公开(公告)号：US20140256707A1

公开(公告)日：2014-09-11

申请号：US14238816

申请日：2012-08-16

申请人： Thomas Dineen ,  Isaac E. Marx ,  Hanh Nho Nguyen ,  Matthew Weiss

发明人： Thomas Dineen ,  Isaac E. Marx ,  Hanh Nho Nguyen ,  Matthew Weiss

IPC分类号： C07D471/04 ,  C07D417/12 ,  C07D403/14 ,  C07D417/14

CPC分类号： C07D471/04 ,  C07D403/14 ,  C07D417/12 ,  C07D417/14

摘要： The present invention provides compounds of Formula I or II, or pharmaceutically acceptable salts thereof, that are inhibitors of voltage-gated sodium channels, in particular Nav 1.7. The compounds are useful for the treatment of diseases treatable by inhibition of channels such as pain disorders. Also provided are pharmaceutical compositions containing compounds of the present invention.

摘要翻译： 本发明提供式I或II的化合物或其药学上可接受的盐，其是电压门控钠通道的抑制剂，特别是Nav 1.7。 该化合物可用于治疗通过抑制诸如疼痛障碍的通道可治疗的疾病。 还提供含有本发明化合物的药物组合物。

公开(公告)号：US08497264B2

公开(公告)日：2013-07-30

申请号：US13047693

申请日：2011-03-14

申请人： Jian J. Chen ,  Wenge Zhong ,  Bryant Yang ,  Ryan White ,  Matthew Weiss ,  Timothy Powers ,  Yuan Cheng

发明人： Jian J. Chen ,  Wenge Zhong ,  Bryant Yang ,  Ryan White ,  Matthew Weiss ,  Timothy Powers ,  Yuan Cheng

IPC分类号： C07D513/10 ,  C07D498/20 ,  A61K31/547 ,  A61K31/5386

CPC分类号： C07D513/10 ,  C07D498/10 ,  C07D498/20 ,  C07D513/20

摘要： The present invention comprises a new class of compounds useful for the modulation of Beta-secretase enzyme activity and for the treatment of Beta-secretase mediated diseases, including Alzheimer's disease (AD) and related conditions. In one embodiment, the compounds have a general Formula I wherein A1, A2, A3, A4, A5, A6, R2, R7, X, Y and Z of Formula I are defined herein. The invention also includes use of these compounds in pharmaceutical compositions for treatment, prophylactic or therapeutic, of disorders and conditions related to the activity of beta-secretase protein. Such disorders include, for example, Alzheimer's Disease, cognitive deficits, cognitive impairment, schizophrenia and other central nervous system conditions related to and/or caused by the formation and/or deposition of plaque on the brain. The invention also comprises further embodiments of Formula I, intermediates and processes useful for the preparation of compounds of Formula I.

公开(公告)号：US08957083B2

公开(公告)日：2015-02-17

申请号：US13988745

申请日：2011-11-18

申请人： Ana Elena Minatti ,  Oleg Epstein ,  Ryan White ,  Matthew Weiss ,  Wenge Zhong ,  Jonathan D. Low

发明人： Ana Elena Minatti ,  Oleg Epstein ,  Ryan White ,  Matthew Weiss ,  Wenge Zhong ,  Jonathan D. Low

IPC分类号： C07D491/107 ,  C07D491/20

CPC分类号： C07D491/107 ,  C07D491/20

摘要： The present invention provides a new class of compounds useful for the modulation of beta-secretase enzyme (BACE) activity. The compounds have a general Formula I: wherein variables A1, A3, A4, A5, A6, A8, L, R2, R7, R9, W and Y of Formula I are defined herein. The invention also provides pharmaceutical compositions comprising the compounds, and corresponding uses of the compounds and compositions for treatment of disorders and/or conditions related to plaque formation and deposition, resulting from the activity of BACE. Such BACE mediated disorders include, for example, Alzheimer's Disease, cognitive deficits, cognitive impairments, schizophrenia and other central nervous system conditions. The invention further provides compounds of Formulas II and III, sub-Formula embodiments of Formulas I, II and III, intermediates and processes and methods useful for the preparation of compounds of Formulae I-III.

