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116 条记录 (耗时 0.04 秒)

    Combination of a NSAID and a PDE-4 inhibitor
    21.
    发明申请
    Combination of a NSAID and a PDE-4 inhibitor 有权
    组合NSAID和PDE-4抑制剂

    公开(公告)号：US20080255209A1

    公开(公告)日：2008-10-16

    申请号：US12003129

    申请日：2007-12-20

    申请人： Thomas Klein ,  Hans-Peter Kley

    发明人： Thomas Klein ,  Hans-Peter Kley

    IPC分类号： A61K31/44 ,  A61P1/00 ,  A61P3/10

    CPC分类号： A61K45/06 ,  A61K31/00 ,  A61K2300/00

    摘要： The invention relates to the combined use of a PDE4 inhibitor and a conventional NSAID in the treatment of an inflammatory disease and/or an inflammation-associated disorder while minimizing gastrointestinal side effects, such as gastric erosions and ulcer, which are frequently associated with the use of conventional NSAIDs. A preferred PDE 4 inhibitor for this combination is roflumilast or a derivative thereof. A preferred conventional NSAID for this combination is diclofenac or a derivative thereof.

    摘要翻译： 本发明涉及PDE4抑制剂和常规NSAID在治疗炎性疾病和/或炎症相关疾病中的综合应用，同时最小化胃肠道副作用，例如经常与使用相关的胃糜烂和溃疡 的常规NSAIDs。 用于该组合的优选的PDE4抑制剂是罗氟司特或其衍生物。 用于该组合的优选的常规NSAID是双氯芬酸或其衍生物。

    Method and apparatus for loading and unloading flexographic plates for computer-to-plate imaging
    25.
    发明授权
    Method and apparatus for loading and unloading flexographic plates for computer-to-plate imaging 有权
    用于装载和卸载用于计算机对板成像的柔性版的方法和装置

    公开(公告)号：US06981447B2

    公开(公告)日：2006-01-03

    申请号：US10791305

    申请日：2004-03-02

    申请人： Thomas Klein ,  Jan Buchweitz

    发明人： Thomas Klein ,  Jan Buchweitz

    IPC分类号： B41L47/14 ,  B65H1/04

    CPC分类号： B65H5/04 ,  B65H2405/3311 ,  B65H2701/1928

    摘要： A method and apparatus to aid the loading and unloading of flexographic plates to and from an imager. The apparatus includes a magazine containing a plurality of compartments each for holding a single flexographic plate, the compartments arranged vertically, and movable in a vertical direction, a lifting mechanism to lift and lower the compartments; and a control system to control the lifting and lowering by the lifting mechanism. The control system is such that a particular compartment is moved from its rest vertical position at a rest horizontal position to a loading vertical position and a loading horizontal position at which the particular compartment is at a height for loading onto the imager.

    摘要翻译： 一种用于帮助将柔版印版装载到成像器和从成像器装载的方法和装置。 该装置包括一个盒子，该盒子包含多个隔室，每个隔间用于容纳一个柔版印版，该隔间垂直布置并可在垂直方向上移动;提升机构，用于提升和降低隔间; 以及通过提升机构来控制升降的控制系统。 控制系统使得特定隔室在静止水平位置处从其静止垂直位置移动到加载垂直位置和装载水平位置，在该水平位置处，特定隔室处于加载到成像器上的高度。

    Operating device
    27.
    发明授权
    Operating device 有权
    操作装置

    公开(公告)号：US06410866B1

    公开(公告)日：2002-06-25

    申请号：US09354197

    申请日：1999-07-15

    申请人： Thomas Klein ,  Thomas Keller

    发明人： Thomas Klein ,  Thomas Keller

    IPC分类号： H01H900

    CPC分类号： B60K37/06

    摘要： In an operating devise with which functional groups, functions and/or function values can be dialed by the handle of a rotary switch being rotated, and selected by one or more input switches, at least one input switch (2) is arranged on or beside the outer periphery of the handle of the rotary switch or within the handle (1) of the rotary switch.

