公开(公告)号：US07938799B2

公开(公告)日：2011-05-10

申请号：US11780885

申请日：2007-07-20

申请人： Samuel J. Epstein ,  Toby Freyman ,  Chad G. Harris ,  Timothy J. Mickley

发明人： Samuel J. Epstein ,  Toby Freyman ,  Chad G. Harris ,  Timothy J. Mickley

IPC分类号： A61M31/00 ,  A61M37/00

CPC分类号： A61M29/02 ,  A61B17/12022 ,  A61B17/1204 ,  A61B17/12104 ,  A61B17/12131 ,  A61B17/12172 ,  A61B2017/1205 ,  A61M2025/0024 ,  A61M2025/1052 ,  A61M2025/1081 ,  A61M2025/1095

摘要： The invention provides devices that can be used to deliver a therapeutic agent to a treatment site within the vessel of a patient at increased pressure, while limiting the contact with and pressure placed on the vessel walls. Devices according to the invention include an expandable structure arranged around and on a tube having a lumen. The expandable structure may include a sealing ring that makes contact with the interior surface of a vessel to prevent or decrease fluid flow during delivery of a therapeutic agent. This allows delivery of a therapeutic agent with decreased risk of injury to the treatment site. The invention also provides for large lumen diameters, preventing shearing stress on therapeutic agents such as cell slurries.

摘要翻译： 本发明提供了可用于将治疗剂递送到患者血管内的治疗部位的装置，所述治疗部位在增加的压力下同时限制与血管壁上的接触和压力。 根据本发明的装置包括布置在具有内腔的管周围和管上的可扩张结构。 可膨胀结构可包括与血管内表面接触以防止或减少递送治疗剂期间的流体流动的密封环。 这允许递送具有降低治疗部位损伤风险的治疗剂。 本发明还提供大的管腔直径，防止治疗剂如细胞浆液的剪切应力。

公开(公告)号：US07645268B2

公开(公告)日：2010-01-12

申请号：US10808357

申请日：2004-03-25

申请人： Timothy J. Mickley ,  John E. Uschold

发明人： Timothy J. Mickley ,  John E. Uschold

IPC分类号： A61M5/32 ,  A61M31/00

CPC分类号： A61M5/3286

摘要： A needle having a shaft with a distal end defining a distal opening. The shaft has a longitudinal axis that extends through the distal opening and the distal opening has a projected area that is smaller than a cross-sectional area of a section of the shaft proximal to the distal end of the shaft. Also provided are methods of directly delivering a therapeutic agent to a target site using a Huber needle or pencil-point needle.

摘要翻译： 具有轴的针，其具有限定远端开口的远端。 轴具有延伸穿过远侧开口的纵向轴线，并且远侧开口具有小于轴的远侧轴端部分的横截面面积的突出面积。 还提供了使用Huber针或铅笔针将治疗剂直接递送至靶位点的方法。

公开(公告)号：US07625356B2

公开(公告)日：2009-12-01

申请号：US11405553

申请日：2006-04-18

申请人： Timothy J. Mickley

发明人： Timothy J. Mickley

IPC分类号： A61M5/178

CPC分类号： A61M25/0136 ,  A61M25/0041 ,  A61M25/0084 ,  A61M25/0133 ,  A61M25/0662 ,  A61M2025/0089 ,  A61M2025/0681

摘要： Devices and methods for delivering therapeutic or diagnostic agents to a target tissue of a human body are disclosed. A catheter in accordance with the present invention includes an injection catheter assembly having a first elongated member with a proximal end, a distal end, an external surface, and an inside surface defining a first lumen. The catheter includes a second elongated member having a proximal region and a distal region. The second elongated member is positioned at least partially within the first elongated member. The second elongated member has a second helical member fixed to an end. The catheter also includes a third elongated member. The third elongated member defines a lumen along a portion of the length of the first elongated member. The third elongated member has a first helical member. The second helical member is longitudinally moveable within the lumen of the first helical member to move the second elongated member longitudinally.

