公开(公告)号：US20210210331A1

公开(公告)日：2021-07-08

申请号：US15734124

申请日：2019-05-24

申请人： Thermo Finnigan LLC

发明人： Michael W. SENKO ,  Jesse D. CANTERBURY

IPC分类号： H01J49/42 ,  H01J49/00 ,  H01J49/02

摘要： Apparatus and methods for performing charge detection mass spectrometry are disclosed. An analyte ion is injected into an electrostatic trap, which has electrodes shaped and arranged to establish a trapping field that causes the analyte ion to undergo harmonic motion along a longitudinal axis. A time-varying signal is generated by a detector representative of the harmonic motion. A data system processes the time-varying signal to derive the frequency of ion motion and the amplitude at the harmonic motion frequency, and determines the mass-to-charge ratio (m/z) of the ion based on the derived frequency and the charge from the derived amplitude. The product of the experimentally determined m/z and charge yields the mass of the analyte ion. The electrodes preferably include an elongated inner electrode surrounded by an outer electrode, forming an orbital or non-orbital electrostatic trap.

公开(公告)号：US20160336163A1

公开(公告)日：2016-11-17

申请号：US14709329

申请日：2015-05-11

申请人： Thermo Finnigan LLC

发明人： Philip M. REMES ,  Michael W. SENKO ,  Jae C. SCHWARTZ

IPC分类号： H01J49/42

CPC分类号： H01J49/422 ,  H01J49/428

摘要： A mass spectrometer includes a radio frequency ion trap; and a controller. The controller is configured to cause an ion population to be injected into the radio frequency ion trap; supply a first isolation waveform to the radio frequency ion trap for a first duration, and supply a second isolation waveform to the radio frequency ion trap for a second duration. The first isolation waveform has at least a first wide notch at a first mass-to-charge ratio, and the second isolation waveform has at least a first narrow notch at the first mass-to-charge ratio. The first and second isolation waveforms are effective to isolate one or more precursor ions from the ion population.

摘要翻译： 质谱仪包括射频离子阱; 和控制器。 控制器配置成使离子群体注入射频离子阱; 在第一持续时间内向射频离子阱提供第一隔离波形，并在第二持续时间内向射频离子阱提供第二隔离波形。 第一隔离波形具有至少第一宽电容比的第一宽陷波，第二隔离波形至少具有第一质荷比的第一窄陷波。 第一和第二隔离波形对从离子群体分离一个或多个前体离子是有效的。

公开(公告)号：US20160042937A1

公开(公告)日：2016-02-11

申请号：US14885755

申请日：2015-10-16

申请人： Thermo Finnigan LLC

发明人： Philip M. REMES ,  Michael W. SENKO ,  Justin BLETHROW

IPC分类号： H01J49/42

CPC分类号： H01J49/4265 ,  H01J49/0009 ,  H01J49/0027 ,  H01J49/0031 ,  H01J49/0036 ,  H01J49/004 ,  H01J49/26

摘要： A method for mass analyzing ions comprising a restricted range mass-to-charge (m/z) ratios comprising (i) performing a survey mass analysis, using a first mass analyzer employing indirect detection of ions by image current detection, to measure a flux of ions having m/z ratios within said range and (ii) performing a dependent mass analysis, using a second mass analyzer, of an optimal quantity of ions having m/z ratios within said range, said optimal quantity collected for a time period determined by the measured ion flux, the method characterized in that: the time period is determined using a corrected ion flux that includes a correction that comprises an estimate of the quantity of ions that are undetected by the first mass analyzer.

摘要翻译： 一种用于质量分析离子的方法，包括受限范围的质荷比（m / z）比，其包括：（i）使用通过图像电流检测间接检测离子的第一质量分析器进行测量质量分析，以测量通量 的离子，其m / z比在所述范围内，并且（ii）使用第二质量分析器进行在所述范围内具有m / z比的最佳离子量的依赖质量分析，所述最佳量在所确定的时间段内收集 通过测量的离子通量，该方法的特征在于：使用包括校正的校正离子通量来确定时间段，该校正包括由第一质量分析器未检测到的离子量的估计。

公开(公告)号：US20140361158A1

公开(公告)日：2014-12-11

申请号：US14297092

申请日：2014-06-05

申请人： Thermo Finnigan LLC

发明人： Philip M. REMES ,  Michael W. SENKO ,  Justin BLETHROW

IPC分类号： H01J49/00 ,  H01J49/26

CPC分类号： H01J49/4265 ,  H01J49/0009 ,  H01J49/0027 ,  H01J49/0031 ,  H01J49/0036 ,  H01J49/004 ,  H01J49/26

摘要： A method for mass analyzing ions comprising a restricted range mass-to-charge (m/z) ratios comprising (i) performing a survey mass analysis, using a first mass analyzer employing indirect detection of ions by image current detection, to measure a flux of ions having m/z ratios within said range and (ii) performing a dependent mass analysis, using a second mass analyzer, of an optimal quantity of ions having m/z ratios within said range, said optimal quantity collected for a time period determined by the measured ion flux, the method characterized in that: the time period is determined using a corrected ion flux that includes a correction that comprises an estimate of the quantity of ions that are undetected by the first mass analyzer.

摘要翻译： 一种用于质量分析离子的方法，包括受限范围的质荷比（m / z）比，其包括：（i）使用通过图像电流检测间接检测离子的第一质量分析器进行测量质量分析，以测量通量 的离子，其m / z比在所述范围内，并且（ii）使用第二质量分析器进行在所述范围内具有m / z比的最佳离子量的依赖质量分析，所述最佳量在所确定的时间段内收集 通过测量的离子通量，该方法的特征在于：使用包括校正的校正离子通量来确定时间段，该校正包括由第一质量分析器未检测到的离子量的估计。