公开(公告)号：US06854668B2

公开(公告)日：2005-02-15

申请号：US10136270

申请日：2002-04-29

申请人： Thomas Francis Wancho ,  David Mann

发明人： Thomas Francis Wancho ,  David Mann

IPC分类号： A62C31/02 ,  B05B1/26 ,  A62C37/08

CPC分类号： B05B1/265 ,  A62C31/02 ,  A62C37/14

摘要： A sprinkler discharges a column of water downwardly onto a deflector that has a plurality of peripheral tines with a respective non-radial tapered notch separating each adjacent pair of tines. Opposed cutouts with tabs in the central portion of the deflector combine with the notches and with depressed peripheral tabs to produce a predetermined spray pattern.

摘要翻译： 喷洒器将一列水向下排放到具有多个周边齿的偏转器上，该偏转器具有分开每个相邻齿尖的相应的非径向锥形切口。 在偏转器的中心部分中具有突片的相对的切口与凹口结合并且具有凹陷的周边突片以产生预定的喷射图案。

公开(公告)号：US20190022170A1

公开(公告)日：2019-01-24

申请号：US15502170

申请日：2015-08-04

申请人： David MANN ,  Erkki RUOSLAHTI ,  Masanobu KOMATSU ,  Vascular BioSciences ,  Sanford Burnham Prebys Medical Discovery Institute

发明人： David Mann ,  Erkki Ruoslahti ,  Masanobu Komatsu

IPC分类号： A61K38/12 ,  A61K38/08 ,  A61K47/64 ,  A61K31/436 ,  A61K31/438 ,  A61K31/18 ,  A61K31/337 ,  A61K31/506 ,  A61P13/12 ,  A61P31/00 ,  A61P11/00 ,  A61P1/16 ,  A61P35/00 ,  A61P9/12 ,  G01N33/50 ,  C40B50/02

摘要： Compositions and methods useful for delivery of targeted therapies for pulmonary arterial hypertension, sepsis, cancer and cachexia. The compositions and methods are based on peptide pharmacophores that selectively bind to and home to diseased tissue and enable targeted therapies to affect a beneficial therapeutic result. Peptide pharmacophores may selectively target tumor vasculature, regenerating tissue, wounded tissue, inflamed tissue, fibrotic tissue, remodeled tissue, tissue characterized by elevated heparanase levels, and have the ability to internalize into such diseased cells.

公开(公告)号：US20160022759A1

公开(公告)日：2016-01-28

申请号：US14649455

申请日：2013-12-03

申请人： David MANN ,  Vascular BioSciences

发明人： David Mann

IPC分类号： A61K38/08 ,  A61K45/06 ,  C12Q1/34

CPC分类号： A61K38/08 ,  A61K45/06 ,  C12Q1/34 ,  G01N33/6893 ,  G01N2333/926 ,  G01N2800/12 ,  G01N2800/321

摘要： Disclosed are compositions and methods for triggering disease selective macropinocytosis. The compositions can serve as a marker of disease activity and as a trigger of enhanced macropinocytosis in tissues undergoing disease remodeling such as wound healing, cancer, PAH, inflammation, diabetes, Crohn's disease, ulcerative colitis, ankylosing spondylitis, diseases of the endometrium, psoriasis, irritable bowel syndrome, arthritis, fibrotic disorders, interstitial cystitis, autoimmune diseases, asthma, acute lung injury, and adult respiratory distress syndrome. The compositions can also serve as a receptor for disease selective cell penetrating peptides in the cells and extracellular matrix of diseased tissues.

