公开(公告)号：US20120277143A1

公开(公告)日：2012-11-01

申请号：US13458578

申请日：2012-04-27

Applicant: Steven Jacobs ,  Karyn O'Neil ,  Michael Baumann ,  Gaby Sennhauser

Inventor： Steven Jacobs ,  Karyn O'Neil ,  Michael Baumann ,  Gaby Sennhauser

IPC: C07K14/00 ,  A61P11/00 ,  A61P11/06 ,  A61P9/00 ,  A61P35/00 ,  C12P21/02 ,  C12N15/11 ,  C12N15/63 ,  C12N1/21 ,  C12N1/19 ,  C12N7/01 ,  C12N5/10 ,  A61K38/16 ,  A61P17/00

CPC classification number: C07K14/705 ,  A61K38/00 ,  C07K14/47 ,  C07K2319/70 ,  Y02A50/409 ,  Y02A50/423

Abstract: IL4/IL13-binding proteins comprise binding domains, which inhibit IL4/IL13 binding to IL4Ralpaha and common gamma chain complexes (Type 1) and inhibit IL4 binding to IL4Ralpha and IL13Ralpha1 complexes (Type 2), and IL13 binding to IL13Ralpha1 and/or IL13Ralpha2, are useful in the treatment of cancer, inflammatory, and other pathological conditions, such as allergic or fibrotic conditions, especially pulmonary conditions.

Abstract translation: IL4 / IL13结合蛋白包含结合结构域，其抑制IL4 / IL13与IL4Ralpaha和常见的γ链复合物（1型）结合并抑制IL4与IL4Rα和IL13Ralpha1复合物（2型）的结合，IL13与IL13Rα1和/或IL13Rα2的结合 ，可用于治疗癌症，炎症和其他病理状况，如过敏或纤维化病症，特别是肺部疾病。

公开(公告)号：US20100216708A1

公开(公告)日：2010-08-26

申请号：US12606382

申请日：2009-10-27

Applicant: Steven Jacobs ,  Karyn O'Neil

Inventor： Steven Jacobs ,  Karyn O'Neil

IPC: A61K38/16 ,  C07K14/00 ,  C40B50/00 ,  C40B40/10 ,  C07H21/04 ,  C12N15/63 ,  C12N1/21 ,  C12N1/19 ,  C12N5/10

CPC classification number: C07K14/78 ,  C40B40/08 ,  C40B50/06

Abstract: A protein scaffold based on a consensus sequence of fibronectin type III (FN3) proteins, such as the tenth FN3 repeat from human fibronectin (human Tenascin), including isolated nucleic acids that encode a protein scaffold, vectors, host cells, and methods of making and using thereof have applications in diagnostic and/or therapeutic compositions, methods and devices. In particular, protein scaffold molecules binding to IgG have been identified as useful for diagnostic and/or therapeutic applications.

Abstract translation: 基于纤连蛋白III（FN3）蛋白的共有序列的蛋白质支架，例如来自人纤连蛋白（人腱生蛋白）的第十FN3重复序列，包括编码蛋白质支架的分离的核酸，载体，宿主细胞和制备方法 并且其使用在诊断和/或治疗组合物，方法和装置中具有应用。 特别地，已经鉴定了结合IgG的蛋白质支架分子可用于诊断和/或治疗应用。

公开(公告)号：US20070147752A1

公开(公告)日：2007-06-28

申请号：US11449947

申请日：2006-06-09

Applicant: Ori Weisberg ,  Gregor Dellemann ,  Uri Kolodny ,  David Torres ,  Charalambos Anastassiou ,  Steven Jacobs ,  Gil Shapira ,  Burak Temelkuran ,  Aaron Micetich ,  Rokan Ahmad ,  Ytshak Avrahami ,  Yelena Kann ,  Max Shurgalin ,  Yoel Fink ,  Tairan Wang

Inventor： Ori Weisberg ,  Gregor Dellemann ,  Uri Kolodny ,  David Torres ,  Charalambos Anastassiou ,  Steven Jacobs ,  Gil Shapira ,  Burak Temelkuran ,  Aaron Micetich ,  Rokan Ahmad ,  Ytshak Avrahami ,  Yelena Kann ,  Max Shurgalin ,  Yoel Fink ,  Tairan Wang

IPC: G02B6/032

CPC classification number: A61B18/22 ,  A61B18/201 ,  A61B2018/207 ,  A61B2018/2244 ,  G02B6/02304 ,  G02B6/02385 ,  G02B6/03638 ,  G02B6/03661

Abstract: In general, in one aspect, the invention features methods that include guiding radiation at a first wavelength, λ1, through a core of a photonic crystal fiber and guiding radiation at a second wavelength, λ2, through the photonic crystal fiber, wherein |λ1−λ2|>100 nm.

