公开(公告)号：US20120162607A1

公开(公告)日：2012-06-28

申请号：US13340998

申请日：2011-12-30

申请人： Sverker Norrby

发明人： Sverker Norrby

IPC分类号： A61B3/00 ,  G06G7/60

CPC分类号： A61F2/1613 ,  A61B3/0025 ,  A61F2240/002

摘要： The invention relates to devices and methods for selecting IOLs for implantation and eye models useful with the methods. One method comprises the steps of determining the axial eye length, the pupil size at a desired light level; the desired postoperative refraction; determining an aspheric representation of the corneal curvature and determining the location of the plane of fixation of the IOL following implantation.

摘要翻译： 本发明涉及用于选择用于植入的IOL和用于该方法的眼模型的装置和方法。 一种方法包括以下步骤：确定轴向眼睛长度，在期望的光水平下的瞳孔尺寸; 所需的术后折射; 确定角膜曲率的非球面表示并确定植入后IOL的固定平面的位置。

公开(公告)号：US20110128502A1

公开(公告)日：2011-06-02

申请号：US13021498

申请日：2011-02-04

申请人： Sverker Norrby ,  Rolf Bergman

发明人： Sverker Norrby ,  Rolf Bergman

IPC分类号： A61B3/10

CPC分类号： A61F2/1613 ,  A61B3/0025 ,  A61B3/103 ,  A61B3/107

摘要： A system for providing an intraocular lens includes a processor and a computer readable memory. The computer readable memory is configured to communicate with the processor, the memory having stored therein at least one of: one or more ocular dimensions, and at least one predetermined refractive outcome. The memory further includes a sequence of instructions which, when executed by the processor, cause the processor to select an intraocular lens, select a power of an intraocular lens, or provide an intraocular lens. The sequence of instructions includes determining one or more dimensions of an eye. The instructions also include calculating, based on a mathematical relationship, a distance from an apex of a cornea of the eye to an apex or plane of the intraocular lens after insertion into the eye. The instructions further calculating an optical power of the intraocular lens suitable for providing a predetermined refractive outcome. The mathematical relationship includes an axial length of the eye, an anterior chamber depth of the natural crystalline lens, and a corneal radius of the eye, but is independent of a thickness of the natural crystalline lens.

摘要翻译： 用于提供眼内透镜的系统包括处理器和计算机可读存储器。 计算机可读存储器被配置为与处理器通信，其中存储有存储器中的至少一个：一个或多个眼睛尺寸和至少一个预定折射结果。 所述存储器还包括指令序列，当由所述处理器执行时，使所述处理器选择人工晶状体，选择人工晶状体的能量或提供眼内透镜。 指令序列包括确定眼睛的一个或多个维度。 说明书还包括基于数学关系计算在插入眼睛之后从眼睛的角膜的顶点到眼内透镜的顶点或平面的距离。 所述指令还计算适于提供预定屈光结果的眼内透镜的光焦度。 数学关系包括眼睛的轴向长度，天然晶状体的前房深度和眼睛的角膜半径，但是与天然晶状体的厚度无关。

公开(公告)号：US07811267B2

公开(公告)日：2010-10-12

申请号：US10438618

申请日：2003-05-15

申请人： Sverker Norrby ,  Rolf Bergman ,  Jöns Hillborn

发明人： Sverker Norrby ,  Rolf Bergman ,  Jöns Hillborn

IPC分类号： A61M35/00

CPC分类号： A61F2/1616 ,  A61F9/00736 ,  A61L31/044 ,  A61L31/046 ,  C09J189/00

摘要： A kit is provided, which comprises a) a collagen patch and b) an adhesive composition comprising (i) fibrin, fibrinogen or a combination thereof, and (ii) a biocompatible polymer capable of forming a viscous aqueous solution.Also provided is use of the kit for the preparation of a sealing device for use in ophthalmic surgery to replace a natural lens which has been removed, in which sealing device the collagen patch of the kit is adapted to seal an opening in a capsular bag of an eye while admitting the entrance of an injection device through the opening for injection of a lens-forming material into the capsule; and in which sealing device the adhesive composition of the kit is adapted to be applied to the collagen patch so as to enable adhesion of the collagen patch to the capsular bag.Also provided are methods for sealing an opening in a capsular bag of an eye, in which methods the kit is employed.

