公开(公告)号：US11109789B1

公开(公告)日：2021-09-07

申请号：US13962533

申请日：2013-08-08

申请人： Stéphane Bibian ,  Tatjana Zikov ,  Sankar Barua

发明人： Stéphane Bibian ,  Tatjana Zikov ,  Sankar Barua

IPC分类号： A61B5/372 ,  A61B5/291

摘要： A system and method for using electroencephalographic (EEG) signals to monitor brain function, preferably detect occurrence of traumatic brain injury (TBI) to screen, assess, and potentially provide mitigating treatment to improve short and long term adverse outcomes of mild TBI (mTBI) and TBI. The system and method provides a readily available tool to assist in accurate and objective assessment of subjects with TBI, immediately at the point of injury (POI), during transportation, or upon arrival at a care facility, that preferably is applicable without advanced training or expertise.

公开(公告)号：US09554721B1

公开(公告)日：2017-01-31

申请号：US12148815

申请日：2008-04-23

申请人： Tatjana Zikov ,  Stéphane Bibian ,  Mohammad Modarres

发明人： Tatjana Zikov ,  Stéphane Bibian ,  Mohammad Modarres

IPC分类号： A61B5/04 ,  A61B5/0476 ,  A61B5/048

CPC分类号： A61B5/0476 ,  A61B5/0006 ,  A61B5/04001 ,  A61B5/04012 ,  A61B5/048 ,  A61B5/1128 ,  A61B5/4094 ,  A61B5/4839 ,  A61B5/721 ,  A61B5/7235 ,  A61B5/743 ,  A61N1/36064

摘要： The present invention relates to a brain dysfunction and seizure detector monitor and system, and a method of detecting brain dysfunction and/or seizure of a subject. The various embodiments of the system of the present invention were developed for the brain activity and preferably EEG monitoring of a single patient or multiple patients. Preferably, the system or monitor of the present invention also includes one or more seizure detection algorithms. The analysis method is specifically optimized to amplify abnormal brain activity and minimize normal background activity. This analysis yields a seizure index whose value is directly related to the current presence of ictal activity in the signal. In addition, a seizure probability index based on historical values of the aforementioned seizure index, is derived for diagnostic purposes. The seizure probability index quantifies the probability that the patient has exhibited abnormal brain activity since the beginning of the recording. The real-time seizure index, and the historical seizure probability index, can be used in the context of an emergency and/or clinical situation to assess the status and well being of a patient's brain, or can be used to automatically administer treatment to stop the seizure before clinical signs appear.

摘要翻译： 本发明涉及脑功能障碍和癫痫发作检测器监测和系统，以及检测受试者脑功能障碍和/或发作的方法。 本发明的系统的各种实施方案是针对脑活动而开发的，优选地对单个患者或多个患者进行EEG监测。 优选地，本发明的系统或监视器还包括一个或多个发作检测算法。 分析方法被特别优化，以扩大异常大脑活动并最小化正常的背景活动。 该分析产生一个缉获指数，其价值与信号中当前存在的动作直接相关。 此外，基于上述扣押指数的历史值的缉获概率指数被推导出用于诊断目的。 癫痫发作概率指数量化自记录开始以来患者表现出异常脑活动的可能性。 可以在紧急情况和/或临床情况的情况下使用实时癫痫发作指数和历史发作概率指数来评估患者的大脑的状态和健康状况，或者可以用于自动管理治疗停止 临床前出现癫痫发作。

公开(公告)号：US08108039B2

公开(公告)日：2012-01-31

申请号：US11827906

申请日：2007-07-13

申请人： Thomas V. Saliga ,  Stephane Bibian ,  Tatjana Zikov

发明人： Thomas V. Saliga ,  Stephane Bibian ,  Tatjana Zikov

IPC分类号： A61B5/00 ,  A61B5/04

CPC分类号： A61B5/7217 ,  A61B5/04004 ,  A61B5/0428 ,  A61B5/0476 ,  A61B5/0488 ,  A61B5/0496 ,  A61B5/4839 ,  A61B5/7221 ,  A61B5/725 ,  A61B18/1402 ,  A61B2018/00601 ,  A61B2018/00839 ,  A61B2018/1412 ,  G01R29/26

摘要： The present invention, herein is a method and apparatus that significantly limits the effect of high frequency (“HF”) interferences on acquired electro-physiological signals, such as the EEG and EMG. Preferably, this method comprises of two separate electronic circuitries and steps or electronics for processing the signals. One circuit is used to block the transmission of HF interferences to the instrumentation amplifiers. It is comprised of a front-end active filter, a low frequency electromagnetic interference (“EMI”) shield, and an isolation barrier interface which isolates the patient from earth ground. The second circuit is used to measure the difference in potential between the two isolated sides of the isolation barrier. This so-called “cross-barrier” voltage is directly representative of the interference level that the instrumentation amplifier is subjected to. This circuit is used to confirm that the acquired signals are not corrupted by the interference.