摘要翻译： 本发明提供了一类可用于调节β-分泌酶（BACE）活性的化合物。 化合物具有通式I：其中式I的变量A1，A3，A4，A5，A6，A8，L，R2，R7，R9，W和Y在本文中定义。 本发明还提供包含该化合物的药物组合物，以及用于治疗由于BACE的活性而导致的斑块形成和沉积相关疾病和/或病症的化合物和组合物的相应用途。 这种BACE介导的疾病包括例如阿尔茨海默病，认知缺陷，认知障碍，精神分裂症和其他中枢神经系统疾病。 本发明还提供式II和III的化合物，式I，II和III的次级实施方案，可用于制备式I-III化合物的中间体和方法和方法。

公开(公告)号：US20130338177A1

公开(公告)日：2013-12-19

申请号：US13988745

申请日：2011-11-18

申请人： Ana Elena Minatti ,  Oleg Epstein ,  Ryan White ,  Matthew Weiss ,  Wenge Zhong ,  Jonathan D. Low

发明人： Ana Elena Minatti ,  Oleg Epstein ,  Ryan White ,  Matthew Weiss ,  Wenge Zhong ,  Jonathan D. Low

IPC分类号： C07D491/107 ,  C07D491/20

CPC分类号： C07D491/107 ,  C07D491/20

摘要： The present invention provides a new class of compounds useful for the modulation of beta-secretase enzyme (BACE) activity. The compounds have a general Formula (I), wherein variables A1, A3, A4, A5, A6, A8, L, R2, R7, R9, W and Y of Formula (I) are defined herein. The invention also provides pharmaceutical compositions comprising the compounds, and corresponding uses of the compounds and compositions for treatment of disorders and/or conditions related to plaque formation and deposition, resulting from the activity of BACE. Such BACE mediated disorders include, for example, Alzheimer's Disease, cognitive deficits, cognitive impairments, schizophrenia and other central nervous system conditions. The invention further provides compounds of Formulas (II) and (III), sub-Formula embodiments of Formulas (I), (II) and (III), intermediates and processes and methods useful for the preparation of compounds of Formulae (I-III).

摘要翻译： 本发明提供了一类可用于调节β-分泌酶（BACE）活性的化合物。 化合物具有通式（I），其中式（I）的变量A1，A3，A4，A5，A6，A8，L，R2，R7，R9，W和Y如本文所定义。 本发明还提供包含该化合物的药物组合物，以及用于治疗由于BACE的活性而导致的斑块形成和沉积相关疾病和/或病症的化合物和组合物的相应用途。 这种BACE介导的疾病包括例如阿尔茨海默病，认知缺陷，认知障碍，精神分裂症和其他中枢神经系统疾病。 本发明还提供式（II）和（III）的化合物，式（I），（II）和（III）的分式实施方案，可用于制备式（I-III）化合物的中间体和方法和方法 ）。

公开(公告)号：US20080155928A1

公开(公告)日：2008-07-03

申请号：US11968615

申请日：2008-01-02

申请人： Matthew Weiss

发明人： Matthew Weiss

IPC分类号： E04F13/08

CPC分类号： E04F13/0864

摘要： A panel siding assembly adapted to be mounted to an outside surface of a wall in a manner to provide an air space between the siding assembly and the wall so that moist air in the air space is able to escape from the air space. The assembly comprises a plurality of laterally aligned panels having upper and lower panel edge portions and outside and inside surfaces. The panels are located at vertically spaced locations so that each pair of upper and lower adjacent panels are positioned so that an upper front surface portion of the lower panel of the pair is adjacent to a lower rear surface portion of the upper panel of the pair at a laterally extending juncture location. There is a plurality of spacing and locating devices which are positioned at spaced locations along the juncture location.

摘要翻译： 一种面板壁板组件，其适于以在壁板组件和壁之间提供空气空间的方式安装到壁的外表面，使得空气空间中的湿空气能够从空气空间逸出。 该组件包括多个横向排列的面板，其具有上和下面板边缘部分以及外表面和内表面。 面板位于垂直间隔的位置，使得每对上下相邻面板被定位成使得该对的下面板的上前表面部分与该对的上面板的下后表面部分相邻， 横向延伸的接合位置。 存在多个间隔和定位装置，其位于沿着接合位置的间隔位置处。

公开(公告)号：US20070185144A1

公开(公告)日：2007-08-09

申请号：US11595187

申请日：2006-11-10

申请人： Wenge Zhong ,  Stephen Hitchcock ,  Brian Albrecht ,  Michael Bartberger ,  James Brown ,  Ryan Brown ,  Stuart Chaffee ,  Yuan Cheng ,  Michael Croghan ,  Russell Graceffa ,  Scott Harried ,  Dean Hickman ,  Daniel Horne ,  Randall Hungate ,  Ted Judd ,  Matthew Kaller ,  Charles Kreiman ,  Daniel La ,  Patricia Lopez ,  Craig Masse ,  Holger Monenschein ,  Thomas Nguyen ,  Thomas Nixey ,  Vinod Patel ,  Lewis Pennington ,  Matthew Weiss ,  Qiufen Xue ,  Bryant Yang