摘要翻译： 提供了一种试剂盒，其包括a）胶原蛋白片和b）包含（i）纤维蛋白，纤维蛋白原或其组合的粘合剂组合物，和（ii）能够形成粘性水溶液的生物相容性聚合物。 还提供了该套件的用途，用于制备用于眼科手术中的密封装置，以取代已经去除的天然晶状体，其中该成套件的胶原贴片的密封装置适于密封囊袋中的开口 眼睛同时通过用于将透镜形成材料注入胶囊的开口进入注射装置; 并且其中将所述试剂盒的粘合剂组合物适用于所述胶原蛋白贴片的密封装置，以便能够将所述胶原蛋白贴片粘附到所述胶囊袋上。 还提供了用于密封眼睛囊袋中的开口的方法，其中采用该试剂盒的方法。

公开(公告)号：US20070188700A1

公开(公告)日：2007-08-16

申请号：US11734238

申请日：2007-04-11

申请人： Patricia Piers ,  Hendrik Weeber ,  Sverker Norrby

发明人： Patricia Piers ,  Hendrik Weeber ,  Sverker Norrby

IPC分类号： G02C7/04

CPC分类号： A61F2/1618 ,  A61B3/0025 ,  A61F2/1613 ,  A61F2/1616 ,  A61F2/1637 ,  A61F2/164 ,  A61F2/1654 ,  A61F2002/1681 ,  A61F2002/1696 ,  A61F2240/001 ,  A61F2240/002 ,  G01J9/00 ,  G02C7/028 ,  G02C7/041 ,  G02C7/042 ,  G02C7/044 ,  G02C7/06 ,  G02C2202/20 ,  G02C2202/22

摘要： A method of designing a multifocal ophthalmic lens with one base focus and at least one additional focus, capable of reducing aberrations of the eye for at least one of the foci after its implantation, comprising the steps of: (i) characterizing at least one corneal surface as a mathematical model; (ii) calculating the resulting aberrations of said corneal surface(s) by employing said mathematical model; (iii) modeling the multifocal ophthalmic lens such that a wavefront arriving from an optical system comprising said lens and said at least one corneal surface obtains reduced aberrations for at least one of the foci. There is also disclosed a method of selecting a multifocal intraocular lens, a method of designing a multifocal ophthalmic lens based on corneal data from a group of patients, and a multifocal ophthalmic lens.

摘要翻译： 一种设计具有一个基底焦点和至少一个附加焦点的多焦点眼科镜片的方法，其能够在其植入之后减少至少一个焦点的眼睛的像差，包括以下步骤：（i）表征至少一个角膜 表面作为数学模型; （ii）通过使用所述数学模型来计算所得到的所述角膜表面的像差; （iii）对多焦点眼科镜片进行建模，使得从包括所述透镜和所述至少一个角膜表面的光学系统到达的波前获得至少一个焦点的减少的像差。 还公开了一种选择多焦点眼内透镜的方法，基于来自一组患者的角膜数据设计多焦点眼科镜片的方法和多焦点眼科镜片。

公开(公告)号：US20060244905A1

公开(公告)日：2006-11-02

申请号：US11426187

申请日：2006-06-23

申请人： Patricia Piers ,  Hendrik Weeber ,  Sverker Norrby

发明人： Patricia Piers ,  Hendrik Weeber ,  Sverker Norrby

IPC分类号： G02C7/04

CPC分类号： A61F2/1618 ,  A61B3/0025 ,  A61F2/1613 ,  A61F2/1616 ,  A61F2/1637 ,  A61F2/164 ,  A61F2/1654 ,  A61F2002/1681 ,  A61F2002/1696 ,  A61F2240/001 ,  A61F2240/002 ,  G01J9/00 ,  G02C7/028 ,  G02C7/041 ,  G02C7/042 ,  G02C7/044 ,  G02C7/06 ,  G02C2202/20 ,  G02C2202/22

摘要： A method of designing a multifocal ophthalmic lens with one base focus and at least one additional focus, capable of reducing aberrations of the eye for at least one of the foci after its implantation, comprising the steps of: (i) characterizing at least one corneal surface as a mathematical model; (ii) calculating the resulting aberrations of said corneal surface(s) by employing said mathematical model; (iii) modelling the multifocal ophthalmic lens such that a wavefront arriving from an optical system comprising said lens and said at least one corneal surface obtains reduced aberrations for at least one of the foci. There is also disclosed a method of selecting a multifocal intraocular lens, a method of designing a multifocal ophthalmic lens based on corneal data from a group of patients, and a multifocal ophthalmic lens.