Abstract translation: 通常，在一个方面，本发明的特征在于方法包括通过光子晶体光纤的芯引导第一波长λ1的辐射，并引导第二波长λλ的辐射， 通过光子晶体光纤，其中λ1→λ2→100nm。

公开(公告)号：US20070053640A1

公开(公告)日：2007-03-08

申请号：US11366345

申请日：2006-03-02

Applicant: James Goell ,  Marin Soljacic ,  Steven Jacobs ,  Tairan Wang ,  Gokhan Ulu ,  Burak Temelkuran ,  Steven Johnson

Inventor： James Goell ,  Marin Soljacic ,  Steven Jacobs ,  Tairan Wang ,  Gokhan Ulu ,  Burak Temelkuran ,  Steven Johnson

IPC: G02B6/02

CPC classification number: G02B6/02304 ,  A61B1/018 ,  A61B18/201 ,  A61B18/22 ,  A61B2018/2272 ,  A61F9/008 ,  A61F9/00802 ,  A61F9/00821 ,  A61F9/00825 ,  A61F2009/00863 ,  A61F2009/00891 ,  C03B2201/86 ,  C03B2203/12 ,  C03B2203/14 ,  C03B2203/16 ,  C03B2203/18 ,  C03B2203/42 ,  G02B6/023 ,  G02B6/02385 ,  G02B6/03622 ,  G02B6/03638 ,  G02B6/03694 ,  Y02P40/57

Abstract: In general, in a first aspect, the invention features photonic crystal fibers that include a core extending along a waveguide axis, a confinement region extending along the waveguide axis surrounding the core, and a cladding extending along the waveguide axis surrounding the confinement region, wherein the cladding has an asymmetric cross-section.

Abstract translation: 通常，在第一方面，本发明的特征在于光子晶体光纤，其包括沿着波导轴延伸的芯，沿着围绕芯的波导轴延伸的约束区域以及沿着围绕限制区域的波导轴延伸的包层，其中 包层具有不对称的横截面。

公开(公告)号：USD484321S1

公开(公告)日：2003-12-30

申请号：US29150144

申请日：2001-11-09

Applicant: Steven Jacobs

Designer： Steven Jacobs

公开(公告)号：USD378709S

公开(公告)日：1997-04-08

申请号：US40459

申请日：1995-06-19

Applicant: Steven Jacobs ,  Julie B. Kampf

Designer： Steven Jacobs ,  Julie B. Kampf

公开(公告)号：US08415291B2

公开(公告)日：2013-04-09

申请号：US12606396

申请日：2009-10-27

Applicant: Steven Jacobs ,  Karyn O'Neil

Inventor： Steven Jacobs ,  Karyn O'Neil

IPC: A61K38/00 ,  C07K1/00 ,  C07K16/00 ,  C12P21/08

CPC classification number: G01N33/54306 ,  A61K38/39 ,  C07K14/78 ,  Y02A50/385 ,  Y02A50/401 ,  Y02A50/409 ,  Y02A50/411 ,  Y02A50/463

Abstract: A protein scaffold based on a consensus sequence of the tenth fibronectin type III (FN3) repeat from human fibronectin, preferably human Tenascin, that binds to human TNFα including isolated nucleic acids that encode a protein scaffold, vectors, host cells, and methods of making and using thereof have applications in diagnostic and/or therapeutic compositions, methods and devices.

Abstract translation: 基于来自人纤连蛋白（优选人腱生蛋白）的第十纤维连接蛋白III型（FN3）重复序列的蛋白质支架，其结合人TNFα，包括编码蛋白质支架的分离的核酸，载体，宿主细胞和制备方法 并且其使用在诊断和/或治疗组合物，方法和装置中具有应用。

公开(公告)号：US20130079243A1

公开(公告)日：2013-03-28

申请号：US13628393

申请日：2012-09-27

Applicant: Michael Diem ,  Steven Jacobs

Inventor： Michael Diem ,  Steven Jacobs

IPC: C40B40/10 ,  C40B30/04 ,  C40B50/06

CPC classification number: G01N33/6845 ,  C12N15/1044 ,  C40B30/04 ,  C40B40/08 ,  C40B50/06 ,  G01N2333/78

Abstract: Protein scaffolds and scaffold libraries based on a fibronectin type III (FN3) repeat with an alternative binding surface design, isolated nucleic acids encoding the protein scaffolds, vectors, host cells, and methods of making thereof are useful in the generation of therapeutic molecules and treatment and diagnosis of diseases and disorders.