摘要翻译： 公开了将治疗剂或诊断剂递送到人体的靶组织的装置和方法。 根据本发明的导管包括具有第一细长构件的注射导管组件，所述第一细长构件具有近端，远端，外表面和限定第一腔的内表面。 导管包括具有近端区域和远侧区域的第二细长构件。 第二细长构件至少部分地定位在第一细长构件内。 第二细长构件具有固定到一端的第二螺旋构件。 导管还包括第三细长构件。 第三细长构件沿着第一细长构件的长度的一部分限定内腔。 第三细长构件具有第一螺旋构件。 第二螺旋构件可以在第一螺旋构件的内腔内纵向移动以纵向移动第二细长构件。

公开(公告)号：US07399294B2

公开(公告)日：2008-07-15

申请号：US10454624

申请日：2003-06-05

申请人： Timothy J. Mickley

发明人： Timothy J. Mickley

IPC分类号： A61M5/00

CPC分类号： A61M25/0084 ,  A61M25/0069 ,  A61M2025/0089

摘要： An injection catheter assembly is provided. This assembly can include an outer elongated member having a proximal end, a distal end, and an external diameter and an inner elongated member having a proximal region and a distal region. The inner elongated member may be positioned at least partially within the outer elongated member, may have a piercing tip at the end of the proximal region and may be rotatable within the outer elongated member with the degree of rotation of the inner elongated member adjusting the distance that the piercing tip can extend from the distal end of the outer elongated member.

摘要翻译： 提供了一种注射导管组件。 该组件可以包括具有近端，远端和外径的外部细长构件和具有近侧区域和远侧区域的内部细长构件。 内部细长构件可以至少部分地定位在外部细长构件内，可以在近端区域的端部处具有穿刺尖端，并且可以在外部细长构件内旋转，内部细长构件的旋转程度调节距离 穿刺尖端可以从外部细长构件的远端延伸。

公开(公告)号：US07211067B2

公开(公告)日：2007-05-01

申请号：US10844425

申请日：2004-05-13

申请人： Matthew Hawk ,  Scott Larson ,  Timothy J. Mickley ,  Chad Harris

发明人： Matthew Hawk ,  Scott Larson ,  Timothy J. Mickley ,  Chad Harris

IPC分类号： A61M5/178

CPC分类号： A61M25/0069 ,  A61B17/3478 ,  A61B2017/00247 ,  A61B2017/22069 ,  A61B2017/22077 ,  A61B2017/348 ,  A61B2017/3488 ,  A61B2018/00392 ,  A61B2018/00738 ,  A61B2090/036 ,  A61B2218/002 ,  A61M25/10 ,  A61M2025/1093

摘要： An elongate medical device that may be used for performing medical procedures on a patient is provided. This elongate medical device may include a first member having an elongated configuration, a second member pivotally coupled to the first member at a pivot area of the first member, and a manipulation member extending through either a first lumen or a second lumen of the first member. The second member of this device may have a first region on one side of the pivot area and a second region on a different side of the pivot area. The medical device may also include a third member slidable within one of the lumens of the first member.

摘要翻译： 提供了可用于对患者执行医疗程序的细长医疗装置。 这种细长的医疗装置可以包括具有细长构型的第一构件，在第一构件的枢转区域处枢转地联接到第一构件的第二构件，以及延伸穿过第一构件的第一腔或第二腔的操作构件 。 该装置的第二构件可以具有在枢转区域的一侧上的第一区域和在枢转区域的不同侧上的第​​二区域。 医疗装置还可以包括可在第一构件的腔内的一个内滑动的第三构件。

公开(公告)号：US06767338B2

公开(公告)日：2004-07-27

申请号：US10379591

申请日：2003-03-06

申请人： Matthew Hawk ,  Scott Larson ,  Timothy J. Mickley ,  Chad Harris

发明人： Matthew Hawk ,  Scott Larson ,  Timothy J. Mickley ,  Chad Harris

IPC分类号： A61M5178

CPC分类号： A61M25/0069 ,  A61B17/3478 ,  A61B2017/00247 ,  A61B2017/22069 ,  A61B2017/22077 ,  A61B2017/348 ,  A61B2017/3488 ,  A61B2018/00392 ,  A61B2018/00738 ,  A61B2090/036 ,  A61B2218/002 ,  A61M25/10 ,  A61M2025/1093

摘要： A therapeutic catheter is provided. This therapeutic catheter may include an outer tube with a distal piercing end and a first lumen which may have a stop positioned within it. The first lumen may also have a plug positioned within it wherein the stop may have an inside diameter smaller than the inside diameter of the first lumen and the plug may be sized to prevent travel of the stop outside of the distal end of the outer tube.