摘要翻译： 公开了用于引发疾病选择性巨噬细胞增多症的组合物和方法。 组合物可以作为疾病活动的标志物，并且作为经历疾病重塑的组织中增强的巨噬细胞增多的触发因素，例如伤口愈合，癌症，PAH，炎症，糖尿病，克罗恩病，溃疡性结肠炎，强直性脊柱炎，子宫内膜疾病，牛皮癣 肠易激综合征，关节炎，纤维化疾病，间质性膀胱炎，自身免疫疾病，哮喘，急性肺损伤和成人呼吸窘迫综合征。 组合物还可以用作疾病选择性细胞穿透肽在患病组织的细胞和细胞外基质中的受体。

公开(公告)号：US20100307321A1

公开(公告)日：2010-12-09

申请号：US12791798

申请日：2010-06-01

申请人： David Mann ,  Francesco Gerald Capodieci ,  Reza Rassool

发明人： David Mann ,  Francesco Gerald Capodieci ,  Reza Rassool

IPC分类号： G10H1/38

CPC分类号： G10H7/00 ,  G06F3/0481 ,  G06F3/167 ,  G09B15/00 ,  G10H1/0025 ,  G10H1/38 ,  G10H2210/125 ,  G10H2220/101 ,  G10H2220/111 ,  G10H2230/015 ,  G10H2240/075

摘要： An apparatus for enhancing audio comprising a first interface and a harmonizing module is disclosed. The first interface receive a first audio segment from a first source. The harmonizing module is coupled to the first interface. The harmonizing module is configured to identify at least one musical property of the first audio segment; calculate a subset of notes that are harmonious with the first audio segment based on the at least one musical property; and select from the subset of notes to generate an audio track to be played substantially synchronously with the first audio segment. A second interface may also be provided to receive a second audio segment from a second source. In this case, the harmonizing module may be configured to generate the audio track by transforming one or more notes of the second audio segment. A method is also provided.

摘要翻译： 公开了一种用于增强音频的装置，包括第一接口和协调模块。 第一个接口从第一个源接收第一个音频段。 协调模块耦合到第一接口。 协调模块被配置为识别第一音频段的至少一个音乐属性; 基于所述至少一个音乐属性计算与所述第一音频段和谐的音符的子集; 并且从音符子集中选择以产生要与第一音频段基本同步地播放的音轨。 还可以提供第二接口以从第二源接收第二音频段。 在这种情况下，协调模块可以被配置为通过变换第二音频段的一个或多个音符来生成音轨。 还提供了一种方法。

公开(公告)号：US20080056964A1

公开(公告)日：2008-03-06

申请号：US11932140

申请日：2007-10-31

申请人： SHASHI SINGH ,  David Mann ,  Anant Pisut

发明人： SHASHI SINGH ,  David Mann ,  Anant Pisut

IPC分类号： B01J19/00

CPC分类号： C01C1/0423 ,  B01J8/008 ,  B01J8/067 ,  B01J23/462 ,  B01J2208/00212 ,  B01J2208/00221 ,  B01J2208/00513 ,  B01J2208/00548 ,  B01J2219/00238 ,  C01C1/0441 ,  C01C1/0482 ,  Y02E60/364 ,  Y02P20/52

摘要： An ammonia converter is disclosed. The converter can alter the conversion of ammonia by controlling the reaction temperature of the exothermic reaction along the length of the reactor to parallel the equilibrium curve for the desired product. The converter can comprise a shell 101 and internal catalyst tubes 109. The feed gas stream enters the reactor, flows through the shell 101, and is heated by indirect heat exchange with the catalyst tubes 109. The catalyst tubes 109 comprise reactive zones 122 having catalyst and reaction limited zones 124 that can comprise inert devices that function to both separate the reactive zones, increase heat transfer area, and reduce the temperature of the reaction mixture as the effluent passes through the catalyst tube 109

摘要翻译： 公开了一种氨转化器。 转化器可以通过控制沿着反应器长度的放热反应的反应温度来平行所需产物的平衡曲线来改变氨的转化率。 转化器可以包括壳体101和内部催化剂管109.进料气体流进入反应器，流过壳体101，并通过与催化剂管109的间接热交换而加热。催化剂管109包含具有催化剂的反应区域122 以及反应限制区124，其可以包括用于分离反应性区域的惰性装置，增加传热面积，并且当流出物通过催化剂管109时降低反应混合物的温度

