公开(公告)号：US20060084182A1

公开(公告)日：2006-04-20

申请号：US11098844

申请日：2005-04-05

Applicant: Stuart Farquharson ,  Frank Inscore ,  Alan Gift ,  Chetan Shende

Inventor： Stuart Farquharson ,  Frank Inscore ,  Alan Gift ,  Chetan Shende

IPC: G01N21/00

CPC classification number: G01N21/658 ,  Y10T436/141111 ,  Y10T436/147777 ,  Y10T436/163333 ,  Y10T436/25375 ,  Y10T436/255

Abstract: The method and apparatus rapidly separate drugs and their metabolites from saliva and, in a continuous sequence of steps, rapidly detect, identify and quantify them through surface-enhanced Raman spectroscopy.

Abstract translation: 该方法和装置将药物及其代谢物从唾液中快速分离，并以连续的步骤顺序通过表面增强拉曼光谱快速检测，鉴定和定量。

公开(公告)号：US20060084181A1

公开(公告)日：2006-04-20

申请号：US10967486

申请日：2004-10-18

Applicant: Stuart Farquharson ,  Alan Gift ,  Frank Inscore ,  Chetan Shende

Inventor： Stuart Farquharson ,  Alan Gift ,  Frank Inscore ,  Chetan Shende

IPC: G01N21/00

CPC classification number: G01N21/658 ,  Y10T436/141111 ,  Y10T436/147777 ,  Y10T436/163333 ,  Y10T436/25375 ,  Y10T436/255

Abstract: The method and apparatus rapidly separate drugs and their metabolites from saliva and, in a continuous sequence of steps, rapidly detect, identify and quantify them through surface-enhanced Raman spectroscopy.

公开(公告)号：US20050266583A1

公开(公告)日：2005-12-01

申请号：US10854134

申请日：2004-05-26

Applicant: Stuart Farquharson ,  Frank Inscore ,  Chetan Shende ,  Alan Gift

Inventor： Stuart Farquharson ,  Frank Inscore ,  Chetan Shende ,  Alan Gift

IPC: G01N21/27 ,  G01N21/47 ,  G01N21/62 ,  G01N21/65

CPC classification number: G01N21/658 ,  G01N21/278

Abstract: A method for obtaining quantitative surface-enhanced Raman (SER) spectra that corrects for deficiencies of, and variations in, the materials and devices employed, especially the SER-active media utilized, employs a reference chemical, having an effective surface-enhanced Raman factor, of known concentration within the same SER experimental field of view as the analyte chemical being measured. Knowledge of the relative amounts of SER-scattering for the reference chemical and analyte chemical allows calculating the concentration of the latter to a high degree of accuracy and precision.

Abstract translation: 获得定量表面增强拉曼（SER）光谱的方法，其校正所用材料和装置的缺陷和变化，特别是所用的SER活性介质，采用具有有效表面增强拉曼因子的参考化学品 在与测量的分析物质相同的SER实验视野内具有已知浓度。 了解参考化学品和分析物化学品的SER散射的相对量，可以高精度和精确地计算后者的浓度。

公开(公告)号：US5120129A

公开(公告)日：1992-06-09

申请号：US597941

申请日：1990-10-15

Applicant: Stuart Farquharson ,  Leslie J. May ,  Terry D. Haymon

Inventor： Stuart Farquharson ,  Leslie J. May ,  Terry D. Haymon

IPC: G01N21/03 ,  G01N21/05 ,  G01N30/74

CPC classification number: G01N21/05 ,  G01N2021/0389

Abstract: An improvement upon spectroscopic cells of the type that have a single window sealed to each window opening of the cell body. The improvement is: (1) to position an additional window at each such opening, each such window being juxtaposed, spaced apart and biplanar with each original window so that there is a sealed space between each additional window and each original window; and (2) to position at least two passageways through the body of the cell, each such passageway in fluid communication with each of the above formed sealed spaces so that any leakage of a sample past the original seal is vented from the cell via one of the passageways to a detector to be detected. In a highly preferred embodiment of the present invention each such sealed space contains a spacer ring and the body is provided with additional passageways so that a purge fluid, such as nitrogen, can be flowed through the passageways and the sealed space to a flow through detector, such as a thermal conductivity detector, to detect any leakage of a fluid sample past one of the original seals.

Abstract translation: 对具有密封到单元体的每个窗口的单个窗口的类型的光谱单元的改进。 改进之处在于：（1）在每个这样的开口处设置一个附加的窗口，每个这样的窗口与每个原始窗口并置和间隔开并具有双平面，使得在每个附加窗口和每个原始窗口之间存在密封空间; 和（2）将至少两个通道定位在单元的主体中，每个这样的通道与上述每个形成的密封空间流体连通，使得样品通过原始密封件的任何泄漏通过以下之一从单元排出： 通向要检测的检测器。 在本发明的一个非常优选的实施例中，每个这样的密封空间包含间隔环，并且主体设置有附加的通道，使得吹扫流体（例如氮气）可以流过通道和密封空间到流过检测器 ，例如热导率检测器，以检测通过其中一个原始密封件的流体样品的任何泄漏。

