公开(公告)号：US20170196862A2

公开(公告)日：2017-07-13

申请号：US14876525

申请日：2015-10-06

Applicant: Mark Thomas Miller ,  Corey Anderson ,  Vijayalaksmi Arumugam ,  Brian Richard Bear ,  Hayley Marie Binch ,  Jeremy J. Ciemens ,  Thomas Cleveland ,  Erica Conroy ,  Timothy Richard Coon ,  Bryan A. Frieman ,  Peter Diederik Jan Grootenhuis ,  Raymond Stanley Gross ,  Sara Sabina Hadida-Ruah ,  Haripada Khatuya ,  Pramod Virupax Joshi ,  Paul John Krenitsky ,  Chun-Chieh Lin ,  Gulin Erdogan Marelius ,  Vito Melillo ,  Jason McCartney ,  Georgia McGaughey Nicholls ,  Fabrice Jean Denis Pierre ,  Alina Silina ,  Andreas P. Termin ,  Johnny Uy ,  Jinglan Zhou

Inventor： Mark Thomas Miller ,  Corey Anderson ,  Vijayalaksmi Arumugam ,  Brian Richard Bear ,  Hayley Marie Binch ,  Jeremy J. Ciemens ,  Thomas Cleveland ,  Erica Conroy ,  Timothy Richard Coon ,  Bryan A. Frieman ,  Peter Diederik Jan Grootenhuis ,  Raymond Stanley Gross ,  Sara Sabina Hadida-Ruah ,  Haripada Khatuya ,  Pramod Virupax Joshi ,  Paul John Krenitsky ,  Chun-Chieh Lin ,  Gulin Erdogan Marelius ,  Vito Melillo ,  Jason McCartney ,  Georgia McGaughey Nicholls ,  Fabrice Jean Denis Pierre ,  Alina Silina ,  Andreas P. Termin ,  Johnny Uy ,  Jinglan Zhou

IPC: A61K31/506 ,  A61K31/4418 ,  A61K31/444 ,  A61K31/44 ,  C07D213/84 ,  C07D231/14 ,  A61K31/415 ,  C07D209/42 ,  A61K31/404 ,  C07D401/12 ,  A61K31/4439 ,  C07D401/14 ,  C07D231/12 ,  A61K31/497 ,  C07D417/12 ,  C07D405/14 ,  A61K31/4545 ,  A61K31/4709 ,  A61K31/496 ,  A61K31/4525 ,  A61J1/03 ,  C07D213/82

CPC classification number: A61K31/506 ,  A61J1/035 ,  A61K31/404 ,  A61K31/415 ,  A61K31/44 ,  A61K31/4418 ,  A61K31/4439 ,  A61K31/444 ,  A61K31/4525 ,  A61K31/4545 ,  A61K31/4709 ,  A61K31/496 ,  A61K31/497 ,  C07D209/18 ,  C07D209/42 ,  C07D209/49 ,  C07D213/64 ,  C07D213/73 ,  C07D213/82 ,  C07D213/84 ,  C07D231/12 ,  C07D231/14 ,  C07D231/20 ,  C07D235/24 ,  C07D239/34 ,  C07D401/04 ,  C07D401/12 ,  C07D401/14 ,  C07D403/10 ,  C07D403/12 ,  C07D405/14 ,  C07D407/12 ,  C07D413/14 ,  C07D417/12

Abstract: The present invention features a compound of formula I: or a pharmaceutically acceptable salt thereof, where R1, R2, R3, W, X, Y, Z, n, o, p, and q are defined herein, for the treatment of CFTR mediated diseases, such as cystic fibrosis. The present invention also features pharmaceutical compositions, method of treating, and kits thereof.

公开(公告)号：US20150065313A1

公开(公告)日：2015-03-05

申请号：US14012300

申请日：2013-08-28

Applicant: Corey Anderson Cooper

Inventor： Corey Anderson Cooper

IPC: A63B21/075

CPC classification number: A63B21/075 ,  A63B21/0603 ,  A63B21/0609 ,  A63B21/072

Abstract: A method or apparatus for the following medicine ball design to increase or decrease the pounds of the device; without altering the shape. The right and left weight attachment slots on the device are designed to connect multiple fitness workout devices. These attachments allow the device to operate as a single source multi workout apparatus.

