公开(公告)号：US5969097A

公开(公告)日：1999-10-19

申请号：US903029

申请日：1992-06-23

申请人： Roger C. Wiegand ,  Mark G. Currie ,  Kam Fook Fok

发明人： Roger C. Wiegand ,  Mark G. Currie ,  Kam Fook Fok

IPC分类号： C07K14/47 ,  C07K14/00 ,  C07K14/435

CPC分类号： C07K14/4705

摘要： A novel pentadecapeptide is disclosed which is useful for the control of intestinal fluid absorption and that has the following amino acid sequencePro-Gly-Thr-Cys-Glu-Ile-Cys-Ala-Tyr-Ala- 1 5 10 - Ala-Cys-Thr-Gly-Cys (SEQ ID NO.1) 15

摘要翻译： 公开了一种新颖的十五肽，其可用于控制肠液吸收，并具有以下氨基酸序列：Pro-Gly-Thr-Cys-Glu-Ile-Cys-Ala-Tyr-Ala- Ala-Cys-Thr-Gly-Cys（SEQ ID NO.1）-15-

公开(公告)号：US5837698A

公开(公告)日：1998-11-17

申请号：US643018

申请日：1996-05-02

申请人： Foe S. Tjoeng ,  Mark G. Currie ,  Mark E. Zupec

发明人： Foe S. Tjoeng ,  Mark G. Currie ,  Mark E. Zupec

IPC分类号： A61K31/57 ,  C07J41/00 ,  C07J71/00 ,  A61K31/58 ,  C07J17/00

CPC分类号： C07J71/0031 ,  C07J41/005

摘要： The present invention relates to a pharmaceutical composition or preparation which comprises hydroxyl containing steroidal hormones and organic nitrite/nitrate or other nitric oxide donating agents.

摘要翻译： 本发明涉及包含含羟基的甾体激素和有机亚硝酸盐/硝酸盐或其它一氧化氮给药剂的药物组合物或制剂。

公开(公告)号：US20140348942A1

公开(公告)日：2014-11-27

申请号：US14124286

申请日：2012-06-08

申请人： Mark G. Currie ,  Daniel P. Zimmer ,  Angelika Fretzen ,  Marco Kassler ,  Brian M. Cali

发明人： Mark G. Currie ,  Daniel P. Zimmer ,  Angelika Fretzen ,  Marco Kassler ,  Brian M. Cali

IPC分类号： C07K7/08 ,  A61K45/06 ,  A61K38/10

CPC分类号： C07K7/08 ,  A61K38/10 ,  A61K38/51 ,  A61K45/06

摘要： The present invention provides pharmaceutical compositions and methods of treating lower gastrointestinal disorders, including inflammatory bowel disease (IBD), diverticulitis, colon cancer, an inflammatory disorder, obesity, congestive heart failure, benign prostatic hyperplasia (BPH), pain, salt retention or fluid retention.

摘要翻译： 本发明提供了治疗下消化道疾病的药物组合物和方法，包括炎症性肠病（IBD），憩室炎，结肠癌，炎症性疾病，肥胖，充血性心力衰竭，良性前列腺增生（BPH），疼痛，盐滞留或流体 保留。

公开(公告)号：US20120088902A1

公开(公告)日：2012-04-12

申请号：US12306788

申请日：2007-06-27

申请人： Mark G. Currie ,  Daniel P. Zimmer

发明人： Mark G. Currie ,  Daniel P. Zimmer

IPC分类号： C07K14/00 ,  C07K7/08 ,  C07K7/06

CPC分类号： C07K14/4705 ,  A61K38/00

摘要： Compositions and related methods for treating IBS and other gastrointestinal disorders and conditions (e.g., gastrointestinal motility disorders, functional gastrointestinal disorders, gastroesophageal reflux disease (GERD), duodenogastric reflux, Crohn's disease, ulcerative colitis, inflammatory bowel disease, functional heartburn, dyspepsia (including functional dyspepsia or nonulcer dyspepsia), gastroparesis, chronic intestinal pseudo-obstruction (or colonic pseudoobstruction), disorders and conditions associated with constipation, e.g., constipation associated with use of opiate pain killers, post-surgical constipation, and constipation associated with neuropathic disorders and disorders and conditions associated with excess fluid and/or salt retention as well as other conditions and disorders are described. The compositions feature polypeptides that activate the guanylate cyclase C (GC-C) receptor.