公开(公告)号：US20240416337A1

公开(公告)日：2024-12-19

申请号：US18742202

申请日：2024-06-13

Applicant: Stuart Farquharson ,  Chetan Shende ,  Duncan Farquharson

Inventor： Stuart Farquharson ,  Chetan Shende ,  Duncan Farquharson

IPC: B01L3/00 ,  G01N33/53 ,  G01N33/543 ,  G01N33/569

Abstract: The present invention provides a novel method and apparatus that employs a signal-enhancing probe in combination with a flow assay strip to bind a target analyte with substantial selectivity, sensitivity, speed, and convenience, through the use of target analyte-specific binding agents and smartphone camera measurement and analysis. The present invention is advantageous for detecting, identifying, quantifying, and analyzing target analytes, such as chemical, biochemical, or biological substances, in analyte samples. The present invention is most effective in detecting, identifying, quantifying, and analyzing drugs, bacterial and viral pathogens in body fluids, such as blood, blood plasma, exhaled breath, nasopharyngeal mucus, and saliva.

公开(公告)号：US08781757B2

公开(公告)日：2014-07-15

申请号：US12734091

申请日：2008-10-10

Applicant: Stuart Farquharson ,  Wayne W. Smith

Inventor： Stuart Farquharson ,  Wayne W. Smith

IPC: G06F19/00

CPC classification number: G01N21/359 ,  G01N21/3577 ,  G01N21/65 ,  G01N21/84 ,  G01N2021/6421 ,  G01N2021/8411 ,  G01N2201/1293

Abstract: The method and apparatus are used to determine class, grade and properties of fuel samples, regardless of ambient, instrument, or sample temperature, using mathematical correlations between fuel class, grade and properties and their spectra developed from a database of samples with measured properties and spectra. The ability to measure a fuel sample using the present method and apparatus is useful in identifying unknown fuel samples, determining suitability in equipment, and monitoring and controlling fuel processes, such as blending operations, distillation, and synthesis.

Abstract translation: 该方法和设备用于确定燃料样品的等级，等级和性能，无论环境，仪器或样品温度如何，使用燃料类别，等级和性质之间的数学相关性以及从具有测量性质的样品数据库开发的光谱，以及 光谱。 使用本方法和装置测量燃料样品的能力可用于识别未知燃料样品，确定设备的适用性，以及监测和控制燃料过程，例如混合操作，蒸馏和合成。

公开(公告)号：US07713914B2

公开(公告)日：2010-05-11

申请号：US11355782

申请日：2006-02-16

Applicant: Stuart Farquharson ,  Frank E. Inscore ,  Alan D. Gift ,  Chetan Shrikant Shende

Inventor： Stuart Farquharson ,  Frank E. Inscore ,  Alan D. Gift ,  Chetan Shrikant Shende

IPC: C40B30/00

CPC classification number: C12Q1/04 ,  G01N2333/32 ,  G01N2333/33 ,  Y02A50/451

Abstract: A weak organic acid is used to effect the release of CaDPA from Bacillus or Clostridium endospores, rapidly and at room temperature, to enable detection and measurement of DPA and thereby the assessment of risk associated with exposure to Bacillus anthracis, Clostridium botulinum, and like spores. The method can be applied to airborne, food-borne, and water-borne spores, as well as to spores collected from surfaces or contained in body fluids, and analysis is advantageously carried out using surface-enhanced Raman spectroscopy.

Abstract translation: 使用弱有机酸快速和室温下从芽孢杆菌或梭状芽孢杆菌内孢子中释放CaDPA，以便能够检测和测量DPA，从而评估与接触炭疽芽孢杆菌，肉毒梭菌和类似孢子相关的风险 。 该方法可以应用于空气传播，食源性和水性孢子，以及从表面收集的或包含在体液中的孢子，并且有利地使用表面增强拉曼光谱进行分析。

公开(公告)号：US20050266584A1

公开(公告)日：2005-12-01

申请号：US10902511

申请日：2004-07-29

Applicant: Stuart Farquharson

Inventor： Stuart Farquharson

IPC: G01N21/27 ,  G01N21/47 ,  G01N21/62 ,  G01N21/65

CPC classification number: G01N21/658 ,  G01N21/278

Abstract: Apparatus for use in effecting surface-enhanced Raman spectroscopy comprises first and second containment means, the first containment means containing a known quantity of a reference chemical having an effective surface-enhanced Raman factor, and the second containment means containing a surface-enhanced Raman-active medium and being sufficiently transparent, at least at one optical access location, to permit both the excitation irradiation of, and also the collection of surface-enhanced Raman scattered radiation from, a common field of view of the surface-enhanced Raman-active medium. The apparatus is constructed for carrying out the method of the invention; i.e., for effecting intimate mixing, substantially prior to introduction to the surface-enhanced Raman-active medium contained in the second containment means, of the reference chemical with an analyte chemical-containing solution introduced through an entrance into the first containment means. The homogeneous test solution so formed permeates the SER-active material in the second containment means, which is irradiated at the common field of view so as to produce SER scattered radiation for collection and quantitative analysis.

