利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

39 条记录 (耗时 0.031 秒)

    Use of Buckysome or Carbon Nanotube for Drug Delivery
    22.
    发明申请
    Use of Buckysome or Carbon Nanotube for Drug Delivery 审中-公开
    使用Buckysome或碳纳米管进行药物输送

    公开(公告)号：US20110045031A1

    公开(公告)日：2011-02-24

    申请号：US12876695

    申请日：2010-09-07

    申请人： Andreas Hirsch ,  Uri Sagman ,  Stephen R. Wilson

    发明人： Andreas Hirsch ,  Uri Sagman ,  Stephen R. Wilson

    IPC分类号： A61K9/00 ,  A61P35/00 ,  B82Y5/00

    CPC分类号： A61K9/127 ,  A61K9/0092 ,  A61K47/6923 ,  A61K47/6925 ,  A61K47/6949 ,  A61K49/0004 ,  B82Y5/00 ,  B82Y30/00 ,  B82Y40/00 ,  C01B32/152 ,  C01B32/174

    摘要： Compositions and methods for administering a therapeutic agent to a mammal are disclosed. The compositions comprise either (i) vesicles comprising an amphiphilic substituted fullerene, wherein the therapeutic agent is present in the vesicle interior or between layers of the vesicle wall, (ii) a substituted fullerene, comprising a fullerene core and a functional moiety, wherein the therapeutic agent is associated with the substituted fullerene, or (iii) carbon nanotubes, wherein the therapeutic agent is covalently bonded to the carbon nanotubes.

    摘要翻译： 公开了向哺乳动物施用治疗剂的组合物和方法。 所述组合物包含（i）包含两亲性取代的富勒烯的囊泡，其中所述治疗剂存在于泡囊内部或囊泡壁的层之间，（ii）包含富勒烯核心和功能部分的取代的富勒烯，其中 治疗剂与取代的富勒烯相关，或（iii）碳纳米管，其中治疗剂与碳纳米管共价键合。

    Suspension for bicycles
    25.
    再颁专利
    Suspension for bicycles 失效
    悬挂自行车

    公开(公告)号：USRE35401E

    公开(公告)日：1996-12-17

    申请号：US534616

    申请日：1995-09-27

    申请人： Stephen R. Wilson ,  Douglas J. Halpin

    发明人： Stephen R. Wilson ,  Douglas J. Halpin

    IPC分类号： B62K21/02 ,  B62K25/08

    CPC分类号： B62K21/02 ,  B62K25/08 ,  B62K2201/02

    摘要： A front wheel shock absorbing system for a bicycle wherein the legs of the front wheel fork include struts slidable in tubes. A cross brace bridges the front wheel and interconnects the struts to insure parallel movement of the struts. Elastomer pads between the tube ends and struts provide spring action. A cap in the tube ends provides access to the pads. A strut protruded from the cap down through a center bore in the pads maintains the pads in alignment. The strut end is flanged and removal of the cap, withdraws the strut and pads which are held onto the strut by the flange end. The flange is configured to permit the elastomer pads to be forced over the flange for replacement of the pads.

    摘要翻译： 一种用于自行车的前轮冲击吸收系统，其中前轮叉的腿部包括可在管中滑动的支柱。 十字支架桥接前轮并互连支柱以确保支柱的平行移动。 管端和支柱之间的弹性垫可提供弹簧作用。 管末端的一个盖子可以进入垫片。 从盖子向下突出穿过垫中的中心孔的支柱将保持垫对准。 支柱端是带凸缘的，并且移除盖子，通过法兰端取出支撑件和支撑件。 凸缘被构造成允许弹性体垫被迫超过凸缘以更换垫。

    Compounds having glutathione peroxidase activity and use thereof
    27.
    发明授权
    Compounds having glutathione peroxidase activity and use thereof 失效
    具有谷胱甘肽过氧化物酶活性的化合物及其用途

    公开(公告)号：US5321138A

    公开(公告)日：1994-06-14

    申请号：US692931

    申请日：1991-04-29

    申请人： Abraham Spector ,  Stephen R. Wilson ,  Paul A. Zucker

    发明人： Abraham Spector ,  Stephen R. Wilson ,  Paul A. Zucker

    IPC分类号： C07C391/02 ,  C07C37/02 ,  A01K31/095

    CPC分类号： C07C391/02

    摘要： The present invention provides compounds having glutathione peroxidase activity and, therefore, are effective glutathione peroxidase replacements. These compounds are useful as drugs for the prevention of cataracts and as anti-oxidants for H.sub.2 O.sub.2 and other peroxides. The present invention also provides methods and pharmaceutical compositions of the compound.

