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公开(公告)号：US5770369A
公开(公告)日：1998-06-23
申请号：US660534
申请日：1996-06-07
IPC分类号： C12N15/09 , C07H21/00 , C07H23/00 , C12Q1/68 , G01N33/566 , C07H21/04 , C12P19/34 , C12Q1/70
CPC分类号： C12Q1/6818 , B82Y30/00 , C07H21/00 , C07H23/00 , C12Q1/6825
摘要： The present invention provides for the selective covalent modification of nucleic acids with redox active moieties such as transition metal complexes. Electron donor and electron acceptor moieties are covalently bound to the ribose-phosphate backbone of a nucleic acid at predetermined positions. The resulting complexes represent a series of new derivatives that are bimolecular templates capable of transferring electrons over very large distances at extremely fast rates. These complexes possess unique structural features which enable the use of an entirely new class of bioconductors and photoactive probes.
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公开(公告)号：US5705348A
公开(公告)日：1998-01-06
申请号：US709265
申请日：1996-09-06
IPC分类号： C12N15/09 , C07H21/00 , C07H23/00 , C12Q1/68 , G01N33/566 , C07H21/02 , C07H21/04 , C12Q1/70
CPC分类号： C07H23/00 , C07H21/00 , C12Q1/6818 , C12Q1/6825 , C12Q1/6827
摘要： The present invention provides for the selective covalent modification of nucleic acids with redox active moieties such as transition metal complexes. Electron donor and electron acceptor moieties are covalently bound to the ribose-phosphate backbone of a nucleic acid at predetermined positions. The resulting complexes represent a series of new derivatives that are bimolecular templates capable of transferring electrons over very large distances at extremely fast rates. These complexes possess unique structural features which enable the use of an entirely new class of bioconductors and photoactive probes.
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公开(公告)号：US5591578A
公开(公告)日：1997-01-07
申请号：US166036
申请日：1993-12-10
申请人： Thomas J. Meade , Jon F. Kayyem , Scott E. Fraser
发明人： Thomas J. Meade , Jon F. Kayyem , Scott E. Fraser
CPC分类号： C07H23/00 , C07H21/00 , C12Q1/6818 , C12Q1/6825 , C12Q1/6827
摘要： The present invention provides for the selective covalent modification of nucleic acids with redox active moieties such as transition metal complexes. Electron donor and electron acceptor moieties are covalently bound to the ribose-phosphate backbone of the nucleic acid at predetermined positions. The resulting complexes represent a series of new derivatives that are bimolecular templates capable of transferring electrons over very large distances at extremely fast rates. These complexes possess unique structural features which enable the use of an entirely new class of bioconductors and photoactive probes. Hybridization assays employing these complexes are disclosed.
摘要翻译： 本发明提供了用氧化还原活性部分如过渡金属配合物选择性共价修饰核酸。 电子供体和电子受体部分在预定位置上与核酸的核糖 - 磷酸骨架共价结合。 所得的复合物表示一系列新的衍生物，其是能够以非常快的速率在非常大的距离上转移电子的双分子模板。 这些复合物具有独特的结构特征，可以使用全新的生物传感器和光敏探针。 公开了使用这些复合物的杂交测定。
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公开(公告)号：US08834840B1
公开(公告)日：2014-09-16
申请号：US11906825
申请日：2007-10-04
申请人： Steve R. Bull , Thomas J. Meade , Samuel I. Stupp
发明人： Steve R. Bull , Thomas J. Meade , Samuel I. Stupp
CPC分类号： A61K38/07 , A61K38/03 , A61K49/103 , A61K49/105 , A61K49/108 , C07K7/06 , G01R33/5601
摘要： Compositions and/or mixtures comprising peptide amphiphile compounds comprising one or more contrast agents, as can be used in a range of magnetic resonance imaging applications.
