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公开(公告)号:US06312937B1
公开(公告)日:2001-11-06
申请号:US09372154
申请日:1999-08-11
申请人: Jian Ni , Steve Ruben , Laurie Brewer , Reiner Gentz , Craig Rosen
发明人: Jian Ni , Steve Ruben , Laurie Brewer , Reiner Gentz , Craig Rosen
IPC分类号: C12N950
CPC分类号: C12N9/6489 , A61K38/00 , C07K14/47 , C07K14/705 , C07K14/70535 , C12N9/00 , C12N9/6475 , C12N9/6491 , C12N2799/026
摘要: The present invention relates to novel metalloproteinase- like proteins. In particular, isolated nucleic acid molecules are provided encoding the human TACE-like and matrilysin-like proteins. TACE-like and matrilysin-like polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of TACE-like and matrilysin-like activity. Also provided are diagnostic methods for detecting cancer and therapeutic methods for cancer and other disorders characterized by an over or under production of these metalloproteinases.
摘要翻译: 本发明涉及新型金属蛋白酶样蛋白质。 特别地,提供了分离的核酸分子,其编码人类TACE样和基质溶素样蛋白。 TACE样和基质溶素样多肽也可以作为载体,宿主细胞和用于制备它们的重组方法提供。 本发明进一步涉及用于鉴定TACE样和基质溶素样活性的激动剂和拮抗剂的筛选方法。 还提供了用于检测癌症的诊断方法和癌症的治疗方法以及特征在于这些金属蛋白酶过度或过量生产的其它病症。
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公开(公告)号:US6046031A
公开(公告)日:2000-04-04
申请号:US9156
申请日:1998-01-20
申请人: Jian Ni , Steve Ruben , Laurie Brewer , Reiner Gentz , Craig Rosen
发明人: Jian Ni , Steve Ruben , Laurie Brewer , Reiner Gentz , Craig Rosen
IPC分类号: A61K38/00 , C07K14/47 , C07K14/705 , C07K14/735 , C12N1/21 , C12N9/00 , C12N9/64 , C12N15/57 , C12P21/06
CPC分类号: C12N9/6489 , C07K14/47 , C07K14/705 , C07K14/70535 , C12N9/00 , C12N9/6475 , C12N9/6491 , A61K38/00 , C12N2799/026
摘要: The present invention relates to novel metalloproteinase-like proteins. In particular, isolated nucleic acid molecules are provided encoding the human TACE-like and matrilysin-like proteins. TACE-like and matrilysin-like polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of TACE-like and matrilysin-like activity. Also provided are diagnostic methods for detecting cancer and therapeutic methods for cancer and other disorders characterized by an over or under production of these metalloproteinases.
摘要翻译: 本发明涉及新型金属蛋白酶样蛋白质。 特别地,提供了分离的核酸分子,其编码人类TACE样和基质溶素样蛋白。 TACE样和基质溶素样多肽也可以作为载体,宿主细胞和用于制备它们的重组方法提供。 本发明进一步涉及用于鉴定TACE样和基质溶素样活性的激动剂和拮抗剂的筛选方法。 还提供了用于检测癌症的诊断方法和癌症的治疗方法以及特征在于这些金属蛋白酶过度或过量生产的其它病症。
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公开(公告)号:US08808997B2
公开(公告)日:2014-08-19
申请号:US13005031
申请日:2011-01-12
申请人: Charles Birse , Marcia Lewis , Steve Ruben , Mehdi Mesri
发明人: Charles Birse , Marcia Lewis , Steve Ruben , Mehdi Mesri
IPC分类号: G01N33/53
CPC分类号: G01N33/57423 , C12Q1/6886 , C12Q2600/106 , C12Q2600/112 , C12Q2600/118 , C12Q2600/136 , C12Q2600/158 , G01N33/57488 , G01N33/57492 , G01N2333/8114 , G01N2333/96486 , G01N2800/56
摘要: Methods and compositions are provided for assessing (e.g., diagnosing), treating, and preventing diseases, especially cancer, and particular lung cancer, using lung cancer markers (LCM). Individual LCM and panels comprising multiple LCM are provided for these and other uses. Methods and compositions are also provided for determining or predicting the effectiveness of a treatment or for selecting a treatment using LCM. Methods and compositions are further provided for modulating cell function using LCM. Also provided are compositions that modulate LCM (e.g., antagonists or agonists), such as antibodies, proteins, small molecule compounds, and nucleic acid agents (e.g., RNAi and antisense agents), as well as pharmaceutical compositions thereof. Further provided are methods of screening for agents that modulate LCM, and agents identified by these screening methods.