Abstract translation: 一种用于以下药物球设计以增加或减少装置磅数的方法或装置; 而不改变形状。 设备上的右和左重量附件插槽设计用于连接多个健身锻炼装置。 这些附件允许设备作为单个源多重锻炼设备操作。

公开(公告)号：US08343763B2

公开(公告)日：2013-01-01

申请号：US13402519

申请日：2012-02-22

Applicant: Nicole Hilgraf ,  Peter Diederik Jan Grootenhuis ,  Mehdi Numa ,  Dean Stamos ,  Corey Anderson ,  Tara Whitney

Inventor： Nicole Hilgraf ,  Peter Diederik Jan Grootenhuis ,  Mehdi Numa ,  Dean Stamos ,  Corey Anderson ,  Tara Whitney

IPC: A61K31/427 ,  A61P29/00 ,  A61P19/02 ,  A61P25/06 ,  A61P25/00 ,  A61P25/08 ,  A61P25/28 ,  A61P25/24 ,  A61P25/22 ,  A61P9/06 ,  A61P25/18 ,  A61P21/00 ,  A61P1/00 ,  A61P13/10 ,  A61P9/12

CPC classification number: C07D417/14

Abstract: The present invention relates to heterocyclic derivatives useful as inhibitors of ion channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.

Abstract translation: 本发明涉及可用作离子通道抑制剂的杂环衍生物。 本发明还提供包含本发明化合物的药学上可接受的组合物和使用该组合物治疗各种疾病的方法。

公开(公告)号：US08211935B2

公开(公告)日：2012-07-03

申请号：US12971609

申请日：2010-12-17

Applicant: Andreas P. Termin ,  Esther Ann Martinborough ,  Nicole Hilgraf ,  Charles J. Cohen ,  Corey Anderson

Inventor： Andreas P. Termin ,  Esther Ann Martinborough ,  Nicole Hilgraf ,  Charles J. Cohen ,  Corey Anderson

IPC: A61K31/496 ,  A61K31/55

CPC classification number: A61K31/405 ,  A61K31/343 ,  A61K31/381 ,  A61K31/404 ,  A61K31/496 ,  A61K31/5377 ,  A61K31/541 ,  A61K31/55

Abstract: Heterocyclic derivatives act as Ca channel antagonists. The compositions are useful for treating or relieving Ca channel mediated conditions.

Abstract translation: 杂环衍生物作为Ca通道拮抗剂。 该组合物可用于治疗或缓解Ca通道介导的病症。

公开(公告)号：US20110306607A1

公开(公告)日：2011-12-15

申请号：US13102335

申请日：2011-05-06

Applicant: Sara Sabina Hadida-Ruah ,  Edward Adam Kallel ,  Mark Thomas Miller ,  Joseph Pontillo ,  Vijayalaksmi Arumugam ,  Nicole Hilgraf ,  Jason McCartney ,  Peter Diederik Jan Grootenhuis ,  Corey Anderson ,  Mehdi Numa ,  Bryan A. Frieman ,  Brian Richard Bear ,  James Philip Johnson, JR.

Inventor： Sara Sabina Hadida-Ruah ,  Edward Adam Kallel ,  Mark Thomas Miller ,  Joseph Pontillo ,  Vijayalaksmi Arumugam ,  Nicole Hilgraf ,  Jason McCartney ,  Peter Diederik Jan Grootenhuis ,  Corey Anderson ,  Mehdi Numa ,  Bryan A. Frieman ,  Brian Richard Bear ,  James Philip Johnson, JR.

IPC: A61K31/5386 ,  C07D491/22 ,  A61K31/438 ,  A61P25/00 ,  A61P19/02 ,  A61P25/06 ,  A61P25/08 ,  A61P25/28 ,  A61P25/18 ,  A61P25/22 ,  A61P25/24 ,  A61P21/00 ,  A61P9/06 ,  A61P25/14 ,  A61P1/00 ,  A61P13/00 ,  A61P3/10 ,  A61P9/10 ,  A61P9/12 ,  A61P29/00 ,  A61P7/06 ,  A61P1/18 ,  A61P13/10 ,  A61P13/08 ,  C07D498/22

CPC classification number: C07D491/20 ,  C07D491/22 ,  C07D498/20 ,  C07D498/22 ,  C07D513/20

Abstract: The invention relates to heterocyclic chromene-spirocyclic piperidine amides useful as inhibitors of ion channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.