公开(公告)号：US20060064163A1

公开(公告)日：2006-03-23

申请号：US11233295

申请日：2005-09-21

申请人： Thom Terwee ,  Sverker Norrby ,  Robert Shimizu ,  Rolf Bergman

发明人： Thom Terwee ,  Sverker Norrby ,  Robert Shimizu ,  Rolf Bergman

IPC分类号： A61F2/16 ,  A61F2/02 ,  A61F9/013

CPC分类号： A61K9/0048 ,  A61L27/20 ,  A61L27/54 ,  A61L2300/416 ,  A61L2430/16 ,  C08L5/08

摘要： The invention relates to method of preparing a viscoelastic therapeutic liquid comprising a viscoelastic agent and a homogenously distributed therapeutically active agent, wherein the therapeutically active agent is distributed throughout the viscoelastic compound when the viscoelastic compound is in dry form. In one embodiment of the invention, the viscoelastic compound in dry form is mixed with an aqueous solution of the therapeutically active agent. The invention further relates to utilities of homogenous viscoelastic compositions in therapeutic applications including ophthalmic surgery.

公开(公告)号：US07883208B2

公开(公告)日：2011-02-08

申请号：US12419230

申请日：2009-04-06

申请人： Sverker Norrby ,  Rolf Bergman

发明人： Sverker Norrby ,  Rolf Bergman

IPC分类号： G02C7/02 ,  A61F2/16

CPC分类号： A61F2/1613 ,  A61B3/0025 ,  A61B3/103 ,  A61B3/107

摘要： A system for providing an intraocular lens includes a processor and a computer readable memory. The computer readable memory is configured to communicate with the processor, the memory having stored therein at least one of: one or more ocular dimensions, and at least one predetermined refractive outcome. The memory further includes a sequence of instructions which, when executed by the processor, cause the processor to select an intraocular lens, select a power of an intraocular lens, or provide an intraocular lens. The sequence of instructions includes determining one or more dimensions of an eye. The instructions also include calculating, based on a mathematical relationship, a distance from an apex of a cornea of the eye to an apex or plane of the intraocular lens after insertion into the eye. The instructions further calculating an optical power of the intraocular lens suitable for providing a predetermined refractive outcome. The mathematical relationship includes an axial length of the eye, an anterior chamber depth of the natural crystalline lens, and a corneal radius of the eye, but is independent of a thickness of the natural crystalline lens.

摘要翻译： 用于提供眼内透镜的系统包括处理器和计算机可读存储器。 计算机可读存储器被配置为与处理器通信，其中存储有存储器中的至少一个：一个或多个眼睛尺寸和至少一个预定折射结果。 所述存储器还包括指令序列，当由所述处理器执行时，使所述处理器选择人工晶状体，选择人工晶状体的能量或提供眼内透镜。 指令序列包括确定眼睛的一个或多个维度。 说明书还包括基于数学关系计算在插入眼睛之后从眼睛的角膜的顶点到眼内透镜的顶点或平面的距离。 所述指令还计算适于提供预定屈光结果的眼内透镜的光焦度。 数学关系包括眼睛的轴向长度，天然晶状体的前房深度和眼睛的角膜半径，但是与天然晶状体的厚度无关。

公开(公告)号：US07847025B2

公开(公告)日：2010-12-07

申请号：US11314930

申请日：2005-12-20

申请人： Yan Liu ,  Jöns Gunnar Hilborn ,  Hendrick Jan Haitjema ,  Sverker Norrby ,  Thom Terwee

发明人： Yan Liu ,  Jöns Gunnar Hilborn ,  Hendrick Jan Haitjema ,  Sverker Norrby ,  Thom Terwee