摘要翻译: 提供了使用肺癌标志物(LCM)评估(例如诊断),治疗和预防疾病,特别是癌症和特定肺癌的方法和组合物。 为这些和其他用途提供了单个LCM和包含多个LCM的面板。 还提供了用于确定或预测治疗的有效性或使用LCM选择治疗的方法和组合物。 还提供了使用LCM调节细胞功能的方法和组合物。 还提供了调节LCM的组合物(例如拮抗剂或激动剂),例如抗体,蛋白质,小分子化合物和核酸试剂(例如RNAi和反义剂),以及其药物组合物。 还提供了筛选调节LCM的试剂的方法以及通过这些筛选方法鉴定的试剂。
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24.
公开(公告)号:US08507213B1
公开(公告)日:2013-08-13
申请号:US11594160
申请日:2006-11-08
申请人: Candy Lee , Steve Ruben , Bruno Domon , Charles E. Birse
发明人: Candy Lee , Steve Ruben , Bruno Domon , Charles E. Birse
IPC分类号: G01N33/574
CPC分类号: C07K16/18 , C07K14/47 , C12N15/113 , G01N33/574 , G01N33/5743 , G01N2333/902
摘要: Methods and compositions for detecting and treating a disease, particularly cancer, associated with differential expression of Maba in disease cells compared to healthy cells. Also provided are antagonists or agonists of Maba, and methods for screening agents that modulate the Maba level or activity in vivo or in vitro.
摘要翻译: 与健康细胞相比,用于检测和治疗与疾病细胞中Maba不同表达相关的疾病,特别是癌症的方法和组合物。 还提供了Maba的拮抗剂或激动剂,以及筛选在体内或体外调节Maba水平或活性的药剂的方法。
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25.
公开(公告)号:US20090196873A1
公开(公告)日:2009-08-06
申请号:US12157164
申请日:2008-06-06
申请人: Bruno Domon , Charles E. Birse , Candy Lee , Steve Ruben
发明人: Bruno Domon , Charles E. Birse , Candy Lee , Steve Ruben
IPC分类号: A61K39/395 , C07K14/00 , A61K38/16 , C12N15/11 , C07K16/18 , C12N5/06 , A01K67/027 , C12N7/00 , G01N33/53 , C12Q1/68
CPC分类号: C07K16/28 , A61K2039/505 , C07K16/30 , C07K2317/73 , C12Q1/6886 , C12Q2600/136 , G01N33/574 , G01N33/57423 , G01N33/57438 , G01N2500/10 , G01N2800/52
摘要: Methods and compositions for detecting and treating a disease, particularly cancer, associated with differential expression of CDCP1 in disease cells compared to healthy cells. Also provided are antagonists or agonists of CDCP1, and methods for screening agents that modulate the CDCP1 level or activity in vivo or in vitro.
摘要翻译: 与健康细胞相比,用于检测和治疗与疾病细胞中CDCP1的差异表达相关的疾病,特别是癌症的方法和组合物。 还提供了CDCP1的拮抗剂或激动剂,以及筛选在体内或体外调节CDCP1水平或活性的药剂的方法。
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公开(公告)号:US07892760B2
公开(公告)日:2011-02-22
申请号:US12273994
申请日:2008-11-19
申请人: Charles Birse , Marcia Lewis , Steve Ruben , Mehdi Mesri
发明人: Charles Birse , Marcia Lewis , Steve Ruben , Mehdi Mesri
IPC分类号: G01N33/53
CPC分类号: G01N33/57423 , C12Q1/6886 , C12Q2600/106 , C12Q2600/112 , C12Q2600/118 , C12Q2600/136 , C12Q2600/158 , G01N33/57488 , G01N33/57492 , G01N2333/8114 , G01N2333/96486 , G01N2800/56
摘要: Methods and compositions are provided for assessing (e.g., diagnosing), treating, and preventing diseases, especially cancer, and particular lung cancer, using lung cancer markers (LCM). Individual LCM and panels comprising multiple LCM are provided for these and other uses. Methods and compositions are also provided for determining or predicting the effectiveness of a treatment or for selecting a treatment using LCM. Methods and compositions are further provided for modulating cell function using LCM. Also provided are compositions that modulate LCM (e.g., antagonists or agonists), such as antibodies, proteins, small molecule compounds, and nucleic acid agents (e.g., RNAi and antisense agents), as well as pharmaceutical compositions thereof. Further provided are methods of screening for agents that modulate LCM, and agents identified by these screening methods.
