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公开(公告)号:US11685710B2
公开(公告)日:2023-06-27
申请号:US17399774
申请日:2021-08-11
Inventor: Daniel J. Siegwart , Jason B. Miller
IPC: C07C311/32 , C12N15/88 , C07F9/09 , C07F9/10 , C12N15/11 , B82Y5/00 , C07C229/06 , A61K47/69 , A61K47/54 , A61K48/00 , C07C309/14 , C12N15/113
CPC classification number: C07C311/32 , A61K47/543 , A61K47/6911 , A61K48/0033 , B82Y5/00 , C07C229/06 , C07C309/14 , C07F9/091 , C07F9/106 , C12N15/11 , C12N15/111 , C12N15/113 , C12N15/88 , C12N2310/14 , C12N2310/20 , C12N2320/32
Abstract: The present disclosure provides one or more amino lipids such as an amino lipids containing a sulfonic acid or sulfonic acid derivative of the formulas:
wherein the variables are as defined herein. These amino lipids may be used in compositions with one or more helper lipids and a nucleic acid therapeutic agent. These compositions may be used to treat a disease or disorder such as cancer, cystic fibrosis, or other genetic diseases.-
公开(公告)号:US11542229B2
公开(公告)日:2023-01-03
申请号:US16744118
申请日:2020-01-15
Inventor: Daniel J. Siegwart , Jason B. Miller
IPC: C07C311/32 , C12N15/88 , C07F9/09 , C07F9/10 , C12N15/11 , B82Y5/00 , C07C229/06 , A61K47/69 , A61K47/54 , A61K48/00 , C07C309/14 , C12N15/113
Abstract: The present disclosure provides one or more amino lipids such as an amino lipids containing a sulfonic acid or sulfonic acid derivative of the formulas: wherein the variables are as defined herein. These amino lipids may be used in compositions with one or more helper lipids and a nucleic acid therapeutic agent. These compositions may be used to treat a disease or disorder such as cancer, cystic fibrosis, or other genetic diseases.
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公开(公告)号:US20220325255A1
公开(公告)日:2022-10-13
申请号:US17710464
申请日:2022-03-31
Inventor: John W. Schoggins , Wenchun Fan , Daniel J. Siegwart , Qiang Cheng
Abstract: Embodiments of the instant disclosure relate to novel antiviral compositions and methods for treating viral infections. In accordance with these embodiments, antiviral compositions can include at least one mRNA encoding for a TRIM7 protein encapsulated into a lipid nanoparticle (LNP). In other embodiments, methods of making antiviral compositions are disclosed as well as methods of administering a composition having at least one mRNA encoding for a TRIM7 protein encapsulated into LNP into a subject.
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公开(公告)号:US11304911B2
公开(公告)日:2022-04-19
申请号:US17473863
申请日:2021-09-13
Inventor: Qiang Cheng , Tuo Wei , Daniel J. Siegwart
Abstract: The present disclosure provides compositions which shown preferential targeting or delivery of a nucleic acid composition to a particular organ. In some embodiments, the composition comprises a steroid or sterol, an ionizable cationic lipid, a phospholipid, a PEG lipid, and a permanently cationic lipid which may be used to deliver a nucleic acid.
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公开(公告)号:US11229609B2
公开(公告)日:2022-01-25
申请号:US17191895
申请日:2021-03-04
Inventor: Qiang Cheng , Tuo Wei , Daniel J. Siegwart
Abstract: The present disclosure provides compositions which shown preferential targeting or delivery of a nucleic acid composition to a particular organ. In some embodiments, the composition comprises a steroid or sterol, an ionizable cationic lipid, a phospholipid, a PEG lipid, and a permanently cationic lipid which may be used to deliver a nucleic acid.
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