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    Multiply-substituted fullerenes
    2.
    发明授权
    Multiply-substituted fullerenes 有权
    多取代富勒烯

    公开(公告)号：US06399785B1

    公开(公告)日：2002-06-04

    申请号：US09702143

    申请日：2000-10-30

    申请人： Randall B. Murphy ,  Stephen R. Wilson ,  Quing Lu

    发明人： Randall B. Murphy ,  Stephen R. Wilson ,  Quing Lu

    IPC分类号： C07D40304

    CPC分类号： G11C13/025 ,  B82Y10/00 ,  C07C61/00 ,  C07C2604/00 ,  C07D209/58 ,  C07D213/16 ,  C07D317/72 ,  C07D333/08 ,  C07D487/06 ,  C40B40/04 ,  C40B50/08 ,  C40B50/14 ,  G11C13/0014 ,  G11C13/0019 ,  Y10S977/734 ,  Y10S977/835 ,  Y10S977/842 ,  Y10S977/881

    摘要： The invention is directed to multiply-substituted fullerene derivatives of novel configurations, and methods for their preparation and use. The methods involve the combinatorial synthesis of a library of fullerene derivatives and comprises the steps of forming a mixture of fullerene derivatives by reacting the Cn fullerene with two or more reactive precursor compounds, and removing the unreacted compounds to yield the fullerene derivatives having the desired activity. Methods for the identification and screening of a combinatorial library of fullerenes by 3He-nuclear magnetic resonance and electrospray mass spectrometry to define members with the optimal desired activity are also provided.

    摘要翻译： 本发明涉及新配置的多取代富勒烯衍生物及其制备和使用方法。 所述方法包括富勒烯衍生物文库的组合合成，包括以下步骤：通过使Cn富勒烯与两种或多种反应性前体化合物反应形成富勒烯衍生物的混合物，并除去未反应的化合物以产生具有所需活性的富勒烯衍生物 。 还提供了通过3He核磁共振和电喷雾质谱鉴定和筛选富勒烯组合文库以定义具有最佳期望活性的成员的方法。

    Bioluminescent Endoscopy Methods and Compounds
    10.
    发明申请
    Bioluminescent Endoscopy Methods and Compounds 审中-公开
    生物发光内窥镜检查方法和化合物

    公开(公告)号：US20130058872A1

    公开(公告)日：2013-03-07

    申请号：US13610242

    申请日：2012-09-11

    申请人： Philip T. Neff ,  Bruce Bryan ,  Randall B. Murphy

    发明人： Philip T. Neff ,  Bruce Bryan ,  Randall B. Murphy

    IPC分类号： A61K49/00

    CPC分类号： G01N21/763 ,  C07D487/04 ,  G01N21/6456

    摘要： Bioluminescent endoscopy methods in which bioluminescent generating system components are combined ex vivo immediately prior to injection or infusion into a tissue area of interest to enable bioluminescent viewing of the tissue. The bioluminescent generating system components are combined by simultaneous injection into a Y tube or other in-line mixing chamber receiving fluid inputs from two or more fluid conduits and providing a fluid output to at least one fluid conduit. The mixed components which are the output of such multi lumen mixing system is injected into a hollow viscus organ or otherwise applied to organs and/or tissues of the body.

    摘要翻译： 生物发光内窥镜检查方法，其中将生物发光发生系统组分在注射或注射到目的组织区域之前离体组合以使组织的生物发光观察。 生物发光发生系统部件通过同时注射到Y管或其它在线混合室中，从两个或更多个流体导管接收流体输入，并向至少一个流体导管提供流体输出。 作为这种多腔混合系统的输出的混合成分被注射到空心粘液器官中或以其它方式施加到身体的器官和/或组织上。