Abstract translation: 用于实现表面增强拉曼光谱的装置包括第一和第二容纳装置，第一容纳装置含有已知量的具有有效表面增强拉曼因子的参考化学品，第二容纳装置含有表面增强拉曼光谱， 至少在一个光学接近位置处，至少在一个光学接近位置处具有足够的透明度，以允许来自表面增强拉曼活性介质的共同视野的激发照射和表面增强拉曼散射辐射的收集 。 该装置被构造用于实施本发明的方法; 即在进入第二容纳装置中的表面增强拉曼活性介质引入参考化学品之前，通过入口进入第一容纳装置，进行紧密混合。 如此形成的均匀试验溶液渗透到第二容纳装置中的SER活性物质，其在公共视野下照射，以产生用于收集和定量分析的SER散射辐射。

公开(公告)号：US5604581A

公开(公告)日：1997-02-18

申请号：US319749

申请日：1994-10-07

Applicant: Shaohua Liu ,  Peter R. Solomon ,  Peter A. Rosenthal ,  Stuart Farquharson

Inventor： Shaohua Liu ,  Peter R. Solomon ,  Peter A. Rosenthal ,  Stuart Farquharson

IPC: G01B11/06 ,  G01N21/41

CPC classification number: G01B11/0625

Abstract: The method determines the thickness and the free carrier concentration of at least one layer of a structure. An exposed surface of the structure is irradiated using spectral radiation, and the measured reflectance spectrum is compared to a calculated spectrum. Using algorithms that include terms representative of complex refractive indices, layer thickness, dielectric constants, and free carrier concentrations, values are iteratively assigned to the thickness and free carrier concentration parameters so as to produce a best fit relationship between the compared spectra, and to thereby determine those parameters.

Abstract translation: 该方法确定至少一层结构的厚度和自由载流子浓度。 使用光谱辐射照射结构的暴露表面，并将测量的反射光谱与计算的光谱进行比较。 使用包括代表复折射率，层厚度，介电常数和自由载流子浓度的术语的算法被迭代地分配给厚度和自由载流子浓度参数，以便产生比较光谱之间的最佳拟合关系，从而 确定这些参数。

公开(公告)号：US5062713A

公开(公告)日：1991-11-05

申请号：US608066

申请日：1990-11-01

Applicant: Stuart Farquharson ,  Peter T. Keillor, III

Inventor： Stuart Farquharson ,  Peter T. Keillor, III

IPC: B29C47/92 ,  G01N21/31 ,  G01N21/85

CPC classification number: B29C47/92 ,  G01N21/85 ,  B29C2947/92057 ,  B29C2947/92409 ,  B29C2947/92485 ,  B29C47/0014 ,  B29C47/0026 ,  G01N2021/1746 ,  G01N2021/3137 ,  G01N21/314

Abstract: A method for the on-line determination of the residence time distribution of a polymer extruder by injecting a quantity of dye, such as Mobay Red 5B, into the feed throat of the extruder and then photometrically monitoring the polymer flowing from the extruder for the dye. The advance of the present invention is to direct a single beam of polychromatic light through the polymer flowing from the extruder, e.g., by using a quartz-halogen light source and an optical fiber, and then to split this single beam of light that has passed through the polymer into two beams, e.g., by the use of a bifurcated optical fiber, each of which resulting beams are then passed through a separate filter to a separate photodetector. The wavelength of maximum transmission of one of the filters is selected to be near the wavelength of maximum light absorption of the dye so that the signal from the photodetector associated with this filter is a function of the concentration of the dye in the polymer flowing from the extruder. The wavelength of maximum transmission of the other filter is selected to be near the wavelength of minimum light adsorption of the dye and the polymer so that the signal from the photodetector associated with this filter is a function of the background light absorption of the polymer flowing from the extruder. The noise level of the dye concentration signal can be a problem due to bubbles and inclusions in the polymer flowing from the extruder and this noise level is substantially reduced by correcting the dye concentration signal with the background signal.

Abstract translation: 通过将一定量的染料（例如Mobay Red 5B）注射到挤出机的进料喉中，然后对从染料的挤出机流出的聚合物进行光度监测来在线测定聚合物挤出机的停留时间分布的方法 。 本发明的进步是通过例如通过使用石英卤素光源和光纤从挤出机流出的聚合物引导单个多色光束，然后将已经通过的单光束 通过聚合物分成两个光束，例如通过使用分叉光纤，然后将所得到的光束中的每一个通过单独的滤光器到单独的光电检测器。 选择一个滤光器的最大透射波长接近于染料的最大光吸收波长，使得与该滤光片相关的来自光电检测器的信号是从聚合物流中的染料浓度的函数 挤出机。 选择另一个滤光器的最大透射波长接近于染料和聚合物的最小光吸收波长，使得来自与该滤光片相关联的光电检测器的信号是从该滤光片流出的聚合物的背景光吸收的函数 挤出机。 染料浓度信号的噪声水平可能是由于挤出机中流出的聚合物中的气泡和夹杂物引起的问题，并且通过用背景信号校正染料浓度信号，该噪声水平被显着降低。