Abstract translation: 基于具有替代结合表面设计的纤连蛋白III型（FN3）重复的蛋白质支架和支架文库，编码蛋白质支架的分离的核酸，载体，宿主细胞及其制备方法可用于产生治疗分子和治疗 和疾病和病症的诊断。

公开(公告)号：US20110274623A1

公开(公告)日：2011-11-10

申请号：US13097587

申请日：2011-04-29

Applicant: Steven Jacobs

Inventor： Steven Jacobs

IPC: A61K49/00 ,  C40B50/00 ,  C40B40/08 ,  C40B40/02 ,  C40B30/04 ,  C07H21/00 ,  C12N15/63 ,  C12N1/21 ,  C12N1/19 ,  C12N5/10 ,  A61K38/16 ,  A61P25/00 ,  A61K38/22 ,  A61P7/00 ,  A61P27/02 ,  A61P35/00 ,  A61P9/00 ,  A61P27/16 ,  A61P11/00 ,  A61P1/00 ,  A61P43/00 ,  A61P37/02 ,  A61P11/02 ,  A61P31/00 ,  C07K14/00

CPC classification number: C12N15/1044 ,  A61K38/00 ,  C07K14/78 ,  C07K16/18 ,  C07K2318/20 ,  Y02A50/473

Abstract: A protein scaffold based on a consensus sequence of fibronectin type III (FN3) proteins, such as the tenth FN3 repeat from human fibronectin (human Tenascin), including isolated nucleic acids that encode a protein scaffold, vectors, host cells, and methods of making and using thereof, exhibit enhanced thermal and chemical stability while presenting six modifiable loop domains which can be engineered to form a binding partner capable of binding to a target for applications in diagnostic and/or therapeutic compositions, methods and devices.

Abstract translation: 基于纤连蛋白III（FN3）蛋白的共有序列的蛋白质支架，例如来自人纤连蛋白（人腱生蛋白）的第十FN3重复序列，包括编码蛋白质支架的分离的核酸，载体，宿主细胞和制备方法 并且其使用表现出增强的热和化学稳定性，同时呈现六个可修饰的环结构域，其可被工程化以形成能够结合靶标的结合配偶体，用于诊断和/或治疗组合物，方法和装置中的应用。

公开(公告)号：US20100255056A1

公开(公告)日：2010-10-07

申请号：US12704824

申请日：2010-02-12

Applicant: Steven Jacobs ,  Karyn O'Neil

Inventor： Steven Jacobs ,  Karyn O'Neil

IPC: A61K9/00 ,  C07K14/78 ,  C40B50/00 ,  C07H21/00 ,  C12N15/74 ,  C40B40/10 ,  C12N1/21 ,  C12N1/19 ,  C12N5/10 ,  A61K38/14 ,  A61P35/00 ,  A61P9/10 ,  A61P25/00 ,  A61P11/00

CPC classification number: C12N15/1044 ,  A61K38/00 ,  C07K14/78 ,  C40B40/08 ,  C40B50/06

Abstract: A protein scaffold based on a consensus sequence of the tenth fibronectin type III (FN3) repeat from human fibronectin, including isolated nucleic acids that encode a protein scaffold, vectors, host cells, and methods of making and using thereof have applications in diagnostic and/or therapeutic compositions, methods and devices. In particular, protein scaffold molecules binding to IgG based on the consensus sequence have been identified as useful for diagnostic and/or therapeutic applications.

Abstract translation: 基于来自人纤连蛋白的第十纤维连接蛋白III型（FN3）重复共有序列的蛋白质支架，包括编码蛋白质支架的分离的核酸，载体，宿主细胞及其制备和使用的方法具有诊断和/ 或治疗组合物，方法和装置。 特别地，已经鉴定了基于共有序列与IgG结合的蛋白质支架分子对于诊断和/或治疗应用是有用的。