expressed predominately in bone marrow, HLRRBM1
    28.
    发明申请
    Human leucine-rich repeat containing protein expressed predominately in bone marrow, HLRRBM1 有权
    人类含有亮氨酸的重复含有蛋白质主要在骨髓HLRRBM1中表达

    公开(公告)号：US20050203048A1

    公开(公告)日：2005-09-15

    申请号：US11107572

    申请日：2005-04-15

    申请人： John Feder ,  Chandra Ramanathan ,  Gabriel Mintier ,  David Bol ,  Donald Hawken

    发明人： John Feder ,  Chandra Ramanathan ,  Gabriel Mintier ,  David Bol ,  Donald Hawken

    IPC分类号： A61K38/00 ,  C07K14/47 ,  C07K16/18 ,  C12Q1/68 ,  A61K48/00 ,  C07H21/04 ,  C07K14/82 ,  G01N33/574

    CPC分类号： C07K16/18 ,  A61K38/00 ,  A61K2039/53 ,  C07K14/47

    摘要： The present invention provides novel polynucleotides encoding HLRRBM1 polypeptides, fragments and homologues thereof. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The invention further relates to diagnostic and therapeutic methods for applying these novel HLRRBM1 polypeptides to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides, particularly immune diseases and/or disorders. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention.

    摘要翻译： 本发明提供了编码HLRRBM1多肽的新型多核苷酸，其片段及其同源物。 还提供了载体，宿主细胞，抗体以及用于产生所述多肽的重组和合成方法。 本发明还涉及将这些新型HLRRBM1多肽应用于诊断，治疗和/或预防与这些多肽，特别是免疫疾病和/或病症相关的各种疾病和/或病症的诊断和治疗方法。 本发明还涉及用于鉴定本发明的多核苷酸和多肽的激动剂和拮抗剂的筛选方法。

    Novel human G-protein coupled receptor, HGPRBMY29sv1 polypeptides
    29.
    发明申请
    Novel human G-protein coupled receptor, HGPRBMY29sv1 polypeptides 有权
    新型人G蛋白偶联受体HGPRBMY29sv1多肽

    公开(公告)号：US20050148016A1

    公开(公告)日：2005-07-07

    申请号：US11070456

    申请日：2005-03-02

    申请人： John Feder ,  Chandra Ramanathan ,  Gabriel Mintier ,  David Bol ,  Donald Hawken

    发明人： John Feder ,  Chandra Ramanathan ,  Gabriel Mintier ,  David Bol ,  Donald Hawken

    IPC分类号： A61K38/00 ,  C07K14/705 ,  C12Q1/68 ,  C07H21/04 ,  C07K16/28

    CPC分类号： A61K49/0008 ,  A61K38/00 ,  C07K14/705 ,  C07K16/2863 ,  C07K2317/21 ,  C07K2317/622 ,  Y10S435/975

    摘要： The present invention provides novel polynucleotides encoding HGPRBMY28 and HGPRBMY29 polypeptides, fragments and homologues thereof. The present invention also provides polynucleotides encoding splice variants of HGPRBMY29 polypeptides, HGPRBMY29v1 and HGPRBMY29v2. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The invention further relates to diagnostic and therapeutic methods for applying these novel HGPRBMY28, HGPRBMY29, HGPRBMY29v1, and HGPRBMY29v2 polypeptides to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention.

    摘要翻译： 本发明提供编码HGPRBMY28和HGPRBMY29多肽的新型多核苷酸，其片段及其同源物。 本发明还提供编码HGPRBMY29多肽，HGPRBMY29v1和HGPRBMY29v2的剪接变体的多核苷酸。 还提供了载体，宿主细胞，抗体以及用于产生所述多肽的重组和合成方法。 还提供了载体，宿主细胞，抗体以及用于产生所述多肽的重组和合成方法。 本发明还涉及将这些新型HGPRBMY28，HGPRBMY29，HGPRBMY29v1和HGPRBMY29v2多肽应用于诊断，治疗和/或预防与这些多肽相关的各种疾病和/或病症的诊断和治疗方法。 本发明还涉及用于鉴定本发明的多核苷酸和多肽的激动剂和拮抗剂的筛选方法。

    ACETYL COA CARBOXYLASE 2 SEQUENCES AND METHODS
    30.
    发明申请
    ACETYL COA CARBOXYLASE 2 SEQUENCES AND METHODS 审中-公开
    乙酰丙酮羧酸酶2序列和方法

    公开(公告)号：US20080026363A1

    公开(公告)日：2008-01-31

    申请号：US11684339

    申请日：2007-03-09

    申请人： Dong Cheng ,  John Feder ,  Luping Chen ,  Ching-Hsuen Chu

    发明人： Dong Cheng ,  John Feder ,  Luping Chen ,  Ching-Hsuen Chu

    IPC分类号： C12N9/00 ,  C07H21/02 ,  C07K16/40 ,  C12N1/00 ,  C12P21/02 ,  C12Q1/00 ,  C12N15/09 ,  C12N15/52 ,  C12N15/63

    CPC分类号： C12N9/93 ,  C12Y604/01002

    摘要： The present invention relates generally to novel nucleotide and amino acid sequences, and more particularly to novel human acetyl CoA carboxylase 2 (ACC2) and rat ACC2 sequences. The sequences provided herein can be expressed in a recombinant format. Methods of isolating the ACC2 sequence are also provided, which can be employed to isolate any ACC sequence. The ACC2 sequences can be employed in therapeutic applications to diagnose or treat a condition associated with ACC2. The invention also relates to the identification of modulators of ACC activity using the recombinant human ACC2 enzyme as the screening target.

    摘要翻译： 本发明一般涉及新的核苷酸和氨基酸序列，更具体地涉及新的人乙酰CoA羧化酶2（ACC2）和大鼠ACC2序列。 本文提供的序列可以以重组形式表达。 还提供了分离ACC2序列的方法，其可用于分离任何ACC序列。 ACC2序列可用于治疗应用以诊断或治疗与ACC2相关的病症。 本发明还涉及使用重组人ACC2酶作为筛选靶标鉴定ACC活性的调节剂。