摘要翻译： 本发明是一种显着限制高频（“HF”）干扰对所获得的电生理信号如EEG和EMG的影响的方法和装置。 优选地，该方法包括用于处理信号的两个单独的电子电路和步骤或电子装置。 一个电路用于阻止HF干扰对仪表放大器的传输。 它由前端有源滤波器，低频电磁干扰（“EMI”）屏蔽以及将患者与地面隔离的隔离屏障接口组成。 第二电路用于测量隔离屏障的两个隔离侧之间的电位差。 这种所谓的“交叉屏障”电压直接代表了仪表放大器受到的干扰电平。 该电路用于确认所采集的信号没有被干扰破坏。

公开(公告)号：US07603168B2

公开(公告)日：2009-10-13

申请号：US12148151

申请日：2008-04-17

申请人： Stéphane Bibian ,  Tatjana Zikov ,  Guy Albert Dumont ,  Craig Robert Ries ,  Ernest Puil ,  Hosaain Cyrus Ahmadi ,  Mihai Huzmezan ,  Bernard Ansell MacLeod

发明人： Stéphane Bibian ,  Tatjana Zikov ,  Guy Albert Dumont ,  Craig Robert Ries ,  Ernest Puil ,  Hosaain Cyrus Ahmadi ,  Mihai Huzmezan ,  Bernard Ansell MacLeod

IPC分类号： A61B5/04

CPC分类号： A61B5/4821 ,  A61B5/048 ,  A61B5/4035 ,  A61B5/7217 ,  A61B5/726 ,  A61B5/7267

摘要： A method and apparatus to monitor and control the anesthesia state of a patient undergoing general anesthesia is provided. Previous automated systems to monitor the anesthesia state of a patient undergoing general anesthesia involve a significant time delay between the patient's true anesthesia state and the computed indices. The present invention reduces this time delay by using a novel analysis technique applied to spontaneous electrophysiological activity. A transformation and statistical analysis of the observed electrophysiological activity is conducted and compared to reference data to provide numerical indicators. In addition, these indicators are consistent with the levels of depression of patients CNS and ANS states. This method is illustrated in detail by CNS monitoring of electroencephalogram signals.

摘要翻译： 提供了一种用于监测和控制进行全身麻醉的患者的麻醉状态的方法和装置。 以前的自动系统监测患者进行全身麻醉的麻醉状态涉及患者真实麻醉状态与计算出的指数之间的显着时间延迟。 本发明通过使用应用于自发电生理活动的新型分析技术来减少该时间延迟。 对观察到的电生理活动进行转化和统计分析，并与参考数据进行比较以提供数值指标。 此外，这些指标与患者CNS和ANS状态的抑郁水平一致。 CNS对脑电图信号的监测详细说明了该方法。

公开(公告)号：US20090018429A1

公开(公告)日：2009-01-15

申请号：US11827906

申请日：2007-07-13

申请人： Thomas V. Saliga ,  Stephane Bibian ,  Tatjana Zikov

发明人： Thomas V. Saliga ,  Stephane Bibian ,  Tatjana Zikov

IPC分类号： A61B5/04

CPC分类号： A61B5/7217 ,  A61B5/04004 ,  A61B5/0428 ,  A61B5/0476 ,  A61B5/0488 ,  A61B5/0496 ,  A61B5/4839 ,  A61B5/7221 ,  A61B5/725 ,  A61B18/1402 ,  A61B2018/00601 ,  A61B2018/00839 ,  A61B2018/1412 ,  G01R29/26

摘要： The present invention, herein is a method and apparatus that significantly limits the effect of high frequency (“HF”) interferences on acquired electro-physiological signals, such as the EEG and EMG. Preferably, this method comprises of two separate electronic circuitries and steps or electronics for processing the signals. One circuit is used to block the transmission of HF interferences to the instrumentation amplifiers. It is comprised of a front-end active filter, a low frequency electromagnetic interference (“EMI”) shield, and an isolation barrier interface which isolates the patient from earth ground. The second circuit is used to measure the difference in potential between the two isolated sides of the isolation barrier. This so-called “cross-barrier” voltage is directly representative of the interference level that the instrumentation amplifier is subjected to. This circuit is used to confirm that the acquired signals are not corrupted by the interference.

