公开(公告)号：US20170035868A1

公开(公告)日：2017-02-09

申请号：US15331491

申请日：2016-10-21

Applicant: TORAY INDUSTRIES, INC.

Inventor： Masaki ISHIBASHI ,  Fumiyoshi OKANO

IPC: A61K39/00

CPC classification number: A61K39/0011 ,  A61K38/208 ,  A61K38/212 ,  A61K38/215 ,  A61K2039/53 ,  A61K2300/00

Abstract: An immunity-inducing agent comprising as an effective ingredient a specific polypeptide is disclosed. These polypeptides were isolated, by the SEREX method using a cDNA library derived from canine testis and serum from a cancer-bearing dog, as a polypeptide which binds to an antibody existing specifically in serum derived from a cancer-bearing living body. The polypeptides can induce immunity in a living body and cause regression of a tumor in a cancer-bearing living body. Therefore, these polypeptides are especially effective as a therapeutic and/or prophylactic agent for a cancer(s).

公开(公告)号：US20160136252A1

公开(公告)日：2016-05-19

申请号：US15008101

申请日：2016-01-27

Applicant: TORAY INDUSTRIES, INC.

Inventor： Akira KURIHARA ,  Fumiyoshi OKANO

IPC: A61K39/00 ,  C12N5/0783 ,  C12Q1/68 ,  C12N5/0784

CPC classification number: A61K39/0011 ,  A61K35/17 ,  A61K38/16 ,  C12N5/0636 ,  C12N5/0639 ,  C12Q1/6886 ,  C12Q2600/158

Abstract: An immunity-inducing agent comprising as an effective ingredient(s) a polypeptide(s) selected from the polypeptides: (a) a polypeptide consisting essentially of not less than 7 consecutive amino acids in any one of the amino acid sequences shown in SEQ ID NOs:2, 4, 6, 8, 10, 12 and 44 in SEQUENCE LISTING; (b) a polypeptide having a sequence identity of not less than 90% with the polypeptide (a) and consisting essentially of not less than 7 amino acids; and (c) a polypeptide comprising the polypeptide (a) or (b) as a partial sequence thereof; which polypeptide(s) has/have an immunity-inducing activity/activities, or as an effective ingredient(s) a recombinant vector(s) which comprise(s) a polynucleotide(s) encoding the polypeptide(s) and is/are capable of expressing the polypeptide(s) in vivo, is useful as a therapeutic and/or prophylactic agent for cancer, and/or the like.

Abstract translation: 一种免疫诱导剂，其包含选自以下多肽作为有效成分的多肽：（a）基本上由SEQ ID NO：1所示氨基酸序列中的任一个中不少于7个连续氨基酸组成的多肽 序号：2，4，6，8，10，12和44; （b）与多肽（a）具有不小于90％的序列同一性并且基本上由不少于7个氨基酸组成的多肽; 和（c）包含多肽（a）或（b）作为其部分序列的多肽; 哪些多肽具有/具有免疫诱导活性/活性，或作为有效成分的重组载体，其包含编码多肽的多核苷酸并且是/ 能够在体内表达多肽，可用作癌症的治疗和/或预防剂和/或类似物。

公开(公告)号：US20140341919A1

公开(公告)日：2014-11-20

申请号：US14452746

申请日：2014-08-06

Applicant: TORAY INDUSTRIES, INC.

Inventor： Shinichi KOBAYASHI ,  Fumiyoshi OKANO ,  Takanori SAITO

IPC: C07K16/30

CPC classification number: C07K16/30 ,  A61K39/395 ,  C07K14/4748 ,  C07K16/28 ,  C07K2317/34 ,  C07K2317/732

Abstract: According to the present invention, a cancer antigen protein to be specifically expressed on the surfaces of cancer cells is identified and thus the use of an antibody targeting the cancer antigen protein as an agent for treating and/or preventing a cancer is provided. Specifically, the present invention provides a pharmaceutical composition for treating and/or preventing a cancer, which comprises an antibody or a fragment thereof as an active ingredient having immunological reactivity with a partial polypeptide of CAPRIN-1, wherein CAPRIN-1 is represented by any of the even-numbered sequences of SEQ ID NOS: 2 to 30, and wherein the partial polypeptide comprises the amino acid sequence represented by SEQ ID NO: 37 or an amino acid sequence having 80% or more sequence identity with the amino acid sequence.