    摘要翻译： 在通过旋转开关的手柄旋转并由一个或多个输入开关选择功能组，功能和/或功能值的操作设备中，至少一个输入开关（2）布置在或旁边 旋转开关的手柄的外周或旋转开关的手柄（1）内。

    Copy protected security print
    28.
    发明授权
    Copy protected security print 有权
    复制受保护的安全打印

    公开(公告)号：US06209922B1

    公开(公告)日：2001-04-03

    申请号：US09252964

    申请日：1999-02-19

    申请人： Thomas Klein

    发明人： Thomas Klein

    IPC分类号： B42D1500

    CPC分类号： B42D25/405 ,  B41M3/14 ,  B42D25/29 ,  B42D2035/16 ,  B42D2035/44 ,  Y10S283/902

    摘要： A security print contains a background pattern formed for example of dots or lines. An object, for example the text “BEWARE OF FORGERY”, is worked into this regular background pattern for copy protection. The text is worked in by the individual lines of the background pattern being split at the places where the text is located into two partial lines which are each only about half as wide as the original line. With the naked eye this split of the background pattern components is not, or barely, recognizable. When such an original security print is copied on a conventional copying machine the original, relatively wide lines of the background pattern appear on the copy but the partial lines formed by the split thereof are not, or very poorly, copied so that the text “BEWARE OF FORGERY” appears clearly in the copy.

    摘要翻译： 安全打印包含例如形成点或线形的背景图案。 一个对象，例如文本“BEWARE OF FORGERY”，被用于这种常规的背景图案以进行复制保护。 文本由背景图案的各个行被处理，该背景图案被分割在文本所处的位置处，分成两条直线，每条分割线仅为原始行宽的一半。 用肉眼看，背景图案组件的这种分割不是或几乎不可识别的。 当这种原始的安全印刷品被复制在传统的复印机上时，背景图案的原始相对较宽的线条出现在复印件上，但由其分割形成的部分线条不复制或非常差地被复制，使得文本“BEWARE OF FORGERY“显示在副本中。

    Method of maintaining an angle between a doctor blade and an opposing surface at a predetermined value
    29.
    发明授权
    Method of maintaining an angle between a doctor blade and an opposing surface at a predetermined value 失效
    将刮刀和相对表面之间的角度保持在预定值的方法

    公开(公告)号：US6071550A

    公开(公告)日：2000-06-06

    申请号：US118243

    申请日：1998-07-17

    申请人： Manfred Ueberschar ,  Thomas Klein ,  Franz Fischer

    发明人： Manfred Ueberschar ,  Thomas Klein ,  Franz Fischer

    IPC分类号： B05D3/00 ,  B05C3/132 ,  B05C11/04 ,  B05C11/10 ,  D21H25/10 ,  B05D3/12

    CPC分类号： B05C11/041 ,  D21H25/10 ,  B05C11/10

    摘要： A device for the application of a liquid or viscous medium onto a running opposing surface includes a doctor blade that is mounted on a support beam, whereby the relative positions of the support beam and the opposing surface are adjustable by use of a regulating device. A flexible pressure tubing that is adjustable against the doctor blade is also provided on the support beam. In the process of controlling/regulating the device, the operating condition of the coating applicator is recorded, control values are established on the basis of the recorded results, and the regulating device and/or fluid pressure in the flexible pressure tubing is influenced on the basis of the established control values. Control/adjustments are made in such a manner that the angle of attack between the doctor blade and the opposing surface is maintained at a predetermined value. The tension condition of the flexible pressure tubing is recorded as an operating condition value and information regarding the deformation characteristics of the flexible pressure tubing, as well as the bending characteristics of the doctor blade, are considered when establishing the control values.

    摘要翻译： 用于在流动的相对表面上施加液体或粘性介质的装置包括安装在支撑梁上的刮刀，由此通过使用调节装置可以调节支撑梁和相对表面的相对位置。 也可以在支撑梁上提供可相对于刮刀调节的柔性压力管。 在控制/调节装置的过程中，记录涂布器的操作状态，基于记录结果建立控制值，并且柔性压力管中的调节装置和/或流体压力受到影响 建立控制值的基础。 以这样一种方式进行控制/调节，使得刮刀和相对表面之间的迎角保持在预定值。 记录柔性压力管的张力状态作为操作状态值，并且在建立控制值时考虑关于柔性压力管的变形特性以及刮刀的弯曲特性的信息。