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29 条记录 (耗时 0.03 秒)

    Lung cancer markers, and uses thereof
    1.
    发明授权
    Lung cancer markers, and uses thereof 有权
    肺癌标志物及其用途

    公开(公告)号：US07892760B2

    公开(公告)日：2011-02-22

    申请号：US12273994

    申请日：2008-11-19

    申请人： Charles Birse ,  Marcia Lewis ,  Steve Ruben ,  Mehdi Mesri

    发明人： Charles Birse ,  Marcia Lewis ,  Steve Ruben ,  Mehdi Mesri

    IPC分类号： G01N33/53

    CPC分类号： G01N33/57423 ,  C12Q1/6886 ,  C12Q2600/106 ,  C12Q2600/112 ,  C12Q2600/118 ,  C12Q2600/136 ,  C12Q2600/158 ,  G01N33/57488 ,  G01N33/57492 ,  G01N2333/8114 ,  G01N2333/96486 ,  G01N2800/56

    摘要： Methods and compositions are provided for assessing (e.g., diagnosing), treating, and preventing diseases, especially cancer, and particular lung cancer, using lung cancer markers (LCM). Individual LCM and panels comprising multiple LCM are provided for these and other uses. Methods and compositions are also provided for determining or predicting the effectiveness of a treatment or for selecting a treatment using LCM. Methods and compositions are further provided for modulating cell function using LCM. Also provided are compositions that modulate LCM (e.g., antagonists or agonists), such as antibodies, proteins, small molecule compounds, and nucleic acid agents (e.g., RNAi and antisense agents), as well as pharmaceutical compositions thereof. Further provided are methods of screening for agents that modulate LCM, and agents identified by these screening methods.

    摘要翻译： 提供了使用肺癌标志物（LCM）评估（例如诊断），治疗和预防疾病，特别是癌症和特定肺癌的方法和组合物。 为这些和其他用途提供了单个LCM和包含多个LCM的面板。 还提供了用于确定或预测治疗的有效性或使用LCM选择治疗的方法和组合物。 还提供了使用LCM调节细胞功能的方法和组合物。 还提供了调节LCM的组合物（例如拮抗剂或激动剂），例如抗体，蛋白质，小分子化合物和核酸试剂（例如RNAi和反义剂）及其药物组合物。 还提供了筛选调节LCM的试剂的方法以及通过这些筛选方法鉴定的试剂。

    Lung cancer markers, and uses thereof
    2.
    发明授权
    Lung cancer markers, and uses thereof 有权
    肺癌标志物及其用途

    公开(公告)号：US08808997B2

    公开(公告)日：2014-08-19

    申请号：US13005031

    申请日：2011-01-12

    申请人： Charles Birse ,  Marcia Lewis ,  Steve Ruben ,  Mehdi Mesri

    发明人： Charles Birse ,  Marcia Lewis ,  Steve Ruben ,  Mehdi Mesri

    IPC分类号： G01N33/53

    CPC分类号： G01N33/57423 ,  C12Q1/6886 ,  C12Q2600/106 ,  C12Q2600/112 ,  C12Q2600/118 ,  C12Q2600/136 ,  C12Q2600/158 ,  G01N33/57488 ,  G01N33/57492 ,  G01N2333/8114 ,  G01N2333/96486 ,  G01N2800/56

    摘要： Methods and compositions are provided for assessing (e.g., diagnosing), treating, and preventing diseases, especially cancer, and particular lung cancer, using lung cancer markers (LCM). Individual LCM and panels comprising multiple LCM are provided for these and other uses. Methods and compositions are also provided for determining or predicting the effectiveness of a treatment or for selecting a treatment using LCM. Methods and compositions are further provided for modulating cell function using LCM. Also provided are compositions that modulate LCM (e.g., antagonists or agonists), such as antibodies, proteins, small molecule compounds, and nucleic acid agents (e.g., RNAi and antisense agents), as well as pharmaceutical compositions thereof. Further provided are methods of screening for agents that modulate LCM, and agents identified by these screening methods.

    摘要翻译： 提供了使用肺癌标志物（LCM）评估（例如诊断），治疗和预防疾病，特别是癌症和特定肺癌的方法和组合物。 为这些和其他用途提供了单个LCM和包含多个LCM的面板。 还提供了用于确定或预测治疗的有效性或使用LCM选择治疗的方法和组合物。 还提供了使用LCM调节细胞功能的方法和组合物。 还提供了调节LCM的组合物（例如拮抗剂或激动剂），例如抗体，蛋白质，小分子化合物和核酸试剂（例如RNAi和反义剂），以及其药物组合物。 还提供了筛选调节LCM的试剂的方法以及通过这些筛选方法鉴定的试剂。

    Lung disease targets and uses thereof
    7.
    发明授权
    Lung disease targets and uses thereof 有权
    肺疾病的目标及其用途

    公开(公告)号：US07521195B1

    公开(公告)日：2009-04-21

    申请号：US11490329

    申请日：2006-07-21

    申请人： Elizabeth Joseloff ,  Aiqun Li ,  Tao He ,  Steve Ruben

    发明人： Elizabeth Joseloff ,  Aiqun Li ,  Tao He ,  Steve Ruben

    IPC分类号： G01N33/53

    CPC分类号： G01N33/57423 ,  G01N2500/04 ,  Y10T436/143333

    摘要： The present invention provides a method for diagnosing and detecting diseases associated with lung. The present invention provides one or more proteins or fragments thereof, peptides or nucleic acid molecules differentially expressed in lung diseases (LCAT) and antibodies binds to LCATs. The present invention provides that LCATs are used as targets for screening agents that modulates the LCAT activities. Further the present invention provides methods for treating diseases associated with lung.

    摘要翻译： 本发明提供了诊断和检测与肺相关疾病的方法。 本发明提供在肺部疾病（LCAT）中差异表达的一种或多种蛋白质或其片段，肽或核酸分子，并且抗体结合LCAT。 本发明提供LCAT作为调节LCAT活性的筛选剂的靶标。 此外，本发明提供了治疗与肺相关疾病的方法。

    Kidney disease targets and uses thereof
    8.
    发明授权
    Kidney disease targets and uses thereof 有权
    肾脏疾病的目标及其用途

    公开(公告)号：US07611703B1

    公开(公告)日：2009-11-03

    申请号：US11717149

    申请日：2007-03-13

    申请人： Elizabeth G. Joseloff ,  Yeoun Jin Kim ,  Tao He ,  Steve Ruben

    发明人： Elizabeth G. Joseloff ,  Yeoun Jin Kim ,  Tao He ,  Steve Ruben

    IPC分类号： A61K39/395

    CPC分类号： C07K14/4748 ,  A61K2039/505 ,  C07K16/3038

    摘要： The present invention provides a method for diagnosing and detecting diseases associated with kidney. The present invention provides one or more proteins or fragments thereof, peptides or nucleic acid molecules differentially expressed in kidney diseases (KCAT) and antibodies binds to KCATs. The present invention provides that KCATs are used as targets for screening agents that modulates the KCAT activities. Further the present invention provides methods for treating diseases associated with kidney.

    摘要翻译： 本发明提供了诊断和检测与肾相关的疾病的方法。 本发明提供在肾脏疾病（KCAT）中差异表达的一种或多种蛋白质或其片段，肽或核酸分子，并且抗体结合KCAT。 本发明提供KCAT作为调节KCAT活性的筛选剂的靶标。 此外，本发明提供了治疗与肾相关的疾病的方法。