    摘要翻译： 本发明提供具有谷胱甘肽过氧化物酶活性的化合物，因此是有效的谷胱甘肽过氧化物酶替代物。 这些化合物可用作预防白内障的药物和作为H 2 O 2和其它过氧化物的抗氧化剂。 本发明还提供了该化合物的方法和药物组合物。

    Quick release dropout for bicycle wheel
    28.
    发明授权
    Quick release dropout for bicycle wheel 失效
    自行车轮的快速释放脱落

    公开(公告)号：US5238259A

    公开(公告)日：1993-08-24

    申请号：US909218

    申请日：1992-07-06

    申请人： Stephen R. Wilson ,  Douglas J. Halpin

    发明人： Stephen R. Wilson ,  Douglas J. Halpin

    IPC分类号： B62K25/08

    CPC分类号： B62K25/08 ,  B62K2201/02

    摘要： A front wheel shock absorbing system for a bicycle wherein the legs of the front wheel fork includes struts slidable in tubes. The struts are attached at one end to the wheel axle using a quick release clamping mechanism. Brackets on the strut ends are U shaped and simply drop over the axle and as a result of the clamping action are clamped onto the axle. To avoid upsetting of the parallel relation of the struts, one of the brackets is equipped with an axially slidable U shaped shoe. Thus, the clamping action merely moves the shoe of the one bracket closer to or farther from the other bracket but without affecting the spacing between the brackets and, thus, the struts. Fasteners fasten the shoe to the bracket following the clamping action.

    摘要翻译： 一种用于自行车的前轮减震系统，其中前轮叉的腿包括可在管中滑动的支柱。 使用快速释放夹紧机构将支柱的一端连接到轮轴上。 支柱端的支架是U形的，并且简单地落在轴上，并且夹紧动作的结果被夹紧到轴上。 为了避免支柱的平行关系的歪曲，其中一个支架配备有可轴向滑动的U形鞋。 因此，夹紧动作仅仅使一个支架的鞋子更靠近或远离另一个支架，而不会影响支架之间的间隔，从而影响支柱。 紧固件在夹紧动作之后将鞋子固定在支架上。

    26-aminocholesterol and derivatives and analogs thereof in the regulation of cholesterol accumulation in body tissue
    29.
    发明授权
    26-aminocholesterol and derivatives and analogs thereof in the regulation of cholesterol accumulation in body tissue 失效
    26-氨基胆固醇及其衍生物和类似物在体内组织中胆固醇积累的调节

    公开(公告)号：US4939134A

    公开(公告)日：1990-07-03

    申请号：US246444

    申请日：1988-09-19

    申请人： Norman B. Javitt ,  Stephen R. Wilson

    发明人： Norman B. Javitt ,  Stephen R. Wilson

    IPC分类号： A61K31/575 ,  C07J9/00

    CPC分类号： A61K31/575

    摘要： This invention relates to cholesterol synthesis and to the accumulation and regulation of cholesterol levels in body tissue. More specifically, the invention provides that the compound 26-aminocholesterol, ##STR1## and analogs and derivatives thereof, exhibit biological activity as a potent inhibitor of cholesterol synthesis and/or cholesterol accumulation in body tissue. The compounds strongly inhibit of the enzyme HMGCoA reductase and low density lipoprotein accumulation by non-hepatic cells. Surprisingly, it has been discovered that 26-aminocholesterol is selective for fibroblast (plasma) cells, and has little or no effect on hepato (liver) cells. Therapeutic compounds according to the invention include substituted or unsubstituted sterols of the formula: ##STR2## wherein the carbon atoms at positions 5 and 6 of the sterol are one of saturated and unsaturated, R.sub.1 is one of a 3-hydroxyl group and a 3-keto group, R.sub.2 is one of a hydroxyl group and a keto group, and wherein at least one of R.sub.3, R.sub.4 and R.sub.5 is an amino group and the others are each selected from the group consisting of hydrogen and an amino group.