公开(公告)号：US08101579B2

公开(公告)日：2012-01-24

申请号：US12568107

申请日：2009-09-28

申请人： Mark G. Currie ,  Shalina Mahajan-Miklos ,  Li Jing Sun

发明人： Mark G. Currie ,  Shalina Mahajan-Miklos ,  Li Jing Sun

IPC分类号： A61K38/10 ,  A61K31/74

CPC分类号： C07K7/08 ,  A61K38/00

摘要： Compositions and related methods for treating IBS and other gastrointestinal disorders and conditions (e.g., gastrointestinal motility disorders, functional gastrointestinal disorders, gastroesophageal reflux disease (GERD), duodenogastric reflux, Crohn's disease, ulcerative colitis, inflammatory bowel disease, functional heartburn, dyspepsia (including functional dyspepsia or nonulcer dyspepsia), gastroparesis, chronic intestinal pseudo-obstruction (or colonic pseudoobstruction), and disorders and conditions associated with constipation, e.g., constipation associated with use of opiate pain killers, post-surgical constipation, and constipation associated with neuropathic disorders as well as other conditions and disorders are described. The compositions feature peptides that activate the guanylate cyclase C (GC-C) receptor.

摘要翻译： 用于治疗IBS和其他胃肠道疾病和病症的组合物和相关方法（例如，胃肠动力障碍，功能性胃肠道疾病，胃食管反流病（GERD），十二指肠胃反流，克罗恩病，溃疡性结肠炎，炎性肠病，功能性胃灼热，消化不良（包括 功能性消化不良或非溃疡性消化不良），胃轻瘫，慢性肠假性梗阻（或结肠假性梗阻）以及与便秘相关的疾病和病症，例如与使用阿片类止痛药相关的便秘，手术后便秘和与神经性疾病相关的便秘 描述了其它条件和病症，组合物具有激活鸟苷酸环化酶C（GC-C）受体的肽。

公开(公告)号：US08088935B2

公开(公告)日：2012-01-03

申请号：US10587054

申请日：2004-12-23

申请人： James Pearson ,  John J. Talley ,  Mark G. Currie

发明人： James Pearson ,  John J. Talley ,  Mark G. Currie

IPC分类号： C07D311/22 ,  A61K31/353

CPC分类号： C07D491/04 ,  A61K31/353 ,  A61K31/4741 ,  A61K31/506 ,  C07D311/24 ,  C07D405/14 ,  C07D409/14

摘要： Compounds and methods for the treatment of asthma are disclosed. The methods involve mast cell stabilization together with selective inhibition of iNOS. The compounds are combinations of a mast cell inhibiting moiety and an inhibitor of iNOS. An example is:

摘要翻译： 公开了治疗哮喘的化合物和方法。 该方法涉及肥大细胞稳定化以及iNOS的选择性抑制。 化合物是肥大细胞抑制部分和iNOS抑制剂的组合。 一个例子是：

公开(公告)号：US20110160225A1

公开(公告)日：2011-06-30

申请号：US12950283

申请日：2010-11-19

申请人： Mark G. Currie ,  John Jeffrey Talley ,  Brian Cali

发明人： Mark G. Currie ,  John Jeffrey Talley ,  Brian Cali

IPC分类号： A61K31/496 ,  C07C203/04 ,  A61K31/21 ,  A61K31/24 ,  C07C69/716 ,  A61K31/216 ,  C07D263/28 ,  A61K31/421 ,  C07D207/22 ,  A61K31/40 ,  C07D403/04 ,  C07D239/42 ,  A61K31/505 ,  C07D209/24 ,  A61K31/405 ,  C07D403/12 ,  A61K31/41 ,  C07D403/14 ,  A61P3/06 ,  A61P3/10

CPC分类号： C07D257/06 ,  C07C69/712 ,  C07C69/732 ,  C07C203/04 ,  C07C235/30 ,  C07C259/06 ,  C07C279/12 ,  C07C279/14 ,  C07C279/22 ,  C07C281/16 ,  C07C291/02 ,  C07C2602/10 ,  C07C2602/28 ,  C07D207/22 ,  C07D207/34 ,  C07D209/24 ,  C07D239/42 ,  C07D263/28 ,  C07D403/04 ,  C07D403/12 ,  C07D403/14 ,  C07D413/12

摘要： Disclosed herein are novel compositions and methods for treating or preventing a variety of disorders and conditions associated with lipid metabolism. The methods generally include administering to a patient in need thereof a therapeutically effective amount of a pharmaceutical composition comprising one or more fibric acid or statin derivative compositions alone or in combination with one or more lipid altering agents and/or PDE inhibitors.