发明人： Wenge Zhong ,  Stephen Hitchcock ,  Brian Albrecht ,  Michael Bartberger ,  James Brown ,  Ryan Brown ,  Stuart Chaffee ,  Yuan Cheng ,  Michael Croghan ,  Russell Graceffa ,  Scott Harried ,  Dean Hickman ,  Daniel Horne ,  Randall Hungate ,  Ted Judd ,  Matthew Kaller ,  Charles Kreiman ,  Daniel La ,  Patricia Lopez ,  Craig Masse ,  Holger Monenschein ,  Thomas Nguyen ,  Thomas Nixey ,  Vinod Patel ,  Lewis Pennington ,  Matthew Weiss ,  Qiufen Xue ,  Bryant Yang

IPC分类号： A61K31/4747 ,  A61K31/4743 ,  A61K31/4741 ,  A61K31/4025 ,  A61K31/353 ,  A61K31/277 ,  A61K31/165 ,  C07D491/02

CPC分类号： C07D405/12 ,  C07D311/68 ,  C07D413/12 ,  C07D491/052

摘要： The present invention comprises a new class of compounds useful for the modulation of Beta-secretase enzyme activity and for the treatment of Beta-secretase mediated diseases, including Alzheimer's disease (AD) and related conditions. In one embodiment, the compounds have a general Formula I wherein A, B, W, R3, R4, R5, i and j are defined herein. The invention also comprises pharmaceutical compositions including one or more compounds of Formula I, methods of use for these compounds, including treatment of AD and related diseases, by administering the compound(s) of Formula I, or compositions including them, to a subject. The invention also comprises further embodiments of Formulas II and III, intermediates and processes useful for the preparation of compounds of the invention.

摘要翻译： 本发明包括可用于调节β-分泌酶酶活性和用于治疗β-分泌酶介导的疾病（包括阿尔茨海默病（AD））和相关病症的新一类化合物。 在一个实施方案中，化合物具有通式I，其中A，B，W，R 3，R 4，R 5，i和 j在本文中定义。 本发明还包括药物组合物，其包括一种或多种式I化合物，这些化合物的使用方法，包括治疗AD和相关疾病，通过给受试者施用式I化合物或包含它们的组合物。 本发明还包括式II和III的其它实施方案，可用于制备本发明化合物的中间体和方法。

公开(公告)号：US20070185103A1

公开(公告)日：2007-08-09

申请号：US11600264

申请日：2006-11-14

申请人： Brian Albrecht ,  Denise Andersen ,  Michael Bartberger ,  James Brown ,  Ryan Brown ,  Stuart Chaffee ,  Yuan Cheng ,  Michael Croghan ,  Russell Graceffa ,  Scott Harried ,  Stephen Hitchcock ,  Randall Hungate ,  Ted Judd ,  Matthew Kaller ,  Charles Kreiman ,  Daniel La ,  Patricia Lopez ,  Craig Masse ,  Holger Monenschein ,  Thomas Nguyen ,  Thomas Nixey ,  Vinod Patel ,  Lewis Pennington ,  Matthew Weiss ,  Quifen Xue ,  Bryant Yang ,  Wenge Zhong

发明人： Brian Albrecht ,  Denise Andersen ,  Michael Bartberger ,  James Brown ,  Ryan Brown ,  Stuart Chaffee ,  Yuan Cheng ,  Michael Croghan ,  Russell Graceffa ,  Scott Harried ,  Stephen Hitchcock ,  Randall Hungate ,  Ted Judd ,  Matthew Kaller ,  Charles Kreiman ,  Daniel La ,  Patricia Lopez ,  Craig Masse ,  Holger Monenschein ,  Thomas Nguyen ,  Thomas Nixey ,  Vinod Patel ,  Lewis Pennington ,  Matthew Weiss ,  Quifen Xue ,  Bryant Yang ,  Wenge Zhong

IPC分类号： A61K31/538 ,  A61K31/503 ,  A61K31/4704 ,  A61K31/4745 ,  A61K31/4188 ,  A61K31/4162 ,  C07D487/02 ,  C07D471/02

CPC分类号： C07D405/12 ,  C07D413/12

摘要： The present invention comprises a new class of compounds useful for the modulation of Beta-secretase enzyme activity and for the treatment of Beta-secretase mediated diseases, including Alzheimer's disease (AD) and related conditions. In one embodiment, the compounds have a general Formula I wherein A, B, R3, R4, R5, i and j are defined herein. The invention also comprises pharmaceutical compositions including one or more compounds of Formula I, methods of use for these compounds, including treatment of AD and related diseases, by administering the compound(s) of Formula I, or compositions including them, to a subject. The invention also comprises further embodiments of Formulas II and III, intermediates and processes useful for the preparation of compounds of the invention.