公开(公告)号：US20070007221A1

公开(公告)日：2007-01-11

申请号：US11456085

申请日：2006-07-06

申请人： David Mann

发明人： David Mann

IPC分类号： A47F1/04

CPC分类号： A47F1/087 ,  A47F1/126

摘要： A retail merchandising apparatus affording assured automatic product rotation, labor-savings associated with reduced stocking times and the elimination for the need to manually rotate product. The apparatus also provides greatly enhanced permanent brand-identification, brand exposure and distinction from competitor's in the grocery aisle due to the product always being in an upright position throughout the loading and dispensing process and the superior graphic presence presented on the apparatus.

摘要翻译： 零售商品设备提供了确保的自动产品旋转，与减少库存时间相关的劳动力节省以及消除了手动旋转产品的需要。 该设备还提供了极大增强的永久品牌识别，品牌曝光和与杂货通道中竞争对手的区别，因为产品在整个装载和分发过程中始终处于直立位置，并且在设备上呈现出卓越的图形存在。

公开(公告)号：US20060082262A1

公开(公告)日：2006-04-20

申请号：US11175732

申请日：2005-07-06

申请人： Christopher DeMarco ,  Luanne Dino ,  David Mann ,  Dan Riley

发明人： Christopher DeMarco ,  Luanne Dino ,  David Mann ,  Dan Riley

IPC分类号： A47B53/00

CPC分类号： A47F1/12 ,  A47F1/087 ,  A47F7/28

摘要： An apparatus is provides which includes a frame configured to be supported by a customer-accessible lower shelf, the lower shelf being adapted to support a plurality of items, and an upper shelf supported by the frame at an angle thereto, the upper shelf also being adapted to support a plurality of items and having an opening at a lower end thereof, so that an item supported by the upper shelf drops onto the lower shelf, through the opening, after an item is removed from the lower shelf.

摘要翻译： 提供了一种设备，其包括构造成由客户可访问的下架支撑的框架，下搁架适于支撑多个物品，以及由框架以一定角度支撑的上搁架，上搁架还 适于支撑多个物品并且在其下端具有开口，使得在从下搁板移除物品之后，由上搁架支撑的物品通过开口落到下架上。

公开(公告)号：US20050039294A1

公开(公告)日：2005-02-24

申请号：US10643626

申请日：2003-08-19

申请人： David Mann

发明人： David Mann

IPC分类号： B05C17/02 ,  B05C21/00

CPC分类号： B44D3/128 ,  B05C17/0245

摘要： Paint roller grid includes a pair of hooks each including a rearwardly extending upper portion and a downwardly extending inturned lip having a forwardly facing inwardly angled surface for engaging an outer cylindrical surface of a container below the container rim when the hooks are hooked over the container rim and the grid is inserted into the top opening of the container. The hooks may be spaced from a bottom edge of the grid a distance slightly greater than the height of the container, whereby when the grid is inserted into the container opening and the hooks are hooked over the container rim, the bottom edge of the grid will engage the inside bottom surface of the container. A pair of feet may extend rearwardly from the grid for engagement with the inner cylindrical surface of the container to prevent the grid from moving within the container during rolling of a roller cover on the grid wiping surface.

摘要翻译： 油漆滚筒网格包括一对钩，每个钩包括向后延伸的上部部分和向下延伸的内侧唇缘，其具有朝前的向内成角度的表面，用于当钩钩在容器边缘上方时接合容器边缘下方的容器的外圆柱形表面 并且格栅被插入容器的顶部开口中。 钩子可以与网格的底部边缘间隔开一个略大于容器高度的距离，由此当格栅插入容器开口中并且钩被钩在容器边缘上时，网格的底部边缘将 接合容器的内底面。 一对脚可以从网格向后延伸以与容器的内圆柱形表面接合，以防止在滚子盖在网格擦拭表面上滚动时格栅在容器内移动。