摘要翻译： 本文公开了用于治疗或预防与脂质代谢相关的多种病症和病症的新型组合物和方法。 所述方法通常包括向有需要的患者施用治疗有效量的药物组合物，其包含一种或多种纤维酸或他汀类衍生物组合物，或与一种或多种脂质改变剂和/或PDE抑制剂组合。

公开(公告)号：US20110129433A1

公开(公告)日：2011-06-02

申请号：US13000679

申请日：2009-06-26

申请人： Mark G. Currie

发明人： Mark G. Currie

IPC分类号： A61K31/785 ,  A61K31/575 ,  A61K31/4178 ,  A61K31/336 ,  A61K31/738 ,  A61P1/04 ,  A61P11/00

CPC分类号： A61K31/785 ,  A61K31/56 ,  A61K45/06 ,  A61K2300/00

摘要： Disclosed herein are novel compositions and methods for treating or preventing GI tract disorders and/or GERD-related respiratory disorders as well as protecting stratified squamous epithelium against injury by a noxious substance. The methods generally include administering to a patient in need thereof a therapeutically effective amount of a pharmaceutical composition comprising at least one bile acid sequestrant, alone or in combination with at least one proton pump inhibitor, and optionally one or more agent chosen from antacids, histamine H2-receptor antagonists, γ-aminobutyricacid-b (GABA-B) agonists, prodrugs of GABA-B agonists, and protease inhibitors.

摘要翻译： 本文公开了用于治疗或预防胃肠道疾病和/或GERD相关呼吸障碍以及保护分层鳞状上皮免受有害物质损伤的新型组合物和方法。 所述方法通常包括向有需要的患者施用治疗有效量的包含至少一种胆汁酸多价螯合剂的药物组合物，其单独或与至少一种质子泵抑制剂组合，以及任选的一种或多种选自抗酸剂，组胺 H2-受体拮抗剂，γ-氨基丁酸-b（GABA-B）激动剂，GABA-B激动剂的前药和蛋白酶抑制剂。

公开(公告)号：US20110124583A1

公开(公告)日：2011-05-26

申请号：US12754138

申请日：2010-04-05

申请人： Mark G. Currie ,  Shalina Mahajan-Miklos ,  Thea Norman ,  G. Todd Milne

发明人： Mark G. Currie ,  Shalina Mahajan-Miklos ,  Thea Norman ,  G. Todd Milne

IPC分类号： A61K38/10 ,  C07K7/00 ,  A61P1/00

CPC分类号： C07K7/08 ,  A61K38/00 ,  C07K14/245

摘要： The present invention features compositions and related methods for treating IBS and other gastrointestinal disorders and conditions (e.g., gastrointestinal motility disorders, functional gastrointestinal disorders, gastroesophageal reflux disease (GERD), Crohn's disease, ulcerative colitis, Inflammatory bowel disease, functional heartburn, dyspepsia (including functional dyspepsia or nonulcer dyspepsia), gastroparesis, chronic intestinal pseudo-obstruction (or colonic pseudo-obstruction), and disorders and conditions associated with constipation, e.g., constipation associated with use of opiate pain killers, post-surgical constipation, and constipation associated with neuropathic disorders as well as other conditions and disorders using peptides and other agents that activate the guanylate cyclase C (GC-C) receptor.

摘要翻译： 本发明的特征在于用于治疗IBS和其他胃肠道疾病和病症（例如胃肠蠕动障碍，功能性胃肠道疾病，胃食管反流病（GERD），克罗恩病，溃疡性结肠炎，炎性肠病，功能性胃灼热，消化不良（ 包括功能性消化不良或非溃疡性消化不良），胃轻瘫，慢性肠假性梗阻（或结肠假性梗阻）以及与便秘相关的疾病和病症，例如与使用阿片类止痛药相关的便秘，手术后便秘和便秘​​相关 与使用活化鸟苷酸环化酶C（GC-C）受体的肽和其他试剂的神经性疾病以及其它病症和病症。

公开(公告)号：US20090305993A1

公开(公告)日：2009-12-10

申请号：US12280376

申请日：2007-02-26

申请人： Mark G. Currie

发明人： Mark G. Currie

IPC分类号： A61K38/10 ,  C07K7/08

CPC分类号： A61K31/56 ,  A61K38/10 ,  C07K7/08 ,  A61K2300/00

摘要： Pharmaceutical compositions comprising certain peptides that are capable of activating the guanylate-cyclase C (GC-C) receptor are described as are the peptides and method for using the peptides and pharmaceutical compositions for treating gastrointestinal disorders and other disorder.

摘要翻译： 描述能够激活鸟苷酸环化酶C（GC-C）受体的某些肽的药物组合物是用于治疗胃肠道疾病和其它病症的肽和药物组合物的肽和方法。