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公开(公告)号：US09120776B2
公开(公告)日：2015-09-01
申请号：US14346071
申请日：2012-09-21
发明人： Satoshi Yamamoto , Junya Shirai , Yoshiyuki Fukase , Yoshihide Tomata , Ayumu Sato , Atsuko Ochida , Kazuko Yonemori , Hideyuki Nakagawa
IPC分类号： A61K31/403 , A61K31/404 , C07D401/12 , C07D209/88 , C07D209/08
CPC分类号： C07D401/12 , A61K31/403 , A61K31/404 , C07D209/08 , C07D209/88
摘要： The present invention provides a fused heterocyclic compound having an RORγt inhibitory action. The present invention relates to a compound represented by the formula (I′): wherein each symbol is as defined in the specification, provided that 2-(2-((4-cyanophenyl)amino)-2-oxoethoxy)-N-(9-ethyl-9H-carbazol-3-yl)acetamide and N-(4-cyanophenyl)-N′-(9-ethyl-9H-carbazol-3-yl)-3-methylpentanediamide are excluded, or a thereof.
摘要翻译： 本发明提供具有RORγt抑制作用的稠合杂环化合物。 本发明涉及由式（I'）表示的化合物：其中每个符号如说明书中所定义，条件是2-（2 - （（2-氰基苯基）氨基）-2-氧代乙氧基）-N-（ 9-乙基-9H-咔唑-3-基）乙酰胺和N-（4-氰基苯基）-N' - （9-乙基-9H-咔唑-3-基）-3-甲基戊二酰胺或其中的一种。
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公开(公告)号：US10519110B2
公开(公告)日：2019-12-31
申请号：US16175144
申请日：2018-10-30
发明人： Yasutomi Asano , Takuto Kojima , Osamu Kurasawa , Tzu-Tshin Wong , Yasuhiro Hirata , Naoki Iwamura , Bunnai Saito , Yuta Tanaka , Ryosuke Arai , Shinichi Imamura , Kazuko Yonemori , Yasufumi Miyamoto , Shuji Kitamura , Osamu Sano
IPC分类号： C07D211/58 , C07F9/6509 , C07D401/14 , A61K31/437 , A61K31/443 , A61K31/4433 , A61K31/4436 , A61K31/4439 , A61K31/444 , A61K31/4468 , A61K31/451 , A61K31/452 , A61K31/4709 , A61K31/498 , A61K31/506 , A61K31/517 , A61K31/5355 , A61K31/661 , A61K33/22 , C07D215/42 , C07D401/06 , C07D401/12 , C07D409/12 , C07D413/06 , C07D417/06 , C07D417/12 , C07D417/14 , C07D471/04 , C07D487/04 , C07D498/04 , C07D513/04 , C07D519/00 , C07F5/02 , A61P3/00 , A61P35/00 , C07B59/00 , C07D405/06 , C07D413/14
摘要： The present invention relates to a compound which can be useful for the treatment or prevention of SPT-related diseases including cancer and congenital diseases associated with sphingolipid accumulation (including Niemann-Pick disease).
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公开(公告)号：US20140243310A1
公开(公告)日：2014-08-28
申请号：US14353622
申请日：2012-10-23
发明人： Tohru Yamashita , Takuya Fujimoto , Ryo Mizojiri , Kazuko Yonemori , Hideki Hirose , Zenichi Ikeda , Ikuo Fujimori , Kyoko Toyofuku , Tsuneo Yasuma , Nobuyuki Matsunaga
IPC分类号： C07D231/56 , C07D498/04 , C07D307/80 , C07D413/04 , C07D263/57 , C07D235/18
CPC分类号： C07D231/56 , A61K31/343 , A61K31/416 , A61K31/4184 , A61K31/422 , A61K31/423 , A61K31/437 , A61K31/4439 , C07D235/18 , C07D263/57 , C07D307/80 , C07D413/04 , C07D498/04 , C07D513/04
摘要： The present invention provides a compound represented by the formula (I): wherein each symbol is as defined in the specification, or a salt thereof.
摘要翻译： 本发明提供由式（I）表示的化合物：其中每个符号如说明书中所定义，或其盐。
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公开(公告)号：US10189785B2
公开(公告)日：2019-01-29
申请号：US15565891
申请日：2016-04-19
发明人： Yasutomi Asano , Takuto Kojima , Osamu Kurasawa , Tzu-Tshin Wong , Yasuhiro Hirata , Naoki Iwamura , Bunnai Saito , Yuta Tanaka , Ryosuke Arai , Shinichi Imamura , Kazuko Yonemori , Yasufumi Miyamoto , Shuji Kitamura , Osamu Sano
IPC分类号： C07D211/58 , C07D215/42 , C07D401/02 , C07D413/06 , C07D413/14 , A61K31/444 , A61K31/4709 , C07F9/6509 , C07D401/14 , A61K31/437 , A61K31/443 , A61K31/4433 , A61K31/4436 , A61K31/4439 , A61K31/4468 , A61K31/451 , A61K31/452 , A61K31/498 , A61K31/506 , A61K31/517 , A61K31/5355 , A61K31/661 , A61K33/22 , C07D401/06 , C07D401/12 , C07D409/12 , C07D417/06 , C07D417/12 , C07D417/14 , C07D471/04 , C07D487/04 , C07D498/04 , C07D513/04 , C07D519/00 , C07F5/02 , A61P3/00 , A61P35/00 , C07B59/00 , C07D405/06
摘要： The present invention relates to a compound which can be useful for the treatment or prevention of SPT-related diseases including cancer and congenital diseases associated with sphingolipid accumulation (including Niemann-Pick disease).
