公开(公告)号：US08178105B2

公开(公告)日：2012-05-15

申请号：US12519190

申请日：2007-12-14

申请人： Toshikazu Kamiya ,  Shun Kayahashi ,  Akio Shirai

发明人： Toshikazu Kamiya ,  Shun Kayahashi ,  Akio Shirai

IPC分类号： A61K36/06

CPC分类号： A61K36/07 ,  A61K31/198

摘要： The invention provides a composition containing a fruit body of Agaricus blazei murill or an extract of the fruit body, and an amino acid constituting the ornithine cycle or a salt thereof, wherein the pharmacological activities of the fruit body of Agaricus blazei murill or the extract of the fruit body and the amino acid constituting the omithine cycle or the salt thereof are increased synergistically. Such a composition can contain a fruit body of Agaricus blazei murill or an extract of the fruit body, and an amino acid constituting the ornithine cycle or a salt thereof in 10-100 parts by weight per 1 part by weight of the fruit body or the extract.

摘要翻译： 本发明提供一种含有姬松茸的水果体或果实的提取物的组合物和构成鸟氨酸循环的氨基酸或其盐，其中，姬松茸蕈果实果实的药理活性或提取物 水果体和构成奥米星循环的氨基酸或其盐的协同增加。 这种组合物可以含有10-100重量份的每1重量份水果体或果实体的水果体的果实体或果实的提取物，以及构成鸟氨酸循环的氨基酸或其盐 提取。

公开(公告)号：US20100093780A1

公开(公告)日：2010-04-15

申请号：US12440807

申请日：2007-09-19

申请人： Mika Sumi ,  Fumiko Ogino ,  Toshikazu Kamiya ,  Masahiko Nakano ,  Kazutoshi Kikkawa

发明人： Mika Sumi ,  Fumiko Ogino ,  Toshikazu Kamiya ,  Masahiko Nakano ,  Kazutoshi Kikkawa

IPC分类号： A61K31/437 ,  A61P3/10

CPC分类号： A61K31/437 ,  A23G3/364 ,  A23G4/12 ,  A23L33/10 ,  A23V2002/00 ,  A23V2200/328 ,  C07D471/04 ,  Y10S514/866

摘要： An object of the present invention is to provide a safe and highly effective insulin resistance improving agent or therapeutic agent for type II diabetes. According to the present invention, an insulin resistance improving agent or a therapeutic agent for type II diabetes comprising a compound represented by general formula (I) (wherein R1, R2, and R3 are the same as or different from each other, and each represents lower alkyl, lower alkenyl, lower alkynyl, aralkyl, araryl, phenyl, or a hydrogen atom) or a salt thereof as an active ingredient can be provided.

摘要翻译： 本发明的目的是提供一种安全高效的胰岛素抵抗改善剂或II型糖尿病治疗剂。 根据本发明，提供一种胰岛素抵抗性改善剂或II型糖尿病治疗剂，其含有通式（I）表示的化合物（其中，R1，R2和R3彼此相同或不同，表示 低级烷基，低级烯基，低级炔基，芳烷基，芳芳基，苯基或氢原子）或其盐作为有效成分。

公开(公告)号：US07485662B2

公开(公告)日：2009-02-03

申请号：US10549155

申请日：2004-03-19

申请人： Toshikazu Kamiya ,  Akio Shirai ,  Miho Takada ,  Fumiko Ogino

发明人： Toshikazu Kamiya ,  Akio Shirai ,  Miho Takada ,  Fumiko Ogino

IPC分类号： A61K31/40 ,  A61K31/21

CPC分类号： A61K31/401 ,  A23K20/142 ,  A23L2/52 ,  A23L33/175 ,  A23V2002/00 ,  A23V2250/064

摘要： An object of the present invention is to provide a therapeutic agent for diabetes mellitus or insulin resistance improving agent, or to provide foods and drinks, food and drink additives, and feeds or feed additives for treating diabetes mellitus or improving insulin diabetes.In order to achieve such an object, the present invention provides a therapeutic agent for diabetes mellitus and insulin resistance improving agent comprising hydroxyproline, a hydroxyproline derivative or a pharmaceutically acceptable salt thereof or foods and drinks, food and drink additives, feeds or feed additives for treatment of diabetes mellitus or improvement of insulin resistance comprising the same.

