-
公开(公告)号：US06764461B2
公开(公告)日：2004-07-20
申请号：US09138131
申请日：1998-08-21
IPC分类号： A61F1320
CPC分类号： A61M25/104 , A61M5/00 , A61M29/02 , A61M2025/0057 , A61M2025/1013 , A61M2025/105 , A61M2025/1086 , A61M2025/1093
摘要： A catheter system includes a catheter having a proximal end, a distal end, and a lumen extending therein. An administering portion is disposed at the distal end of the catheter and is configured to administer a bolus of liquid in response to positive pressure in a distal portion of the lumen. The catheter system of the present invention has a dead space of less 0.32 cc and preferably less than 0.15 cc in which residual therapeutic agents remain after delivery. The present invention also includes a method of administering a liquid to a treatment site. The distal end of the catheter is transluminally positioned proximate the treatment site. The catheter is charged by placing a bolus of the liquid in the lumen A positive pressure is created to drive the bolus to the administering tip to express the bolus from the distal end of the catheter.
摘要翻译： 导管系统包括具有近端，远端和在其中延伸的内腔的导管。 给药部分设置在导管的远端处，并且构造成响应于内腔的远端部分中的正压而施用大量液体。 本发明的导管系统具有小于0.32cc，优选小于0.15cc的死空间，其中残留的治疗剂在分娩后残留。 本发明还包括向处理部位施用液体的方法。 导管的远端位于治疗部位附近。 导管通过将大量液体放置在内腔中来进行充电。产生正压力以将推注驱动到施用尖端以从导管的远端表达推注。
-
公开(公告)号：US07695455B2
公开(公告)日：2010-04-13
申请号：US10882397
申请日：2004-07-02
CPC分类号： A61M25/104 , A61M5/00 , A61M29/02 , A61M2025/0057 , A61M2025/1013 , A61M2025/105 , A61M2025/1086 , A61M2025/1093
摘要： A catheter system includes a catheter having a proximal end, a distal end, and a lumen extending therein. An administering portion is disposed at the distal end of the catheter and is configured to administer a bolus of liquid in response to positive pressure in a distal portion of the lumen. The catheter system of the present invention has a dead space of less 0.32 cc and preferably less than 0.15 cc in which residual therapeutic agents remain after delivery. The present invention also includes a method of administering a liquid to a treatment site. The distal end of the catheter is transluminally positioned proximate the treatment site. The catheter is charged by placing a bolus of the liquid in the lumen. A positive pressure is created to drive the bolus to the administering tip to express the bolus from the distal end of the catheter.
摘要翻译： 导管系统包括具有近端，远端和在其中延伸的内腔的导管。 给药部分设置在导管的远端处，并且构造成响应于内腔的远端部分中的正压而施用大量液体。 本发明的导管系统具有小于0.32cc，优选小于0.15cc的死空间，其中残留的治疗剂在分娩后残留。 本发明还包括向处理部位施用液体的方法。 导管的远端位于治疗部位附近。 通过将大量液体放置在管腔中来对导管进行充电。 产生正压力以将推注剂驱动到施用尖端以从导管的远端表达推注。
-
3.发明授权公开(公告)号：US06238406B1
公开(公告)日：2001-05-29
申请号：US09516531
申请日：2000-03-01
IPC分类号： A61B1732
CPC分类号： A61B17/32002 , A61B17/320758 , A61B17/3468 , A61B17/3478 , A61B90/39 , A61B2017/00247 , A61B2017/003 , A61B2017/22077 , A61B2017/320084 , A61B2018/00208 , A61B2018/00392 , A61B2018/1425 , A61B2018/1861 , A61F2/2493 , A61M2025/0089
摘要： Devices and methods for increasing blood perfusion within the myocardium of the heart by wounding the myocardium and applying growth factors to promote vascularization. One method includes driving spikes into the myocardium from within the heart, with the spikes being formed of biodegradable material, containing releasable growth factors, and having lumens and side holes. An alternative method utilizes non-biodegradable spikes with lumens and side holes. Another method promotes vascularization by injecting angiogenic material into holes bored into the myocardium, leaving a patent hole. Another method includes injecting angiogenic material into the myocardium without boring, leaving no patent hole. The angiogenic material can be carried in a biodegradable adhesive. Revascularization of the myocardium is promoted in one method by externally wounding the heart and applying a patch including growth factors.