IPC分类号： C08L83/08

CPC分类号： A61K31/695 ,  A61L24/046 ,  A61L27/34 ,  Y10S623/926 ,  C08L83/04

摘要： The present invention relates to amphiphilic block copolymers comprising at least one block of hydrophilic units and at least one block of hydrophobic units, wherein at least one hydrophobic block contains siloxane units. The present invention may be particularly useful as a tissue adhesive or as a coating for an intraocular lens (IOL). As an IOL coating, copolymers according to the invention may be used, for example, to promote tissue adhesion for the prevention of posterior capsule opacification.

摘要翻译： 本发明涉及包含至少一个亲水单元嵌段和至少一个疏水单元嵌段的两亲嵌段共聚物，其中至少一个疏水嵌段含有硅氧烷单元。 本发明可以特别用作组织粘合剂或用作眼内透镜（IOL）的涂层。 作为IOL涂层，根据本发明的共聚物可用于例如促进组织粘连以防止后囊混浊。

公开(公告)号：US07794697B2

公开(公告)日：2010-09-14

申请号：US11740677

申请日：2007-04-26

申请人： Arlene Gwon ,  Sverker Norrby ,  Thomas Terwee ,  Steven Koopmans

发明人： Arlene Gwon ,  Sverker Norrby ,  Thomas Terwee ,  Steven Koopmans

IPC分类号： A61K31/74

CPC分类号： A61F2/1613 ,  A61L27/18 ,  A61L2430/16 ,  C08L83/04

摘要： The present invention addresses the treatment of ocular conditions by the enhancement of lens regeneration. Enhancement of lens regeneration is accomplished by the administration of a composition comprising a polysiloxane polymer having functional acryl groups useful in the preparation of intraocular lenses (IOLs).

摘要翻译： 本发明通过增强透镜再生来处理眼睛状况。 透镜再生的增强通过施用包含可用于制备眼内透镜（IOL）的具有功能性丙烯酰基的聚硅氧烷聚合物的组合物来实现。

公开(公告)号：US20090251664A1

公开(公告)日：2009-10-08

申请号：US12419230

申请日：2009-04-06

申请人： Sverker Norrby ,  Rolf Bergman

发明人： Sverker Norrby ,  Rolf Bergman

IPC分类号： A61B3/10

CPC分类号： A61F2/1613 ,  A61B3/0025 ,  A61B3/103 ,  A61B3/107

摘要： A system for providing an intraocular lens includes a processor and a computer readable memory. The computer readable memory is configured to communicate with the processor, the memory having stored therein at least one of: one or more ocular dimensions, and at least one predetermined refractive outcome. The memory further includes a sequence of instructions which, when executed by the processor, cause the processor to select an intraocular lens, select a power of an intraocular lens, or provide an intraocular lens. The sequence of instructions includes determining one or more dimensions of an eye. The instructions also include calculating, based on a mathematical relationship, a distance from an apex of a cornea of the eye to an apex or plane of the intraocular lens after insertion into the eye. The instructions further calculating an optical power of the intraocular lens suitable for providing a predetermined refractive outcome. The mathematical relationship includes an axial length of the eye, an anterior chamber depth of the natural crystalline lens, and a corneal radius of the eye, but is independent of a thickness of the natural crystalline lens.

摘要翻译： 用于提供眼内透镜的系统包括处理器和计算机可读存储器。 计算机可读存储器被配置为与处理器通信，其中存储有存储器中的至少一个：一个或多个眼睛尺寸和至少一个预定折射结果。 所述存储器还包括指令序列，当由所述处理器执行时，使所述处理器选择人工晶状体，选择人工晶状体的能量或提供眼内透镜。 指令序列包括确定眼睛的一个或多个维度。 说明书还包括基于数学关系计算在插入眼睛之后从眼睛的角膜的顶点到眼内透镜的顶点或平面的距离。 所述指令还计算适于提供预定屈光结果的眼内透镜的光焦度。 数学关系包括眼睛的轴向长度，天然晶状体的前房深度和眼睛的角膜半径，但是与天然晶状体的厚度无关。