摘要翻译： 本发明包括可用于调节β-分泌酶酶活性和用于治疗β-分泌酶介导的疾病（包括阿尔茨海默病（AD））和相关病症的新一类化合物。 在一个实施方案中，化合物具有通式I，其中A，B，R 3，R 4，R 5，i和j分别为 本文定义。 本发明还包括药物组合物，其包括一种或多种式I化合物，这些化合物的使用方法，包括治疗AD和相关疾病，通过给受试者施用式I化合物或包含它们的组合物。 本发明还包括式II和III的其它实施方案，可用于制备本发明化合物的中间体和方法。

公开(公告)号：US20060241115A1

公开(公告)日：2006-10-26

申请号：US11042634

申请日：2005-01-24

申请人： Michele Potashman ,  Tae-Seong Kim ,  Steven Bellon ,  Shon Booker ,  Yuan Cheng ,  Joseph Kim ,  Andrew Tasker ,  Ning Xi ,  Shimin Xu ,  Jean-Christophe Harmange ,  George Borg ,  Matthew Weiss ,  Brian Hodous ,  Russell Graceffa ,  William Buckner ,  Craig Masse ,  Deborah Choquette ,  Matthew Martin ,  Julie Germain ,  Lucian DiPietro ,  Stuart Chaffee ,  Joseph Nunes ,  John Buchanan ,  Gregory Habgood ,  David McGowan ,  Douglas Whittington

发明人： Michele Potashman ,  Tae-Seong Kim ,  Steven Bellon ,  Shon Booker ,  Yuan Cheng ,  Joseph Kim ,  Andrew Tasker ,  Ning Xi ,  Shimin Xu ,  Jean-Christophe Harmange ,  George Borg ,  Matthew Weiss ,  Brian Hodous ,  Russell Graceffa ,  William Buckner ,  Craig Masse ,  Deborah Choquette ,  Matthew Martin ,  Julie Germain ,  Lucian DiPietro ,  Stuart Chaffee ,  Joseph Nunes ,  John Buchanan ,  Gregory Habgood ,  David McGowan ,  Douglas Whittington

IPC分类号： A61K31/517 ,  A61K31/502 ,  A61K31/498 ,  A61K31/4709 ,  C07D43/02

CPC分类号： C07D213/64 ,  C07D213/81 ,  C07D215/233 ,  C07D215/38 ,  C07D215/48 ,  C07D215/54 ,  C07D237/34 ,  C07D239/34 ,  C07D239/47 ,  C07D239/84 ,  C07D239/94 ,  C07D401/12 ,  C07D403/12 ,  C07D405/12 ,  C07D409/12 ,  C07D413/12 ,  C07D417/12 ,  C07D471/04 ,  C07D487/04

摘要： Selected compounds are effective for prophylaxis and treatment of diseases, such as HGF mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving, cancer and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.

公开(公告)号：US20220358816A1

公开(公告)日：2022-11-10

申请号：US17870048

申请日：2022-07-21

申请人： Matthew Weiss

发明人： Matthew Weiss

IPC分类号： G07F17/32

摘要： A method for playing a cooperative card wagering game for a plurality of players and a dealer using a customer cooperative wagering table and a deck of cards with each card having a numerical value, the cooperative wagering table having a dealer table edge, a community table edge, and a community line positioned therebetween, each player has an individual hand, and contributes a card to form a community hand by placing the card upon the community line, the players cooperate to maximize the value of the community hand, while also maximizing their respective individual hands, whereby the players cannot obtain a player win result if the community hand is less than the dealer's hand in value.

公开(公告)号：US11430302B2

公开(公告)日：2022-08-30

申请号：US17198571

申请日：2021-03-11

申请人： Matthew Weiss

发明人： Matthew Weiss

IPC分类号： G07F17/32

摘要： A method for playing a cooperative card wagering game for a plurality of players and a dealer using a customer cooperative wagering table and a deck of cards with each card having a numerical value, the cooperative wagering table having a dealer table edge, a community table edge, and a community line positioned therebetween, each player has an individual hand, and contributes a card to form a community hand by placing the card upon the community line, the players cooperate to maximize the value of the community hand, while also maximizing their respective individual hands, whereby the players cannot obtain a player win result if the community hand is less than the dealer's hand in value.