摘要翻译： 通过伤害心肌并应用生长因子促进血管形成来增加心脏心肌内的血液灌注的装置和方法。 一种方法包括从心脏内将尖峰驱动到心肌中，其中尖峰由可生物降解的材料形成，包含可释放的生长因子，并具有流明和侧孔。 一种替代方法是利用不可生物降解的钉与流明和侧孔。 另一种方法通过将血管生成材料注入穿入心肌的孔中来促进血管形成，留下专利孔。 另一种方法包括将血管生成物质注入到心肌中而无需镗孔，没有留下专利孔。 血管生成物质可以携带在可生物降解的粘合剂中。 通过外部伤心并施用包括生长因子的贴片在一种方法中促进心肌的血运重建。
-
4.发明授权
公开(公告)号：US6045565A
公开(公告)日：2000-04-04
申请号：US184220
申请日：1998-11-02
CPC分类号： A61B17/32002 , A61B17/3468 , A61B17/3478 , A61F2/2493 , A61B17/320758 , A61B2017/00247 , A61B2017/003 , A61B2017/22077 , A61B2017/320084 , A61B2018/00208 , A61B2018/00392 , A61B2018/1425 , A61B2018/1861 , A61B90/39 , A61M2025/0089
摘要： Devices and methods for increasing blood perfusion within the myocardium of the heart by wounding the myocardium and applying growth factors to promote vascularization. One method includes driving spikes into the myocardium from within the heart, with the spikes being formed of biodegradable material, containing releasable growth factors, and having lumens and side holes. An alternative method utilizes non-biodegradable spikes with lumens and side holes. Another method promotes vascularization by injecting angiogenic material into holes bored into the myocardium, leaving a patent hole. Another method includes injecting angiogenic material into the myocardium without boring, leaving no patent hole. The angiogenic material can be carried in a biodegradable adhesive. Revascularization of the myocardium is promoted in one method by externally wounding the heart and applying a patch including growth factors.
摘要翻译： 通过伤害心肌并应用生长因子促进血管形成来增加心脏心肌内的血液灌注的装置和方法。 一种方法包括从心脏内将尖峰驱动到心肌中，其中尖峰由可生物降解的材料形成，包含可释放的生长因子，并且具有腔和侧孔。 一种替代方法是利用不可生物降解的钉与流明和侧孔。 另一种方法通过将血管生成材料注入穿入心肌的孔中来促进血管形成，留下专利孔。 另一种方法包括将血管生成物质注入到心肌中而无需镗孔，没有留下专利孔。 血管生成物质可以携带在可生物降解的粘合剂中。 通过外部伤心并施用包括生长因子的贴片在一种方法中促进心肌的血运重建。
-
公开(公告)号：US20100145306A1
公开(公告)日：2010-06-10
申请号：US12509105
申请日：2009-07-24
申请人： Timothy J. Mickley , Grace Kim , Samuel J. Epstein , Mark Griffin , John Edrington , Greg Furnish
发明人： Timothy J. Mickley , Grace Kim , Samuel J. Epstein , Mark Griffin , John Edrington , Greg Furnish
CPC分类号： A61M25/0068 , A61B17/3478 , A61B2017/00243 , A61B2017/00247 , A61B2018/00392 , A61B2090/036 , A61B2090/08021 , A61M25/0069 , A61M25/0074 , A61M25/0082 , A61M25/0084 , A61M2025/0089 , A61M2025/0096 , A61M2025/0681 , A61M2025/1093 , A61M2210/125 , A61M2230/04
摘要： A catheter device comprising a proboscis shaft and a proboscis disposed within the proboscis shaft. In certain embodiments, the catheter device further comprises an elongate tubular member, wherein the proboscis shaft is disposed within the elongate tubular member. In certain embodiments, the catheter device comprises a tissue surface engagement structure, which has a first configuration and a second configuration. In the second configuration, the tissue surface engagement structure presents a larger transverse profile in comparison to the first configuration. The tissue surface engagement structure may have any of various designs, including an expandable assembly and a hinged assembly. In certain embodiments, a deformable cushion is positioned at the distal end of the proboscis shaft. The deformable cushion comprises a pocket that is filled with a reshapeable material. In certain embodiments, the proboscis shaft comprises a longitudinally compressible portion.