Abstract translation: 根据本发明，鉴定在癌细胞表面特异性表达的癌抗原蛋白，因此提供了靶向癌抗原蛋白的抗体作为治疗和/或预防癌症的药剂的用途。 具体地说，本发明提供了用于治疗和/或预防癌症的药物组合物，其包含抗体或其片段作为与CAPRIN-1的部分多肽具有免疫反应性的活性成分，其中CAPRIN-1由任何 的SEQ ID NO：2至30的偶数序列，并且其中所述部分多肽包含由SEQ ID NO：37表示的氨基酸序列或与氨基酸序列具有80％或更多序列同一性的氨基酸序列。

公开(公告)号：US20130230488A1

公开(公告)日：2013-09-05

申请号：US13888137

申请日：2013-05-06

Applicant: TORAY INDUSTRIES, INC.

Inventor： Fumiyoshi OKANO ,  Masaki SHIMIZU ,  Takanori SAITO

IPC: A61K39/00 ,  C12N5/078 ,  C12N5/0783

CPC classification number: A61K39/0011 ,  A61K38/00 ,  A61K38/19 ,  A61K2039/53 ,  C07K14/47 ,  C07K14/4748 ,  C12N5/0634 ,  C12N5/0636 ,  A61K2300/00

Abstract: The invention relates to an immunity-inducing agent comprising, as an active ingredient, at least one polypeptide having immunity-inducing activity that is selected from among polypeptides (a), (b), and (c): (a) a polypeptide of at least seven contiguous amino acids of the amino acid sequence shown by any even SEQ ID number selected from SEQ ID NOs: 2 to 30 listed in the Sequence Listing; (b) a polypeptide of at least seven amino acids having 90% or more sequence identity with the polypeptide (a); and (c) a polypeptide comprising the polypeptide (a) or (b) as a partial sequence thereof, or a recombinant vector comprising a polynucleotide encoding said polypeptide and capable of expressing said polypeptide in vivo.

Abstract translation: 本发明涉及一种免疫诱导剂，其包含作为活性成分的至少一种具有免疫诱导活性的多肽，其选自多肽（a），（b）和（c）：（a）多肽 氨基酸序列的至少七个连续氨基酸由选自序列表中所列的SEQ ID NO：2至30的任何偶数SEQ ID号表示; （b）与多肽（a）具有90％或更多序列同一性的至少7个氨基酸的多肽; 以及（c）包含多肽（a）或（b）作为其部分序列的多肽，或包含编码所述多肽并能够在体内表达所述多肽的多核苷酸的重组载体。

公开(公告)号：US20240374716A1

公开(公告)日：2024-11-14

申请号：US18686924

申请日：2022-08-29

Applicant: TORAY INDUSTRIES, INC.

Inventor： Kyoko SHIBAHARA ,  Fumiyoshi OKANO ,  Joonsik PARK

IPC: A61K39/39 ,  A61K9/113 ,  A61K9/14 ,  A61K31/716 ,  A61K31/78 ,  A61K39/00 ,  A61P37/04

Abstract: Provided is a composition for enhancing immunogenicity, having potent immuno-stimulating capacity. A composition for enhancing immunogenicity, containing, as an active ingredient, a mixture and an immuno-stimulating factor, wherein the mixture comprises a particle comprising an amphiphilic polymer in which a hydrophobic segment is poly(hydroxy acid) and a hydrophilic segment is β-glucan, and an antigen.

公开(公告)号：US20240366739A1

公开(公告)日：2024-11-07

申请号：US18692396

申请日：2022-09-15

Applicant: TORAY INDUSTRIES, INC.