摘要翻译： 本发明的目的是提供糖尿病或胰岛素抵抗性改善剂的治疗剂，或提供食品和饮料，食品和饮料添加剂以及用于治疗糖尿病或改善胰岛素糖尿病的饲料或饲料添加剂。 为了达到上述目的，本发明提供了含有羟脯氨酸，羟脯氨酸衍生物或其药学上可接受的盐或食品和饮料的糖尿病和胰岛素抵抗改善剂的治疗剂，食品和饮料添加剂，饲料添加剂或饲料添加剂 糖尿病的治疗或胰岛素抵抗的改善包括它们。

公开(公告)号：US20070167512A1

公开(公告)日：2007-07-19

申请号：US10549156

申请日：2004-03-26

申请人： Toshikazu Kamiya ,  Akio Shirai

发明人： Toshikazu Kamiya ,  Akio Shirai

IPC分类号： A61K31/4015 ,  A61K47/00

CPC分类号： A23K20/142 ,  A23L33/175 ,  A61K31/401 ,  C07D207/16

摘要： An object of the present invention is to provide a lipid metabolism improving agent, or to provide foods and drinks, food and drink additives, and feeds or feed additives for improving lipid metabolism. In order to achieve such an object, the present invention provides a lipid metabolism improving agent comprising hydroxyproline, a hydroxyproline derivative or a pharmaceutically acceptable salt thereof or foods and drinks, food and drink additives, feeds or feed additives for improvement of lipid metabolism comprising the same.

摘要翻译： 本发明的目的是提供脂质代谢改善剂，或提供食品和饮料，食品和饮料添加剂以及用于改善脂质代谢的饲料或饲料添加剂。 为了实现这一目的，本发明提供了包含羟脯氨酸，羟脯氨酸衍生物或其药学上可接受的盐或食品和饮料，用于改善脂质代谢的食品和饮料添加剂，饲料或饲料添加剂的脂质代谢改善剂，其包括 相同。

公开(公告)号：US07138386B2

公开(公告)日：2006-11-21

申请号：US10250373

申请日：2001-12-27

申请人： Ryusuke Nakagiri ,  Toshikazu Kamiya

发明人： Ryusuke Nakagiri ,  Toshikazu Kamiya

IPC分类号： A61K31/715 ,  A61K31/726 ,  A61K31/70

CPC分类号： A61K9/0095 ,  A23K20/105 ,  A23K20/142 ,  A23K50/00 ,  A23K50/40 ,  A23L33/17 ,  A23L33/175 ,  A61K9/0056 ,  A61K9/0058 ,  A61K9/1623 ,  A61K9/2013 ,  A61K9/2018 ,  A61K9/4858 ,  A61K31/00 ,  A61K31/401 ,  A61K31/726 ,  A61K31/737 ,  C07D207/16 ,  A61K2300/00

摘要： The present invention relates to pharmaceuticals, foods and drinks, food additives, animal feeds and feed additives comprising an N-acylated hydroxyproline derivative or a salt thereof, and an amino sugar or a salt thereof and/or a glycosaminoglycan or a salt thereof as active ingredients, use of an Nacylated hydroxyproline derivative or a salt thereof for the production of an arthritis preventing or treating agent, and a method for preventing or treating arthritis which comprises administering an N-acylated hydroxyproline derivative or a salt thereof, and an amino sugar or a salt thereof and/or a glycosaminoglycan or a salt thereof.

摘要翻译： 本发明涉及作为活性物质的药物，食品和饮料，食品添加剂，动物饲料和包含N-酰化羟脯氨酸衍生物或其盐的饲料添加剂和氨基糖或其盐和/或糖胺聚糖或其盐 成分，使用N-羟基脯氨酸衍生物或其盐用于制备关节炎预防或治疗剂，以及预防或治疗关节炎的方法，其包括施用N-酰化羟脯氨酸衍生物或其盐，以及氨基糖或 其盐和/或糖胺聚糖或其盐。