Abstract translation: 本发明涉及可用作离子通道抑制剂的杂环色烯 - 螺环哌啶酰胺。 本发明还提供包含本发明化合物的药学上可接受的组合物和使用该组合物治疗各种疾病的方法。

公开(公告)号：US20110178061A1

公开(公告)日：2011-07-21

申请号：US12971609

申请日：2010-12-17

Applicant: Andreas P. Termin ,  Esther Ann Martinborough ,  Nicole Hilgraf ,  Charles J. Cohen ,  Corey Anderson

Inventor： Andreas P. Termin ,  Esther Ann Martinborough ,  Nicole Hilgraf ,  Charles J. Cohen ,  Corey Anderson

IPC: A61K31/55 ,  C12N5/00 ,  A61K31/4525 ,  A61K31/4545 ,  A61K31/453 ,  A61K31/454 ,  A61K31/5377 ,  A61K31/506 ,  A61K31/443 ,  A61K31/541 ,  A61K31/496 ,  A61P29/00 ,  A61P25/24 ,  A61P25/28 ,  A61P25/22 ,  A61P25/08 ,  A61P9/06

CPC classification number: A61K31/405 ,  A61K31/343 ,  A61K31/381 ,  A61K31/404 ,  A61K31/496 ,  A61K31/5377 ,  A61K31/541 ,  A61K31/55

Abstract: Heterocyclic derivatives act as Ca channel antagonists. The compositions are useful for treating or relieving Ca channel mediated conditions.

Abstract translation: 杂环衍生物作为Ca通道拮抗剂。 该组合物可用于治疗或缓解Ca通道介导的病症。

公开(公告)号：US20110077269A1

公开(公告)日：2011-03-31

申请号：US12879237

申请日：2010-09-10

Applicant: Esther Martinborough ,  Andreas P. Termin ,  Timothy D. Neubert ,  Nicole Hilgraf ,  Corey Anderson

Inventor： Esther Martinborough ,  Andreas P. Termin ,  Timothy D. Neubert ,  Nicole Hilgraf ,  Corey Anderson

IPC: A61K31/4709 ,  C12N5/00 ,  A61K31/454 ,  A61P29/00 ,  A61P25/06 ,  A61P19/02 ,  A61P25/22 ,  A61P25/24 ,  A61K31/445 ,  A61K31/404

CPC classification number: C07D401/08 ,  C07D207/10 ,  C07D207/12 ,  C07D211/54 ,  C07D401/06 ,  C07D401/12 ,  C07D403/06 ,  C07D403/08

Abstract: Sulfonamide derivatives act as ion channel antagonists. The compositions are useful for treating or relieving pain-related conditions.

Abstract translation: 磺酰胺衍生物作为离子通道拮抗剂。 该组合物可用于治疗或缓解疼痛相关病症。

公开(公告)号：US20130035310A1

公开(公告)日：2013-02-07

申请号：US13633478

申请日：2012-10-02

Applicant: Esther Ann Martinborough ,  Lev Tyler Dewey Fanning ,  Urvi Jagdishbhai Sheth ,  Dean Mitchell Wilson ,  Andreas P. Termin ,  Timothy Donald Neubert ,  Nicole Hilgraf ,  Tara Leanne Hampton ,  Tara Whitney ,  Aarti Sameer Kawatkar ,  Danielle Lehsten ,  Dean Stamos ,  Jinglan Zhou ,  Vijayalaksmi Arumugam ,  Corey Anderson

Inventor： Esther Ann Martinborough ,  Lev Tyler Dewey Fanning ,  Urvi Jagdishbhai Sheth ,  Dean Mitchell Wilson ,  Andreas P. Termin ,  Timothy Donald Neubert ,  Nicole Hilgraf ,  Tara Leanne Hampton ,  Tara Whitney ,  Aarti Sameer Kawatkar ,  Danielle Lehsten ,  Dean Stamos ,  Jinglan Zhou ,  Vijayalaksmi Arumugam ,  Corey Anderson

