公开(公告)号：US08507213B1

公开(公告)日：2013-08-13

申请号：US11594160

申请日：2006-11-08

申请人： Candy Lee ,  Steve Ruben ,  Bruno Domon ,  Charles E. Birse

发明人： Candy Lee ,  Steve Ruben ,  Bruno Domon ,  Charles E. Birse

IPC分类号： G01N33/574

CPC分类号： C07K16/18 ,  C07K14/47 ,  C12N15/113 ,  G01N33/574 ,  G01N33/5743 ,  G01N2333/902

摘要： Methods and compositions for detecting and treating a disease, particularly cancer, associated with differential expression of Maba in disease cells compared to healthy cells. Also provided are antagonists or agonists of Maba, and methods for screening agents that modulate the Maba level or activity in vivo or in vitro.

摘要翻译： 与健康细胞相比，用于检测和治疗与疾病细胞中Maba不同表达相关的疾病，特别是癌症的方法和组合物。 还提供了Maba的拮抗剂或激动剂，以及筛选在体内或体外调节Maba水平或活性的药剂的方法。

公开(公告)号：US20090196873A1

公开(公告)日：2009-08-06

申请号：US12157164

申请日：2008-06-06

申请人： Bruno Domon ,  Charles E. Birse ,  Candy Lee ,  Steve Ruben

发明人： Bruno Domon ,  Charles E. Birse ,  Candy Lee ,  Steve Ruben

IPC分类号： A61K39/395 ,  C07K14/00 ,  A61K38/16 ,  C12N15/11 ,  C07K16/18 ,  C12N5/06 ,  A01K67/027 ,  C12N7/00 ,  G01N33/53 ,  C12Q1/68

CPC分类号： C07K16/28 ,  A61K2039/505 ,  C07K16/30 ,  C07K2317/73 ,  C12Q1/6886 ,  C12Q2600/136 ,  G01N33/574 ,  G01N33/57423 ,  G01N33/57438 ,  G01N2500/10 ,  G01N2800/52

摘要： Methods and compositions for detecting and treating a disease, particularly cancer, associated with differential expression of CDCP1 in disease cells compared to healthy cells. Also provided are antagonists or agonists of CDCP1, and methods for screening agents that modulate the CDCP1 level or activity in vivo or in vitro.

摘要翻译： 与健康细胞相比，用于检测和治疗与疾病细胞中CDCP1的差异表达相关的疾病，特别是癌症的方法和组合物。 还提供了CDCP1的拮抗剂或激动剂，以及筛选在体内或体外调节CDCP1水平或活性的药剂的方法。

公开(公告)号：US07776555B1

公开(公告)日：2010-08-17

申请号：US11822094

申请日：2007-07-02

申请人： Bruno Domon ,  Steve Ruben ,  Charles E. Birse ,  Yeoun Jin Kim ,  Tao He ,  Ian McCaffery

发明人： Bruno Domon ,  Steve Ruben ,  Charles E. Birse ,  Yeoun Jin Kim ,  Tao He ,  Ian McCaffery

IPC分类号： G01N33/53

CPC分类号： G01N33/57419

摘要： The present invention provides a method for diagnosing and detecting diseases associated with colon. The present invention provides one or more proteins or fragments thereof, peptides or nucleic acid molecules differentially expressed in colon diseases (CCAT) and antibodies binds to CCAT. The present invention provides that CCAT is used as targets for screening agents that modulates the CCAT activities. Further the present invention provides methods for treating diseases associated with colon.

公开(公告)号：US20070031419A1

公开(公告)日：2007-02-08

申请号：US11476141

申请日：2006-06-28

申请人： Bruno Domon ,  Charles Birse ,  Candy Lee ,  Steve Ruben

发明人： Bruno Domon ,  Charles Birse ,  Candy Lee ,  Steve Ruben

IPC分类号： A61K48/00 ,  C12Q1/68 ,  G01N33/53 ,  A61K39/395

CPC分类号： C07K16/28 ,  A61K2039/505 ,  C07K16/30 ,  C07K2317/73 ,  C12Q1/6886 ,  C12Q2600/136 ,  G01N33/574 ,  G01N33/57423 ,  G01N33/57438 ,  G01N2500/10 ,  G01N2800/52

摘要： Methods and compositions for detecting and treating a disease, particularly cancer, associated with differential expression of CDCP1 in disease cells compared to healthy cells. Also provided are antagonists or agonists of CDCP1, and methods for screening agents that modulate the CDCP1 level or activity in vivo or in vitro.