摘要翻译： 包含可用于一系列磁共振成像应用的包含一种或多种造影剂的肽两亲物化合物的组合物和/或混合物。
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公开(公告)号：US08802390B2
公开(公告)日：2014-08-12
申请号：US13353001
申请日：2012-01-18
申请人： Paul A. Bertin , Michael Ahrens , Dimitra Georganopoulou , Harry B. Gray , Thomas J. Meade , Markus Franz Wunder
发明人： Paul A. Bertin , Michael Ahrens , Dimitra Georganopoulou , Harry B. Gray , Thomas J. Meade , Markus Franz Wunder
IPC分类号： C12Q1/37
CPC分类号： G01N27/30 , C12Q1/003 , C12Q1/37 , C12Q1/485 , Y10T29/49117
摘要： The invention relates to novel compositions and methods for the detection of enzymes using the nuclear reorganization energy, λ, of an electron transfer process.
摘要翻译： 本发明涉及使用电子转移过程的核重组能量λ检测酶的新型组合物和方法。
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公开(公告)号：US20130303737A1
公开(公告)日：2013-11-14
申请号：US13861011
申请日：2013-04-11
CPC分类号： C07K19/00 , A61K31/7135 , C07H23/00
摘要： The present invention provides targeted Schiff base complexes. In particular the present invention provides biopolymer targeted transition metal complexes configured to inhibit the activity of targeted proteins, methods of synthesis thereof, and pharmaceutical compositions and uses thereof.
摘要翻译： 本发明提供目标希夫碱配合物。 特别地，本发明提供了配置成抑制靶向蛋白质活性的生物聚合物靶向过渡金属络合物，其合成方法及其药物组合物及其用途。
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公开(公告)号：US20130108554A1
公开(公告)日：2013-05-02
申请号：US13720160
申请日：2012-12-19
申请人： Elise A. Schultz Sikma , Mohammed Aslam , Vinayak P. Dravid , Thomas J. Meade , Bradley D. Ulrich
发明人： Elise A. Schultz Sikma , Mohammed Aslam , Vinayak P. Dravid , Thomas J. Meade , Bradley D. Ulrich
CPC分类号： A61K49/14 , A61B5/055 , A61B5/416 , A61K49/085 , A61K49/1824 , A61K49/183 , A61K49/186 , B82Y5/00 , Y10S977/773 , Y10S977/811 , Y10S977/838 , Y10S977/93
摘要： The present invention relates generally to multimodal magnetic resonance imaging (MRI) contrast agents. In particular, the present invention provides a MRI contrast agent configured to manipulate both the longitudinal (T1) and transverse (T2) relaxation times of surrounding water proton spins.
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公开(公告)号：US20120199499A1
公开(公告)日：2012-08-09
申请号：US13366068
申请日：2012-02-03
IPC分类号： G01N27/26
CPC分类号： G01N27/3277 , B82Y15/00 , B82Y30/00 , G01N33/5438 , G01N33/58 , G01N33/84 , G01N2458/30 , G01N2800/04
摘要： The present invention is directed to the detection of target analytes using electronic techniques, particularly AC techniques.
摘要翻译： 本发明涉及使用电子技术，特别是AC技术检测目标分析物。
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公开(公告)号：US07601507B2
公开(公告)日：2009-10-13
申请号：US11981645
申请日：2007-10-30
IPC分类号： G01N33/53
CPC分类号： G01N27/3277 , B82Y15/00 , B82Y30/00 , G01N33/5438 , G01N33/58 , G01N33/84 , G01N2458/30 , G01N2800/04
摘要： The present invention is directed to the detection of target analytes using electronic techniques, particularly AC techniques.
摘要翻译： 本发明涉及使用电子技术，特别是AC技术检测目标分析物。
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公开(公告)号：US07595153B2
公开(公告)日：2009-09-29
申请号：US11980203
申请日：2007-10-30
申请人： Thomas J. Meade
发明人： Thomas J. Meade
CPC分类号： B82Y30/00 , B82Y5/00 , B82Y15/00 , G01N33/542 , G01N33/5438
摘要： The invention relates to novel methods and compositions for the detection of analytes using the nuclear reorganization energy, λ, of an electron transfer process.
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