摘要翻译： 本发明是一种显着限制高频（“HF”）干扰对所获得的电生理信号如EEG和EMG的影响的方法和装置。 优选地，该方法包括用于处理信号的两个单独的电子电路和步骤或电子装置。 一个电路用于阻止HF干扰对仪表放大器的传输。 它由前端有源滤波器，低频电磁干扰（“EMI”）屏蔽以及将患者与地面隔离的隔离屏障接口组成。 第二电路用于测量隔离屏障的两个隔离侧之间的电位差。 这种所谓的“交叉屏障”电压直接代表了仪表放大器受到的干扰电平。 该电路用于确认所采集的信号没有被干扰破坏。

公开(公告)号：US11565042B1

公开(公告)日：2023-01-31

申请号：US13962565

申请日：2013-08-08

申请人： Stéphane Bibian ,  Tatjana Zikov ,  Sankar Barua

发明人： Stéphane Bibian ,  Tatjana Zikov ,  Sankar Barua

IPC分类号： A61B5/0476 ,  A61M5/172 ,  A61B5/369 ,  A61M5/142

摘要： A system and method provides closed-loop sedation, anesthesia, or analgesia by monitoring EEG and automatically adjusting the delivery of sedative, anesthetic, and/or analgesic drugs to maintain that desired level of cortical activity for transportation or evacuation of the injured, and for closed-loop anesthesia during surgical care, and at all echelons of care.

公开(公告)号：US09439601B1

公开(公告)日：2016-09-13

申请号：US14687159

申请日：2015-04-15

申请人： Thomas V. Saliga ,  Stéphane Bibian ,  Tatjana Zikov

发明人： Thomas V. Saliga ,  Stéphane Bibian ,  Tatjana Zikov

IPC分类号： H03F1/26 ,  A61B5/00 ,  A61B5/0476 ,  A61B5/0488 ,  A61B5/0428 ,  A61B5/0496

CPC分类号： A61B5/7217 ,  A61B5/04004 ,  A61B5/0428 ,  A61B5/0476 ,  A61B5/0488 ,  A61B5/0496 ,  A61B5/4839 ,  A61B5/7221 ,  A61B5/725 ,  A61B18/1402 ,  A61B2018/00601 ,  A61B2018/00839 ,  A61B2018/1412 ,  G01R29/26

摘要： The present invention, herein is a method and apparatus that significantly limits the effect of high frequency (“HF”) interferences on acquired electro-physiological signals, such as the EEG and EMG. Preferably, this method comprises of two separate electronic circuitries and steps or electronics for processing the signals. One circuit is used to block the transmission of HF interferences to the instrumentation amplifiers. It is comprised of a front-end active filter, a low frequency electromagnetic interference (“EMI”) shield, and an isolation barrier interface which isolates the patient from earth ground. The second circuit is used to measure the difference in potential between the two isolated sides of the isolation barrier. This so-called “cross-barrier” voltage is directly representative of the interference level that the instrumentation amplifier is subjected to. This circuit is used to confirm that the acquired signals are not corrupted by the interference.

摘要翻译： 本发明是一种显着限制高频（“HF”）干扰对所获得的电生理信号如EEG和EMG的影响的方法和装置。 优选地，该方法包括用于处理信号的两个单独的电子电路和步骤或电子装置。 一个电路用于阻止HF干扰对仪表放大器的传输。 它由前端有源滤波器，低频电磁干扰（“EMI”）屏蔽以及将患者与地面隔离的隔离屏障接口组成。 第二电路用于测量隔离屏障的两个隔离侧之间的电位差。 这种所谓的“交叉屏障”电压直接代表了仪表放大器受到的干扰电平。 该电路用于确认所采集的信号没有被干扰破坏。

公开(公告)号：US08798735B1

公开(公告)日：2014-08-05

申请号：US12584083

申请日：2009-08-31

申请人： Stéphane Bibian ,  Tatjana Zikov ,  Guy Albert Dumont ,  Craig Robert Ries ,  Ernest Puil ,  Hossain Cyrus Ahmadi ,  Mihai Huzmezan ,  Bernard Ansell Macleod

发明人： Stéphane Bibian ,  Tatjana Zikov ,  Guy Albert Dumont ,  Craig Robert Ries ,  Ernest Puil ,  Hossain Cyrus Ahmadi ,  Mihai Huzmezan ,  Bernard Ansell Macleod

IPC分类号： A61B5/00

CPC分类号： A61B5/4821 ,  A61B5/048 ,  A61B5/4035 ,  A61B5/7217 ,  A61B5/726 ,  A61B5/7267

摘要： A method and apparatus to monitor the neurologic state of a patient undergoing general anesthesia is provided. Previous automated systems to monitor the neurologic state of a patient undergoing general anesthesia involve a significant time delay between the patient's true hypnotic state and the computed indices. The present invention reduces this time delay by using a different analysis technique applied to spontaneous EEG. A wavelet decomposition and statistical analysis of the observed EEG is conducted and compared to reference data to provide a numerical indicator. In addition, this indicator is more consistent with the patient's loss of consciousness indicated by the loss of count event than previous systems.

