-
公开(公告)号：US11439609B2
公开(公告)日：2022-09-13
申请号：US15735122
申请日：2016-06-10
摘要： A polymeric composition includes poly(lactide-co-glycolide) (PLGA) microspheres; and at least one of a discrete RSNO adduct or a polymeric RSNO encapsulated within the microspheres, with the at least one of the discrete RSNO adduct or the polymeric RSNO adduct capable of releasing nitric oxide (NO). The polymeric composition exhibits stability under dry conditions at 37° C. and prolonged and controllable NO release rates, when exposed to light capable of photolyzing an RSNO bond, or when exposed to moisture, for a predetermined amount of time from the at least one of the discrete RSNO adduct or the polymeric RSNO adduct.
-
公开(公告)号：US11103622B2
公开(公告)日：2021-08-31
申请号：US14765828
申请日：2014-02-06
IPC分类号： A61K31/197 , A61L29/16 , A61L29/08 , A61K31/198 , A61K33/00 , A61L33/04 , C08J5/18 , A61L33/00 , C08J7/046 , A61K9/70 , C08J7/02 , C08J7/06
摘要： A polymeric film includes a polymer matrix having at least one of a discrete RSNO adduct or a polymeric RSNO adduct associated therewith, by: covalent attachment to the polymer matrix; dispersion within the polymer matrix; or both, with the at least one of the discrete RSNO adduct or the polymeric RSNO adduct capable of releasing nitric oxide (NO). The polymer matrix is a polyurethane polymer matrix, a silicone rubber polymer matrix, or a copolymer matrix of polyurethane and silicone rubber. The polymeric film is to exhibit stability under dry conditions at 37° C. and prolonged and controllable NO release rates, when exposed to moisture or light capable of photolyzing an RSNO bond, for a predetermined amount of time from the at least one of the discrete RSNO adduct or the polymeric RSNO adduct.
-
公开(公告)号：US20200316605A1
公开(公告)日：2020-10-08
申请号：US16841215
申请日：2020-04-06
摘要： Provided herein is technology relating to microfluidics and particularly, but not exclusively, to devices, methods, and systems for detecting and/or quantifying analytes in samples using a microfluidic sensor device.
-
公开(公告)号：US10449321B2
公开(公告)日：2019-10-22
申请号：US15484981
申请日：2017-04-11
发明人： Mark E. Meyerhoff , Nicolai Lehnert , Yu Qin , Andrew P. Hunt , Elizabeth J. Brisbois , Hang Ren
摘要： A gas delivery device includes a nitric oxide generating system. The system has a medium including a source of nitrite ions. A working electrode is in contact with the medium. A Cu(II)-ligand complex is in contact with the working electrode. A reference/counter electrode is, or a reference electrode and a counter electrode are in contact with the medium and separated from the working electrode. An inlet conduit is to deliver nitrogen gas to the medium, and an outlet conduit is to transport a stream of nitrogen gas and nitric oxide from the medium. An inspiratory gas conduit is operatively connected to the outlet conduit to introduce an oxygen-containing gas and form an output gas stream of the gas delivery device.
-
25.发明授权Sustained nitric oxide release coating using diazeniumdiolate-doped polymer matrix with ester capped poly(lactic-co-glycolic acid) additive 有权使用掺二氮烯二恶英掺杂聚合物基质和酯封端聚（乳酸 - 乙醇酸）添加剂的持续一氧化氮释放涂层公开(公告)号：US09566372B2
公开(公告)日：2017-02-14
申请号：US14430545
申请日：2013-09-25
发明人： Hitesh Handa , Mark E. Meyerhoff , Robert H. Bartlett , Elizabeth J. Brisbois , Lahdan Refahiyat
IPC分类号： A61L31/16 , C08L27/06 , C08G18/61 , A61L29/04 , A61L29/14 , A61L29/16 , A61L31/04 , A61L31/14
CPC分类号： A61L31/16 , A61L29/049 , A61L29/141 , A61L29/16 , A61L31/041 , A61L31/141 , A61L2300/114 , A61L2300/802 , C08G18/61 , C08K5/32 , C08L27/06 , C08L67/04 , C08L83/04
摘要： A polymeric composition includes a polymer matrix having a lipophilic discrete nitric oxide adduct and/or a polymeric nitric oxide adduct associated therewith, by covalent attachment to the polymer matrix and/or by dispersion within the polymer matrix, with the discrete nitric oxide adduct and/or the polymeric nitric oxide adduct being capable of releasing nitric oxide (NO). The polymeric composition further includes an ester capped poly(lactide-co-glycolide) (PLGA) additive to at least one of increase, prolong, and control NO release rates from the lipophilic discrete nitric oxide adduct and/or the polymeric nitric oxide adduct.