摘要翻译： 提供治疗导管。 该治疗导管可以包括具有远端穿刺端的外管和可位于其内的停止的第一内腔。 第一内腔还可以具有位于其内的塞子，其中止动件可以具有小于第一内腔的内径的内径，并且塞子的尺寸可以设计成防止止动件在外管远端的行进。

公开(公告)号：US06764461B2

公开(公告)日：2004-07-20

申请号：US09138131

申请日：1998-08-21

申请人： Timothy J. Mickley ,  Thomas R. Hektner ,  Louis Ellis ,  Gary L. Hendrickson

发明人： Timothy J. Mickley ,  Thomas R. Hektner ,  Louis Ellis ,  Gary L. Hendrickson

IPC分类号： A61F1320

CPC分类号： A61M25/104 ,  A61M5/00 ,  A61M29/02 ,  A61M2025/0057 ,  A61M2025/1013 ,  A61M2025/105 ,  A61M2025/1086 ,  A61M2025/1093

摘要： A catheter system includes a catheter having a proximal end, a distal end, and a lumen extending therein. An administering portion is disposed at the distal end of the catheter and is configured to administer a bolus of liquid in response to positive pressure in a distal portion of the lumen. The catheter system of the present invention has a dead space of less 0.32 cc and preferably less than 0.15 cc in which residual therapeutic agents remain after delivery. The present invention also includes a method of administering a liquid to a treatment site. The distal end of the catheter is transluminally positioned proximate the treatment site. The catheter is charged by placing a bolus of the liquid in the lumen A positive pressure is created to drive the bolus to the administering tip to express the bolus from the distal end of the catheter.

摘要翻译： 导管系统包括具有近端，远端和在其中延伸的内腔的导管。 给药部分设置在导管的远端处，并且构造成响应于内腔的远端部分中的正压而施用大量液体。 本发明的导管系统具有小于0.32cc，优选小于0.15cc的死空间，其中残留的治疗剂在分娩后残留。 本发明还包括向处理部位施用液体的方法。 导管的远端位于治疗部位附近。 导管通过将大量液体放置在内腔中来进行充电。产生正压力以将推注驱动到施用尖端以从导管的远端表达推注。

公开(公告)号：US06264630B1

公开(公告)日：2001-07-24

申请号：US09219802

申请日：1998-12-23

申请人： Timothy J. Mickley ,  Chad G. Harris

发明人： Timothy J. Mickley ,  Chad G. Harris

IPC分类号： A61M2900

CPC分类号： A61M25/104 ,  A61B17/22012 ,  A61M25/0043 ,  A61M25/0054 ,  A61M25/1006 ,  A61M2025/0063 ,  A61M2025/0081 ,  A61M2025/1079 ,  A61M2025/1093

摘要： A catheter is disclosed which includes an over-the-wire type balloon catheter, with a guide wire, wherein the catheter incorporates an axially movable inner tubular member which extends proximally through a proximal manifold lumen. The inner tubular member extends distally beyond the distal end of the outer tubular member with the balloon member distal waist affixed to the inner tubular member proximate the distal end. The catheter incorporates axial tension members which function to transmit force to the distal tip when the movable inner tubular member is oscillated axially. The axial tension members are preferably a plurality of wires, each having a proximal end affixed to the outside diameter of the inner tubular member proximate the manifold, and each having a distal end affixed to the outside diameter of the inner tubular member a substantial distance distal of the manifold. When the inner tubular member is pulled proximally, energy is stored in the catheter, which when the inner is released, forces the distal tip forward with added force from the distal point of attachment of the axial tension members. An actuator and a valve assembly are preferably included.