摘要翻译： 提供了一种监测患有全身麻醉的患者的神经状态的方法和装置。 以前用于监测患有全身麻醉的患者的神经状态的自动化系统涉及患者真实催眠状态与计算出的指数之间的显着时间延迟。 本发明通过使用应用于自发性EEG的不同分析技术来减少该时间延迟。 进行观察脑电图的小波分解和统计分析，并与参考数据进行比较以提供数值指标。 此外，该指标与以前系统的计数事件丢失所表示的患者意识丧失更为一致。

公开(公告)号：US20110295142A1

公开(公告)日：2011-12-01

申请号：US13104167

申请日：2011-05-10

申请人： Niranjan Chakravarthy ,  Stephane Bibian ,  Tatjana Zikov

发明人： Niranjan Chakravarthy ,  Stephane Bibian ,  Tatjana Zikov

IPC分类号： A61B5/0476

CPC分类号： A61B5/0476 ,  A61B5/4094 ,  A61B5/4812 ,  A61B5/7203 ,  A61B5/721 ,  A61B5/7221

摘要： The present invention relates to a physiological monitor and system, particularly to an electroencephalogram (EEG) monitor and system, and a method of detecting the presence and absence of artifacts and possibly removing artifacts from an EEG, other physiological signal or sensor signal without corrupting or compromising the signal. The accurate, real-time detection of the presence or absence of artifacts and removal of artifacts in EEG or other signals allows for increased reliability in the efficacy of those signals. The strategy of rejecting artifact-corrupted EEG can result in unacceptable data loss, and asking subjects to minimize movements in order to minimize artifacts is not always feasible. The present invention allows for increased accuracy in detection and removal of artifacts from physiological signals, substantially in real time, and without loss or corruption of signal or data in order to increase the accuracy of such signals for diagnosis and treatment purposes.

摘要翻译： 本发明涉及一种生理监视器和系统，特别涉及脑电图（EEG）监视器和系统，以及一种检测伪影的存在和不存在以及可能从脑电图，其他生理信号或传感器信号中除去伪像而不破坏或 妥协信号。 在脑电图或其他信号中准确，实时地检测伪像的存在或不存在以及去除伪影，可以提高这些信号的功效的可靠性。 拒绝人为损坏的脑电图的策略可能导致不可接受的数据丢失，并且要求受试者最小化移动以最小化伪影并不总是可行的。 本发明允许基本上实时地检测和从生理信号中去除伪影，并且不会丢失或破坏信号或数据，从而提高这些信号的诊断和处理目的的准确性。

公开(公告)号：US20110130675A1

公开(公告)日：2011-06-02

申请号：US12628568

申请日：2009-12-01

申请人： Stéphane Bibian ,  Tatjana Zikov

发明人： Stéphane Bibian ,  Tatjana Zikov

IPC分类号： A61B5/0476

CPC分类号： A61B5/0476 ,  A61B5/4064 ,  A61B5/4082 ,  A61B5/4821 ,  A61B5/6843 ,  A61B5/7203 ,  A61B5/7221 ,  A61B5/7225 ,  A61B5/7257 ,  A61B5/726 ,  A61M5/1723

摘要： The present invention relates to a quantitative electroencephalogram (QEEG) monitor and system capable of monitoring and displaying simultaneously neuropathological characteristic and activity of both sides of a subject's brain. The methods include various indices and examination of differences in these indices by which neurophysiological conditions or problems can be identified and treated. These methods, and the systems and devices using these methods preferably can be used for identifying these neurophysiological conditions or brain dysfunction with monitors and methods for seizure detection, for sedation monitoring, for anesthesia monitoring, and the like. These bilateral brain monitoring methods and systems, and the devices using these methods can be used by individuals or clinicians with little or no training in signal analysis or processing. These bilateral monitoring methods can also be used in a range of applications.

摘要翻译： 本发明涉及一种能够同时监测和显示受试者脑部两侧的神经病理特征和活动的定量脑电图（QEEG）监测器和系统。 这些方法包括各种指标和检查这些指标的差异，通过这些指标可以识别和治疗神经生理学条件或问题。 使用这些方法的这些方法以及使用这些方法的系统和装置优选地可以用于通过用于缉获检测的监测器和方法来鉴别这些神经生理学状况或脑功能障碍，用于镇静监测，用于麻醉监测等。 这些双侧大脑监测方法和系统以及使用这些方法的装置可以由信号分析或处理中很少或根本没有训练的个人或临床医生使用。 这些双边监测方法也可用于一系列应用。