摘要翻译： 聚合物组合物包括具有亲脂性离散一氧化氮加合物和/或与其相关的聚合一氧化氮加合物的聚合物基质，通过共价连接到聚合物基质和/或通过聚合物基质内的分散体与离散的一氧化氮加合物和/ 或能够释放一氧化氮（NO）的聚合一氧化氮加合物。 所述聚合物组合物还包含酯封端的聚（丙交酯 - 共 - 乙交酯）（PLGA）添加剂，用于增加，延长和控制来自亲脂性离散一氧化氮加合物和/或聚合一氧化氮加合物的NO释放速率中的至少一种。
-
26.发明申请SUSTAINED NITRIC OXIDE RELEASE COATING USING DIAZENIUMDIOLATE-DOPED POLYMER MATRIX WITH ESTER CAPPED POLY(LACTIC-CO-GLYCOLIC ACID) ADDITIVE 有权使用具有ESTER CAPPED POLY（LACTIC-CO-GLYCOLIC ACID）添加剂的DIAZENIUMPOLATE-DOPED POLYMER MATRIX的持久氮氧化物涂层公开(公告)号：US20150238662A1
公开(公告)日：2015-08-27
申请号：US14430545
申请日：2013-09-25
发明人： Hitesh Handa , Mark E. Meyerhoff , Robert H. Bartlett , Elizabeth J. Brisbois , Lahdan Refahiyat
CPC分类号： A61L31/16 , A61L29/049 , A61L29/141 , A61L29/16 , A61L31/041 , A61L31/141 , A61L2300/114 , A61L2300/802 , C08G18/61 , C08K5/32 , C08L27/06 , C08L67/04 , C08L83/04
摘要： A polymeric composition includes a polymer matrix having a lipophilic discrete nitric oxide adduct and/or a polymeric nitric oxide adduct associated therewith, by covalent attachment to the polymer matrix and/or by dispersion within the polymer matrix, with the discrete nitric oxide adduct and/or the polymeric nitric oxide adduct being capable of releasing nitric oxide (NO). The polymeric composition further includes an ester capped poly(lactide-co-glycolide) (PLGA) additive to at least one of increase, prolong, and control NO release rates from the lipophilic discrete nitric oxide adduct and/or the polymeric nitric oxide adduct.
摘要翻译： 聚合物组合物包括具有亲脂性离散一氧化氮加合物和/或与其相关的聚合一氧化氮加合物的聚合物基质，通过共价连接到聚合物基质和/或通过聚合物基质内的分散体与离散的一氧化氮加合物和/ 或能够释放一氧化氮（NO）的聚合一氧化氮加合物。 所述聚合物组合物还包含酯封端的聚（丙交酯 - 共 - 乙交酯）（PLGA）添加剂，用于增加，延长和控制来自亲脂性离散一氧化氮加合物和/或聚合一氧化氮加合物的NO释放速率中的至少一种。
-
27.发明申请METHOD FOR DETERMINING TEAR GLUCOSE CONCENTRATION WITH BLOOD GLUCOSE TEST STRIPS 审中-公开用于测定葡萄糖葡萄糖浓度的方法公开(公告)号：US20140262830A1
公开(公告)日：2014-09-18
申请号：US14208891
申请日：2014-03-13
IPC分类号： C12Q1/00
CPC分类号： C12Q1/006
摘要： A method for determining glucose concentration in tear fluid includes providing a blood glucose test strip having glucose dehydrogenase as an active enzyme provided therein, receiving a tear fluid sample via fluid communication of the blood glucose test strip with an eye region of a subject, and processing the tear fluid sample to determine a tear glucose concentration. The method may further include correlating the determined tear glucose concentration with a blood glucose concentration.
摘要翻译： 用于测定泪液中的葡萄糖浓度的方法包括提供具有葡萄糖脱氢酶作为其中提供的活性酶的血糖测试条，通过血糖测试条与受试者的眼睛区域的流体连通接收泪液样品，以及处理 泪液样品确定泪液葡萄糖浓度。 该方法还可以包括将确定的泪液葡萄糖浓度与血糖浓度相关联。
-
-
-
-
-
-
搜索结果
27 条记录 (耗时 0.024 秒)