公开(公告)号：US20060193962A1

公开(公告)日：2006-08-31

申请号：US10552526

申请日：2004-04-09

申请人： Toshikazu Kamiya ,  Ryusuke Nakagiri

发明人： Toshikazu Kamiya ,  Ryusuke Nakagiri

IPC分类号： A23L1/212

CPC分类号： A61K31/726 ,  A23K10/30 ,  A23K20/10 ,  A23K20/163 ,  A23L33/105 ,  A23V2002/00 ,  A61K31/7008 ,  A61K36/185 ,  A61K2300/00 ,  A23V2250/21 ,  A23V2250/308

摘要： An object of the present invention is to provide a preventing agent or a treating agent for arthritis or to provide foods and drinks, additives for foods and drinks, feeds or additives for feeds for prevention or treatment of arthritis. In order to achieve the above object, the present invention provides a preventing or treating agent for arthritis or foods and drinks, additives for foods and drinks, feeds or additives for feeds for prevention or treatment of arthritis comprising plant belonging to the genus Hydrangea or an extract of the plant and amino sugar or a salt thereof and/or glycosaminoglycan or a salt thereof as active ingredients.

摘要翻译： 本发明的目的是提供一种用于关节炎的预防剂或治疗剂或提供食品和饮料，食品和饮料的添加剂，用于预防或治疗关节炎的饲料的饲料或添加剂。 为了实现上述目的，本发明提供了用于关节炎或食品和饮料的预防或治疗剂，用于食品和饮料的添加剂，用于预防或治疗关节炎的饲料的饲料或添加剂，所述关节炎包括属于绣球属属的植物或 植物提取物和氨基糖或其盐和/或糖胺聚糖或其盐作为活性成分。

公开(公告)号：US06946451B2

公开(公告)日：2005-09-20

申请号：US10356564

申请日：2003-02-03

申请人： Miho Takada ,  Toshikazu Kamiya ,  Tetsuo Endo ,  Satoshi Koizumi

发明人： Miho Takada ,  Toshikazu Kamiya ,  Tetsuo Endo ,  Satoshi Koizumi

IPC分类号： A21D2/18 ,  A21D13/08 ,  A23K1/16 ,  A23L1/09 ,  A23L1/30 ,  A61K31/7012 ,  A61K31/7016 ,  A61K31/702

CPC分类号： A23K20/163 ,  A21D2/181 ,  A21D13/80 ,  A23L29/30 ,  A23L33/10 ,  A23L33/125 ,  A61K31/7012 ,  A61K31/7016 ,  A61K31/702

摘要： Provided are a method for promoting insulin secretion, a method for suppressing the elevation of a blood glucose level, a method for ameliorating diabetes mellitus, a method for promoting growth of an animal, and a method for increasing an insulin level in breast milk. These methods comprising administering at least one member selected from the group consisting of a di- or a higher saccharide containing galactose, a derivative thereof, a saccharide containing N-acetylneuraminic acid, and a derivative thereof, to a patient in need thereof or an animal.

摘要翻译： 提供促进胰岛素分泌的方法，抑制血糖水平升高的方法，改善糖尿病的方法，促进动物生长的方法以及增加母乳中胰岛素水平的方法。 这些方法包括向有需要的患者或动物施用至少一种选自二糖或高级糖的半乳糖，其衍生物，含有N-乙酰神经氨酸的糖及其衍生物的成员 。

公开(公告)号：US06256566B1

公开(公告)日：2001-07-03

申请号：US09210302

申请日：1998-12-11

申请人： Toshikazu Kamiya ,  Kunio Maki

发明人： Toshikazu Kamiya ,  Kunio Maki

IPC分类号： G06F770

CPC分类号： B66F17/003

摘要： A lift vehicle and a method for initializing a controller for controlling a lifting mechanism of lift vehicle. The controller controls the maximum forward tilt angle of a mast by controlling a solenoid of a hydraulic circuit. The controller employs a stored map or equation that defines a relationship between the forward tilt limit and another parameter. When the mast is tilted at two degrees, a CPU reads the detection value of a tilt angle sensor and sets it as a reference value. The reference value is used to calibrate the controller. The same function information can be used for many types of lift vehicles by selecting the appropriate control ranges for each vehicle.