摘要翻译： 与健康细胞相比，用于检测和治疗与疾病细胞中CDCP1的差异表达相关的疾病，特别是癌症的方法和组合物。 还提供了CDCP1的拮抗剂或激动剂，以及筛选在体内或体外调节CDCP1水平或活性的药剂的方法。

公开(公告)号：US20090123461A1

公开(公告)日：2009-05-14

申请号：US12255340

申请日：2008-10-21

申请人： William Fitzhugh ,  Steve Ruben ,  Vaibhav Narayan ,  Charles E. Birse

发明人： William Fitzhugh ,  Steve Ruben ,  Vaibhav Narayan ,  Charles E. Birse

IPC分类号： A61K39/395 ,  C07K14/00 ,  C07K16/00 ,  C07H21/00 ,  A01K67/027 ,  C12N15/63 ,  A61P35/00 ,  C12N5/10 ,  C12P21/00 ,  C12Q1/68 ,  G01N33/53

CPC分类号： C12Q1/6886 ,  A01K2217/05 ,  C07K14/705 ,  C12Q2600/136 ,  G01N2333/70596

摘要： The present invention provides a method for diagnosing and detecting cancer. The present invention provides one or more proteins or fragments thereof, peptides or nucleic acid molecules differentially expressed in cancer (podocalyxin) and antibodies that bind podocalyxins. The present invention provides that podocalyxins are used as targets for screening agents that modulate podocalyxin activities. Further the present invention provides methods for treating diseases associated with podocalyxin expression.

摘要翻译： 本发明提供一种诊断和检测癌症的方法。 本发明提供了一种或多种在癌症（podocalyxin）中差异表达的蛋白质或其片段，肽或核酸分子以及结合足芽荚膜球蛋白的抗体。 本发明提供了足孢菌素作为调节球蛋白活性的筛选剂的靶标。 此外，本发明提供了用于治疗与足荚体蛋白表达相关的疾病的方法。

公开(公告)号：US07842467B1

公开(公告)日：2010-11-30

申请号：US12156431

申请日：2008-05-29

申请人： Jenny Heidbrink ,  Steve Ruben ,  Charles E. Birse ,  Tao He

发明人： Jenny Heidbrink ,  Steve Ruben ,  Charles E. Birse ,  Tao He

IPC分类号： G01N33/53

CPC分类号： G01N33/57415

摘要： The present invention provides a method for diagnosing and detecting diseases associated with breast. The present invention provides one or more proteins or fragments thereof, peptides or nucleic acid molecules differentially expressed in breast diseases (BCAT) and antibodies binds to BCAT. The present invention provides that BCAT is used as targets for screening agents that modulates the BCAT activities. Further the present invention provides methods for treating diseases associated with breast.

摘要翻译： 本发明提供了诊断和检测与乳腺相关疾病的方法。 本发明提供在乳腺疾病（BCAT）中差异表达的一种或多种蛋白质或其片段，肽或核酸分子，并且抗体结合BCAT。 本发明提供了将BCAT用作调节BCAT活性的筛选试剂的靶标。 此外，本发明提供了治疗与乳腺相关疾病的方法。

公开(公告)号：US07842291B1

公开(公告)日：2010-11-30

申请号：US11802321

申请日：2007-05-22

申请人： Steve Ruben ,  Paul A. Moore ,  Tao He ,  Candy N. Lee ,  Karen Van Orden ,  Charles E. Birse ,  Mehdi Mesri ,  Elizabeth G. Joseloff

发明人： Steve Ruben ,  Paul A. Moore ,  Tao He ,  Candy N. Lee ,  Karen Van Orden ,  Charles E. Birse ,  Mehdi Mesri ,  Elizabeth G. Joseloff

IPC分类号： A16K39/395

CPC分类号： C07K16/3076 ,  A61K38/00 ,  A61K2039/505 ,  C07K14/4748 ,  C07K14/705 ,  C07K14/70546 ,  C07K14/70596 ,  C07K16/18 ,  C07K16/2839 ,  C07K16/2896 ,  C07K16/30 ,  C07K16/303 ,  C07K16/40 ,  C07K2317/54 ,  C07K2317/55 ,  C07K2317/56 ,  C07K2317/732 ,  C07K2317/734 ,  C12N9/18 ,  C12N9/6424 ,  C12N15/113 ,  C12N15/1137 ,  C12N15/1138 ,  C12N2310/14 ,  C12N2320/30 ,  C12Q1/6886 ,  C12Q2600/158 ,  C12Y301/01 ,  C12Y304/21 ,  C12Y304/21109 ,  G01N33/57488 ,  G01N33/57492

摘要： Methods and compositions are provided for assessing, treating, and preventing diseases, especially cancer, using cancer-associated targets (CAT). Methods and compositions are also provided for determining or predicting the effectiveness of a treatment for these diseases or for selecting a treatment, using CAT. Methods and compositions are further provided for modulating cell function using CAT. Also provided are compositions that modulate CAT (e.g., antagonists or agonists), such as antibodies, proteins, small molecule compounds, and nucleic acid agents (e.g., RNAi and antisense agents), as well as pharmaceutical compositions thereof. Further provided are methods of screening for agents that modulate CAT, and agents identified by these screening methods.

