公开(公告)号：US20150018547A1

公开(公告)日：2015-01-15

申请号：US14380215

申请日：2013-02-22

Applicant: TAKEDA PHARMACEUTICAL COMPANY LIMITED

Inventor： Nobuyuki Takakura ,  Yoshihiro Banno ,  Yoshito Terao ,  Atsuko Ochida ,  Sachie Morimoto ,  Shuji Kitamura ,  Yoshihide Tomata ,  Tsuneo Yasuma ,  Minoru Ikoma ,  Kei Masuda

IPC: C07D333/60 ,  C07D307/80 ,  C07D495/04 ,  C07D417/12 ,  C07D333/70 ,  C07D333/64 ,  C07D409/12 ,  C07D405/12

CPC classification number: C07D333/60 ,  C07D307/79 ,  C07D307/80 ,  C07D307/81 ,  C07D307/84 ,  C07D333/54 ,  C07D333/64 ,  C07D333/70 ,  C07D405/04 ,  C07D405/12 ,  C07D409/06 ,  C07D409/12 ,  C07D417/12 ,  C07D495/04

Abstract: The present invention provides a compound having a GOAT inhibitory action, which is useful for the prophylaxis or treatment of obesity and the like, and has superior efficacy. The present invention is a compound represented by the formula (I): wherein each symbol is as defined in the specification, or a salt thereof.

Abstract translation: 本发明提供具有GOAT抑制作用的化合物，其可用于预防或治疗肥胖症等，并且具有优异的疗效。 本发明是由式（I）表示的化合物：其中各符号如说明书中所定义，或其盐。

公开(公告)号：US20140228409A1

公开(公告)日：2014-08-14

申请号：US14346071

申请日：2012-09-21

Applicant: Takeda Pharmaceutical Company Limited

Inventor： Satoshi Yamamoto ,  Junya Shirai ,  Yoshiyuki Fukase ,  Yoshihide Tomata ,  Ayumu Sato ,  Atsuko Ochida ,  Kazuko Yonemori ,  Hideyuki Nakagawa

IPC: C07D401/12 ,  C07D209/08 ,  C07D209/88

CPC classification number: C07D401/12 ,  A61K31/403 ,  A61K31/404 ,  C07D209/08 ,  C07D209/88

Abstract: The present invention provides a fused heterocyclic compound having an RORγt inhibitory action. The present invention relates to a compound represented by the formula (I′): wherein each symbol is as defined in the specification, provided that 2-(2-((4-cyanophenyl)amino)-2-oxoethoxy)-N-(9-ethyl-9H-carbazol-3-yl)acetamide and N-(4-cyanophenyl)-N′-(9-ethyl-9H-carbazol-3-yl)-3-methylpentanediamide are excluded, or a salt thereof.

Abstract translation: 本发明提供具有RORγt抑制作用的稠合杂环化合物。 本发明涉及由式（I'）表示的化合物：其中每个符号如说明书中所定义，条件是2-（2 - （（2-氰基苯基）氨基）-2-氧代乙氧基）-N-（ 9-乙基-9H-咔唑-3-基）乙酰胺和N-（4-氰基苯基）-N' - （9-乙基-9H-咔唑-3-基）-3-甲基戊二酰胺或其盐。