公开(公告)号：US11642391B2

公开(公告)日：2023-05-09

申请号：US15502170

申请日：2015-08-04

申请人： Vascular BioSciences ,  Sanford Burnham Prebys Medical Discovery Institute ,  David Mann ,  Erkki Ruoslahti ,  Masanobu Komatsu

发明人： David Mann ,  Erkki Ruoslahti ,  Masanobu Komatsu

IPC分类号： A61K38/12 ,  G16B35/00 ,  G16C20/60 ,  A61K31/337 ,  A61K31/506 ,  A61K38/55 ,  A61K45/06 ,  A61K31/222 ,  A61K31/573 ,  A61K47/68 ,  A61K47/64 ,  G01N33/15 ,  G16B35/20 ,  G16B35/10 ,  A61P31/00 ,  A61P1/16 ,  A61P9/12 ,  A61P13/12 ,  A61P11/00 ,  A61P35/00 ,  A61K31/18 ,  A61K31/436 ,  A61K31/438 ,  A61K38/08 ,  G01N33/50

CPC分类号： A61K38/12 ,  A61K31/18 ,  A61K31/222 ,  A61K31/337 ,  A61K31/436 ,  A61K31/438 ,  A61K31/506 ,  A61K31/573 ,  A61K38/08 ,  A61K38/55 ,  A61K45/06 ,  A61K47/64 ,  A61K47/643 ,  A61K47/6811 ,  A61K47/6851 ,  A61P1/16 ,  A61P9/12 ,  A61P11/00 ,  A61P13/12 ,  A61P31/00 ,  A61P35/00 ,  G01N33/15 ,  G01N33/5008 ,  G16B35/00 ,  G16B35/10 ,  G16B35/20 ,  G16C20/60 ,  A61K31/506 ,  A61K2300/00 ,  A61K31/222 ,  A61K2300/00 ,  A61K31/337 ,  A61K2300/00 ,  A61K31/573 ,  A61K2300/00

摘要： Compositions and methods useful for delivery of targeted therapies for pulmonary arterial hypertension, sepsis, cancer and cachexia. The compositions and methods are based on peptide pharmacophores that selectively bind to and home to diseased tissue and enable targeted therapies to affect a beneficial therapeutic result. Peptide pharmacophores may selectively target tumor vasculature, regenerating tissue, wounded tissue, inflamed tissue, fibrotic tissue, remodeled tissue, tissue characterized by elevated heparanase levels, and have the ability to internalize into such diseased cells.

公开(公告)号：US08389119B2

公开(公告)日：2013-03-05

申请号：US11881746

申请日：2007-07-26

申请人： Matthew Panzer ,  Kenneth E. Goodson ,  Xuejiao Hu ,  David Mann

发明人： Matthew Panzer ,  Kenneth E. Goodson ,  Xuejiao Hu ,  David Mann

IPC分类号： H01L23/373 ,  H01L23/42

CPC分类号： B32B37/02 ,  B32B2038/0092 ,  B32B2309/02 ,  B32B2309/105 ,  B32B2311/00 ,  B32B2313/04 ,  B82Y10/00 ,  B82Y30/00 ,  H01L23/373 ,  H01L2924/0002 ,  Y10T428/14 ,  Y10T428/24124 ,  Y10T428/24132 ,  Y10T428/24174 ,  Y10T428/249927 ,  Y10T428/30 ,  H01L2924/00

摘要： A thermal interface material includes a mechanically compliant vertically aligned nanofiber film and a binder material for joining the nanofibers of the film to the surfaces of two substrates. Preferably, the binder material comprises a non-hydrocarbon-based material such as a metallic eutectic with a melting temperature below a nanofiber thermal damage threshold temperature of the film. The film is grown on a substrate which is then bonded to another substrate by the binder material in an adhesion process that may include pressure and heat. Alternatively, the film may be released from the substrate to produce a stand-alone thermal tape which may later be placed between two substrates and bonded.