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公开(公告)号：US09834520B2
公开(公告)日：2017-12-05
申请号：US14775514
申请日：2014-03-13
发明人： Satoshi Yamamoto , Junya Shirai , Yoshiyuki Fukase , Ayumu Sato , Mitsunori Kouno , Yoshihide Tomata , Atsuko Ochida , Kazuko Yonemori , Tsuneo Oda , Tomoya Yukawa
IPC分类号： A61K31/517 , C07D239/72 , C07D239/96 , C07D403/12 , C07D401/12 , C07D409/12 , C07D239/80 , C07D413/12 , C07D417/12 , C07D471/04 , C07D265/36 , C07D217/24 , C07D405/06 , C07D475/04 , C07F7/08
CPC分类号： C07D239/96 , C07D217/24 , C07D239/80 , C07D265/36 , C07D401/12 , C07D403/12 , C07D405/06 , C07D409/12 , C07D413/12 , C07D417/12 , C07D471/04 , C07D475/04 , C07F7/0812
摘要： The present invention provides a heterocyclic compound having an RORγt inhibitory action.The present invention relates to a compound represented by the formula (I): wherein Ar is a the partial structure (1) to the partial structure (5), Q is a bivalent group selected from the group consisting of (Ia)-(If), and B is a ring optionally having substituent(s), or a salt thereof.
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公开(公告)号：US20160229814A1
公开(公告)日：2016-08-11
申请号：US14775514
申请日：2014-03-13
发明人： Satoshi Yamamoto , Junya Shirai , Yoshiyuki Fukase , Ayumu Sato , Mitsunori Kouno , Yoshihide Tomata , Atsuko Ochida , Kazuko Yonemori , Tsuneo Oda , Takashi Imada , Tomoya Yukawa
IPC分类号： C07D239/96 , C07D265/36 , C07F7/08 , C07D401/12 , C07D217/24 , C07D417/12 , C07D409/12 , C07D413/12 , C07D475/04 , C07D405/06 , C07D471/04 , C07D403/12
CPC分类号： C07D239/96 , C07D217/24 , C07D239/80 , C07D265/36 , C07D401/12 , C07D403/12 , C07D405/06 , C07D409/12 , C07D413/12 , C07D417/12 , C07D471/04 , C07D475/04 , C07F7/0812
摘要： The present invention provides a heterocyclic compound having an RORγt inhibitory action.The present invention relates to a compound represented by the formula (I): wherein Ar is a the partial structure (1) to the partial structure (5), Q is a bivalent group selected from the group consisting of (Ia)-(If), and B is a ring optionally having substituent(s), or a salt thereof.
摘要翻译： 本发明提供具有RORγt抑制作用的杂环化合物。 本发明涉及由式（I）表示的化合物：其中Ar是部分结构（5）的部分结构（1），Q是选自（Ia） - （If ），B是任选具有取代基的环或其盐。
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公开(公告)号：US09133129B2
公开(公告)日：2015-09-15
申请号：US14353622
申请日：2012-10-23
发明人： Tohru Yamashita , Takuya Fujimoto , Ryo Mizojiri , Kazuko Yonemori , Hideki Hirose , Zenichi Ikeda , Ikuo Fujimori , Kyoko Toyofuku , Tsuneo Yasuma , Nobuyuki Matsunaga
IPC分类号： A61K31/437 , C07D471/04 , C07D231/56 , A61K31/343 , A61K31/416 , A61K31/4184 , A61K31/422 , A61K31/423 , A61K31/4439 , C07D413/04 , C07D498/04 , C07D307/80 , C07D235/18 , C07D263/57 , C07D513/04
CPC分类号： C07D231/56 , A61K31/343 , A61K31/416 , A61K31/4184 , A61K31/422 , A61K31/423 , A61K31/437 , A61K31/4439 , C07D235/18 , C07D263/57 , C07D307/80 , C07D413/04 , C07D498/04 , C07D513/04
摘要： The present invention provides a compound represented by the formula (I): wherein each symbol is as defined in the specification, or a salt thereof.
摘要翻译： 本发明提供由式（I）表示的化合物：其中每个符号如说明书中所定义，或其盐。
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公开(公告)号：US20140228409A1
公开(公告)日：2014-08-14
申请号：US14346071
申请日：2012-09-21
发明人： Satoshi Yamamoto , Junya Shirai , Yoshiyuki Fukase , Yoshihide Tomata , Ayumu Sato , Atsuko Ochida , Kazuko Yonemori , Hideyuki Nakagawa
IPC分类号： C07D401/12 , C07D209/08 , C07D209/88
CPC分类号： C07D401/12 , A61K31/403 , A61K31/404 , C07D209/08 , C07D209/88
摘要： The present invention provides a fused heterocyclic compound having an RORγt inhibitory action. The present invention relates to a compound represented by the formula (I′): wherein each symbol is as defined in the specification, provided that 2-(2-((4-cyanophenyl)amino)-2-oxoethoxy)-N-(9-ethyl-9H-carbazol-3-yl)acetamide and N-(4-cyanophenyl)-N′-(9-ethyl-9H-carbazol-3-yl)-3-methylpentanediamide are excluded, or a salt thereof.
摘要翻译： 本发明提供具有RORγt抑制作用的稠合杂环化合物。 本发明涉及由式（I'）表示的化合物：其中每个符号如说明书中所定义，条件是2-（2 - （（2-氰基苯基）氨基）-2-氧代乙氧基）-N-（ 9-乙基-9H-咔唑-3-基）乙酰胺和N-（4-氰基苯基）-N' - （9-乙基-9H-咔唑-3-基）-3-甲基戊二酰胺或其盐。
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