公开(公告)号：US10130766B1

公开(公告)日：2018-11-20

申请号：US14874736

申请日：2015-10-05

申请人： Stéphane Bibian ,  Tatjana Zikov

发明人： Stéphane Bibian ,  Tatjana Zikov

IPC分类号： A61M21/00 ,  A61M5/172 ,  A61B5/0476 ,  A61B5/00 ,  A61B5/04 ,  A61M16/00

摘要： A system and method provides closed-loop sedation, anesthesia, or analgesia by monitoring EEG and automatically adjusting the delivery of sedative, anesthetic, and/or analgesic drugs to maintain that desired or predetermined level of cortical at all echelons of care. The system and method further monitor the subject's cortical activity to detect occurrence of burst suppression which can be indicative of unsafe depth of anesthesia or sedation. Further, the system and methods provide for alteration or cessation of the administration of anesthesia or sedation based on the occurrence of burst suppression to mitigate harm to the subject.

公开(公告)号：US09901278B1

公开(公告)日：2018-02-27

申请号：US14701944

申请日：2015-05-01

申请人： Stéphane Bibian ,  Tatjana Zikov

发明人： Stéphane Bibian ,  Tatjana Zikov

IPC分类号： A61B5/0478 ,  A61B5/00 ,  A61B5/0492 ,  A61B5/0408 ,  A61B5/0496

CPC分类号： A61B5/0478 ,  A61B5/0408 ,  A61B5/042 ,  A61B5/0492 ,  A61B5/0496 ,  A61B5/6833 ,  A61B5/6839 ,  A61B2562/0209 ,  A61B2562/14 ,  A61B2562/242

摘要： The present invention relates to a physiological recording electrode, and, more particularly, to an EEG (electroencephalography) recording electrode that can be used without the need for numerous steps in preparing the subject's skin and the electrode itself. The invention further relates to a surface feature or penetrator with a size and shape which that will not bend or break, which limits the depth of application, and/or anchors the electrode or other device during normal application; and a packaging system comprising a well and electrolytic fluid for maintaining a coating of said electrolytic fluid on the surface feature or penetrator.

公开(公告)号：US20150018657A1

公开(公告)日：2015-01-15

申请号：US14324719

申请日：2014-07-07

申请人： Stéphane Bibian ,  Tatjana Zikov

发明人： Stéphane Bibian ,  Tatjana Zikov

IPC分类号： A61B5/0478 ,  A61B5/0496 ,  A61B5/0492 ,  A61B5/00 ,  A61B5/042

CPC分类号： A61B5/0478 ,  A61B5/0408 ,  A61B5/042 ,  A61B5/0492 ,  A61B5/0496 ,  A61B5/6833 ,  A61B5/6839 ,  A61B2562/0209 ,  A61B2562/14 ,  A61B2562/242

摘要： The present invention relates to a physiological recording electrode, and, more particularly, to an EEG (electroencephalography) recording electrode that can be used without the need for numerous steps in preparing the subject's skin and the electrode itself. The invention further relates to a surface feature or penetrator with a size and shape which that will not bend or break, which limits the depth of application, and/or anchors the electrode or other device during normal application; and a packaging system comprising a well and electrolytic fluid for maintaining a coating of said electrolytic fluid on the surface feature or penetrator.

公开(公告)号：US08805469B1

公开(公告)日：2014-08-12

申请号：US14058709

申请日：2013-10-21

申请人： Stéphane Bibian ,  Tatjana Zikov

发明人： Stéphane Bibian ,  Tatjana Zikov

IPC分类号： A61B5/0478

CPC分类号： A61B5/0478 ,  A61B5/0408 ,  A61B5/042 ,  A61B5/0492 ,  A61B5/0496 ,  A61B5/6833 ,  A61B5/6839 ,  A61B2562/0209 ,  A61B2562/14 ,  A61B2562/242

摘要： The present invention relates to a physiological recording electrode, and, more particularly, to an EEG (electroencephalography) recording electrode that can be used without the need for numerous steps in preparing the subject's skin and the electrode itself. The invention further relates to a surface feature or penetrator with a size and shape which that will not bend or break, which limits the depth of application, and/or anchors the electrode or other device during normal application; and a packaging system comprising a well and electrolytic fluid for maintaining a coating of said electrolytic fluid on the surface feature or penetrator.

