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公开(公告)号：US08163737B2
公开(公告)日：2012-04-24
申请号：US11955874
申请日：2007-12-13
申请人： Corey Anderson , Andreas Termin , Sara Hadida-Ruah , Pramod Joshi , Sanghee Yoo , Daniele Bergeron , Hayley Binch , Jon Come , Jingrong Cao , Suganthi Nanthakumar , Elaine Krueger , John Maxwell , Arnaud Le Tiran , Yusheng Liao
发明人： Corey Anderson , Andreas Termin , Sara Hadida-Ruah , Pramod Joshi , Sanghee Yoo , Daniele Bergeron , Hayley Binch , Jon Come , Jingrong Cao , Suganthi Nanthakumar , Elaine Krueger , John Maxwell , Arnaud Le Tiran , Yusheng Liao
IPC分类号： A61K31/551 , A61K31/496 , A61K31/437 , C07D417/14 , C07D471/04 , A61P25/06 , A61P19/02
CPC分类号： C07D277/14 , C07D417/06 , C07D417/14 , C07D471/04 , C07D471/10 , C07D498/10 , C07D513/10
摘要： The present invention relates to CGRP receptor antagonists, pharmaceutical compositions thereof, and methods therewith for treating CGRP receptor-mediated diseases and conditions.
摘要翻译： 本发明涉及CGRP受体拮抗剂，其药物组合物及其用于治疗CGRP受体介导的疾病和病症的方法。
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公开(公告)号：US07985762B2
公开(公告)日：2011-07-26
申请号：US11511109
申请日：2006-08-28
申请人： Kevin M. Cottrell , John Maxwell , Qing Tang , Anne-Laure Grillot , Arnaud Le Tiran , Emanuele Perola
发明人： Kevin M. Cottrell , John Maxwell , Qing Tang , Anne-Laure Grillot , Arnaud Le Tiran , Emanuele Perola
IPC分类号： C07D209/54 , C07D401/14 , C07D413/14 , C07D237/30 , A61K31/424 , A61K31/421 , A61K31/422 , A61K31/4439 , A61K31/4709 , A61K31/502 , A61K31/437 , A61K31/497
CPC分类号： C07D498/10 , A61K38/00 , C07D498/20 , C07D519/00 , C07K5/06026 , C07K5/06191 , C07K5/0804 , C07K5/0808 , C07K5/081 , C07K5/0827
摘要： The present invention relates to compounds of formula I: or a pharmaceutically acceptable salt or mixtures thereof that inhibit serine protease activity, particularly the activity of hepatitis C virus NS3—NS4A protease.
摘要翻译： 本发明涉及抑制丝氨酸蛋白酶活性，特别是丙型肝炎病毒NS3-NS4A蛋白酶活性的式I化合物或其药学上可接受的盐或混合物。
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公开(公告)号：US09125922B2
公开(公告)日：2015-09-08
申请号：US13527832
申请日：2012-06-20
申请人： Youssef Laafiret Bennani , Paul S. Charifson , Anne-Laure Grillot , Arnaud Le Tiran , Hardwin O'Dowd
发明人： Youssef Laafiret Bennani , Paul S. Charifson , Anne-Laure Grillot , Arnaud Le Tiran , Hardwin O'Dowd
IPC分类号： A61K31/685 , C07D405/14 , A61K31/688 , A61K45/06 , C07F9/6558
CPC分类号： A61K31/685 , A61K31/688 , A61K45/06 , C07B2200/05 , C07D405/14 , C07F9/65586
摘要： The present invention relates to phosphate esters of compounds that inhibit bacterial gyrase and/or Topoisomerase IV and pharmaceutical compositions thereof. These phosphate esters are useful for treating bacterial infections.
摘要翻译： 本发明涉及抑制细菌促旋酶和/或拓扑异构酶IV的化合物的磷酸酯及其药物组合物。 这些磷酸酯可用于治疗细菌感染。
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公开(公告)号：US08481551B2
公开(公告)日：2013-07-09
申请号：US13349789
申请日：2012-01-13
申请人： Arnaud Le Tiran , Anne-Laure Grillot , Paul S. Charifson , Yousef Laafiret Bennani , Hardwin O'Dowd , Emanuele Perola
发明人： Arnaud Le Tiran , Anne-Laure Grillot , Paul S. Charifson , Yousef Laafiret Bennani , Hardwin O'Dowd , Emanuele Perola
IPC分类号： A01N43/54 , C07D239/42 , C07D471/04
CPC分类号： C07D405/14 , C07F9/65586
摘要： The present invention relates to a compound of formula (I) or a pharmaceutically acceptable salt thereof wherein X and R are as defined herein. The compounds of formula (I) are useful as gyrase and/or topoisomerase IV inhibitors for treating bacterial infections. The compounds of formula (I) either possess a broad range of anti-bacterial activity and advantageous toxicological properties or are prodrugs of compounds having said activity.
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公开(公告)号：US07964624B1
公开(公告)日：2011-06-21
申请号：US11711845
申请日：2007-02-27
申请人： Kevin M. Cottrell , John Maxwell , Qing Tang , Anne-Laure Grillot , Arnaud Le Tiran , Emanuele Perola
发明人： Kevin M. Cottrell , John Maxwell , Qing Tang , Anne-Laure Grillot , Arnaud Le Tiran , Emanuele Perola
IPC分类号： A61K31/42 , A61K31/4245 , A61K31/4439 , A61K31/454 , A61K31/4725 , C07D498/10 , C07D261/04 , C07D413/04
CPC分类号： C07D498/10
摘要： The present invention relates to compounds of formula (I): or a pharmaceutically acceptable salt thereof. These compounds inhibit serine protease, particularly the hepatitis C virus NS3-NS4A protease.