摘要翻译： 导管装置，其包括设置在所述长鼻轴内的长鼻轴和长鼻。 在某些实施例中，导管装置还包括细长管状构件，其中，长鼻管轴设置在细长管状构件内。 在某些实施例中，导管装置包括具有第一构造和第二构造的组织表面接合结构。 在第二构造中，与第一构造相比，组织表面接合结构呈现较大的横向轮廓。 组织表面接合结构可以具有各种设计中的任何一种，包括可扩张组件和铰接组件。 在某些实施例中，可变形缓冲垫位于长鼻杆的远端。 可变形的衬垫包括一个填充有可再形成材料的口袋。 在某些实施例中，长鼻杆包括纵向可压缩部分。
-
公开(公告)号：US07544183B2
公开(公告)日：2009-06-09
申请号：US11360764
申请日：2006-02-24
申请人： Matthew Hawk , Scott Larson , Timothy J. Mickley , Chad Harris
发明人： Matthew Hawk , Scott Larson , Timothy J. Mickley , Chad Harris
IPC分类号： A61M5/178
CPC分类号： A61M25/0069 , A61B17/3478 , A61B2017/00247 , A61B2017/22069 , A61B2017/22077 , A61B2017/348 , A61B2017/3488 , A61B2018/00392 , A61B2018/00738 , A61B2090/036 , A61B2218/002 , A61M25/10 , A61M2025/1093
摘要： An elongate medical device that may be used for performing medical procedures on a patient is provided. This elongate medical device may include a first member having a distal end, an outer surface, and a first lumen, where the first member may have an elongated configuration such that the length of the first member is at least ten times greater than the width of the first member. The elongate medical device may also have a second member positioned within the first member and a hood stop. The hood stop in this device may be positioned within the first member and may have a distal region and a shoulder region where the shoulder region may be configured to limit the travel of the first member or the second member past the hood stop.
摘要翻译： 提供了可用于对患者执行医疗程序的细长医疗装置。 该细长的医疗装置可以包括具有远端，外表面和第一内腔的第一构件，其中第一构件可以具有细长构造，使得第一构件的长度比第一构件的宽度大至少十倍 第一个成员。 细长医疗装置还可以具有定位在第一构件内的第二构件和罩止动件。 该装置中的罩止挡件可以定位在第一构件内并且可以具有远侧区域和肩部区域，其中肩部区域可以被配置为限制第一构件或第二构件经过罩止挡件的移动。
-
公开(公告)号：US06595958B1
公开(公告)日：2003-07-22
申请号：US09634117
申请日：2000-08-08
申请人： Timothy J. Mickley
发明人： Timothy J. Mickley
IPC分类号： A61M5178
CPC分类号： A61M25/0136 , A61M25/0041 , A61M25/0084 , A61M25/0133 , A61M25/0662 , A61M2025/0089 , A61M2025/0681
摘要： Devices and methods for delivering therapeutic or diagnostic agents to a target tissue of a human body are disclosed. A catheter in accordance with the present invention includes an elongate shaft having a distal end, a proximal end, and a lumen therethrough. The elongate shaft includes a first curved portion proximate the distal end of the elongate shaft. The first curved portion of the elongate shaft defines a first plane. The elongate shaft also includes a second curved portion disposed between the distal end of the elongate shaft and the first curved portion of the elongate shaft. The second curved portion of the elongate shaft defines a second plane. The second plane intersects the first plane at an angle.