摘要翻译： 本发明涉及一种生理记录电极，更具体地说，涉及一种EEG（脑电图）记录电极，其可以在制备受试者的皮肤和电极本身时不需要许多步骤而使用。 本发明还涉及具有不会弯曲或断裂的尺寸和形状的表面特征或穿透器，这限制了施加深度，和/或在正常应用期间锚定电极或其它装置; 以及包括井和电解液的包装系统，用于将所述电解液的涂层保持在表面特征或穿透器上。

公开(公告)号：US08538512B1

公开(公告)日：2013-09-17

申请号：US12259652

申请日：2008-10-28

申请人： Stéphane Bibian ,  Tatjana Zikov ,  Mohammad Modarres

发明人： Stéphane Bibian ,  Tatjana Zikov ,  Mohammad Modarres

IPC分类号： A61B5/02

CPC分类号： A61B5/0476 ,  A61B5/0006 ,  A61B5/04001 ,  A61B5/04012 ,  A61B5/048 ,  A61B5/1128 ,  A61B5/4094 ,  A61B5/4839 ,  A61B5/721 ,  A61B5/7235 ,  A61B5/743 ,  A61N1/36064

摘要： The present invention relates to a brain dysfunction and seizure detector monitor and system, and a method of detecting brain dysfunction and/or seizure of a subject. The various embodiments of the system of the present invention were developed for the brain activity and preferably EEG monitoring of a single patient or multiple patients. Preferably, the system or monitor of the present invention also includes one or more seizure detection algorithms. The analysis method is specifically optimized to amplify abnormal brain activity and minimize normal background activity. This analysis yields a seizure index whose value is directly related to the current presence of ictal activity in the signal. In addition, a seizure probability index based on historical values of the aforementioned seizure index, is derived for diagnostic purposes. The seizure probability index quantifies the probability that the patient has exhibited abnormal brain activity since the beginning of the recording. The real-time seizure index, and the historical seizure probability index, can be used in the context of an emergency and/or clinical situation to assess the status and well being of a patient's brain, or can be used to automatically administer treatment to stop the seizure before clinical signs appear.

摘要翻译： 本发明涉及脑功能障碍和癫痫发作检测器监测和系统，以及检测受试者脑功能障碍和/或发作的方法。 本发明的系统的各种实施方案是针对脑活动而开发的，并且优选地对单个患者或多个患者进行EEG监测。 优选地，本发明的系统或监视器还包括一个或多个发作检测算法。 分析方法被特别优化，以扩大异常大脑活动并最小化正常的背景活动。 该分析产生一个缉获指数，其价值与信号中当前存在的动作直接相关。 此外，基于上述扣押指数的历史值的缉获概率指数被推导出用于诊断目的。 癫痫发作概率指数量化自记录开始以来患者表现出异常脑活动的可能性。 可以在紧急情况和/或临床情况的情况下使用实时癫痫发作指数和历史发作概率指数来评估患者的大脑的状态和健康状况，或者可以用于自动管理治疗停止 临床前出现癫痫发作。

公开(公告)号：US20110295099A1

公开(公告)日：2011-12-01

申请号：US13110533

申请日：2011-05-18

申请人： Stéphane Bibian ,  Tatjana Zikov

发明人： Stéphane Bibian ,  Tatjana Zikov

IPC分类号： A61B5/0478

CPC分类号： A61B5/0478

摘要： Electrodes for use in electroencephalographic recording, including consciousness and seizure monitoring applications, have novel features that speed, facilitate or enforce proper placement of the electrodes, including aligning tabs and arrowed aligning juts, color coding, and an insulating bridge between reference and ground electrodes which ensures a safe application distance between the conductive regions of the two electrodes in the event of cardiac defibrillation. A method of using a set of four such electrodes is also disclosed.

摘要翻译： 用于脑电记录的电极，包括意识和癫痫发作监测应用，具有加速，促进或实施电极正确放置的新颖特征，包括对准翼片和箭头对齐突起，颜色编码以及参考电极和接地电极之间的绝缘桥， 确保在心脏除颤的情况下两个电极的导电区域之间的安全施用距离。 还公开了使用一组四个这样的电极的方法。