摘要翻译： 提供用于评估，治疗和预防使用癌症相关靶（CAT）的疾病，特别是癌症的方法和组合物。 还提供了用于确定或预测这些疾病的治疗或使用CAT选择治疗的有效性的方法和组合物。 还提供了使用CAT调节细胞功能的方法和组合物。 还提供了调节CAT（例如拮抗剂或激动剂）如抗体，蛋白质，小分子化合物和核酸试剂（例如RNAi和反义试剂）的组合物及其药物组合物。 进一步提供了筛选调节CAT的试剂的方法，以及通过这些筛选方法鉴定的试剂。

公开(公告)号：US08110373B2

公开(公告)日：2012-02-07

申请号：US12504826

申请日：2009-07-17

申请人： Steve Ruben ,  Candy N. Lee ,  Bruno Domon

发明人： Steve Ruben ,  Candy N. Lee ,  Bruno Domon

IPC分类号： G01N33/574

CPC分类号： G01N33/57484 ,  A61K38/00 ,  A61K47/6843 ,  A61K2039/505 ,  C07K14/47 ,  C07K16/18 ,  C07K2317/24 ,  C07K2317/54 ,  C07K2317/55 ,  C07K2317/56 ,  C07K2317/622 ,  C12N15/113 ,  C12N2310/14 ,  C12Q1/6886 ,  C12Q2600/106 ,  C12Q2600/118 ,  C12Q2600/136 ,  G01N33/574 ,  G01N33/57423 ,  G01N33/6893 ,  G01N2500/10 ,  Y10T436/143333

摘要： Methods and compositions for diagnosing and treating diseases, particularly cancer, associated with differential expression of cancer-associated targets (CAT) in disease cells compared to healthy cells are provided. Also provided are antagonists and agonists of CAT, and methods for screening agents that modulate CAT level or activity in vivo or in vitro.

摘要翻译： 提供了与健康细胞相比，用于诊断和治疗与疾病细胞中癌症相关靶（CAT）不同表达相关的疾病，特别是癌症的方法和组合物。 还提供了CAT的拮抗剂和激动剂，以及用于筛选在体内或体外调节CAT水平或活性的药剂的方法。

公开(公告)号：US20080219992A1

公开(公告)日：2008-09-11

申请号：US12070053

申请日：2008-02-13

申请人： Kim Alving ,  Steve Ruben ,  Ian McCaffery ,  Bruno Domon

发明人： Kim Alving ,  Steve Ruben ,  Ian McCaffery ,  Bruno Domon

IPC分类号： A61K39/395 ,  A61P35/00 ,  C07K14/47 ,  A61K38/17 ,  C12N15/12 ,  C12Q1/68 ,  G01N33/566 ,  C07K16/18 ,  C12N5/16 ,  C12N5/10

CPC分类号： C07K14/4748 ,  G01N33/57438

摘要： The present invention provides a method for diagnosing and detecting diseases associated with pancreas. The present invention provides one or more proteins or fragments thereof, peptides or nucleic acid molecules differentially expressed in pancreatic diseases (PCAST) and antibodies binds to PCAST. The present invention provides that PCAST is used as targets for screening agents that modulates the PCAST activities. Further the present invention provides methods for treating diseases associated with pancreas.

公开(公告)号：US08334106B2

公开(公告)日：2012-12-18

申请号：US13339833

申请日：2011-12-29

申请人： Steve Ruben ,  Candy N. Lee ,  Bruno Domon

发明人： Steve Ruben ,  Candy N. Lee ,  Bruno Domon

IPC分类号： G01N33/574

CPC分类号： G01N33/57484 ,  A61K38/00 ,  A61K47/6843 ,  A61K2039/505 ,  C07K14/47 ,  C07K16/18 ,  C07K2317/24 ,  C07K2317/54 ,  C07K2317/55 ,  C07K2317/56 ,  C07K2317/622 ,  C12N15/113 ,  C12N2310/14 ,  C12Q1/6886 ,  C12Q2600/106 ,  C12Q2600/118 ,  C12Q2600/136 ,  G01N33/574 ,  G01N33/57423 ,  G01N33/6893 ,  G01N2500/10 ,  Y10T436/143333

摘要： Methods and compositions for diagnosing and treating diseases, particularly cancer, associated with differential expression of cancer-associated targets (CAT) in disease cells compared to healthy cells are provided. Also provided are antagonists and agonists of CAT, and methods for screening agents that modulate CAT level or activity in vivo or in vitro.