-
公开(公告)号：US06582400B1
公开(公告)日：2003-06-24
申请号：US09695527
申请日：2000-10-24
申请人： Matthew Hawk , Scott Larson , Timothy J. Mickley , Chad Harris
发明人： Matthew Hawk , Scott Larson , Timothy J. Mickley , Chad Harris
IPC分类号： A61M5178
CPC分类号： A61M25/0069 , A61B17/3478 , A61B2017/00247 , A61B2017/22069 , A61B2017/22077 , A61B2017/348 , A61B2017/3488 , A61B2018/00392 , A61B2018/00738 , A61B2090/036 , A61B2218/002 , A61M25/10 , A61M2025/1093
摘要： Therapeutic catheters for increasing myocardial blood perfusion in procedures including percutaneous myocardial revascularization (PMR), which can include tips for cutting into the myocardium to stimulate a healing response and/or for injecting angiogenic substances. PMR catheters can include an outer shaft slidably housing an inner shaft having a distal therapeutic tip. The outer shaft can be slidably disposed in a guide catheter and have an expandable atraumatic distal tip for presenting an enlarged distal profile against the heart chamber wall. The enlarged atraumatic profile can reduce the likelihood of the outer shaft penetrating undesirably into the myocardium. One expandable distal tip expands radially when forced against the endocardium. Another expandable tip expands when unconstrained by the guide catheter. Yet another expandable tip expands when manipulated by an elongate manipulation member.
摘要翻译： 用于在包括经皮心肌血运重建（PMR）的手术中增加心肌血液灌注的治疗导管，其可以包括切入心肌以刺激愈合反应和/或注射血管生成物质的尖端。 PMR导管可以包括可滑动地容纳具有远侧治疗末端的内轴的外轴。 外轴可以可滑动地设置在引导导管中并且具有可膨胀的无创伤的远侧末端，用于呈现抵靠心室壁的扩大的远端轮廓。 扩大的无创伤轮廓可以减少外轴不期望地进入心肌的可能性。 一个可扩展的远侧末端在被迫靠在心内膜上时径向扩张。 当引导导管不受约束时，另一个可扩展的尖端膨胀。 当由细长的操纵构件操纵时，另一个可膨胀尖端膨胀。
-
公开(公告)号：US06530914B1
公开(公告)日：2003-03-11
申请号：US09695525
申请日：2000-10-24
申请人： Timothy J. Mickley
发明人： Timothy J. Mickley
IPC分类号： A61M2501
CPC分类号： A61M25/0147 , A61M25/0662 , A61M2025/0063 , A61M2025/0161
摘要： Guide catheters which can be used in percutaneous myocardial revascularization (PMR) to deliver therapeutic catheters to difficult to reach heart chamber wall regions. Some guide catheters include distal regions which can be bent under control from the proximal region of the catheter. One steerable guide catheter has a flexible distal region, a more proximal, less flexible intermediate region, a first lumen for receiving a therapeutic catheter, and an elongate manipulation member slidably disposed in a second, blind lumen. The elongate manipulation member can be secured off-center near the distal end of the flexible distal region. The distal region can be bent by retracting the manipulation member and straightened by pushing the manipulation member. Controllably bendable guide catheters according to the present invention can be nested inside other, similar guide catheters. The invention also includes means for resisting free rotation of guide catheters relative to other adjacent catheters or tubes.
-
公开(公告)号：US08740844B2
公开(公告)日：2014-06-03
申请号：US10645653
申请日：2003-08-20
CPC分类号： A61M29/02 , A61M25/1029 , A61M2025/0057 , A61M2025/105
摘要： The present invention generally relates to a medical device for delivering a therapeutic agent to an internal portion of a patient's body. The medical device includes a shaft and a self-expanding delivery member in operative communication with the shaft. The delivery member is shaped from a porous material that is capable of releasing a therapeutic agent to an internal portion of a patient's body. The medical device further includes a therapeutic agent delivery lumen in fluid communication with the delivery member to fluidly connect the delivery member with a therapeutic agent source. A retention member may also be provided to selectively collapse the delivery member.
摘要翻译： 本发明一般涉及用于将治疗剂递送到患者身体的内部的医疗装置。 该医疗装置包括轴和与该轴可操作地连通的自扩张输送构件。 递送构件由能够将治疗剂释放到患者身体的内部的多孔材料成形。 医疗装置还包括与递送构件流体连通以将递送构件与治疗剂源流体连接的治疗剂递送腔。 还可以设置保持构件以选择性地折叠输送构件。
-
-
-
-
-
-
-
-
-
搜索结果
53 条记录 (耗时 0.029 秒)