摘要翻译： 公开了一种导管，其包括具有导丝的超线型气囊导管，其中所述导管包括沿近侧延伸通过近端歧管内腔的可轴向移动的内部管状构件。 内部管状构件向远侧延伸超过外部管状构件的远端，球囊构件远端腰部靠近远端固定到内部管状构件。 该导管包括轴向张力构件，当可移动的内部管状构件轴向摆动时，该张力构件用于将力传递到远侧末端。 轴向张力构件优选地是多个线，每个线具有固定到靠近歧管的内部管状构件的外径的近端，并且每个具有固定到内部管状构件的外径的远端，远端远离 的歧管。 当内部管状构件被向近侧拉动时，能量被存储在导管中，当内部被释放时，其能够通过来自轴向张力构件的远端附接点的附加力向前推动远侧末端。 优选地包括致动器和阀组件。

公开(公告)号：US5961536A

公开(公告)日：1999-10-05

申请号：US950520

申请日：1997-10-14

申请人： Timothy J. Mickley ,  Steven P. Mertens ,  Christopher R. Larson ,  Chad G. Harris ,  John H. Carlson, II

发明人： Timothy J. Mickley ,  Steven P. Mertens ,  Christopher R. Larson ,  Chad G. Harris ,  John H. Carlson, II

IPC分类号： A61F2/958 ,  A61M25/10

CPC分类号： A61M25/10 ,  A61M2025/1068

摘要： A variable length balloon catheter is provided. The balloon catheter includes a catheter shaft having a distal portion, a balloon and an adjustment device. The balloon is in fluid communication with a distal end of the catheter shaft. The adjustment device includes an outer sleeve and an attachment structure. The outer sleeve is configured to be generally co-axially received over the distal portion of the catheter shaft and includes a distal end configured to restrict inflation proximal the distal end. Further, the outer sleeve is configured such that at least a portion of the outer sleeve is slidable relative to the distal portion of the catheter shaft such that a distal end of the outer sleeve relative to the balloon can be varied. The attachment structure is similarly disposed at the distal portion of the catheter shaft and is configured to selectively secure at least a portion of the outer sleeve to the distal portion of the catheter shaft such that the outer sleeve will not move upon inflation of the balloon.

摘要翻译： 提供可变长度的球囊导管。 气囊导管包括具有远端部分的导管轴，球囊和调节装置。 气囊与导管轴的远端流体连通。 调节装置包括外套筒和附接结构。 外套管被构造成大致同轴地容纳在导管轴的远侧部分上，并且包括构造成限制近端近端的充气的远端。 此外，外套筒构造成使得外套筒的至少一部分相对于导管轴的远端部分可滑动，使得外套筒相对于球囊的远端可以改变。 附接结构类似地设置在导管轴的远端部分处，并被构造成选择性地将外套筒的至少一部分固定到导管轴的远端部分，使得外套筒在气囊膨胀时不会移动。

公开(公告)号：US08512395B2

公开(公告)日：2013-08-20

申请号：US13239098

申请日：2011-09-21

申请人： Michael P. Meyer ,  Timothy J. Mickley

发明人： Michael P. Meyer ,  Timothy J. Mickley

IPC分类号： A61F2/06

CPC分类号： A61F2/915 ,  A61F2002/91508 ,  A61F2002/91516 ,  A61F2002/91525 ,  A61F2230/0054 ,  A61F2250/0036

摘要： In at least one embodiment, a stent includes an unexpanded configuration, a nominally expanded configuration, and a fully expanded configuration. The stent further includes a plurality of circumferential bands and a plurality of connectors connecting adjacent circumferential bands to one another. Each circumferential band has a plurality of struts interconnected by bridges. Adjacent struts form strut pairs and are connected to one another at a first end or a second end but not both. Each strut pair defines an opening between the struts of the strut pair; the bridges extend into the openings. In the unexpanded configuration, the struts are straight along their length. Also in the unexpanded configuration, the bridges include two adjacent straight segments that are connected by a u-shaped segment, and the straight segments are parallel to one another and to the longitudinal axis of the stent.

摘要翻译： 在至少一个实施例中，支架包括未膨胀构型，标称扩张构型和完全扩张构型。 所述支架还包括多个周向带和将相邻周向带彼此连接的多个连接器。 每个周向带具有通过桥互连的多个支柱。 相邻的支柱形成支柱对，并且在第一端或第二端彼此连接，但不是两者连接。 每个支柱对限定支柱对的支柱之间的开口; 桥梁延伸到开口中。 在未膨胀的配置中，支柱沿其长度是直的。 同样在未膨胀的构造中，桥包括两个相邻的直线段，其通过U形段连接，并且直段彼此平行并且与支架的纵向轴线平行。