    摘要翻译： 本发明涉及胆固醇合成和身体组织中胆固醇水平的积累和调节。 更具体地说，本发明提供化合物26-氨基胆固醇及其类似物及其衍生物作为胆固醇合成和/或体内组织中胆固醇积聚的有效抑制剂具有生物活性。 该化合物强烈地抑制HMGCoA还原酶和非肝细胞的低密度脂蛋白积累。 令人吃惊的是，已经发现26-氨基胆固醇对成纤维细胞（血浆）细胞是选择性的，并且对肝细胞（肝）细胞几乎没有或没有影响。 根据本发明的治疗化合物包括具有下式的取代或未取代的甾醇：其中固醇的5和6位的碳原子是饱和和不饱和的之一，R 1是3-羟基和3- 酮基，R2是羟基和酮基之一，其中R3，R4和R5中的至少一个是氨基，其它各自选自氢和氨基。

    Process for preparing dihydromyrcenol and dihydromyrcenyl acetate
    30.
    发明授权
    Process for preparing dihydromyrcenol and dihydromyrcenyl acetate 失效
    二氢月桂烯醇和二氢月桂烯基乙酸酯的制备方法

    公开(公告)号：US4791222A

    公开(公告)日：1988-12-13

    申请号：US636326

    申请日：1984-07-31

    申请人： Mark A. Sprecker ,  Stephen R. Wilson ,  Leonard Steinbach ,  Thomas O'Rourke

    发明人： Mark A. Sprecker ,  Stephen R. Wilson ,  Leonard Steinbach ,  Thomas O'Rourke

    IPC分类号： B01J23/00 ,  B01J23/02 ,  B01J23/06 ,  B01J27/00 ,  C07B61/00 ,  C07C5/03 ,  C07C17/00 ,  C07C17/02 ,  C07C17/08 ,  C07C19/01 ,  C07C21/04 ,  C07C27/00 ,  C07C29/124 ,  C07C33/025 ,  C07C67/00 ,  C07C67/10 ,  C07C69/145 ,  C07C67/11

    CPC分类号： C07C33/025 ,  C07C17/08 ,  C07C29/124 ,  C07C5/03 ,  C07C67/11 ,  C07C67/54 ,  C07C2102/42

    摘要： Described is a novel process for preparing dihydromyrcenol defined according to the structure: ##STR1## or the acetate thereof comprising the steps of: (i) hydrogenating .alpha.-pinene to form .alpha.-pinane;(ii) pyrolizing the resulting .alpha.-pinane to form a mixture of hydrocarbons including dihydromyrcene (or, in the alternative, forming substantially the same mixture of hydrocarbons by other well known means);(iii) reacting the resulting pinane pyrolyzate or like mixture with hydrogen chloride gas in the presence of an acid catalyst, e.g., Lewis acid or protonic acid, to form a mixture of tertiary chlorides; then(iv) reacting the mixture of tertiary chlorides with water or acetic acid int he presence of a hydroxylation catalyst defined according to the formula:M.sub.P X.sub.Q wherein M represents an element selected from the group consisting of Zn, Ca, Mg, Mn and Co; wherein X represents O or an anion, e.g., halide hydroxide, carbonate, bicarbonate, phosphate, monobasic acid phosphate or dibasic acid phosphate; and wherein P represents an integer of 1 or 3 and Q represents an interger of 1 or 2, with the provisos that when X is a trivalent anion, then p is 3 and Q is 2 and when X is a divalent anion or is O, the P is 1 and Q is 1 and when X is a monovalent anion, then P is 1 and Q is 2; and(v) recovering the dihydromyrcenol or acetate thereof from the reaction product where the dihydromyrcenol or acetate thereof is produced in relatively high yields.

    摘要翻译： 描述了根据以下结构定义的二氢月桂烯醇的新方法：图像或其乙酸酯，其包括以下步骤：（i）氢化α-蒎烯以形成α-蒎烷; （ii）热解所得的α-蒎烷以形成烃类的混合物，包括二氢月桂烯（或者替代地，通过其它众所周知的方法形成基本相同的烃类混合物）; （iii）在酸催化剂例如路易斯酸或质子酸存在下，使得到的蒎烷热解物或类似混合物与氯化氢气体反应，形成叔氯化物的混合物; 然后（iv）使叔氯化物的混合物与水或乙酸反应，存在根据下式定义的羟基化催化剂：MPXQ其中M表示选自Zn，Ca，Mg，Mn和Co的元素; 其中X表示O或阴离子，例如卤化氢，碳酸盐，碳酸氢盐，磷酸盐，一元酸式磷酸盐或二元酸式磷酸盐; 并且其中P表示1或3的整数，Q表示1或2的整数，条件是当X为三价阴离子时，p为3且Q为2，当X为二价阴离子或为O时， P为1，Q为1，X为1价阴离子时，P为1，Q为2。 和（v）从产生二氢月桂烯醇或其乙酸酯的反应产物中以相当高的产率回收二氢月桂烯醇或其乙酸酯。