IPC: A61K31/635 ,  A61K31/454 ,  A61K31/4545 ,  A61K31/496 ,  A61K31/427 ,  A61K31/695 ,  A61P29/00 ,  A61P25/06 ,  A61P25/00 ,  A61P25/22 ,  A61P25/24 ,  A61P25/08 ,  A61P9/06 ,  A61P25/28 ,  A61P19/02 ,  A61P9/12 ,  A61P1/00 ,  A61K31/506

CPC classification number: C07D417/12 ,  C07D239/42 ,  C07D401/12 ,  C07D405/12 ,  C07D417/14 ,  C07D471/10 ,  C07D491/10

Abstract: The present invention relates to piperidine and piperazine phenyl sulfonamides useful as inhibitors of ion channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders, including for example the treatment of pain.

Abstract translation: 本发明涉及可用作离子通道抑制剂的哌啶和哌嗪苯基磺酰胺。 本发明还提供包含本发明化合物的药学上可接受的组合物和使用该组合物治疗各种疾病（包括例如治疗疼痛）的方法。

公开(公告)号：US09694230B2

公开(公告)日：2017-07-04

申请号：US14823368

申请日：2015-08-11

Applicant: Corey Anderson Cooper

Inventor： Corey Anderson Cooper

IPC: A63B21/00 ,  A63B21/075 ,  A63B21/06 ,  A63B21/072

CPC classification number: A63B21/075 ,  A63B21/0603 ,  A63B21/0609 ,  A63B21/072 ,  A63B21/0722

Abstract: A medicine ball includes a central member with a pair of opposing concave sides. Further, convex attachments are each adapted to mate with the concave sides of the central member to form a sphere. These convex attachments are fastened together to the concave sides by a pair of fasteners, such as zippers. Additionally, attachment ports which can receive an exercise attachment are each positioned within the central member. Examples of exercise attachments include a barbell bar, a handgrip, and a pair of roller pairs, among others. In an alternative embodiment the attachment ports are positioned within the convex attachments. Further, an article of clothing has a receptacle to receive the convex attachments.

公开(公告)号：US08309587B2

公开(公告)日：2012-11-13

申请号：US13419936

申请日：2012-03-14

Applicant: Esther Ann Martinborough ,  Lev Tyler Dewey Fanning ,  Urvi Jagdishbhai Sheth ,  Dean Mitchell Wilson ,  Andreas P. Termin ,  Timothy Donald Neubert ,  Nicole Hilgraf ,  Tara Leanne Hampton ,  Tara Whitney ,  Aarti Sameer Kawatkar ,  Danielle Lehsten ,  Dean Stamos ,  Jinglan Zhou ,  Vijayalaksmi Arumugam ,  Corey Anderson

Inventor： Esther Ann Martinborough ,  Lev Tyler Dewey Fanning ,  Urvi Jagdishbhai Sheth ,  Dean Mitchell Wilson ,  Andreas P. Termin ,  Timothy Donald Neubert ,  Nicole Hilgraf ,  Tara Leanne Hampton ,  Tara Whitney ,  Aarti Sameer Kawatkar ,  Danielle Lehsten ,  Dean Stamos ,  Jinglan Zhou ,  Vijayalaksmi Arumugam ,  Corey Anderson

IPC: A01N43/78 ,  A61K31/425

CPC classification number: C07D417/12 ,  C07D239/42 ,  C07D401/12 ,  C07D405/12 ,  C07D417/14 ,  C07D471/10 ,  C07D491/10

Abstract: The present invention relates to piperidine and piperazine phenyl sulfonamides useful as inhibitors of ion channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders, including for example the treatment of pain.

Abstract translation: 本发明涉及可用作离子通道抑制剂的哌啶和哌嗪苯基磺酰胺。 本发明还提供包含本发明化合物的药学上可接受的组合物和使用该组合物治疗各种疾病（包括例如治疗疼痛）的方法。