Inventor： Kyoko SHIBAHARA ,  Fumiyoshi OKANO

IPC: A61K39/00 ,  A61K31/4745 ,  A61K39/39 ,  A61P35/00

Abstract: A combination medicament comprising: a particle comprising an amphiphilic polymer in which a hydrophobic segment is poly(hydroxy acid) and a hydrophilic segment is polysaccharide, and a cancer antigen; and an immuno-stimulating factor, can be used so that the particle and the immuno-stimulating factor are separately administered to a subject, thereby allowing for enhancement in treatment and/or prevention of cancer effect.

公开(公告)号：US20230159635A1

公开(公告)日：2023-05-25

申请号：US17910549

申请日：2021-03-11

Applicant: TORAY INDUSTRIES, INC.

Inventor： Fumiyoshi OKANO

IPC: C07K16/28 ,  A61P35/00

CPC classification number: C07K16/28 ,  C07K16/2818 ,  C07K16/2827 ,  A61P35/00 ,  C07K2317/24 ,  C07K2317/622

Abstract: An object of the present invention is to provide a medicament for treatment and/or prevention of cancer. In order to attain the object, the present invention provides a medicament for treatment and/or prevention of cancer, comprising an antibody or a fragment thereof having an immunological reactivity with CAPRIN-1 protein, and an immune checkpoint inhibitor together or separately in combination.

公开(公告)号：US20230140155A1

公开(公告)日：2023-05-04

申请号：US17910544

申请日：2021-03-11

Applicant: TORAY INDUSTRIES, INC.

Inventor： Fumiyoshi OKANO

IPC: A61K39/395 ,  A61K31/282 ,  A61K31/7068 ,  A61P35/00 ,  A61P15/08

Abstract: An object of the present invention is to provide a pharmaceutical composition for treatment and/or prevention of cancer. The present invention provides a medicament for treatment and/or prevention of cancer in a cancer patient with a previous history of another cancer treatment, comprising an antibody or a fragment thereof having an immunological reactivity with CAPRIN-1 protein, and a pyrimidine-based drug and carboplatin together or separately in combination.

公开(公告)号：US20230139178A1

公开(公告)日：2023-05-04

申请号：US17910522

申请日：2021-03-11

Applicant: TORAY INDUSTRIES, INC.

Inventor： Fumiyoshi OKANO

IPC: A61K31/505 ,  A61K33/243 ,  C07K16/28

Abstract: An object of the present invention is to provide a medicament for treatment and/or prevention of cancer. The present invention provides a medicament for treatment and/or prevention of cancer, comprising an antibody or a fragment thereof having an immunological reactivity with CAPRIN-1 protein, and a pyrimidine fluoride-based drug, a folinic acid-based drug and one or more additional drugs together or separately in combination.

公开(公告)号：US20230030982A1

公开(公告)日：2023-02-02

申请号：US17960354

申请日：2022-10-05

Applicant: TORAY INDUSTRIES, INC.

Inventor： Takayuki FUJITA ,  Fumiyoshi OKANO

IPC: C07K16/30 ,  A61K45/00 ,  A61K38/00 ,  C07K16/28 ,  A61P35/00 ,  A61K39/395 ,  A61K45/06

Abstract: An object of the present invention is to identify cancer antigen proteins specifically expressed on the surface of cancer cells and to provide a use of antibodies targeting such proteins as therapeutic and/or preventive agents for cancer. The present invention relates to, for example, a pharmaceutical composition for treatment and/or prevention of a cancer, which comprises, as an active ingredient, an antibody or fragment thereof having an immunological reactivity with an MCEMP1 protein having an amino acid sequence shown in any one of the even numbered SEQ ID NOS: 2 to 8 or an amino acid sequence having 80% or more sequence identity with the amino acid sequence, or with a fragment of the MCEMP1 protein comprising 7 or more consecutive amino acids.