摘要翻译： 一种升降车和用于初始化用于控制升降车的提升机构的控制器的方法。 控制器通过控制液压回路的螺线管来控制桅杆的最大前倾角。 控制器使用存储的映射或等式来定义前倾斜极限与另一个参数之间的关系。 当桅杆倾斜两度时，CPU读取倾斜角传感器的检测值，并将其设置为参考值。 参考值用于校准控制器。 通过选择各车辆的适当控制范围，可以为多种类型的起重车辆使用相同的功能信息。

公开(公告)号：US07568547B2

公开(公告)日：2009-08-04

申请号：US11541075

申请日：2006-09-29

申请人： Tadashi Yamada ,  Hidenori Oka ,  Toshikazu Kamiya ,  Kimihide Hasegawa ,  Michihiro Miura ,  Masayuki Takahashi ,  Hirokazu Kobayashi

发明人： Tadashi Yamada ,  Hidenori Oka ,  Toshikazu Kamiya ,  Kimihide Hasegawa ,  Michihiro Miura ,  Masayuki Takahashi ,  Hirokazu Kobayashi

IPC分类号： B66F9/75 ,  B66F17/00 ,  B60K28/08

CPC分类号： B66F17/003 ,  B60Y2200/15 ,  B66F9/07572

摘要： A drive control apparatus for a forklift. Based on the load state, it is determined whether to limit a maximum vehicle speed and an acceleration/deceleration during traveling of the forklift. Limitation contents regarding the maximum vehicle speed and the acceleration/deceleration is determined based on a determination result of whether to put the limitations. A speed of the engine is adjusted based on the determined limitation contents, thereby controlling driving of the forklift. When the determined limitation contents are changed, an acceleration/deceleration limitation value is selected from a plurality of acceleration/deceleration limitation values according to the pattern of the change of the limitation contents, and drive control related to the acceleration/deceleration is executed to limit the acceleration/deceleration of the forklift by using the selected acceleration/deceleration limitation value.

摘要翻译： 一种用于叉车的驱动控制装置。 基于负载状态，确定在叉车行驶期间是否限制最大车速和加速/减速。 关于最大车速和加速/减速的限制内容基于是否限制的确定结果来确定。 基于确定的限制内容来调整发动机的速度，由此控制叉车的行驶。 当确定的限制内容改变时，根据限制内容的改变的模式从多个加速/减速限制值中选择加速/减速限制值，并且执行与加速/减速相关的驱动控制 通过使用所选择的加速/减速限制值来确定叉车的加速/减速。

公开(公告)号：US20070293559A1

公开(公告)日：2007-12-20

申请号：US11663432

申请日：2005-09-21

申请人： Erika Kagami ,  Koji Morishita ,  Toshikazu Kamiya ,  Ayako Kamimura

发明人： Erika Kagami ,  Koji Morishita ,  Toshikazu Kamiya ,  Ayako Kamimura

IPC分类号： A61K31/401 ,  A23J1/00 ,  A23K1/00 ,  A61P17/00 ,  A23L1/305

CPC分类号： A23L2/52 ,  A23K20/142 ,  A23L33/175 ,  A23V2002/00 ,  A61K8/4913 ,  A61K8/64 ,  A61K31/401 ,  A61K2800/92 ,  A61Q19/007 ,  A23V2200/318 ,  A23V2250/064

摘要： Orally administered agents, foods and drinks, feeds, food additives or feed additives for preventing or treating a dry state of the skin accompanied by atopic dermatitis, xeroderma, chapped hand, chapped skin and the like are provided. The present invention can provide orally administered agents, foods and drinks, feeds, food additives or feed additives for preventing or treating a dry state of the skin, which comprise hydroxyproline, an N-acyl derivative of hydroxyproline, especially an N-acetyl derivative, an N-propionyl derivative, an N-butyryl derivative, an N-isobutyryl derivative, or a salt thereof as an active ingredient.

摘要翻译： 提供了口服给药的药剂，食品和饮料，饲料，食品添加剂或饲料添加剂，用于预防或治疗伴随特应性皮炎的皮肤干燥状态，皮肤干燥，劈裂的手，裂纹皮肤等。 本发明可以提供包含羟脯氨酸，羟脯氨酸的N-酰基衍生物，特别是N-乙酰基衍生物的口服给药剂，食品和饮料，饲料，食品添加剂或用于预防或治疗皮肤干燥状态的饲料添加剂， N-丙酰基衍生物，N-丁酰基衍生物，N-异丁酰基衍生物或其盐作为有效成分。