摘要翻译: 提供了使用肺癌标志物(LCM)评估(例如诊断),治疗和预防疾病,特别是癌症和特定肺癌的方法和组合物。 为这些和其他用途提供了单个LCM和包含多个LCM的面板。 还提供了用于确定或预测治疗的有效性或使用LCM选择治疗的方法和组合物。 还提供了使用LCM调节细胞功能的方法和组合物。 还提供了调节LCM的组合物(例如拮抗剂或激动剂),例如抗体,蛋白质,小分子化合物和核酸试剂(例如RNAi和反义剂)及其药物组合物。 还提供了筛选调节LCM的试剂的方法以及通过这些筛选方法鉴定的试剂。
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公开(公告)号:US20080219992A1
公开(公告)日:2008-09-11
申请号:US12070053
申请日:2008-02-13
申请人: Kim Alving , Steve Ruben , Ian McCaffery , Bruno Domon
发明人: Kim Alving , Steve Ruben , Ian McCaffery , Bruno Domon
IPC分类号: A61K39/395 , A61P35/00 , C07K14/47 , A61K38/17 , C12N15/12 , C12Q1/68 , G01N33/566 , C07K16/18 , C12N5/16 , C12N5/10
CPC分类号: C07K14/4748 , G01N33/57438
摘要: The present invention provides a method for diagnosing and detecting diseases associated with pancreas. The present invention provides one or more proteins or fragments thereof, peptides or nucleic acid molecules differentially expressed in pancreatic diseases (PCAST) and antibodies binds to PCAST. The present invention provides that PCAST is used as targets for screening agents that modulates the PCAST activities. Further the present invention provides methods for treating diseases associated with pancreas.
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28.
公开(公告)号:US20060294607A1
公开(公告)日:2006-12-28
申请号:US11391386
申请日:2006-03-29
申请人: William Fitzhugh , Steve Ruben , Vaibhav Narayan , Charles Birse
发明人: William Fitzhugh , Steve Ruben , Vaibhav Narayan , Charles Birse
IPC分类号: A01K67/027 , C12Q1/68 , G01N33/53 , C07H21/04 , C12P21/06 , C07K14/705
CPC分类号: C12Q1/6886 , A01K2217/05 , C07K14/705 , C12Q2600/136 , G01N2333/70596
摘要: The present invention provides a method for diagnosing and detecting cancer. The present invention provides one or more proteins or fragments thereof, peptides or nucleic acid molecules differentially expressed in cancer (podocalyxin) and antibodies that bind podocalyxins. The present invention provides that podocalyxins are used as targets for screening agents that modulate podocalyxin activities. Further the present invention provides methods for treating diseases associated with podocalyxin expression.
摘要翻译: 本发明提供一种诊断和检测癌症的方法。 本发明提供了一种或多种在癌症(podocalyxin)中差异表达的蛋白质或其片段,肽或核酸分子以及结合足芽荚膜球蛋白的抗体。 本发明提供了足孢菌素作为调节球蛋白活性的筛选剂的靶标。 此外,本发明提供了用于治疗与足荚体蛋白表达相关的疾病的方法。
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公开(公告)号:US06482606B1
公开(公告)日:2002-11-19
申请号:US08187757
申请日:1994-01-27
申请人: Mark D. Adams , Robert D. Fleischmann , Claire M. Fraser , Rebecca A. Fuldner , Ewen F. Kirkness , William A. Haseltine , Craig A. Rosen , Steve Ruben , Ying-Fei Wei
发明人: Mark D. Adams , Robert D. Fleischmann , Claire M. Fraser , Rebecca A. Fuldner , Ewen F. Kirkness , William A. Haseltine , Craig A. Rosen , Steve Ruben , Ying-Fei Wei
IPC分类号: C12P2102
CPC分类号: C07K14/47
摘要: The present invention discloses three human DNA repair proteins and DNA (RNA) encoding such proteins. The DNA repair proteins may be produced by recombinant DNA techniques. One of the human DNA repair proteins, hmlh1, has been mapped on chromosome 3. The polynucleotide sequences of DNA repair proteins may be used for diagnosis of a hereditary susceptibility to cancer.
摘要翻译: 本发明公开了三种人类DNA修复蛋白和编码这种蛋白质的DNA(RNA)。 DNA修复蛋白可以通过重组DNA技术产生。 人类DNA修复蛋白之一hmlh1已被绘制在染色体3上.DNA修复蛋白的多核苷酸序列可用于诊断遗传性对癌症的易感性。
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