摘要翻译： 本发明涉及式（I）化合物或其药学上可接受的盐。 这些化合物抑制丝氨酸蛋白酶，特别是丙型肝炎病毒NS3-NS4A蛋白酶。
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公开(公告)号：US20140045791A1
公开(公告)日：2014-02-13
申请号：US13942342
申请日：2013-07-15
申请人： Christopher Phillip Locher , Youssef Laafiret Bennani , Ann-Laure Grillot , Hardwin O'Dowd , Emanuele Perola , Arnaud Le Tiran
发明人： Christopher Phillip Locher , Youssef Laafiret Bennani , Ann-Laure Grillot , Hardwin O'Dowd , Emanuele Perola , Arnaud Le Tiran
IPC分类号： A61K31/506 , A61K31/47 , A61K31/498 , A61K31/496 , A61K31/4709 , A61K31/5377 , A61K31/675 , A61K31/4965
CPC分类号： A61K31/675 , A61K31/132 , A61K31/34 , A61K31/4164 , A61K31/4168 , A61K31/421 , A61K31/454 , A61K31/47 , A61K31/4709 , A61K31/496 , A61K31/4965 , A61K31/498 , A61K31/506 , A61K31/5377 , A61K45/06 , A61K2300/00
摘要： The present invention relates to a compound of formula (I) or a pharmaceutically acceptable salt thereof wherein X and R are as defined herein. The compounds of formula (I) are useful as gyrase and/or topoisomerase IV inhibitors for treating bacterial infections. The compounds of formula (I) either possess a broad range of anti-bacterial activity and advantageous toxicological properties or are prodrugs of compounds having said activity.
摘要翻译： 本发明涉及式（I）化合物或其药学上可接受的盐，其中X和R如本文所定义。 式（I）的化合物可用作用于治疗细菌感染的旋转酶和/或拓扑异构酶IV抑制剂。 式（I）化合物具有广泛的抗菌活性和有利的毒理特性，或具有所述活性的化合物的前药。
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公开(公告)号：US08372873B2
公开(公告)日：2013-02-12
申请号：US13074772
申请日：2011-03-29
申请人： Kevin M. Cottrell , John Maxwell , Qing Tang , Anne-Laure Grillot , Arnaud Le Tiran , Emanuele Perola
发明人： Kevin M. Cottrell , John Maxwell , Qing Tang , Anne-Laure Grillot , Arnaud Le Tiran , Emanuele Perola
IPC分类号： A61K31/42 , A61K31/4245 , A61K31/4439 , A61K31/454 , A61K31/4725
CPC分类号： C07D498/10
摘要： The present invention relates to compounds of formula (I): or a pharmaceutically acceptable salt thereof. These compounds inhibit serine protease, particularly the hepatitis C virus NS3-NS4A protease.
摘要翻译： 本发明涉及式（I）化合物或其药学上可接受的盐。 这些化合物抑制丝氨酸蛋白酶，特别是丙型肝炎病毒NS3-NS4A蛋白酶。
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公开(公告)号：US20120184512A1
公开(公告)日：2012-07-19
申请号：US13349789
申请日：2012-01-13
申请人： Arnaud Le Tiran , Anne-Laure Grillot , Paul S. Charifson , Yousef Laafiret Bennani , Hardwin O'Dowd , Emanuele Perola
发明人： Arnaud Le Tiran , Anne-Laure Grillot , Paul S. Charifson , Yousef Laafiret Bennani , Hardwin O'Dowd , Emanuele Perola
IPC分类号： A61K31/506 , C07F9/09 , A61P31/04 , A01N43/54 , A01N57/16 , A01P1/00 , C07D405/14 , A61K31/675
CPC分类号： C07D405/14 , C07F9/65586
摘要： The present invention relates to a compound of formula (I) or a pharmaceutically acceptable salt thereof wherein X and R are as defined herein. The compounds of formula (I) are useful as gyrase and/or topoisomerase IV inhibitors for treating bacterial infections. The compounds of formula (I) either possess a broad range of anti-bacterial activity and advantageous toxicological properties or are prodrugs of compounds having said activity.
摘要翻译： 本发明涉及式（I）化合物或其药学上可接受的盐，其中X和R如本文所定义。 式（I）的化合物可用作用于治疗细菌感染的旋转酶和/或拓扑异构酶IV抑制剂。 式（I）化合物具有广泛的抗菌活性和有利的毒理特性，或具有所述活性的化合物的前药。
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公开(公告)号：US20090176769A1
公开(公告)日：2009-07-09
申请号：US11955874
申请日：2007-12-13
申请人： Corey Anderson , Andreas Termin , Sara Hadida-Ruah , Pramod Joshi , Sanghee Yoo , Daniele Bergeron , Hayley Binch , Jon Come , Jingrong Cao , Suganthi Nanthakumar , Elaine Krueger , John Maxwell , Arnaud Le Tiran , Yusheng Liao
发明人： Corey Anderson , Andreas Termin , Sara Hadida-Ruah , Pramod Joshi , Sanghee Yoo , Daniele Bergeron , Hayley Binch , Jon Come , Jingrong Cao , Suganthi Nanthakumar , Elaine Krueger , John Maxwell , Arnaud Le Tiran , Yusheng Liao
IPC分类号： A61K31/551 , C07D417/14 , C07D471/04 , A61K31/496 , A61K31/437 , A61P25/06 , A61P19/02
CPC分类号： C07D277/14 , C07D417/06 , C07D417/14 , C07D471/04 , C07D471/10 , C07D498/10 , C07D513/10
摘要： The present invention relates to CGRP receptor antagonists, pharmaceutical compositions thereof, and methods therewith for treating CGRP receptor-mediated diseases and conditions.
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